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ENPP6 Gene(Protein Coding)

Ectonucleotide Pyrophosphatase/Phosphodiesterase 6

GCID:
GC04M184088
GIFtS:
44
Genes Participants
UDN Logo

Aliases for ENPP6 Gene

Aliases for ENPP6 Gene

  • Ectonucleotide Pyrophosphatase/Phosphodiesterase 6 2 3 5
  • Choline-Specific Glycerophosphodiester Phosphodiesterase 3 4
  • Glycerophosphocholine Cholinephosphodiesterase 3 4
  • GPC-Cpde 3 4
  • E-NPP 6 3 4
  • NPP-6 3 4
  • Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 6 3
  • B830047L21Rik 3
  • EC 3.1.4.38 4
  • EC 3.1.4.- 4
  • NPP6 3

External Ids for ENPP6 Gene

Previous GeneCards Identifiers for ENPP6 Gene

  • GC04M185705
  • GC04M185385
  • GC04M185246
  • GC04M185009
  • GC04M180764

Summaries for ENPP6 Gene

GeneCards Summary for ENPP6 Gene

ENPP6 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 6) is a Protein Coding gene. Among its related pathways are PI Metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include phosphoric diester hydrolase activity and glycerophosphocholine cholinephosphodiesterase activity. An important paralog of this gene is ENPP5.

UniProtKB/Swiss-Prot for ENPP6 Gene

  • Choline-specific glycerophosphodiester phosphodiesterase. The preferred substrate may be lysosphingomyelin (By similarity). Hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. Also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently. Hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine in vitro, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5-monophosphate. Does not hydrolyze diacyl phospholipids such as phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidylglycerol and phosphatidic acid.

Additional gene information for ENPP6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENPP6 Gene

Genomics for ENPP6 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for ENPP6 Gene

Promoters and enhancers for ENPP6 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH04I184217 Promoter/Enhancer 0.7 EPDnew Ensembl 550.8 +3.3 3329 0.2 ENPP6 GC04P184127
GH04I184313 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 6.6 -93.6 -93613 3.5 HDGF PKNOX1 SMAD1 KLF5 IRF4 ZNF143 ATF7 ETV6 BCLAF1 IKZF2 MYL12BP2 IRF2 ENSG00000251878 LINC02363 ENPP6 CASP3 GC04P184303
GH04I184287 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 5.6 -67.1 -67140 2.2 HDGF PKNOX1 FOXA2 SMAD1 ZFP64 ARID4B IRF4 ZNF143 ZNF207 ATF7 CASP3 IRF2 ENSG00000251878 PRIMPOL LINC02363 MYL12BP2 ENPP6 CENPU LOC105377582 RN7SL28P
GH04I184280 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 4.9 -61.2 -61218 4.5 HDGF PKNOX1 FOXA2 SMAD1 BMI1 BATF IRF4 RAD21 YY1 ZNF207 MYL12BP2 ENSG00000251878 LINC02363 ENPP6 CENPU CASP3 IRF2 RN7SL28P LOC105377582
GH04I184194 Enhancer 0.6 FANTOM5 11.6 +26.8 26826 0.4 CBX1 SMAD5 POLR2A ZBED1 ENPP6 GC04P184127
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ENPP6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ENPP6 gene promoter:

Genomic Locations for ENPP6 Gene

Genomic Locations for ENPP6 Gene
chr4:184,088,706-184,221,230
(GRCh38/hg38)
Size:
132,525 bases
Orientation:
Minus strand
chr4:185,009,859-185,142,383
(GRCh37/hg19)

Genomic View for ENPP6 Gene

Genes around ENPP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENPP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENPP6 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ENPP6 Gene

Proteins for ENPP6 Gene

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  • Protein details for ENPP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWR7-ENPP6_HUMAN
    Recommended name:
    Ectonucleotide pyrophosphatase/phosphodiesterase family member 6
    Protein Accession:
    Q6UWR7
    Secondary Accessions:
    • Q4W5Q1
    • Q96M57

    Protein attributes for ENPP6 Gene

    Size:
    440 amino acids
    Molecular mass:
    50241 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    • Homodimer; disulfide-linked.

neXtProt entry for ENPP6 Gene

Protein Expression for ENPP6 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ENPP6 Gene

  • Glycosylation at Asn100, Asn118, posLast=341341, and Asn404
  • Modification sites at PhosphoSitePlus

Other Protein References for ENPP6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ENPP6 Gene

Domains & Families for ENPP6 Gene

Gene Families for ENPP6 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for ENPP6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ENPP6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UWR7

UniProtKB/Swiss-Prot:

ENPP6_HUMAN :
  • Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
Family:
  • Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
genes like me logo Genes that share domains with ENPP6: view

Function for ENPP6 Gene

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  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
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  6. Cell Line

Molecular function for ENPP6 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=344 uM for GPC {ECO:0000269 PubMed:15788404}; KM=296 uM for 12:0-LPC {ECO:0000269 PubMed:15788404}; KM=440 uM for 14:0-LPC {ECO:0000269 PubMed:15788404}; KM=165 uM for 16:0-LPC {ECO:0000269 PubMed:15788404}; KM=434 uM for 18:2-LPC {ECO:0000269 PubMed:15788404}; KM=563 uM for 20:4-LPC {ECO:0000269 PubMed:15788404}; Vmax=484 nmol/min/mg enzyme with GPC as substrate {ECO:0000269 PubMed:15788404}; Vmax=463 nmol/min/mg enzyme with 12:0-LPC as substrate {ECO:0000269 PubMed:15788404}; Vmax=367 nmol/min/mg enzyme with 14:0-LPC as substrate {ECO:0000269 PubMed:15788404}; Vmax=89 nmol/min/mg enzyme with 16:0-LPC as substrate {ECO:0000269 PubMed:15788404}; Vmax=285 nmol/min/mg enzyme with 18:2-LPC as substrate {ECO:0000269 PubMed:15788404}; Vmax=470 nmol/min/mg enzyme with 20:4-LPC as substrate {ECO:0000269 PubMed:15788404}; pH dependence: Optimum pH is 8.5-7.5. {ECO:0000269 PubMed:15788404};
UniProtKB/Swiss-Prot CatalyticActivity:
A lysophosphatidylcholine + H(2)O = a monoacylglycerol + phosphocholine.
UniProtKB/Swiss-Prot CatalyticActivity:
sn-glycero-3-phosphocholine + H(2)O = glycerol + phosphocholine.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by EDTA and EGTA in vitro.
UniProtKB/Swiss-Prot Function:
Choline-specific glycerophosphodiester phosphodiesterase. The preferred substrate may be lysosphingomyelin (By similarity). Hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. Also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently. Hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine in vitro, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5-monophosphate. Does not hydrolyze diacyl phospholipids such as phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidylglycerol and phosphatidic acid.

Enzyme Numbers (IUBMB) for ENPP6 Gene

Phenotypes From GWAS Catalog for ENPP6 Gene

Gene Ontology (GO) - Molecular Function for ENPP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008081 phosphoric diester hydrolase activity IDA 15788404
GO:0008889 glycerophosphodiester phosphodiesterase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0047390 glycerophosphocholine cholinephosphodiesterase activity IEA,IDA 15788404
genes like me logo Genes that share ontologies with ENPP6: view
genes like me logo Genes that share phenotypes with ENPP6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ENPP6

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ENPP6 Gene

Localization for ENPP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENPP6 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Note=A small amount of the protein may be found in the extracellular milieu.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ENPP6 gene
Compartment Confidence
plasma membrane 5
extracellular 5
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ENPP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 15788404
GO:0005886 plasma membrane TAS,IEA --
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
GO:0070062 extracellular exosome HDA,IDA 19056867
genes like me logo Genes that share ontologies with ENPP6: view

Pathways & Interactions for ENPP6 Gene

genes like me logo Genes that share pathways with ENPP6: view

Pathways by source for ENPP6 Gene

1 KEGG pathway for ENPP6 Gene

Gene Ontology (GO) - Biological Process for ENPP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA,IDA 15788404
GO:0008152 metabolic process IEA --
GO:0016042 lipid catabolic process IEA --
GO:0019695 choline metabolic process IDA,IEA 15788404
GO:0046475 glycerophospholipid catabolic process TAS --
genes like me logo Genes that share ontologies with ENPP6: view

No data available for SIGNOR curated interactions for ENPP6 Gene

Drugs & Compounds for ENPP6 Gene

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  1. Drug

(4) Drugs for ENPP6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycerol Approved, Investigational Pharma 175
Water Approved Pharma 0
Choline alfoscerate Experimental, Investigational Pharma 0
Phosphorylcolamine Experimental Pharma 0

(63) Additional Compounds for ENPP6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Arachidonylglycerol
  • (5Z,8Z,11Z,14Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoate
  • (5Z,8Z,11Z,14Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoic acid
  • (all-Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoate
  • (all-Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoic acid
  • 1-Monoacylglyceride
 53847-30-6
MG(0:0/14:0/0:0)
  • 1-Monoacylglyceride
  • 1-Monoacylglycerol
  • 2-Myristoyl-glycerol
  • 2-Tetradecanoyl-rac-glycerol
  • b-Monoacylglycerol
MG(0:0/14:1(9Z)/0:0)
  • 1-Monoacylglyceride
  • 1-Monoacylglycerol
  • 2-(9Z-Tetradecenoyl)-rac-glycerol
  • 2-Myristoleoyl-glycerol
  • b-Monoacylglycerol
MG(0:0/15:0/0:0)
  • 1-Monoacylglyceride
  • 1-Monoacylglycerol
  • 2-Pentadecanoyl-glycerol
  • 2-Pentadecanoyl-rac-glycerol
  • b-Monoacylglycerol
MG(0:0/16:0/0:0)
  • 1-Monoacylglyceride
  • 1-Monoacylglycerol
  • 2-Hexadecanoyl-rac-glycerol
  • 2-Palmitoyl-glycerol
  • b-Monoacylglycerol
genes like me logo Genes that share compounds with ENPP6: view

Transcripts for ENPP6 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ENPP6 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(36) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ENPP6 Gene

Ectonucleotide pyrophosphatase/phosphodiesterase 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ENPP6 Gene

No ASD Table

Relevant External Links for ENPP6 Gene

GeneLoc Exon Structure for
ENPP6
ECgene alternative splicing isoforms for
ENPP6

Expression for ENPP6 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ENPP6 Gene

mRNA expression in normal human tissues for ENPP6 Gene
mRNA expression by GTEx for ENPP6 GenemRNA expression by BioGPS for ENPP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ENPP6 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x14.8), Brain - Substantia nigra (x7.0), and Nerve - Tibial (x4.8).

Protein differential expression in normal tissues from HIPED for ENPP6 Gene

This gene is overexpressed in Cerebral cortex (36.7) and Spinal cord (17.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ENPP6 Gene



NURSA nuclear receptor signaling pathways regulating expression of ENPP6 Gene:

ENPP6

SOURCE GeneReport for Unigene cluster for ENPP6 Gene:

Hs.297814

mRNA Expression by UniProt/SwissProt for ENPP6 Gene:

Q6UWR7-ENPP6_HUMAN
Tissue specificity: Predominantly expressed in kidney and brain. In the kidney, expressed specifically in the proximal tubules and thin descending limbs of Henle (at protein level).

Evidence on tissue expression from TISSUES for ENPP6 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with ENPP6: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENPP6 Gene

Orthologs for ENPP6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ENPP6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ENPP6 33 34
  • 99.17 (n)
dog
(Canis familiaris)
 Mammalia ENPP6 33 34
  • 90.05 (n)
rat
(Rattus norvegicus)
 Mammalia Enpp6 33
  • 86.35 (n)
mouse
(Mus musculus)
 Mammalia Enpp6 33 16 34
  • 85.48 (n)
cow
(Bos Taurus)
 Mammalia ENPP6 33 34
  • 84.77 (n)
oppossum
(Monodelphis domestica)
 Mammalia ENPP6 34
  • 79 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia ENPP6 34
  • 66 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves ENPP6 33 34
  • 72.52 (n)
lizard
(Anolis carolinensis)
 Reptilia ENPP6 34
  • 71 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia enpp6 33
  • 67.88 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.18662 33
zebrafish
(Danio rerio)
 Actinopterygii enpp6 33 34
  • 63.05 (n)
sbcb727 33
worm
(Caenorhabditis elegans)
 Secernentea T03G6.3 33 34
  • 40.82 (n)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes NPP2 34
  • 18 (a)
 ManyToMany
NPP1 34
  • 15 (a)
 ManyToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 32 (a)
 OneToOne
Species where no ortholog for ENPP6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ENPP6 Gene

ENSEMBL:
Gene Tree for ENPP6 (if available)
TreeFam:
Gene Tree for ENPP6 (if available)

Paralogs for ENPP6 Gene

Paralogs for ENPP6 Gene

(6) SIMAP similar genes for ENPP6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ENPP6: view

Variants for ENPP6 Gene

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Sequence variations from dbSNP and Humsavar for ENPP6 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000049854 -- 184,176,415(-) AAGTTAAGT/AAGT intron_variant
rs1000050911 -- 184,137,911(-) G/A/T intron_variant
rs1000080292 -- 184,100,582(-) C/T intron_variant
rs1000080694 -- 184,176,116(-) A/G intron_variant
rs1000095011 -- 184,094,928(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ENPP6 Gene

Variant ID Type Subtype PubMed ID
esv3336765 CNV duplication 20981092
esv3350511 CNV duplication 20981092
esv3417901 CNV duplication 20981092
esv3603454 CNV gain 21293372
nsv1026796 CNV gain 25217958
nsv1146419 CNV duplication 26484159
nsv475007 CNV novel sequence insertion 20440878
nsv521658 CNV loss 19592680
nsv819624 CNV loss 19587683
nsv830166 CNV gain 17160897
nsv830167 CNV gain 17160897
nsv949858 CNV deletion 24416366

Variation tolerance for ENPP6 Gene

Residual Variation Intolerance Score: 58.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.88; 35.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ENPP6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ENPP6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENPP6 Gene

Disorders for ENPP6 Gene

Additional Disease Information for ENPP6

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ENPP6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ENPP6 Gene

Publications for ENPP6 Gene

  1. Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family. (PMID: 15788404) Sakagami H … Arai H (The Journal of biological chemistry 2005) 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ENPP6 Gene

Sources for ENPP6 Gene

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