Aliases for ENSG00000256206 Gene

Aliases for ENSG00000256206 Gene

  • Proteasome Subunit Alpha Type 13
  • Novel Protein 5
  • EC 3.4.25.1 13
  • AC018523.2 5

External Ids for ENSG00000256206 Gene

Previous GeneCards Identifiers for ENSG00000256206 Gene

  • GC11M014515

Summaries for ENSG00000256206 Gene

GeneCards Summary for ENSG00000256206 Gene

ENSG00000256206 is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include endopeptidase activity and threonine-type endopeptidase activity. An important paralog of this gene is PSMA1.

Additional gene information for ENSG00000256206 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ENSG00000256206 Gene

Genomics for ENSG00000256206 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ENSG00000256206 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J014518 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.2 215 3.3 SP1 HNRNPL CREB1 PRDM10 REST SIX5 IKZF1 NFKBIZ POLR2A TARDBP ENSG00000256206 lnc-PDE3B-6 lnc-PSMA1-2 PSMA1 COPB1 SPON1 RRAS2
GH11J014498 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 0.4 +20.5 20511 3.7 SP1 HNRNPL CREB1 GATAD2A REST TFE3 ZNF512 SOX13 NFKBIZ POLR2A COPB1 lnc-PSMA1-3 RNU7-49P MN309230 ENSG00000256206 RRAS2
GH11J014536 Enhancer 0.9 FANTOM5 ENCODE 0.4 -17.1 -17089 1.2 CTCF JUND NR2C1 RAD21 TRIM22 SOX6 RELB SMC3 EP400 NR2F2 PSMA1 PDE3B COPB1 lnc-COPB1-35 piR-32559-064 ENSG00000256206
GH11J014577 Enhancer 1.3 FANTOM5 Ensembl ENCODE 0.2 -59.3 -59257 5.2 GATAD2A JUND ETV6 GABPA RXRB IRF2 IKZF2 SP1 HDAC1 FOXJ2 PDE3B COPB1 PSMA1 CYP2R1 piR-31534-093 piR-34696-003 ENSG00000256206
GH11J014544 Enhancer 0.8 ENCODE 0.4 -24.4 -24386 0.2 BACH1 ZNF24 IKZF2 GATAD2B ARID3A RUNX3 NFE2 CEBPB ZNF316 YY1 PDE3B PSMA1 lnc-COPB1-35 ENSG00000256206 piR-37972-093
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ENSG00000256206 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for ENSG00000256206 Gene

Genomic Locations for ENSG00000256206 Gene
chr11:14,493,783-14,520,344
(GRCh38/hg38)
Size:
26,562 bases
Orientation:
Minus strand
chr11:14,515,329-14,541,890
(GRCh37/hg19)
Size:
26,562 bases
Orientation:
Minus strand

Genomic View for ENSG00000256206 Gene

Genes around ENSG00000256206 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENSG00000256206 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENSG00000256206 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

No data available for RefSeq DNA sequence for ENSG00000256206 Gene

Proteins for ENSG00000256206 Gene

  • Protein details for ENSG00000256206 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    B4DEV8-B4DEV8_HUMAN
    Recommended name:
    Proteasome subunit alpha type
    Protein Accession:
    B4DEV8

    Protein attributes for ENSG00000256206 Gene

    Size:
    164 amino acids
    Molecular mass:
    18458 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

neXtProt entry for ENSG00000256206 Gene

Protein Expression for ENSG00000256206 Gene

Post-translational modifications for ENSG00000256206 Gene

No Post-translational modifications

Other Protein References for ENSG00000256206 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for ENSG00000256206 Gene

Domains & Families for ENSG00000256206 Gene

Gene Families for ENSG00000256206 Gene

Unknown:
  • Belongs to the peptidase T1A family.

Protein Domains for ENSG00000256206 Gene

genes like me logo Genes that share domains with ENSG00000256206: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ENSG00000256206 Gene

Function for ENSG00000256206 Gene

Molecular function for ENSG00000256206 Gene

UniProtKB/TrEMBL CatalyticActivity:
Reaction=Cleavage of peptide bonds with very broad specificity.; EC=3.4.25.1; Evidence={ECO:0000256|RuleBase:RU000551};.
  • B4DEV8

Enzyme Numbers (IUBMB) for ENSG00000256206 Gene

Phenotypes From GWAS Catalog for ENSG00000256206 Gene

Gene Ontology (GO) - Molecular Function for ENSG00000256206 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IBA --
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ENSG00000256206: view

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ENSG00000256206 Gene

Localization for ENSG00000256206 Gene

Gene Ontology (GO) - Cellular Components for ENSG00000256206 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IEA --
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005839 proteasome core complex IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ENSG00000256206: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for ENSG00000256206 Gene

Pathways & Interactions for ENSG00000256206 Gene

PathCards logo

SuperPathways for ENSG00000256206 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ENSG00000256206 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0010498 proteasomal protein catabolic process IBA --
GO:0010499 proteasomal ubiquitin-independent protein catabolic process IBA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with ENSG00000256206: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for ENSG00000256206 Gene

Drugs & Compounds for ENSG00000256206 Gene

No Compound Related Data Available

Transcripts for ENSG00000256206 Gene

mRNA/cDNA for ENSG00000256206 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ENSG00000256206 Gene

No ASD Table

Relevant External Links for ENSG00000256206 Gene

GeneLoc Exon Structure for
ENSG00000256206

Expression for ENSG00000256206 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ENSG00000256206 Gene

mRNA expression in normal human tissues for ENSG00000256206 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from MOPED for ENSG00000256206 Gene



Protein tissue co-expression partners for ENSG00000256206 Gene

genes like me logo Genes that share expression patterns with ENSG00000256206: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENSG00000256206 Gene

Orthologs for ENSG00000256206 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ENSG00000256206 Gene

Organism Taxonomy Gene Similarity Type Details
Mouse
(Mus musculus)
Mammalia Psma1 31
  • 47 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia PSMA1 31
  • 47 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 47 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 46 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 7 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves PSMA1 31
  • 46 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 46 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii psma1 31
  • 46 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Pros35 31
  • 27 (a)
ManyToMany
Prosalpha6T 31
  • 25 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea pas-6 31
  • 28 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRE5 31
  • 29 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.5765 31
  • 35 (a)
OneToMany
Species where no ortholog for ENSG00000256206 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for ENSG00000256206 Gene

ENSEMBL:
Gene Tree for ENSG00000256206 (if available)
TreeFam:
Gene Tree for ENSG00000256206 (if available)

Paralogs for ENSG00000256206 Gene

Pseudogenes.org Pseudogenes for ENSG00000256206 Gene

genes like me logo Genes that share paralogs with ENSG00000256206: view

Variants for ENSG00000256206 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Additional Variant Information for ENSG00000256206 Gene

Disorders for ENSG00000256206 Gene

No disorders were found for ENSG00000256206 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for ENSG00000256206 Gene

Publications for ENSG00000256206 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 13

No data available for Mastermind for ENSG00000256206 Gene

Products for ENSG00000256206 Gene

Sources for ENSG00000256206 Gene