Aliases for ENPP6 Gene
Aliases for ENPP6 Gene
External Ids for ENPP6 Gene
- HGNC: 23409
- Entrez Gene: 133121
- Ensembl: ENSG00000164303
- OMIM: 616983
- UniProtKB: Q6UWR7
Previous GeneCards Identifiers for ENPP6 Gene
- GC04M185705
- GC04M185385
- GC04M185246
- GC04M185009
- GC04M180764
Summaries for ENPP6 Gene
GeneCards Summary for ENPP6 Gene
ENPP6 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 6) is a Protein Coding gene. Among its related pathways are Metabolism and PI Metabolism. Gene Ontology (GO) annotations related to this gene include phosphoric diester hydrolase activity and glycerophosphocholine cholinephosphodiesterase activity. An important paralog of this gene is ENPP5.
UniProtKB/Swiss-Prot for ENPP6 Gene
-
Choline-specific glycerophosphodiester phosphodiesterase. The preferred substrate may be lysosphingomyelin (By similarity). Hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. Also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently. Hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine in vitro, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5-monophosphate. Does not hydrolyze diacyl phospholipids such as phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidylglycerol and phosphatidic acid.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENPP6 Gene
Genomics for ENPP6 Gene
GeneHancer (GH) Regulatory Elements for ENPP6 Gene
Promoters and enhancers for ENPP6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around ENPP6 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ENPP6 gene promoter:
-
- Sox5
- AP-4
- NRSF form 2
- NRSF form 1
- E47
- COUP
- COUP-TF
- COUP-TF1
- HNF-4alpha1
- HNF-4alpha2
Regulatory Element Products
Genomic Locations for ENPP6 Gene
Genomic Locations for ENPP6 Gene
- chr4:184,088,706-184,221,230
- (GRCh38/hg38)
- Size:
- 132,525 bases
- Orientation:
- Minus strand
- chr4:185,009,859-185,142,383
- (GRCh37/hg19)
- Size:
- 132,525 bases
- Orientation:
- Minus strand
Genomic View for ENPP6 Gene
Genes around ENPP6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q35.1 by Entrez Gene
- 4q35.1 by HGNC
- 4q35.1 by Ensembl
ENPP6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ENPP6 Gene
Proteins for ENPP6 Gene
-
Protein details for ENPP6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6UWR7-ENPP6_HUMAN
- Recommended name:
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 6
- Protein Accession:
- Q6UWR7
- Q4W5Q1
- Q96M57
Protein attributes for ENPP6 Gene
- Size:
- 440 amino acids
- Molecular mass:
- 50241 Da
- Cofactor:
- Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
- Quaternary structure:
-
- Homodimer; disulfide-linked.
Protein Expression for ENPP6 Gene
Post-translational modifications for ENPP6 Gene
Other Protein References for ENPP6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ENPP6
-
Abcam antibodies for ENPP6
- Invitrogen Antibodies for ENPP6 (AFLGC-ENPP6)
- GeneTex ENPP6 Antibody for ENPP6
-
Boster Bio Antibodies for ENPP6
-
Santa Cruz Biotechnology (SCBT) Antibodies for ENPP6
Protein Products
- R&D Systems Proteins and Enzymes for ENPP6 (ENPP-6)
-
OriGene Purified Proteins for ENPP6
- Search Origene for MassSpec and Protein Over-expression Lysates for ENPP6
- Origene Custom Protein Services for ENPP6
- Search GeneTex for Proteins for ENPP6
-
Abcam proteins for ENPP6
Assay Products
No data available for DME Specific Peptides for ENPP6 Gene
Domains & Families for ENPP6 Gene
Gene Families for ENPP6 Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for ENPP6 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ENPP6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q6UWR7UniProtKB/Swiss-Prot:
ENPP6_HUMAN :- Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
- Family:
-
- Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
Function for ENPP6 Gene
Molecular function for ENPP6 Gene
- UniProtKB/Swiss-Prot Function:
- Choline-specific glycerophosphodiester phosphodiesterase. The preferred substrate may be lysosphingomyelin (By similarity). Hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. Also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently. Hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine in vitro, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5-monophosphate. Does not hydrolyze diacyl phospholipids such as phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidylglycerol and phosphatidic acid.
- UniProtKB/Swiss-Prot CatalyticActivity:
- A lysophosphatidylcholine + H(2)O = a monoacylglycerol + phosphocholine.
- UniProtKB/Swiss-Prot CatalyticActivity:
- sn-glycero-3-phosphocholine + H(2)O = glycerol + phosphocholine.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by EDTA and EGTA in vitro.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=344 uM for GPC {ECO:0000269 PubMed:15788404}; KM=296 uM for 12:0-LPC {ECO:0000269 PubMed:15788404}; KM=440 uM for 14:0-LPC {ECO:0000269 PubMed:15788404}; KM=165 uM for 16:0-LPC {ECO:0000269 PubMed:15788404}; KM=434 uM for 18:2-LPC {ECO:0000269 PubMed:15788404}; KM=563 uM for 20:4-LPC {ECO:0000269 PubMed:15788404}; Vmax=484 nmol/min/mg enzyme with GPC as substrate {ECO:0000269 PubMed:15788404}; Vmax=463 nmol/min/mg enzyme with 12:0-LPC as substrate {ECO:0000269 PubMed:15788404}; Vmax=367 nmol/min/mg enzyme with 14:0-LPC as substrate {ECO:0000269 PubMed:15788404}; Vmax=89 nmol/min/mg enzyme with 16:0-LPC as substrate {ECO:0000269 PubMed:15788404}; Vmax=285 nmol/min/mg enzyme with 18:2-LPC as substrate {ECO:0000269 PubMed:15788404}; Vmax=470 nmol/min/mg enzyme with 20:4-LPC as substrate {ECO:0000269 PubMed:15788404}; pH dependence: Optimum pH is 8.5-7.5. {ECO:0000269 PubMed:15788404};
Enzyme Numbers (IUBMB) for ENPP6 Gene
Phenotypes From GWAS Catalog for ENPP6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008081 | phosphoric diester hydrolase activity | IDA | 15788404 |
| GO:0008889 | glycerophosphodiester phosphodiesterase activity | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0047390 | glycerophosphocholine cholinephosphodiesterase activity | IDA,IEA | 15788404 |
Phenotypes for ENPP6 Gene
- GenomeRNAi human phenotypes for ENPP6:
-
- Decreased viability ratio
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Strongly decreased CFP-tsO45G cell surface transport
- Mitotic spindle defects
- Decreased IL-8 secretion
Animal Model Products
-
Taconic Biosciences Mouse Models for ENPP6
- Cyagen custom Knockout/knockin (KOKI) mouse models for ENPP6
-
CRISPR Products
-
OriGene CRISPR knockouts for ENPP6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ENPP6
- genomics-online: gRNA clones - Search results for 88 available ENPP6 gene related products
- Overview of 88 available ENPP6 gene related products
- Applied Biological Materials CRISPR for ENPP6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ENPP6
- GenScript: Design CRISPR guide RNA sequences for ENPP6
miRNA for ENPP6 Gene
- miRTarBase miRNAs that target ENPP6
-
- hsa-mir-148b-3p (MIRT019285)
- hsa-mir-3622b-5p (MIRT509880)
- hsa-mir-5000-3p (MIRT509881)
- hsa-mir-4436a (MIRT509882)
- hsa-mir-506-5p (MIRT509883)
- hsa-mir-6512-5p (MIRT509884)
- hsa-mir-4666a-5p (MIRT523891)
- hsa-mir-8068 (MIRT523892)
- hsa-mir-143-5p (MIRT523893)
- hsa-mir-5087 (MIRT523894)
- hsa-mir-3944-5p (MIRT523895)
- hsa-mir-657 (MIRT523896)
- hsa-mir-3665 (MIRT523897)
- hsa-mir-298 (MIRT523898)
- hsa-mir-4748 (MIRT523899)
- hsa-mir-4464 (MIRT523900)
- hsa-mir-6077 (MIRT530935)
- hsa-mir-7-5p (MIRT530936)
- hsa-mir-1283 (MIRT530937)
- hsa-mir-4714-3p (MIRT530938)
- hsa-mir-513c-3p (MIRT530939)
- hsa-mir-513a-3p (MIRT530940)
- hsa-mir-3606-3p (MIRT530941)
- hsa-mir-4282 (MIRT530942)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ENPP6
- Browse OriGene Inhibitory RNA Products For ENPP6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ENPP6
- genomics-online: shRNA clones - Search results for 88 available ENPP6 gene related products
- Overview of 88 available ENPP6 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ENPP6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ENPP6
- Applied Biological Materials Clones for ENPP6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ENPP6
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ENPP6 Gene
Localization for ENPP6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ENPP6 Gene
- Cell membrane; Lipid-anchor, GPI-anchor. Note=A small amount of the protein may be found in the extracellular milieu.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
- Golgi apparatus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IDA | 15788404 |
| GO:0005886 | plasma membrane | TAS,IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0031225 | anchored component of membrane | IEA | -- |
| GO:0070062 | extracellular exosome | HDA | 19056867 |
Pathways & Interactions for ENPP6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PI Metabolism |
.63
|
|
| 2 | Metabolism |
.37
|
|
| 3 | Acyl chain remodelling of PE | ||
| 4 | Glycerophospholipid biosynthesis | ||
Pathways by source for ENPP6 Gene
5 Reactome pathways for ENPP6 Gene
1 KEGG pathway for ENPP6 Gene
Interacting Proteins for ENPP6 Gene
GPS-Prot Interaction Network for ENPP6
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | IDA,IEA | 15788404 |
| GO:0008152 | metabolic process | IEA | -- |
| GO:0016042 | lipid catabolic process | IEA | -- |
| GO:0019695 | choline metabolic process | IDA | 15788404 |
| GO:0046475 | glycerophospholipid catabolic process | TAS | -- |
No data available for SIGNOR curated interactions for ENPP6 Gene
Drugs & Compounds for ENPP6 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 2-Arachidonylglycerol |
|
53847-30-6 |
|
|||
| MG(0:0/14:0/0:0) |
|
|
||||
| MG(0:0/14:1(9Z)/0:0) |
|
|
||||
| MG(0:0/15:0/0:0) |
|
|
||||
| MG(0:0/16:0/0:0) |
|
|
Drug Products
Transcripts for ENPP6 Gene
mRNA/cDNA for ENPP6 Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (36) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000296741 3936 bps (uc003iwc.3)
- ENST00000510054 461 bps (uc063bhf.1)
- ENST00000512353 852 bps (uc063bhg.1)
- ENST00000505644 566 bps (uc063bhh.1)
Unigene Clusters for ENPP6 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ENPP6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ENPP6
- genomics-online: gRNA clones - Search results for 88 available ENPP6 gene related products
- Overview of 88 available ENPP6 gene related products
- Applied Biological Materials CRISPR for ENPP6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ENPP6
- GenScript: Design CRISPR guide RNA sequences for ENPP6
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ENPP6
- Browse OriGene Inhibitory RNA Products For ENPP6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ENPP6
- genomics-online: shRNA clones - Search results for 88 available ENPP6 gene related products
- Overview of 88 available ENPP6 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ENPP6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ENPP6
- Applied Biological Materials Clones for ENPP6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for ENPP6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Oligodendrocyte-like cells(Najm FJ et. al. 2011)
-
Glial Cells
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Oligodendrocyte-like cells(Najm FJ et. al. 2011)
- Bone (Muscoskeletal System)
- Spinal Cord (Nervous System)
-
Kidney (Urinary System)
mRNA differential expression in normal tissues according to GTEx for ENPP6 Gene
This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x14.8), Brain - Substantia nigra (x7.0), and Nerve - Tibial (x4.8).
This gene is overexpressed in Cerebral cortex (36.7) and Spinal cord (17.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ENPP6 Gene
NURSA nuclear receptor signaling pathways regulating expression of ENPP6 Gene:
ENPP6SOURCE GeneReport for Unigene cluster for ENPP6 Gene:
Hs.297814mRNA Expression by UniProt/SwissProt for ENPP6 Gene:
Q6UWR7-ENPP6_HUMAN
Tissue specificity:
Predominantly expressed in kidney and brain. In the kidney, expressed specifically in the proximal tubules and thin descending limbs of Henle (at protein level).
Evidence on tissue expression from TISSUES for ENPP6 Gene
- Nervous system(4.7)
Primer Products
-
OriGene qPCR primer pairs for ENPP6
-
OriGene qPCR primer pairs and template standards for ENPP6
- genomics-online: primer clones - Search results for 88 available ENPP6 gene related products
- Overview of 88 available ENPP6 gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENPP6 Gene
Orthologs for ENPP6 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ENPP6 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ENPP6 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Enpp6 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Enpp6 16 34 33 |
|
||
| cow (Bos Taurus) |
Mammalia | ENPP6 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ENPP6 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ENPP6 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ENPP6 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ENPP6 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | enpp6 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.18662 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | enpp6 34 33 |
|
OneToOne | |
| sbcb727 33 |
|
||||
| worm (Caenorhabditis elegans) |
Secernentea | T03G6.3 34 33 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NPP2 34 |
|
ManyToMany | |
| NPP1 34 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for ENPP6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for ENPP6 Gene
- ENSEMBL:
- Gene Tree for ENPP6 (if available)
- TreeFam:
- Gene Tree for ENPP6 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ENPP6: view image
Paralogs for ENPP6 Gene
Variants for ENPP6 Gene
| SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000049854 | -- | 184,176,415(-) | AAGTTAAGT/AAGT | intron_variant | |
| rs1000050911 | -- | 184,137,911(-) | G/A/T | intron_variant | |
| rs1000080292 | -- | 184,100,582(-) | C/T | intron_variant | |
| rs1000080694 | -- | 184,176,116(-) | A/G | intron_variant | |
| rs1000095011 | -- | 184,094,928(-) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3336765 | CNV | duplication | 20981092 |
| esv3350511 | CNV | duplication | 20981092 |
| esv3417901 | CNV | duplication | 20981092 |
| esv3603454 | CNV | gain | 21293372 |
| nsv1026796 | CNV | gain | 25217958 |
| nsv1146419 | CNV | duplication | 26484159 |
| nsv475007 | CNV | novel sequence insertion | 20440878 |
| nsv521658 | CNV | loss | 19592680 |
| nsv819624 | CNV | loss | 19587683 |
| nsv830166 | CNV | gain | 17160897 |
| nsv830167 | CNV | gain | 17160897 |
| nsv949858 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
58.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.88;
35.11% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ENPP6 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ENPP6
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENPP6 Gene
Disorders for ENPP6 Gene
Additional Disease Information for ENPP6
No disorders were found for ENPP6 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ENPP6 Gene
Publications for ENPP6 Gene
- Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family. (PMID: 15788404) Sakagami H … Arai H (The Journal of biological chemistry 2005) 3 4 22 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
Products for ENPP6 Gene
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- OriGene CRISPR knockouts for ENPP6
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- Novus Biologicals
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- Browse Peptides and Proteins
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- Abcam antibodies for ENPP6
- Abcam proteins for ENPP6
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- Taconic Biosciences Mouse Models for ENPP6
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for ENPP6 (AFLGC-ENPP6)
- Cyagen custom Knockout/knockin (KOKI) mouse models for ENPP6
- antibodies-online: Search results for 54 available ENPP6 Antibodies ranked by validation data
- Compare Top ENPP6 Antibodies
- antibodies-online: Search results for available ENPP6 related products ranked by validation data
- antibodies-online: Search results for 8 available ENPP6 Proteins ranked by validation data
- Compare Top ENPP6 Proteins
- Quality Products:
- GeneTex ENPP6 Antibody for ENPP6
- Search GeneTex for Proteins for ENPP6
- Santa Cruz Biotechnology (SCBT) Antibodies for ENPP6
- Search Santa Cruz Biotechnology (SCBT) for ENPP6 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ENPP6
- Horizon Cell Lines for ENPP6
- genomics-online: cdna clones - Search results for 88 available ENPP6 gene related products
- Overview of 88 available ENPP6 gene related products
- orf clones - Search results for 88 available ENPP6 gene related products
- Overview of 88 available ENPP6 gene related products
- genomics-online: gRNA clones - Search results for 88 available ENPP6 gene related products
- Overview of 88 available ENPP6 gene related products
- genomics-online: primer clones - Search results for 88 available ENPP6 gene related products
- Overview of 88 available ENPP6 gene related products
- genomics-online: shRNA clones - Search results for 88 available ENPP6 gene related products
- Overview of 88 available ENPP6 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ENPP6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ENPP6
- GeneCopoeia miRNA 3'UTR Target clone products for ENPP6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ENPP6
- Boster Bio Antibodies for ENPP6
- Browse Boster Bio ELISA Kits
Sources for ENPP6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt