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Aliases for ENPEP Gene

Aliases for ENPEP Gene

  • Glutamyl Aminopeptidase 2 3 3 5
  • Differentiation Antigen Gp160 3 4
  • Aminopeptidase A 3 4
  • AP-A 3 4
  • EAP 3 4
  • Glutamyl Aminopeptidase (Aminopeptidase A) 2
  • CD249 Antigen 4
  • EC 4
  • CD249 3
  • Gp160 3
  • APA 3

External Ids for ENPEP Gene

Previous GeneCards Identifiers for ENPEP Gene

  • GC04P111803
  • GC04P111679
  • GC04P111856
  • GC04P111754
  • GC04P111397
  • GC04P111286
  • GC04P107128

Summaries for ENPEP Gene

GeneCards Summary for ENPEP Gene

ENPEP (Glutamyl Aminopeptidase) is a Protein Coding gene. Diseases associated with ENPEP include Neurogenic Hypertension and Gestational Choriocarcinoma. Among its related pathways are Peptide hormone metabolism and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include peptidase activity and aminopeptidase activity. An important paralog of this gene is ANPEP.

UniProtKB/Swiss-Prot for ENPEP Gene

  • Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells.

Additional gene information for ENPEP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENPEP Gene

Genomics for ENPEP Gene

GeneHancer (GH) Regulatory Elements for ENPEP Gene

Promoters and enhancers for ENPEP Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J110475 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 673.8 +110.5 110515 1.6 TAF1 FEZF1 RAD21 YY1 ZNF335 ZFHX2 GLIS2 EGR1 SCRT2 PRDM10 ENPEP ENSG00000250511 ELOVL6 GC04M110483 GC04M110434 ENSG00000199894
GH04J110364 Enhancer 0.7 Ensembl ENCODE 650.7 -0.3 -304 1.6 SP1 RXRA RAD21 NR2F2 ENPEP LOC105377362
GH04J110484 Enhancer 1 Ensembl ENCODE 33.1 +120.8 120758 4.6 FOXA2 NFIB ARID4B BMI1 IRF4 RAD21 YY1 SCRT2 ATF7 FOS ENPEP GC04M110483 GC04M110434 ENSG00000199894
GH04J110509 Enhancer 0.5 ENCODE 31 +144.6 144613 1.5 CTCF ZNF654 ZNF143 SMC3 REST RAD21 ENPEP RNU6-35P EGF GC04P110502 ENSG00000250511
GH04J110472 Enhancer 0.6 ENCODE 23.2 +107.3 107263 1.6 NANOG RXRA MAX YY1 SP1 CUX1 HNF4A ZBTB33 ENPEP ENSG00000250511 GC04M110483 GC04M110434 ENSG00000199894
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ENPEP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ENPEP gene promoter:

Genomic Locations for ENPEP Gene

Genomic Locations for ENPEP Gene
199,553 bases
Plus strand

Genomic View for ENPEP Gene

Genes around ENPEP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENPEP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENPEP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENPEP Gene

Proteins for ENPEP Gene

  • Protein details for ENPEP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glutamyl aminopeptidase
    Protein Accession:
    Secondary Accessions:
    • Q504U2

    Protein attributes for ENPEP Gene

    957 amino acids
    Molecular mass:
    109244 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for ENPEP Gene

neXtProt entry for ENPEP Gene

Post-translational modifications for ENPEP Gene

  • Glycosylation at isoforms=828, Asn801, isoforms=773, Asn763, isoforms=678, isoforms=607, isoforms=597, Asn589, Asn554, Asn340, isoforms=324, Asn197, and isoforms=124
  • Modification sites at PhosphoSitePlus

Other Protein References for ENPEP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ENPEP Gene

Domains & Families for ENPEP Gene

Gene Families for ENPEP Gene

Human Protein Atlas (HPA):
  • CD markers
  • Enzymes
  • Plasma proteins
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase M1 family.
  • Belongs to the peptidase M1 family.
genes like me logo Genes that share domains with ENPEP: view

Function for ENPEP Gene

Molecular function for ENPEP Gene

UniProtKB/Swiss-Prot Function:
Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells.
UniProtKB/Swiss-Prot CatalyticActivity:
Release of N-terminal glutamate (and to a lesser extent aspartate) from a peptide.
GENATLAS Biochemistry:
glutamyl aminopeptidase,homolog of murine B-lymphocyte differentiation antigen BP-1/6C3

Enzyme Numbers (IUBMB) for ENPEP Gene

Phenotypes From GWAS Catalog for ENPEP Gene

Gene Ontology (GO) - Molecular Function for ENPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004177 aminopeptidase activity IDA,IEA 8244382
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA,EXP 16790432
GO:0008270 zinc ion binding IBA,IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ENPEP: view
genes like me logo Genes that share phenotypes with ENPEP: view

Animal Models for ENPEP Gene

MGI Knock Outs for ENPEP:

Animal Model Products

miRNA for ENPEP Gene

miRTarBase miRNAs that target ENPEP

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ENPEP Gene

Localization for ENPEP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENPEP Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ENPEP gene
Compartment Confidence
plasma membrane 5
extracellular 5
lysosome 5
endoplasmic reticulum 2
cytosol 2
golgi apparatus 2
mitochondrion 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ENPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005765 lysosomal membrane HDA 17897319
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 8244382
GO:0005903 brush border ISS,IEA --
genes like me logo Genes that share ontologies with ENPEP: view

Pathways & Interactions for ENPEP Gene

genes like me logo Genes that share pathways with ENPEP: view

Pathways by source for ENPEP Gene

Gene Ontology (GO) - Biological Process for ENPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis ISS --
GO:0002003 angiotensin maturation IEA,TAS --
GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin NAS 8346219
GO:0006508 proteolysis IEA,IBA --
GO:0007267 cell-cell signaling NAS 8346219
genes like me logo Genes that share ontologies with ENPEP: view

No data available for SIGNOR curated interactions for ENPEP Gene

Drugs & Compounds for ENPEP Gene

(10) Drugs for ENPEP Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutamic Acid Approved Nutra Full agonist, Agonist, Target 251
Zinc Approved, Investigational Pharma 2430
calcium Approved Nutra 0
bestatin Pharma Inhibition, Inhibitor Aminopeptidase inhibitor 0
Angiotensin III (human, mouse) Pharma Aldosterone stimulator 0

(7) Additional Compounds for ENPEP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) ApexBio Compounds for ENPEP Gene

Compound Action Cas Number
Angiotensin III (human, mouse) Aldosterone stimulator 13602-53-4
Bestatin Aminopeptidase inhibitor 58970-76-6
Tosedostat (CHR2797) Aminopeptidase inhibitor 238750-77-1
genes like me logo Genes that share compounds with ENPEP: view

Drug Products

Transcripts for ENPEP Gene

mRNA/cDNA for ENPEP Gene

Unigene Clusters for ENPEP Gene

Glutamyl aminopeptidase (aminopeptidase A):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ENPEP Gene

No ASD Table

Relevant External Links for ENPEP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ENPEP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ENPEP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ENPEP Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x10.5), Kidney - Cortex (x10.2), and Liver (x4.2).

Protein differential expression in normal tissues from HIPED for ENPEP Gene

This gene is overexpressed in Pancreatic juice (24.4) and Urine (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ENPEP Gene

Protein tissue co-expression partners for ENPEP Gene

NURSA nuclear receptor signaling pathways regulating expression of ENPEP Gene:


SOURCE GeneReport for Unigene cluster for ENPEP Gene:


mRNA Expression by UniProt/SwissProt for ENPEP Gene:

Tissue specificity: Expressed by epithelial cells of the proximal tubule cells and the glomerulus of the nephron. Also found in a variety of other tissues.

Evidence on tissue expression from TISSUES for ENPEP Gene

  • Kidney(4.8)
  • Liver(4.4)
  • Bone marrow(4.1)
  • Spleen(2.4)
  • Nervous system(2.4)
  • Blood(2.3)
  • Heart(2.2)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with ENPEP: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ENPEP Gene

Orthologs for ENPEP Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ENPEP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ENPEP 34 33
  • 99.55 (n)
(Bos Taurus)
Mammalia ENPEP 34 33
  • 86.86 (n)
(Canis familiaris)
Mammalia ENPEP 34 33
  • 85.99 (n)
(Rattus norvegicus)
Mammalia Enpep 33
  • 80.54 (n)
(Mus musculus)
Mammalia Enpep 16 34 33
  • 80.47 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 76 (a)
-- 34
  • 72 (a)
(Monodelphis domestica)
Mammalia ENPEP 34
  • 74 (a)
(Gallus gallus)
Aves ENPEP 34 33
  • 69.7 (n)
(Anolis carolinensis)
Reptilia ENPEP 34
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia enpep 33
  • 64.88 (n)
(Danio rerio)
Actinopterygii enpep 34 33
  • 62.29 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32473 34 33
  • 49.56 (n)
CG8774 34 35
  • 36 (a)
CG8773 34 35
  • 36 (a)
CG11951 35
  • 35 (a)
CG14516 35
  • 31 (a)
sda 35
  • 30 (a)
BG:DS00365.1 35
  • 28 (a)
CG5849 35
  • 28 (a)
CG2111 35
  • 26 (a)
CG6071 35
  • 25 (a)
CG4467 35
  • 24 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003077 33
  • 48.16 (n)
(Caenorhabditis elegans)
Secernentea T07F10.1 35
  • 29 (a)
R03G8.6 35
  • 28 (a)
R03G8.4 34 35
  • 24 (a)
T12E12.6 34
  • 22 (a)
Y42A5A.1 34 35
  • 20 (a)
AC3.5 34 35
  • 19 (a)
Y67D8C.9 34 35
  • 19 (a)
Y53F4B.20 34
  • 16 (a)
T16G12.1 34 35
  • 12 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AAP1 34
  • 31 (a)
APE2 34
  • 29 (a)
Species where no ortholog for ENPEP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ENPEP Gene

Gene Tree for ENPEP (if available)
Gene Tree for ENPEP (if available)
Evolutionary constrained regions (ECRs) for ENPEP: view image

Paralogs for ENPEP Gene

Paralogs for ENPEP Gene

(10) SIMAP similar genes for ENPEP Gene using alignment to 14 proteins:

  • H0YA67_HUMAN
  • L8E9Y3_HUMAN Pseudogenes for ENPEP Gene

genes like me logo Genes that share paralogs with ENPEP: view

Variants for ENPEP Gene

Sequence variations from dbSNP and Humsavar for ENPEP Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
VAR_036047 A breast cancer sample p.Arg887Thr
rs1000018112 -- 110,490,534(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000097566 -- 110,541,956(+) TCTCT/TCT intron_variant
rs1000132674 -- 110,492,319(+) C/T intron_variant
rs1000179090 -- 110,516,444(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ENPEP Gene

Variant ID Type Subtype PubMed ID
nsv507187 OTHER sequence alteration 20534489
nsv518506 CNV loss 19592680
nsv830036 CNV gain 17160897
nsv950376 CNV duplication 24416366
nsv964082 CNV duplication 23825009

Variation tolerance for ENPEP Gene

Residual Variation Intolerance Score: 57.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.29; 62.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ENPEP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENPEP Gene

Disorders for ENPEP Gene

MalaCards: The human disease database

(9) MalaCards diseases for ENPEP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
neurogenic hypertension
gestational choriocarcinoma
  • gestational chorionepithelioma
atrial septal defect 3
  • asd3
  • toxemia of pregnancy
syphilitic meningitis
  • syphilitic aseptic meningitis
- elite association - COSMIC cancer census association via MalaCards
Search ENPEP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ENPEP

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ENPEP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ENPEP Gene

Publications for ENPEP Gene

  1. Functional genetic variation in aminopeptidase A (ENPEP): lack of clear association with focal and segmental glomerulosclerosis (FSGS). (PMID: 18206321) Tonna S … Pollak MR (Gene 2008) 3 22 44 58
  2. High-resolution genetic map of the human glutamyl aminopeptidase gene (ENPEP). (PMID: 9268642) Li L … Cooper MD (Genomics 1997) 2 3 22 58
  3. Molecular cloning of the human kidney differentiation antigen gp160: human aminopeptidase A. (PMID: 8346219) Nanus DM … Albino AP (Proceedings of the National Academy of Sciences of the United States of America 1993) 3 4 22 58
  4. cDNA cloning and expression of human glutamyl aminopeptidase (aminopeptidase A). (PMID: 8244382) Li L … Cooper MD (Genomics 1993) 3 4 22 58
  5. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G … Riley BP (Human molecular genetics 2010) 3 44 58

Products for ENPEP Gene

Sources for ENPEP Gene

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