Free for academic non-profit institutions. Other users need a Commercial license
ENPP6 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 6) is a Protein Coding gene. Diseases associated with ENPP6 include Bietti Crystalline Corneoretinal Dystrophy and Neuropathy, Hereditary Sensory And Autonomic, Type Ia. Among its related pathways are Acyl chain remodelling of PE and PI Metabolism. Gene Ontology (GO) annotations related to this gene include phosphoric diester hydrolase activity and glycerophosphocholine cholinephosphodiesterase activity. An important paralog of this gene is ENPP1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003824 | catalytic activity | IEA | -- |
GO:0008081 | phosphoric diester hydrolase activity | IDA | 15788404 |
GO:0008889 | glycerophosphodiester phosphodiesterase activity | IBA | 21873635 |
GO:0016787 | hydrolase activity | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IDA | 15788404 |
GO:0005886 | plasma membrane | IEA,TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0031225 | anchored component of membrane | IEA | -- |
GO:0070062 | extracellular exosome | HDA | 19056867 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | PI Metabolism |
.63
|
|
2 | Metabolism |
.40
|
|
3 | Acyl chain remodelling of PE | ||
4 | Glycerophospholipid biosynthesis |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006629 | lipid metabolic process | IBA,IDA | 15788404 |
GO:0016042 | lipid catabolic process | IEA | -- |
GO:0019695 | choline metabolic process | IBA,IDA | 15788404 |
GO:0046475 | glycerophospholipid catabolic process | TAS | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
2-Arachidonylglycerol |
|
53847-30-6 |
|
|||
MG(0:0/14:0/0:0) |
|
|
||||
MG(0:0/14:1(9Z)/0:0) |
|
|
||||
MG(0:0/15:0/0:0) |
|
|
||||
MG(0:0/16:0/0:0) |
|
|
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ENPP6 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ENPP6 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Enpp6 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Enpp6 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ENPP6 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ENPP6 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | ENPP6 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ENPP6 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ENPP6 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | enpp6 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.18662 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | enpp6 30 31 |
|
OneToOne | |
sbcb727 30 |
|
||||
Worm (Caenorhabditis elegans) |
Secernentea | T03G6.3 30 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NPP2 31 |
|
ManyToMany | |
NPP1 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3336765 | CNV | duplication | 20981092 |
esv3350511 | CNV | duplication | 20981092 |
esv3417901 | CNV | duplication | 20981092 |
esv3603454 | CNV | gain | 21293372 |
nsv1026796 | CNV | gain | 25217958 |
nsv1146419 | CNV | duplication | 26484159 |
nsv475007 | CNV | novel sequence insertion | 20440878 |
nsv521658 | CNV | loss | 19592680 |
nsv819624 | CNV | loss | 19587683 |
nsv830166 | CNV | gain | 17160897 |
nsv830167 | CNV | gain | 17160897 |
nsv949858 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
bietti crystalline corneoretinal dystrophy |
|
|
neuropathy, hereditary sensory and autonomic, type ia |
|
|
cholestasis, intrahepatic, of pregnancy, 1 |
|
|