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Aliases for ENPP6 Gene
Aliases for ENPP6 Gene
External Ids for ENPP6 Gene
- HGNC: 23409
- Entrez Gene: 133121
- Ensembl: ENSG00000164303
- OMIM: 616983
- UniProtKB: Q6UWR7
Previous GeneCards Identifiers for ENPP6 Gene
- GC04M185705
- GC04M185385
- GC04M185246
- GC04M185009
- GC04M180764
Summaries for ENPP6 Gene
GeneCards Summary for ENPP6 Gene
ENPP6 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 6) is a Protein Coding gene. Diseases associated with ENPP6 include Bietti Crystalline Corneoretinal Dystrophy and Neuropathy, Hereditary Sensory And Autonomic, Type Ia. Among its related pathways are Acyl chain remodelling of PE and PI Metabolism. Gene Ontology (GO) annotations related to this gene include phosphoric diester hydrolase activity and glycerophosphocholine cholinephosphodiesterase activity. An important paralog of this gene is ENPP1.
UniProtKB/Swiss-Prot Summary for ENPP6 Gene
-
Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells (PubMed:15788404). Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids (By similarity).
Additional gene information for ENPP6 Gene
- HGNC(23409)
- Entrez Gene(133121)
- Ensembl(ENSG00000164303)
- OMIM(616983)
- UniProtKB(Q6UWR7)
- Open Targets Platform(ENSG00000164303)
- Search for ENPP6 at DataMed
- Search for ENPP6 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ENPP6 Gene
Genomics for ENPP6 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ENPP6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ENPP6 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ENPP6
- Top Transcription factor binding sites by QIAGEN in the ENPP6 gene promoter:
-
- AP-4
- COUP
- COUP-TF
- COUP-TF1
- E47
- HNF-4alpha1
- HNF-4alpha2
- NRSF form 1
- NRSF form 2
- Sox5
Genomic Locations for ENPP6 Gene
Genomic Locations for ENPP6 Gene
- chr4:184,088,706-184,221,230
- (GRCh38/hg38)
- Size:
- 132,525 bases
- Orientation:
- Minus strand
- chr4:185,009,859-185,142,383
- (GRCh37/hg19)
- Size:
- 132,525 bases
- Orientation:
- Minus strand
Genomic View for ENPP6 Gene
Genes around ENPP6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q35.1 by HGNC
- 4q35.1 by Entrez Gene
- 4q35.1 by Ensembl
ENPP6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ENPP6 Gene
Proteins for ENPP6 Gene
-
Protein details for ENPP6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6UWR7-ENPP6_HUMAN
- Recommended name:
- Glycerophosphocholine cholinephosphodiesterase ENPP6
- Protein Accession:
- Q6UWR7
- Q4W5Q1
- Q96M57
Protein attributes for ENPP6 Gene
- Size:
- 440 amino acids
- Molecular mass:
- 50241 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
-
- Homodimer; disulfide-linked. Homotetramer.
Protein Expression for ENPP6 Gene
Post-translational modifications for ENPP6 Gene
Other Protein References for ENPP6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ENPP6
-
Abcam antibodies for ENPP6
- Invitrogen Antibodies for ENPP6 (AFLGC-Enpp6)
-
Biorbyt antibodies for ENPP6
-
Santa Cruz Biotechnology (SCBT) Antibodies for ENPP6
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for ENPP6
- Origene Custom Protein Services for ENPP6
- antibodies-online: Show 8 available ENPP6 Proteins ranked by validation data
- Compare Top ENPP6 Proteins
-
Quality Products:
-
Signalway Proteins for ENPP6
-
Abcam proteins for ENPP6
No data available for DME Specific Peptides for ENPP6 Gene
Domains & Families for ENPP6 Gene
Gene Families for ENPP6 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for ENPP6 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ENPP6 Gene
- GenScript: Design optimal peptide antigens:
-
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 (ENPP6_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q6UWR7UniProtKB/Swiss-Prot:
ENPP6_HUMAN :- Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
- Family:
-
- Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
Function for ENPP6 Gene
Molecular function for ENPP6 Gene
- UniProtKB/Swiss-Prot Function:
- Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells (PubMed:15788404). Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + sn-glycerol 3-phosphocholine = glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:19545, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:17754, ChEBI:CHEBI:295975; EC=3.1.4.38; Evidence={ECO:0000269|PubMed:15788404};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:44720, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58168, ChEBI:CHEBI:64683, ChEBI:CHEBI:295975; Evidence={ECO:0000269|PubMed:15788404};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-O-alkyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:36083, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15850, ChEBI:CHEBI:30909, ChEBI:CHEBI:295975; Evidence={ECO:0000250|UniProtKB:Q8BGN3};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-dodecanoyl-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:41127, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:74966, ChEBI:CHEBI:75529, ChEBI:CHEBI:295975; Evidence={ECO:0000250|UniProtKB:Q8BGN3};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:41119, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:75542, ChEBI:CHEBI:295975; Evidence={ECO:0000250|UniProtKB:Q8BGN3};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:41003, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:34071, ChEBI:CHEBI:74344, ChEBI:CHEBI:295975; Evidence={ECO:0000250|UniProtKB:Q8BGN3};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:40999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:64489, ChEBI:CHEBI:75536, ChEBI:CHEBI:295975; Evidence={ECO:0000250|UniProtKB:Q8BGN3};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + sphing-4-enine-phosphocholine = H(+) + phosphocholine + sphing-4-enine; Xref=Rhea:RHEA:41095, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57756, ChEBI:CHEBI:58906, ChEBI:CHEBI:295975; Evidence={ECO:0000250|UniProtKB:Q8BGN3};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:41091, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28610, ChEBI:CHEBI:75757, ChEBI:CHEBI:295975; Evidence={ECO:0000250|UniProtKB:Q8BGN3};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:41115, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28733, ChEBI:CHEBI:75561, ChEBI:CHEBI:295975; Evidence={ECO:0000250|UniProtKB:Q8BGN3};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=glycero-2-phosphocholine + H2O = glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:61684, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:144950, ChEBI:CHEBI:295975; Evidence={ECO:0000250|UniProtKB:Q8BGN3};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=344 uM for GPC {ECO:0000269|PubMed:15788404}; KM=296 uM for 12:0-LPC {ECO:0000269|PubMed:15788404}; KM=440 uM for 14:0-LPC {ECO:0000269|PubMed:15788404}; KM=165 uM for 16:0-LPC {ECO:0000269|PubMed:15788404}; KM=434 uM for 18:2-LPC {ECO:0000269|PubMed:15788404}; KM=563 uM for 20:4-LPC {ECO:0000269|PubMed:15788404}; Vmax=484 nmol/min/mg enzyme with GPC as substrate {ECO:0000269|PubMed:15788404}; Vmax=463 nmol/min/mg enzyme with 12:0-LPC as substrate {ECO:0000269|PubMed:15788404}; Vmax=367 nmol/min/mg enzyme with 14:0-LPC as substrate {ECO:0000269|PubMed:15788404}; Vmax=89 nmol/min/mg enzyme with 16:0-LPC as substrate {ECO:0000269|PubMed:15788404}; Vmax=285 nmol/min/mg enzyme with 18:2-LPC as substrate {ECO:0000269|PubMed:15788404}; Vmax=470 nmol/min/mg enzyme with 20:4-LPC as substrate {ECO:0000269|PubMed:15788404}; pH dependence: Optimum pH is 8.5-7.5. {ECO:0000269|PubMed:15788404};
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by EDTA and EGTA in vitro.
Enzyme Numbers (IUBMB) for ENPP6 Gene
Phenotypes From GWAS Catalog for ENPP6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0008081 | phosphoric diester hydrolase activity | IDA | 15788404 |
| GO:0008889 | glycerophosphodiester phosphodiesterase activity | IBA | 21873635 |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ENPP6 Gene
- GenomeRNAi human phenotypes for ENPP6:
-
- no effect
- Decreased vaccinia virus (VACV) infection
- Decreased viability ratio
- Decreased viability
- Increased IL-8 secretion
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased cell elongation
- Mitotic spindle defects
Animal Model Products
-
Taconic Biosciences Mouse Models for ENPP6
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ENPP6 - Select products 50% OFF >
- * ENPP6 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ENPP6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ENPP6
-
Santa Cruz Biotechnology (SCBT) CRISPR for ENPP6
miRNA for ENPP6 Gene
- miRTarBase miRNAs that target ENPP6
-
- mmu-miR-144-3p (MIRT001169)
- mmu-miR-32-5p (MIRT001170)
- mmu-miR-219a-5p (MIRT004295)
- hsa-miR-148b-3p (MIRT019285)
- hsa-miR-3622b-5p (MIRT509880)
- hsa-miR-5000-3p (MIRT509881)
- hsa-miR-4436a (MIRT509882)
- hsa-miR-506-5p (MIRT509883)
- hsa-miR-6512-5p (MIRT509884)
- hsa-miR-4666a-5p (MIRT523891)
- hsa-miR-8068 (MIRT523892)
- hsa-miR-143-5p (MIRT523893)
- hsa-miR-5087 (MIRT523894)
- hsa-miR-3944-5p (MIRT523895)
- hsa-miR-657 (MIRT523896)
- hsa-miR-3665 (MIRT523897)
- hsa-miR-298 (MIRT523898)
- hsa-miR-4748 (MIRT523899)
- hsa-miR-4464 (MIRT523900)
- hsa-miR-6077 (MIRT530935)
- hsa-miR-7-5p (MIRT530936)
- hsa-miR-1283 (MIRT530937)
- hsa-miR-4714-3p (MIRT530938)
- hsa-miR-513c-3p (MIRT530939)
- hsa-miR-513a-3p (MIRT530940)
- hsa-miR-3606-3p (MIRT530941)
- hsa-miR-4282 (MIRT530942)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ENPP6
- Browse OriGene Inhibitory RNA Products For ENPP6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ENPP6
Clone Products
- Applied Biological Materials (abm): Clones for ENPP6 - Select products 50% OFF >
- * ENPP6 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ENPP6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ENPP6
Cell Line Products
-
Horizon Cell Lines for ENPP6
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ENPP6 Gene
Localization for ENPP6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ENPP6 Gene
- Cell membrane. Lipid-anchor, GPI-anchor. Note=A small amount of the protein may be found in the extracellular milieu.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| endoplasmic reticulum | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| peroxisome | 0 |
- Golgi apparatus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IDA | 15788404 |
| GO:0005886 | plasma membrane | IEA,TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0031225 | anchored component of membrane | IEA | -- |
| GO:0070062 | extracellular exosome | HDA | 19056867 |
Pathways & Interactions for ENPP6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PI Metabolism |
.63
|
|
| 2 | Metabolism |
.40
|
|
| 3 | Acyl chain remodelling of PE | ||
| 4 | Glycerophospholipid biosynthesis | ||
Pathways by source for ENPP6 Gene
5 Reactome pathways for ENPP6 Gene
1 KEGG pathway for ENPP6 Gene
Interacting Proteins for ENPP6 Gene
Selected Interacting proteins:
Q6UWR7-ENPP6_HUMAN
ENSP00000296741
for ENPP6 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for ENPP6
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | IBA,IDA | 15788404 |
| GO:0016042 | lipid catabolic process | IEA | -- |
| GO:0019695 | choline metabolic process | IBA,IDA | 15788404 |
| GO:0046475 | glycerophospholipid catabolic process | TAS | -- |
No data available for SIGNOR curated interactions for ENPP6 Gene
Drugs & Compounds for ENPP6 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 2-Arachidonylglycerol |
|
53847-30-6 |
|
|||
| MG(0:0/14:0/0:0) |
|
|
||||
| MG(0:0/14:1(9Z)/0:0) |
|
|
||||
| MG(0:0/15:0/0:0) |
|
|
||||
| MG(0:0/16:0/0:0) |
|
|
Transcripts for ENPP6 Gene
mRNA/cDNA for ENPP6 Gene
- 1 REFSEQ mRNAs :
- 5 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000296741 3848 nts (view in UCSC)
- ENST00000510054 461 nts (view in UCSC)
- ENST00000512353 852 nts (view in UCSC)
- ENST00000505644 566 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ENPP6 - Select products 50% OFF >
- * ENPP6 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ENPP6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ENPP6
-
Santa Cruz Biotechnology (SCBT) CRISPR for ENPP6
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ENPP6
- Browse OriGene Inhibitory RNA Products For ENPP6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ENPP6
Clone Products
- Applied Biological Materials (abm): Clones for ENPP6 - Select products 50% OFF >
- * ENPP6 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ENPP6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ENPP6
Relevant External Links for ENPP6 Gene
- GeneLoc Exon Structure for
- ENPP6
Expression for ENPP6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Oligodendrocyte-like cells(Najm FJ et. al. 2011)
-
Glial Cells
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Oligodendrocyte-like cells(Najm FJ et. al. 2011)
- Bone (Muscoskeletal System)
- Spinal Cord (Nervous System)
-
Kidney (Urinary System)
mRNA differential expression in normal tissues according to GTEx for ENPP6 Gene
This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x14.8), Brain - Substantia nigra (x7.0), and Nerve - Tibial (x4.8).
This gene is overexpressed in Cerebral cortex (36.7) and Spinal cord (17.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ENPP6 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ENPP6
SOURCE GeneReport for Unigene cluster for ENPP6 Gene:
Hs.297814mRNA Expression by UniProt/SwissProt for ENPP6 Gene:
Q6UWR7-ENPP6_HUMAN
Tissue specificity:
Predominantly expressed in kidney and brain. In the kidney, expressed specifically in the proximal tubules and thin descending limbs of Henle (at protein level).
Evidence on tissue expression from TISSUES for ENPP6 Gene
- Nervous system(4.8)
- Kidney(2.1)
Primer Products
-
OriGene qPCR primer pairs for ENPP6
-
OriGene qPCR primer pairs and template standards for ENPP6
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENPP6 Gene
Orthologs for ENPP6 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ENPP6 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ENPP6 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Enpp6 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Enpp6 30 17 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ENPP6 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ENPP6 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ENPP6 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ENPP6 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ENPP6 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | enpp6 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.18662 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | enpp6 30 31 |
|
OneToOne | |
| sbcb727 30 |
|
||||
| Worm (Caenorhabditis elegans) |
Secernentea | T03G6.3 30 31 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NPP2 31 |
|
ManyToMany | |
| NPP1 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
- Species where no ortholog for ENPP6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for ENPP6 Gene
- ENSEMBL:
- Gene Tree for ENPP6 (if available)
- TreeFam:
- Gene Tree for ENPP6 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ENPP6: view image
Paralogs for ENPP6 Gene
Variants for ENPP6 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3336765 | CNV | duplication | 20981092 |
| esv3350511 | CNV | duplication | 20981092 |
| esv3417901 | CNV | duplication | 20981092 |
| esv3603454 | CNV | gain | 21293372 |
| nsv1026796 | CNV | gain | 25217958 |
| nsv1146419 | CNV | duplication | 26484159 |
| nsv475007 | CNV | novel sequence insertion | 20440878 |
| nsv521658 | CNV | loss | 19592680 |
| nsv819624 | CNV | loss | 19587683 |
| nsv830166 | CNV | gain | 17160897 |
| nsv830167 | CNV | gain | 17160897 |
| nsv949858 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
58.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.88;
35.11% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ENPP6 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ENPP6
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENPP6 Gene
Disorders for ENPP6 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| bietti crystalline corneoretinal dystrophy |
|
|
| neuropathy, hereditary sensory and autonomic, type ia |
|
|
| cholestasis, intrahepatic, of pregnancy, 1 |
|
|
Search ENPP6 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ENPP6
No data available for UniProtKB/Swiss-Prot and Genatlas for ENPP6 Gene
Publications for ENPP6 Gene
- Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family. (PMID: 15788404) Sakagami H … Arai H (The Journal of biological chemistry 2005) 3 4 23
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
ExternalLinks
Products for ENPP6 Gene
- Custom Antibody Services
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- Find your next knockout model in the Taconic Knockout Repository
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- Humanized Mice
- Invitrogen Antibodies for ENPP6 (AFLGC-Enpp6)
- VectorBuilder Custom and pre-made DNA vectors for ENPP6 (ie. gene expression, shRNA knockdown, CRISPR)
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- VectorBuilder Virus packaging for ENPP6 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ENPP6
- antibodies-online: Show 16 available ENPP6 Antibodies ranked by validation data
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- antibodies-online: Show 8 available ENPP6 Proteins ranked by validation data
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- Quality Products:
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- Biorbyt antibodies for ENPP6
- Signalway Proteins for ENPP6
Sources for ENPP6 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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- (11) Cell Signaling Technology
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- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
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- (35) WormBase
- (36) Pseudogene
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- (38) dbSNP
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- (44) Atlas
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- (60) Sino Biological
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- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
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- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
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- (89) antibodies-online
- (90) CYP
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- (96) Taconic Biosciences
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- (98) ProteomicsDB
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- (104) diseasecard
- (105) NIH Rare Diseases
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- (110) Genetics Home Reference
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- (115) NCBI Bookshelf
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- (148) RNACentral
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- (152) DiseaseEnhancer
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- (154) Biorbyt
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- (156) Mastermind
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