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Aliases for ENOX1 Gene

Aliases for ENOX1 Gene

  • Ecto-NOX Disulfide-Thiol Exchanger 1 2 3 5
  • Candidate Growth-Related And Time Keeping Constitutive Hydroquinone [NADH] Oxidase 3 4
  • Ecto-NADPH Oxidase Disulfide-Thiol Exchanger 1 2 3
  • Cell Proliferation-Inducing Gene 38 Protein 3 4
  • Constitutive Ecto-NOX 3 4
  • CCNOX 3 4
  • CNOX 3 4
  • Candidate Growth-Related And Time Keeping Constitutive Hydroquinone (NADH) Oxidase 3
  • BA64J21.1 3
  • PIG38 3

External Ids for ENOX1 Gene

Previous GeneCards Identifiers for ENOX1 Gene

  • GC13M042687
  • GC13M043787
  • GC13M024589

Summaries for ENOX1 Gene

Entrez Gene Summary for ENOX1 Gene

  • The protein encoded by this gene is involved in plasma membrane electron transport pathways. The encoded protein has both a hydroquinone (NADH) oxidase activity and a protein disulfide-thiol interchange activity. The two activities cycle with a periodicity of 24 minutes, with one activity being at its peak when the other is at its lowest. [provided by RefSeq, Dec 2016]

GeneCards Summary for ENOX1 Gene

ENOX1 (Ecto-NOX Disulfide-Thiol Exchanger 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and oxidoreductase activity. An important paralog of this gene is ENOX2.

UniProtKB/Swiss-Prot for ENOX1 Gene

  • Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock.

Additional gene information for ENOX1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENOX1 Gene

Genomics for ENOX1 Gene

GeneHancer (GH) Regulatory Elements for ENOX1 Gene

Promoters and enhancers for ENOX1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I043783 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 564.5 +1.1 1128 4.9 FOXA2 MZF1 ZNF76 SIN3A BMI1 RAD21 ZNF335 GLIS2 ZNF213 SCRT2 ENOX1 ENSG00000270522 GC13P043776
GH13I043804 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 3.2 -18.2 -18244 1.9 CTCF ZFP64 RAD21 POLR2A ZNF143 SMC3 FOS FOSL2 ZBTB20 ZNF654 CCDC122 LACC1 ENOX1 LOC105370181 GC13P043791
GH13I043685 Enhancer 0.9 Ensembl ENCODE 4.3 +100.4 100369 1.9 ZBTB21 INSM2 KLF17 ZNF366 POLR2A ATF7 FOSL2 FOS ZNF600 MAFK CCDC122 ENOX1 GC13M043559 GC13P043776
GH13I043362 Enhancer 0.8 FANTOM5 Ensembl ENCODE 4.4 +422.8 422795 3 JUN ZIC2 ENOX1 GC13M043326 GC13P043328
GH13I043433 Enhancer 0.5 ENCODE 5.8 +353.1 353076 1.6 ZFHX2 ATF2 RFX5 EGR2 ENOX1 ENOX1-AS2 RPL36P19
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ENOX1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ENOX1 gene promoter:

Genomic Locations for ENOX1 Gene

Genomic Locations for ENOX1 Gene
chr13:43,213,130-43,786,980
(GRCh38/hg38)
Size:
573,851 bases
Orientation:
Minus strand
chr13:43,787,654-44,361,116
(GRCh37/hg19)

Genomic View for ENOX1 Gene

Genes around ENOX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENOX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENOX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENOX1 Gene

Proteins for ENOX1 Gene

  • Protein details for ENOX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TC92-ENOX1_HUMAN
    Recommended name:
    Ecto-NOX disulfide-thiol exchanger 1
    Protein Accession:
    Q8TC92
    Secondary Accessions:
    • A4GU15
    • A6NMH9
    • B7Z5K1
    • Q2TU81
    • Q5VT11
    • Q9NWE0

    Protein attributes for ENOX1 Gene

    Size:
    643 amino acids
    Molecular mass:
    73348 Da
    Cofactor:
    Name=Cu cation; Xref=ChEBI:CHEBI:23378;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ENOX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ENOX1 Gene

Post-translational modifications for ENOX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ENOX1 Gene

Domains & Families for ENOX1 Gene

Gene Families for ENOX1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ENOX1 Gene

Suggested Antigen Peptide Sequences for ENOX1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TC92

UniProtKB/Swiss-Prot:

ENOX1_HUMAN :
  • Belongs to the ENOX family.
Family:
  • Belongs to the ENOX family.
genes like me logo Genes that share domains with ENOX1: view

Function for ENOX1 Gene

Molecular function for ENOX1 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Not inhibited by the antitumor sulfonylurea LY181984, the vabilloid capsaicin, and retinoids.
UniProtKB/Swiss-Prot Function:
Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock.

Phenotypes From GWAS Catalog for ENOX1 Gene

Gene Ontology (GO) - Molecular Function for ENOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with ENOX1: view
genes like me logo Genes that share phenotypes with ENOX1: view

Animal Models for ENOX1 Gene

MGI Knock Outs for ENOX1:

Animal Model Products

  • Taconic Biosciences Mouse Models for ENOX1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ENOX1 Gene

Localization for ENOX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENOX1 Gene

Cell membrane. Secreted, extracellular space. Note=Extracellular and plasma membrane-associated.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ENOX1 gene
Compartment Confidence
plasma membrane 5
extracellular 3
nucleus 2
cytosol 2
cytoskeleton 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ENOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane IDA,IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ENOX1: view

Pathways & Interactions for ENOX1 Gene

SuperPathways for ENOX1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ENOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048511 rhythmic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with ENOX1: view

No data available for Pathways by source and SIGNOR curated interactions for ENOX1 Gene

Drugs & Compounds for ENOX1 Gene

(2) Drugs for ENOX1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma 202
NAD Pharma Full agonist, Agonist 0
genes like me logo Genes that share compounds with ENOX1: view

Transcripts for ENOX1 Gene

mRNA/cDNA for ENOX1 Gene

(23) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ENOX1 Gene

Ecto-NOX disulfide-thiol exchanger 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ENOX1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1: - - - - - - -
SP2: - - - - - - - - -
SP3: - - - -
SP4: - -
SP5: - - - - - - - -
SP6: - - - - - - - - - - - - -
SP7:
SP8:

ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for ENOX1 Gene

GeneLoc Exon Structure for
ENOX1
ECgene alternative splicing isoforms for
ENOX1

Expression for ENOX1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ENOX1 Gene

Protein differential expression in normal tissues from HIPED for ENOX1 Gene

This gene is overexpressed in Stomach (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ENOX1 Gene



Protein tissue co-expression partners for ENOX1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ENOX1 Gene:

ENOX1

SOURCE GeneReport for Unigene cluster for ENOX1 Gene:

Hs.128258

mRNA Expression by UniProt/SwissProt for ENOX1 Gene:

Q8TC92-ENOX1_HUMAN
Tissue specificity: Expressed in lymphocyte cells, breast and breast cancer (at protein level). Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Found also in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed into serum by cancer cells.

Evidence on tissue expression from TISSUES for ENOX1 Gene

  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with ENOX1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENOX1 Gene

Orthologs for ENOX1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ENOX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ENOX1 33 34
  • 99.9 (n)
dog
(Canis familiaris)
Mammalia ENOX1 33 34
  • 92.68 (n)
mouse
(Mus musculus)
Mammalia Enox1 33 16 34
  • 89.74 (n)
cow
(Bos Taurus)
Mammalia ENOX1 33 34
  • 89.63 (n)
rat
(Rattus norvegicus)
Mammalia Enox1 33
  • 89.32 (n)
oppossum
(Monodelphis domestica)
Mammalia ENOX1 34
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ENOX1 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves ENOX1 33 34
  • 85.18 (n)
lizard
(Anolis carolinensis)
Reptilia ENOX1 34
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia enox1 33
  • 77.34 (n)
Str.674 33
zebrafish
(Danio rerio)
Actinopterygii enox1 33 34
  • 70.85 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10948 33 34
  • 51.85 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011541 33
  • 50.39 (n)
Species where no ortholog for ENOX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ENOX1 Gene

ENSEMBL:
Gene Tree for ENOX1 (if available)
TreeFam:
Gene Tree for ENOX1 (if available)

Paralogs for ENOX1 Gene

Paralogs for ENOX1 Gene

(1) SIMAP similar genes for ENOX1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ENOX1: view

Variants for ENOX1 Gene

Sequence variations from dbSNP and Humsavar for ENOX1 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs193920792 uncertain-significance, Malignant tumor of prostate 43,355,977(-) CGGGGAT/ coding_sequence_variant, frameshift, non_coding_transcript_variant
rs1000004372 -- 43,444,117(-) C/G intron_variant
rs1000009200 -- 43,773,390(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000010382 -- 43,631,847(-) G/C genic_upstream_transcript_variant, intron_variant
rs1000012696 -- 43,411,211(-) AGAGAGAA/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ENOX1 Gene

Variant ID Type Subtype PubMed ID
dgv1637n100 CNV gain 25217958
dgv1642n100 CNV gain 25217958
dgv1643n100 CNV gain 25217958
dgv1644n100 CNV gain 25217958
dgv3129n54 CNV gain 21841781
dgv3131n54 CNV gain 21841781
dgv3133n54 CNV gain 21841781
dgv329e214 CNV gain 21293372
dgv542e212 CNV gain 25503493
esv26544 CNV loss 19812545
esv2662839 CNV deletion 23128226
esv2667272 CNV deletion 23128226
esv2747324 CNV deletion 23290073
esv2747325 CNV deletion 23290073
esv2751145 CNV gain 17911159
esv2751146 CNV gain 17911159
esv275158 CNV loss 21479260
esv2763018 CNV loss 21179565
esv3307478 CNV mobile element insertion 20981092
esv3330739 CNV insertion 20981092
esv33538 CNV gain 17666407
esv3550391 CNV deletion 23714750
esv3631919 CNV gain 21293372
esv3631921 CNV loss 21293372
esv3631924 CNV loss 21293372
esv3631925 CNV loss 21293372
esv3892336 CNV loss 25118596
nsv1019 CNV insertion 18451855
nsv1046164 CNV gain 25217958
nsv1070586 CNV deletion 25765185
nsv1111092 CNV tandem duplication 24896259
nsv1113562 CNV deletion 24896259
nsv1116724 CNV tandem duplication 24896259
nsv1134306 CNV deletion 24896259
nsv1138219 CNV deletion 24896259
nsv1145660 CNV deletion 24896259
nsv472557 CNV novel sequence insertion 20440878
nsv516197 CNV gain 19592680
nsv516714 CNV loss 19592680
nsv518904 CNV gain 19592680
nsv526810 CNV loss 19592680
nsv528539 CNV loss 19592680
nsv561573 CNV loss 21841781
nsv826632 CNV loss 20364138
nsv832594 CNV gain+loss 17160897
nsv832595 CNV gain 17160897
nsv930476 CNV insertion 23359205
nsv958157 CNV deletion 24416366

Variation tolerance for ENOX1 Gene

Residual Variation Intolerance Score: 8.51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.99; 60.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ENOX1 Gene

Human Gene Mutation Database (HGMD)
ENOX1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ENOX1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENOX1 Gene

Disorders for ENOX1 Gene

Additional Disease Information for ENOX1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ENOX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ENOX1 Gene

Publications for ENOX1 Gene

  1. A drug-unresponsive and protease-resistant CNOX protein from human sera. (PMID: 11360993) Sedlak D … Mooré DJ (Archives of biochemistry and biophysics 2001) 2 3 4 58
  2. Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. (PMID: 22491018) Wang J … Platt A (The pharmacogenomics journal 2013) 3 44 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Molecular cloning and characterization of a candidate human growth-related and time-keeping constitutive cell surface hydroquinone (NADH) oxidase. (PMID: 19055324) Jiang Z … Morré DJ (Biochemistry 2008) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for ENOX1 Gene

Sources for ENOX1 Gene

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