Aliases for ENSG00000264813 Gene

Aliases for ENSG00000264813 Gene

  • Angiotensin-Converting Enzyme 13
  • Novel Protein 5
  • AC113554.1 5
  • EC 3.4.-.- 13

External Ids for ENSG00000264813 Gene

Previous GeneCards Identifiers for ENSG00000264813 Gene

  • GC17P061562

Summaries for ENSG00000264813 Gene

GeneCards Summary for ENSG00000264813 Gene

ENSG00000264813 is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include metallopeptidase activity and peptidyl-dipeptidase activity. An important paralog of this gene is ACE.

Additional gene information for ENSG00000264813 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ENSG00000264813 Gene

Genomics for ENSG00000264813 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ENSG00000264813 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J063484 Promoter/Enhancer 0.9 EPDnew ENCODE 600.7 +0.1 68 0.1 CREB1 GTF2F1 ZNF444 NFYB RAD21 CTCF RFX5 TFAP4 ZNF687 ELF1 ENSG00000264813 ACE CYB561 DCAF7 TACO1 ACE3P KCNH6
GH17J063486 Promoter 0.5 EPDnew 600.7 +1.8 1788 0.1 ZNF600 EGR2 ENSG00000264813 ACE CYB561 DCAF7 TACO1 ACE3P KCNH6
GH17J063497 Enhancer 1 Ensembl ENCODE 0.4 +16.4 16362 7.6 HNRNPL CREB1 GATAD2A CTCF ZBTB33 TFE3 TARDBP ZIC2 RXRB HES1 KCNH6 ACE FTSJ3 ACE3P ENSG00000264813
GH17J063518 Enhancer 1.1 Ensembl ENCODE 0.3 +35.7 35684 5 CREB1 GATAD2A REST TFE3 SOX13 NFKBIZ RCOR2 RXRB IRF2 SP1 FTSJ3 KCNH6 ACE3P ENSG00000264813
GH17J063517 Enhancer 1 Ensembl ENCODE 0.3 +32.4 32365 0.8 CREB1 GATAD2A ATF7 PRDM10 TFE3 JUND RXRB IRF2 IKZF2 GABPA DDX5 SMARCD2 FTSJ3 POLG2 CEP95 EEF1DP7 DCAF7 ACE PPIAP55 MAP3K3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ENSG00000264813 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for ENSG00000264813 Gene

Genomic Locations for ENSG00000264813 Gene
chr17:63,484,823-63,521,848
(GRCh38/hg38)
Size:
37,026 bases
Orientation:
Plus strand
chr17:61,562,184-61,599,209
(GRCh37/hg19)
Size:
37,026 bases
Orientation:
Plus strand

Genomic View for ENSG00000264813 Gene

Genes around ENSG00000264813 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENSG00000264813 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENSG00000264813 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

No data available for RefSeq DNA sequence for ENSG00000264813 Gene

Proteins for ENSG00000264813 Gene

  • Protein details for ENSG00000264813 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    F6X3S4-F6X3S4_HUMAN
    Recommended name:
    Angiotensin-converting enzyme
    Protein Accession:
    F6X3S4
    Secondary Accessions:
    • L7MUH0

    Protein attributes for ENSG00000264813 Gene

    Size:
    739 amino acids
    Molecular mass:
    83989 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for ENSG00000264813 Gene

Post-translational modifications for ENSG00000264813 Gene

No Post-translational modifications

Other Protein References for ENSG00000264813 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for ENSG00000264813 Gene

Domains & Families for ENSG00000264813 Gene

Gene Families for ENSG00000264813 Gene

Unknown:
  • Belongs to the peptidase M2 family.

Protein Domains for ENSG00000264813 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with ENSG00000264813: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ENSG00000264813 Gene

Function for ENSG00000264813 Gene

Enzyme Numbers (IUBMB) for ENSG00000264813 Gene

Phenotypes From GWAS Catalog for ENSG00000264813 Gene

Gene Ontology (GO) - Molecular Function for ENSG00000264813 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004180 carboxypeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IBA --
GO:0008238 exopeptidase activity IBA --
GO:0008239 dipeptidyl-peptidase activity IBA --
genes like me logo Genes that share ontologies with ENSG00000264813: view

No data available for Molecular function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ENSG00000264813 Gene

Localization for ENSG00000264813 Gene

Gene Ontology (GO) - Cellular Components for ENSG00000264813 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ENSG00000264813: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for ENSG00000264813 Gene

Pathways & Interactions for ENSG00000264813 Gene

PathCards logo

SuperPathways for ENSG00000264813 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ENSG00000264813 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin IBA --
GO:0003084 positive regulation of systemic arterial blood pressure IBA --
GO:0006508 proteolysis IEA --
GO:0045777 positive regulation of blood pressure IBA --
genes like me logo Genes that share ontologies with ENSG00000264813: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for ENSG00000264813 Gene

Drugs & Compounds for ENSG00000264813 Gene

No Compound Related Data Available

Transcripts for ENSG00000264813 Gene

mRNA/cDNA for ENSG00000264813 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ENSG00000264813 Gene

No ASD Table

Relevant External Links for ENSG00000264813 Gene

GeneLoc Exon Structure for
ENSG00000264813

Expression for ENSG00000264813 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENSG00000264813 Gene

Orthologs for ENSG00000264813 Gene

This gene was present in the common ancestor of animals.

Orthologs for ENSG00000264813 Gene

Organism Taxonomy Gene Similarity Type Details
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 56 (a)
OneToMany
Chimpanzee
(Pan troglodytes)
Mammalia ACE 31
  • 47 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 42 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia ACE 31
  • 41 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Ace 31
  • 39 (a)
OneToMany
Chicken
(Gallus gallus)
Aves ACE 31
  • 33 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 32 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii ace 31
  • 31 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Ance 31
  • 43 (a)
ManyToMany
Acer 31
  • 39 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea acn-1 31
  • 20 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 53 (a)
ManyToMany
-- 31
  • 46 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
Species where no ortholog for ENSG00000264813 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for ENSG00000264813 Gene

ENSEMBL:
Gene Tree for ENSG00000264813 (if available)
TreeFam:
Gene Tree for ENSG00000264813 (if available)

Paralogs for ENSG00000264813 Gene

Paralogs for ENSG00000264813 Gene

genes like me logo Genes that share paralogs with ENSG00000264813: view

Variants for ENSG00000264813 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Additional Variant Information for ENSG00000264813 Gene

Disorders for ENSG00000264813 Gene

No disorders were found for ENSG00000264813 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for ENSG00000264813 Gene

Publications for ENSG00000264813 Gene

  1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 13

No data available for Mastermind for ENSG00000264813 Gene

Products for ENSG00000264813 Gene

Sources for ENSG00000264813 Gene