Aliases for ENPP4 Gene
External Ids for ENPP4 Gene
Previous GeneCards Identifiers for ENPP4 Gene
GeneCards Summary for ENPP4 Gene
ENPP4 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 4) is a Protein Coding gene. Among its related pathways are Pyrimidine metabolism (KEGG) and Innate Immune System. Gene Ontology (GO) annotations related to this gene include sulfuric ester hydrolase activity and bis(5-adenosyl)-triphosphatase activity. An important paralog of this gene is ENPP5.
UniProtKB/Swiss-Prot for ENPP4 Gene
Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.