Aliases for ENPP6 Gene
External Ids for ENPP6 Gene
Previous GeneCards Identifiers for ENPP6 Gene
GeneCards Summary for ENPP6 Gene
ENPP6 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 6) is a Protein Coding gene. Diseases associated with ENPP6 include Bietti Crystalline Corneoretinal Dystrophy and Neuropathy, Hereditary Sensory And Autonomic, Type Ia. Among its related pathways are Acyl chain remodelling of PE and PI Metabolism. Gene Ontology (GO) annotations related to this gene include phosphoric diester hydrolase activity and glycerophosphocholine cholinephosphodiesterase activity. An important paralog of this gene is ENPP1.
UniProtKB/Swiss-Prot Summary for ENPP6 Gene
Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells (PubMed:15788404). Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids (By similarity).