Aliases for ENOX2 Gene
External Ids for ENOX2 Gene
Previous HGNC Symbols for ENOX2 Gene
Previous GeneCards Identifiers for ENOX2 Gene
This gene is a tumor-specific member of the ECTO-NOX family of genes that encode cell surface NADH oxidases. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The protein also displays prion-like properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
GeneCards Summary for ENOX2 Gene
ENOX2 (Ecto-NOX Disulfide-Thiol Exchanger 2) is a Protein Coding gene. Diseases associated with ENOX2 include Facial Hemiatrophy and Variegate Porphyria. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and protein disulfide oxidoreductase activity. An important paralog of this gene is ENOX1.
UniProtKB/Swiss-Prot Summary for ENOX2 Gene
May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.