Aliases for ENO2 Gene
External Ids for ENO2 Gene
Previous GeneCards Identifiers for ENO2 Gene
This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. [provided by RefSeq, Jul 2008]
GeneCards Summary for ENO2 Gene
ENO2 (Enolase 2) is a Protein Coding gene. Diseases associated with ENO2 include Granular Cell Tumor and Creutzfeldt-Jakob Disease. Among its related pathways are Glucose metabolism and Citrate cycle (TCA cycle). Gene Ontology (GO) annotations related to this gene include magnesium ion binding and phosphopyruvate hydratase activity. An important paralog of this gene is ENO3.
UniProtKB/Swiss-Prot Summary for ENO2 Gene
Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity).