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Aliases for ENSG00000212598 Gene

Subcategory (RNA class) for ENSG00000212598 Gene

snoRNA

Quality Score for this RNA gene is

15

Aliases for ENSG00000212598 Gene

  • RF00012 5

External Ids for ENSG00000212598 Gene

Previous GeneCards Identifiers for ENSG00000212598 Gene

  • GC03P090164

Summaries for ENSG00000212598 Gene

GeneCards Summary for ENSG00000212598 Gene

ENSG00000212598 is an RNA Gene, and is affiliated with the snoRNA class.

fRNAdb sequence ontologies for ENSG00000212598 Gene - the ORGUL cluster for this gene includes several descriptions:

  • U3_snoRNA: U3 snoRNA is a member of the box C/D class of small nucleolar RNAs. The U3 snoRNA secondary structure is characterised by a small 5' domain (with boxes A and A'), and a larger 3' domain (with boxes B, C, C', and D), the two domains being linked by a single-stranded hinge. Boxes B and C form the B/C motif, which appears to be exclusive to U3 snoRNAs, and boxes C' and D form the C'/D motif. The latter is functionally similar to the C/D motifs found in other snoRNAs. The 5' domain and the hinge region act as a pre-rRNA-binding domain. The 3' domain has conserved protein-binding sites. Both the box B/C and box C'/D motifs are sufficient for nuclear retention of U3 snoRNA. The box C'/D motif is also necessary for nucleolar localization, stability and hypermethylation of U3 snoRNA. Both box B/C and C'/D motifs are involved in specific protein interactions and are necessary for the rRNA processing functions of U3 snoRNA.

  • Small nucleolar RNA U3: Small nucleolar RNAs (snoRNAs) are involved in the processing and modification of rRNA in the nucleolus. There are two main classes of snoRNAs: the box C/D class, and the box H/ACA class. U3 snoRNA is a member of the box C/D class. Indeed, the box C/D element is a subset of the six short sequence elements found in all U3 snoRNAs, namely boxes A, A', B, C, C', and D. The U3 snoRNA secondary structure is characterised by a small 5' domain (with boxes A and A'), and a larger 3' domain (with boxes B, C, C', and D), the two domains being linked by a single-stranded hinge. Boxes B and C form the B/C motif, which appears to be exclusive to U3 snoRNAs, and boxes C' and D form the C'/D motif. The latter is functionally similar to the C/D motifs found in other snoRNAs. The 5' domain and the hinge region act as a pre-rRNA-binding domain. The 3' domain has conserved protein-binding sites. Both the box B/C and box C'/D motifs are sufficient for nuclear retention of U3 snoRNA. The box C'/D motif is also necessary for nucleolar localisation, stability and hyper-methylation of U3 snoRNA. Both box B/C and C'/D motifs are involved in specific protein interactions and are necessary for the rRNA processing functions of U3 snoRNA.

View fRNAdb secondary structures for ENSG00000212598

Additional gene information for ENSG00000212598 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for ENSG00000212598 Gene

Genomics for ENSG00000212598 Gene

GeneHancer (GH) Regulatory Elements for ENSG00000212598 Gene

Promoters and enhancers for ENSG00000212598 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J090009 Enhancer 0.7 Ensembl ENCODE 0.4 -19.6 -19605 2.1 HLF IKZF1 CEBPA CEBPB HNF4A DPF2 ENSG00000212598 GC03P089984
GH03J090015 Enhancer 0.7 Ensembl ENCODE 0.4 -14.1 -14141 1.9 IKZF1 MZF1 EBF1 MEF2B FOS IKZF2 FOXA1 ENSG00000212598 GC03P089984
GH03J090052 Enhancer 0.5 ENCODE 0.3 +24.5 24501 4.9 POLR2A IKZF1 TRIM22 ATF7 DPF2 IKZF2 GC03P090056 ENSG00000212598
GH03J090007 Enhancer 0.4 Ensembl 0.3 -22.3 -22260 0.8 GATA3 POLR2A ENSG00000212598 GC03P089984
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ENSG00000212598 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ENSG00000212598 Gene

Genomic Locations for ENSG00000212598 Gene
chr3:90,030,284-90,030,495
(GRCh38/hg38)
Size:
212 bases
Orientation:
Plus strand
chr3:90,079,434-90,079,644
(GRCh37/hg19)

Genomic View for ENSG00000212598 Gene

Genes around ENSG00000212598 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENSG00000212598 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENSG00000212598 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

ORGUL Member Location for ENSG00000212598 Gene

ORGUL Member Location for ENSG00000212598 gene

No data available for RefSeq DNA sequence for ENSG00000212598 Gene

Proteins for ENSG00000212598 Gene

Post-translational modifications for ENSG00000212598 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ENSG00000212598 Gene

Domains & Families for ENSG00000212598 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ENSG00000212598 Gene

Function for ENSG00000212598 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ENSG00000212598 Gene

Localization for ENSG00000212598 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ENSG00000212598 Gene

Pathways & Interactions for ENSG00000212598 Gene

SuperPathways for ENSG00000212598 Gene

No Data Available

Interacting Proteins for ENSG00000212598 Gene

Gene Ontology (GO) - Biological Process for ENSG00000212598 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ENSG00000212598 Gene

Drugs & Compounds for ENSG00000212598 Gene

No Compound Related Data Available

Transcripts for ENSG00000212598 Gene

fRNAdb Secondary structures for ENSG00000212598 Gene

  • RF00012;U3;DAAB013726380.1/1083-872

mRNA/cDNA for ENSG00000212598 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ENSG00000212598 Gene

No ASD Table

Relevant External Links for ENSG00000212598 Gene

GeneLoc Exon Structure for
ENSG00000212598

Expression for ENSG00000212598 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ENSG00000212598 Gene

genes like me logo Genes that share expression patterns with ENSG00000212598: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENSG00000212598 Gene

Orthologs for ENSG00000212598 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ENSG00000212598 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia U3 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia U3 34
  • 72 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia U3 34
  • 72 (a)
ManyToMany
Species where no ortholog for ENSG00000212598 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ENSG00000212598 Gene

ENSEMBL:
Gene Tree for ENSG00000212598 (if available)
TreeFam:
Gene Tree for ENSG00000212598 (if available)

Paralogs for ENSG00000212598 Gene

No data available for Paralogs for ENSG00000212598 Gene

Variants for ENSG00000212598 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Additional Variant Information for ENSG00000212598 Gene

Disorders for ENSG00000212598 Gene

No disorders were found for ENSG00000212598 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for ENSG00000212598 Gene

Publications for ENSG00000212598 Gene

  1. Nuclear retention elements of U3 small nucleolar RNA. (PMID: 10567566) Speckmann W … Terns MP (Molecular and cellular biology 1999) 1
  2. The uRNA database. (PMID: 9016512) Zwieb C (Nucleic acids research 1997) 1

Products for ENSG00000212598 Gene

Sources for ENSG00000212598 Gene

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