The ENPEP gene encodes glutamyl aminopeptidase, a type II integral membrane protein with an extracellular zinc-binding domain. This protein can upregulate blood pressure by cleaving the N-terminal aspartate from angiotensin II, and can regulate blood vessel formation and enhance tumorigenesis in some tissues. Along with ANPEP and DPP4, ENPEP was found to be a candidate co-recep... See more...

Aliases for ENPEP Gene

Aliases for ENPEP Gene

  • Glutamyl Aminopeptidase 2 3 4 5
  • Differentiation Antigen Gp160 3 4
  • Aminopeptidase A 3 4
  • EC 3.4.11.7 4 50
  • CD249 2 3
  • Gp160 2 3
  • AP-A 3 4
  • EAP 3 4
  • Glutamyl Aminopeptidase (Aminopeptidase A) 2
  • CD249 Antigen 4
  • EC 3.4.11 50
  • ENPEP 5
  • APA 3

External Ids for ENPEP Gene

Previous GeneCards Identifiers for ENPEP Gene

  • GC04P111803
  • GC04P111679
  • GC04P111856
  • GC04P111754
  • GC04P111397
  • GC04P111286
  • GC04P107128

Summaries for ENPEP Gene

Entrez Gene Summary for ENPEP Gene

  • The ENPEP gene encodes glutamyl aminopeptidase, a type II integral membrane protein with an extracellular zinc-binding domain. This protein can upregulate blood pressure by cleaving the N-terminal aspartate from angiotensin II, and can regulate blood vessel formation and enhance tumorigenesis in some tissues. Along with ANPEP and DPP4, ENPEP was found to be a candidate co-receptor for the coronavirus SARS-CoV-2, which causes COVID-19. [provided by RefSeq, Apr 2020]

GeneCards Summary for ENPEP Gene

ENPEP (Glutamyl Aminopeptidase) is a Protein Coding gene. Diseases associated with ENPEP include Choriocarcinoma and Gestational Choriocarcinoma. Among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Peptide hormone metabolism. Gene Ontology (GO) annotations related to this gene include peptidase activity and aminopeptidase activity. An important paralog of this gene is ERAP2.

UniProtKB/Swiss-Prot Summary for ENPEP Gene

  • Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ENPEP Gene

Genomics for ENPEP Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ENPEP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J110475 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE CraniofacialAtlas 273.8 +111.4 111394 3.3 ATF2 ATF3 YY1 FEZF1 RXRA JUND HNF4A RAD21 REST SP1 ENPEP piR-61945-392 ENSG00000250511 ELOVL6 PITX2
GH04J110364 Enhancer 0.6 Ensembl ENCODE 250.7 -0.3 -307 1.6 RAD21 SP1 RXRA NR2F2 ENPEP LOC105377362 lnc-ENPEP-1 ELOVL6
GH04J110484 Enhancer 1 Ensembl ENCODE 40.8 +121.4 121368 7.4 CEBPA NFIC YY1 BCL11A FEZF1 FOXA2 RXRA SAP130 IRF4 CBFB ENPEP piR-61945-392 ENSG00000250511 PITX2
GH04J110413 Enhancer 0.9 Ensembl ENCODE CraniofacialAtlas 34 +48.6 48621 3.1 SCRT1 ZNF18 CEBPB HLF ZXDB ZNF629 KLF8 CEBPG ZNF969P lnc-EGF-3 lnc-PITX2-3 ENPEP HSALNG0036368 PITX2
GH04J110472 Enhancer 0.7 Ensembl ENCODE 23.2 +107.3 107263 1.6 YY1 RXRA CUX1 ZBTB33 HNF4A MAX SP1 NANOG ENPEP ENSG00000250511 piR-61945-392 piR-48965-104 PITX2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ENPEP on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ENPEP

Top Transcription factor binding sites by QIAGEN in the ENPEP gene promoter:
  • FOXD3
  • FOXF2
  • GR
  • GR-alpha
  • HNF-1
  • HNF-1A
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT4

Genomic Locations for ENPEP Gene

Latest Assembly
chr4:110,365,733-110,565,285
(GRCh38/hg38)
Size:
199,553 bases
Orientation:
Plus strand

Previous Assembly
chr4:111,397,311-111,486,441
(GRCh37/hg19 by Entrez Gene)
Size:
89,131 bases
Orientation:
Plus strand

chr4:111,286,889-111,486,441
(GRCh37/hg19 by Ensembl)
Size:
199,553 bases
Orientation:
Plus strand

Genomic View for ENPEP Gene

Genes around ENPEP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENPEP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENPEP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENPEP Gene

Proteins for ENPEP Gene

  • Protein details for ENPEP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07075-AMPE_HUMAN
    Recommended name:
    Glutamyl aminopeptidase
    Protein Accession:
    Q07075
    Secondary Accessions:
    • Q504U2

    Protein attributes for ENPEP Gene

    Size:
    957 amino acids
    Molecular mass:
    109244 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for ENPEP Gene

neXtProt entry for ENPEP Gene

Selected DME Specific Peptides for ENPEP Gene

Q07075:
  • NAKTSDFW
  • EITSVFDGISYSKG
  • PVKEVMDTWT
  • TAEYAANIT
  • GFYRVNY
  • GAMENWG
  • QVKPIADSLGW
  • KPREQVLETVKNNIEWL
  • TYRETNLLYDP
  • KSVPMSTYLVCFAVH
  • IDDAFALARAQLL
  • PVNLRLLVYRYGMQNSGNE
  • YIISMFEDD
  • ARKSFPCFDEP
  • LPKLDKIAIPDFGTGAMENWGL
  • GWLNGSLVGFY
  • WLNEGFA

Post-translational modifications for ENPEP Gene

  • Glycosylation at Asn98, Asn124, Asn197, Asn324, Asn340, Asn554, Asn589, Asn597, Asn607, Asn678, Asn763, Asn773, Asn801, and Asn828
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for ENPEP Gene

Antibodies for research

Domains & Families for ENPEP Gene

Gene Families for ENPEP Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • CD markers
  • Enzymes
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for ENPEP Gene

InterPro:
Blocks:
  • Membrane alanyl dipeptidase (M1) family signature

Suggested Antigen Peptide Sequences for ENPEP Gene

GenScript: Design optimal peptide antigens:
  • Differentiation antigen gp160 (AMPE_HUMAN)
  • Glutamyl aminopeptidase (Aminopeptidase A) (B0BCY7_HUMAN)
  • Glutamyl aminopeptidase (Aminopeptidase A) (B0BCY8_HUMAN)
  • Glutamyl aminopeptidase (Aminopeptidase A) (B0BCY9_HUMAN)
  • Glutamyl aminopeptidase (Aminopeptidase A) (B0BCZ0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q07075

UniProtKB/Swiss-Prot:

AMPE_HUMAN :
  • Belongs to the peptidase M1 family.
Family:
  • Belongs to the peptidase M1 family.
genes like me logo Genes that share domains with ENPEP: view

Function for ENPEP Gene

Molecular function for ENPEP Gene

UniProtKB/Swiss-Prot Function:
Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Release of N-terminal glutamate (and to a lesser extent aspartate) from a peptide.; EC=3.4.11.7; Evidence={ECO:0000269|PubMed:10692253, ECO:0000269|PubMed:23888046};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Substrate specificity is modulated by calcium which enhances the enzymatic activity for cleavage of acidic residues while reducing its activity with basic residues. Inhibited by aminopeptidase inhibitors amastatin and bestatin.
GENATLAS Biochemistry:
glutamyl aminopeptidase,homolog of murine B-lymphocyte differentiation antigen BP-1/6C3

Enzyme Numbers (IUBMB) for ENPEP Gene

Phenotypes From GWAS Catalog for ENPEP Gene

Gene Ontology (GO) - Molecular Function for ENPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004177 aminopeptidase activity IEA,IDA 8244382
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA,IBA 21873635
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ENPEP: view
genes like me logo Genes that share phenotypes with ENPEP: view

Animal Models for ENPEP Gene

MGI Knock Outs for ENPEP:

miRNA for ENPEP Gene

miRTarBase miRNAs that target ENPEP

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ENPEP

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ENPEP Gene

Localization for ENPEP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENPEP Gene

Cell membrane. Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ENPEP gene
Compartment Confidence
plasma membrane 5
extracellular 5
lysosome 4
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
cytosol 2
golgi apparatus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ENPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005765 lysosomal membrane HDA 17897319
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 8244382
GO:0005903 brush border IEA,ISS --
genes like me logo Genes that share ontologies with ENPEP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ENPEP Gene

Pathways & Interactions for ENPEP Gene

genes like me logo Genes that share pathways with ENPEP: view

Pathways by source for ENPEP Gene

Gene Ontology (GO) - Biological Process for ENPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA,ISS --
GO:0002003 angiotensin maturation NAS,TAS --
GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin NAS 8346219
GO:0006508 proteolysis IEA,IBA 21873635
GO:0007165 signal transduction IBA 21873635
genes like me logo Genes that share ontologies with ENPEP: view

No data available for SIGNOR curated interactions for ENPEP Gene

Drugs & Compounds for ENPEP Gene

(10) Drugs for ENPEP Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutamic acid Approved Nutra Target 324
Zinc Approved, Investigational Pharma 1706
bestatin Pharma Aminopeptidase inhibitor 0
Calcium Nutra 6959
Angiotensin III (human, mouse) Pharma Aldosterone stimulator 0

(7) Additional Compounds for ENPEP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) ApexBio Compounds for ENPEP Gene

Compound Action Cas Number
Angiotensin III (human, mouse) Aldosterone stimulator 13602-53-4
Bestatin Aminopeptidase inhibitor 58970-76-6
Tosedostat (CHR2797) Aminopeptidase inhibitor 238750-77-1
genes like me logo Genes that share compounds with ENPEP: view

Drug products for research

Transcripts for ENPEP Gene

mRNA/cDNA for ENPEP Gene

4 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ENPEP

Alternative Splicing Database (ASD) splice patterns (SP) for ENPEP Gene

No ASD Table

Relevant External Links for ENPEP Gene

GeneLoc Exon Structure for
ENPEP

Expression for ENPEP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ENPEP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ENPEP Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x10.5), Kidney - Cortex (x10.2), and Liver (x4.2).

Protein differential expression in normal tissues from HIPED for ENPEP Gene

This gene is overexpressed in Pancreatic juice (24.4) and Urine (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ENPEP Gene



Protein tissue co-expression partners for ENPEP Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ENPEP

SOURCE GeneReport for Unigene cluster for ENPEP Gene:

Hs.435765

mRNA Expression by UniProt/SwissProt for ENPEP Gene:

Q07075-AMPE_HUMAN
Tissue specificity: Expressed in choriocarcinoma cancer cell lines (at protein level) (PubMed:10692253). Expressed by epithelial cells of the proximal tubule cells and the glomerulus of the nephron. Also found in a variety of other tissues.

Evidence on tissue expression from TISSUES for ENPEP Gene

  • Kidney(4.8)
  • Liver(4.5)
  • Bone marrow(4.4)
  • Spleen(2.8)
  • Nervous system(2.7)
  • Heart(2.4)
  • Blood(2.4)
  • Intestine(2.4)
  • Muscle(2.2)
  • Lymph node(2.1)
  • Lung(2.1)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with ENPEP: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ENPEP Gene

Orthologs for ENPEP Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ENPEP Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ENPEP 29 30
  • 99.55 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ENPEP 29 30
  • 86.86 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ENPEP 29 30
  • 85.99 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Enpep 29
  • 80.54 (n)
Mouse
(Mus musculus)
Mammalia Enpep 29 16 30
  • 80.47 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 76 (a)
OneToMany
-- 30
  • 72 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia ENPEP 30
  • 74 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ENPEP 29 30
  • 69.7 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ENPEP 30
  • 63 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia enpep 29
  • 64.88 (n)
Zebrafish
(Danio rerio)
Actinopterygii enpep 29 30
  • 62.29 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG32473 29 30
  • 49.56 (n)
OneToMany
CG8774 30 31
  • 36 (a)
OneToMany
CG8773 30 31
  • 36 (a)
OneToMany
CG11951 31
  • 35 (a)
CG14516 31
  • 31 (a)
sda 31
  • 30 (a)
BG:DS00365.1 31
  • 28 (a)
CG5849 31
  • 28 (a)
CG2111 31
  • 26 (a)
CG6071 31
  • 25 (a)
CG4467 31
  • 24 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003077 29
  • 48.16 (n)
Worm
(Caenorhabditis elegans)
Secernentea T07F10.1 31
  • 29 (a)
R03G8.6 31
  • 28 (a)
R03G8.4 30 31
  • 24 (a)
ManyToMany
T12E12.6 30
  • 22 (a)
ManyToMany
Y42A5A.1 30 31
  • 20 (a)
ManyToMany
AC3.5 30 31
  • 19 (a)
ManyToMany
Y67D8C.9 30 31
  • 19 (a)
ManyToMany
Y53F4B.20 30
  • 16 (a)
ManyToMany
T16G12.1 30 31
  • 12 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AAP1 30
  • 31 (a)
ManyToMany
APE2 30
  • 29 (a)
ManyToMany
Species where no ortholog for ENPEP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ENPEP Gene

ENSEMBL:
Gene Tree for ENPEP (if available)
TreeFam:
Gene Tree for ENPEP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ENPEP: view image
Alliance of Genome Resources:
Additional Orthologs for ENPEP

Paralogs for ENPEP Gene

Paralogs for ENPEP Gene

(10) SIMAP similar genes for ENPEP Gene using alignment to 14 proteins:

  • AMPE_HUMAN
  • B0BCY7_HUMAN
  • B0BCY8_HUMAN
  • B0BCY9_HUMAN
  • B0BCZ0_HUMAN
  • B0BCZ1_HUMAN
  • B0BCZ2_HUMAN
  • B0BCZ3_HUMAN
  • B0BCZ4_HUMAN
  • B0BCZ5_HUMAN
  • B0BCZ6_HUMAN
  • B0BCZ7_HUMAN
  • H0YA67_HUMAN
  • L8E9Y3_HUMAN

Pseudogenes.org Pseudogenes for ENPEP Gene

genes like me logo Genes that share paralogs with ENPEP: view

Variants for ENPEP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ENPEP Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs143212590 Benign: not provided 110,520,270(+) A/T
NM_001977.4(ENPEP):c.1631A>T (p.Tyr544Phe)
MISSENSE
rs34631771 Benign: not provided 110,509,807(+) G/A
NM_001977.4(ENPEP):c.1194G>A (p.Gln398=)
SYNONYMOUS
rs35812243 Benign: not provided 110,553,396(+) C/Ap.Ser861Arg
NM_001977.4(ENPEP):c.2583C>A (p.Ser861Arg)
MISSENSE
rs72890294 Benign: not provided 110,476,508(+) A/G
NM_001977.4(ENPEP):c.94A>G (p.Ile32Val)
MISSENSE
rs76248418 Benign: not provided 110,476,522(+) C/T
NM_001977.4(ENPEP):c.108C>T (p.Ala36=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ENPEP Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ENPEP Gene

Variant ID Type Subtype PubMed ID
nsv507187 OTHER sequence alteration 20534489
nsv518506 CNV loss 19592680
nsv830036 CNV gain 17160897
nsv950376 CNV duplication 24416366
nsv964082 CNV duplication 23825009

Variation tolerance for ENPEP Gene

Residual Variation Intolerance Score: 57.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.29; 62.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ENPEP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ENPEP
Leiden Open Variation Database (LOVD)
ENPEP

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENPEP Gene

Disorders for ENPEP Gene

MalaCards: The human disease database

(10) MalaCards diseases for ENPEP Gene - From: COP and GCD

Disorder Aliases PubMed IDs
choriocarcinoma
  • chorioepithelioma
gestational choriocarcinoma
  • gestational chorionepithelioma
atrial septal defect 3
  • asd3
pre-eclampsia
  • gestational hypertension
atrial septal defect 4
  • asd4
- elite association - COSMIC cancer census association via MalaCards
Search ENPEP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ENPEP

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ENPEP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ENPEP Gene

Publications for ENPEP Gene

  1. Functional genetic variation in aminopeptidase A (ENPEP): lack of clear association with focal and segmental glomerulosclerosis (FSGS). (PMID: 18206321) Tonna S … Pollak MR (Gene 2008) 3 22 40
  2. Expression of aminopeptidase A in human gestational choriocarcinoma cell lines and tissues. (PMID: 10692253) Ino K … Mizutani S (Placenta 2000) 3 4 22
  3. High-resolution genetic map of the human glutamyl aminopeptidase gene (ENPEP). (PMID: 9268642) Li L … Cooper MD (Genomics 1997) 2 3 22
  4. cDNA cloning and expression of human glutamyl aminopeptidase (aminopeptidase A). (PMID: 8244382) Li L … Cooper MD (Genomics 1993) 3 4 22
  5. Molecular cloning of the human kidney differentiation antigen gp160: human aminopeptidase A. (PMID: 8346219) Nanus DM … Albino AP (Proceedings of the National Academy of Sciences of the United States of America 1993) 3 4 22

Products for ENPEP Gene

Sources for ENPEP Gene