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Aliases for ENSG00000255292 Gene

Aliases for ENSG00000255292 Gene

  • AP002884.3 5

External Ids for ENSG00000255292 Gene

Previous GeneCards Identifiers for ENSG00000255292 Gene

  • GC11P111957

Summaries for ENSG00000255292 Gene

GeneCards Summary for ENSG00000255292 Gene

ENSG00000255292 is a Protein Coding gene. Diseases associated with ENSG00000255292 include Mitochondrial Complex Ii Deficiency and Endocrine Gland Cancer. An important paralog of this gene is SDHD.

Additional gene information for ENSG00000255292 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENSG00000255292 Gene

Genomics for ENSG00000255292 Gene

GeneHancer (GH) Regulatory Elements for ENSG00000255292 Gene

Promoters and enhancers for ENSG00000255292 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J112085 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 -0.1 -141 2.5 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SDHD TIMM8B ENSG00000255292 PPP2R1B PIR48704
GH11J111934 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.7 -146.8 -146838 11.8 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 DIXDC1 BCO2 PPP2R1B SDHD C11orf52 HSPB2 HSPB2-C11orf52 ENSG00000255292 TIMM8B FDXACB1
GH11J112155 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 10.8 +74.6 74639 11.5 FOXA2 SIN3A FEZF1 BRCA1 ETS1 YY1 ZFP91 ATF7 FOS RXRA IL18 BCO2 TIMM8B ENSG00000255292 SDHD C11orf88 ENSG00000254638
GH11J112225 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.8 +141.3 141333 5.3 FOXA2 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF143 FOS SP3 PTS LOC283140 PLET1 TIMM8B ENSG00000255292 SDHD BCO2 RPS6P16
GH11J112174 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 10.7 +88.8 88811 2.2 HDAC1 PKNOX1 ATF1 INSM2 ARID4B SIN3A BMI1 RAD21 RARA YY1 BCO2 SDHD TIMM8B ENSG00000255292 KCTD9P4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ENSG00000255292 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ENSG00000255292 Gene

Genomic Locations for ENSG00000255292 Gene
chr11:112,086,903-112,193,805
(GRCh38/hg38)
Size:
106,903 bases
Orientation:
Plus strand
chr11:111,957,627-112,064,528
(GRCh37/hg19)
Size:
106,902 bases
Orientation:
Plus strand

Genomic View for ENSG00000255292 Gene

Genes around ENSG00000255292 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENSG00000255292 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENSG00000255292 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

No data available for RefSeq DNA sequence for ENSG00000255292 Gene

Proteins for ENSG00000255292 Gene

  • Protein details for ENSG00000255292 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H3BRW5-H3BRW5_HUMAN
    Recommended name:
    Succinate dehydrogenase [ubiquinone] cytochrome b small subunit
    Protein Accession:
    H3BRW5

    Protein attributes for ENSG00000255292 Gene

    Size:
    140 amino acids
    Molecular mass:
    15501 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ENSG00000255292 Gene

Post-translational modifications for ENSG00000255292 Gene

No Post-translational modifications

Other Protein References for ENSG00000255292 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for ENSG00000255292 Gene

Domains & Families for ENSG00000255292 Gene

Gene Families for ENSG00000255292 Gene

Unknown:
  • Belongs to the CybS family.

Protein Domains for ENSG00000255292 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ENSG00000255292: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ENSG00000255292 Gene

Function for ENSG00000255292 Gene

Molecular function for ENSG00000255292 Gene

UniProtKB/TrEMBL Function:
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
  • H3BRW5

Gene Ontology (GO) - Molecular Function for ENSG00000255292 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008177 succinate dehydrogenase (ubiquinone) activity IBA --
GO:0020037 heme binding IBA --
GO:0046872 metal ion binding IEA --
GO:0048039 ubiquinone binding IBA --
genes like me logo Genes that share ontologies with ENSG00000255292: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ENSG00000255292 Gene

Localization for ENSG00000255292 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ENSG00000255292 gene
Compartment Confidence
mitochondrion 3
nucleus 1

Gene Ontology (GO) - Cellular Components for ENSG00000255292 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005740 mitochondrial envelope IEA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ENSG00000255292: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ENSG00000255292 Gene

Pathways & Interactions for ENSG00000255292 Gene

SuperPathways for ENSG00000255292 Gene

No Data Available

Interacting Proteins for ENSG00000255292 Gene

Gene Ontology (GO) - Biological Process for ENSG00000255292 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006099 tricarboxylic acid cycle IBA --
GO:0006121 mitochondrial electron transport, succinate to ubiquinone IBA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with ENSG00000255292: view

No data available for Pathways by source and SIGNOR curated interactions for ENSG00000255292 Gene

Drugs & Compounds for ENSG00000255292 Gene

No Compound Related Data Available

Transcripts for ENSG00000255292 Gene

mRNA/cDNA for ENSG00000255292 Gene

(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(5) RNA Central transcripts :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ENSG00000255292 Gene

No ASD Table

Relevant External Links for ENSG00000255292 Gene

GeneLoc Exon Structure for
ENSG00000255292

Expression for ENSG00000255292 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ENSG00000255292 Gene

mRNA expression in normal human tissues for ENSG00000255292 Gene

Evidence on tissue expression from TISSUES for ENSG00000255292 Gene

  • Adrenal gland(2.7)
genes like me logo Genes that share expression patterns with ENSG00000255292: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENSG00000255292 Gene

Orthologs for ENSG00000255292 Gene

This gene was present in the common ancestor of animals.

Orthologs for ENSG00000255292 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SDHD 34
  • 59 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Sdhd 34
  • 54 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 44 (a)
OneToMany
chicken
(Gallus gallus)
Aves SDHD 34
  • 39 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 46 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii sdhdb 34
  • 35 (a)
ManyToMany
sdhda 34
  • 33 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10219 34
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sdhd-1 34
  • 19 (a)
OneToMany
Species where no ortholog for ENSG00000255292 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ENSG00000255292 Gene

ENSEMBL:
Gene Tree for ENSG00000255292 (if available)
TreeFam:
Gene Tree for ENSG00000255292 (if available)

Paralogs for ENSG00000255292 Gene

Paralogs for ENSG00000255292 Gene

genes like me logo Genes that share paralogs with ENSG00000255292: view

Variants for ENSG00000255292 Gene

Variation tolerance for ENSG00000255292 Gene

Gene Damage Index Score: 3.30; 53.17% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Additional Variant Information for ENSG00000255292 Gene

Disorders for ENSG00000255292 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ENSG00000255292 Gene - From: DISEASES

Disorder Aliases PubMed IDs
mitochondrial complex ii deficiency
  • succinate coq reductase deficiency
endocrine gland cancer
  • endocrine neoplasm
lymph node disease
  • disorder of lymph node
lymphatic system disease
  • adenopathy
cerebellopontine angle tumor
  • neoplasm of the cerebellopontine angle
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ENSG00000255292: view

No data available for UniProtKB/Swiss-Prot , Genatlas and External Links for ENSG00000255292 Gene

Publications for ENSG00000255292 Gene

No publications were found for ENSG00000255292 Gene.

Products for ENSG00000255292 Gene

Sources for ENSG00000255292 Gene

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