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This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. [provided by RefSeq, Jul 2008] See more...
Aliases for ENO2 Gene
Aliases for ENO2 Gene
External Ids for ENO2 Gene
- HGNC: 3353
- NCBI Entrez Gene: 2026
- Ensembl: ENSG00000111674
- OMIM®: 131360
- UniProtKB/Swiss-Prot: P09104
Previous GeneCards Identifiers for ENO2 Gene
- GC12M006942
- GC12M007028
- GC12P006902
- GC12P006894
- GC12P006897
- GC12P006898
- GC12P007023
- GC12P007037
- GC12P007067
- GC12P007116
- GC12P007149
Summaries for ENO2 Gene
-
This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. [provided by RefSeq, Jul 2008]
GeneCards Summary for ENO2 Gene
ENO2 (Enolase 2) is a Protein Coding gene. Diseases associated with ENO2 include Granular Cell Tumor and Creutzfeldt-Jakob Disease. Among its related pathways are Glucose metabolism and Carbon metabolism. Gene Ontology (GO) annotations related to this gene include magnesium ion binding and phosphopyruvate hydratase activity. An important paralog of this gene is ENO3.
UniProtKB/Swiss-Prot Summary for ENO2 Gene
-
Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity).
Additional gene information for ENO2 Gene
- HGNC (3353)
- NCBI Entrez Gene (2026)
- Ensembl (ENSG00000111674)
- OMIM® (131360)
- UniProtKB/Swiss-Prot (P09104)
- Open Targets Platform(ENSG00000111674)
- Monarch Initiative
- Search for ENO2 at DataMed
- Search for ENO2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ENO2 Gene
Genomics for ENO2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ENO2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ENO2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ENO2
- Top Transcription factor binding sites by QIAGEN in the ENO2 gene promoter:
-
- AP-1
- ATF-2
- GR
- GR-alpha
- GR-beta
- p53
- STAT3
Genomic Locations for ENO2 Gene
Latest Assembly
- chr12:6,913,745-6,923,698
- (GRCh38/hg38)
- Size:
- 9,954 bases
- Orientation:
- Plus strand
Previous Assembly
- chr12:7,023,744-7,032,860
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 9,117 bases
- Orientation:
- Plus strand
- chr12:7,022,909-7,032,861
- (GRCh37/hg19 by Ensembl)
- Size:
- 9,953 bases
- Orientation:
- Plus strand
Genomic View for ENO2 Gene
Genes around ENO2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p13.31 by HGNC
- 12p13.31 by Entrez Gene
- 12p13.31 by Ensembl
ENO2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ENO2 Gene
Proteins for ENO2 Gene
-
Protein details for ENO2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P09104-ENOG_HUMAN
- Recommended name:
- Gamma-enolase
- Protein Accession:
- P09104
- B7Z2X9
- Q96J33
Protein attributes for ENO2 Gene
- Size:
- 434 amino acids
- Molecular mass:
- 47269 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Mammalian enolase is composed of 3 isozyme subunits, alpha, beta and gamma, which can form homodimers or heterodimers which are cell-type and development-specific.
- SequenceCaution:
-
- Sequence=AAA52388.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for ENO2 Gene
Protein Expression for ENO2 Gene
Selected DME Specific Peptides for ENO2 Gene
- P09104:
-
- TGQIKTG
- LLLKVNQIG
- YPVVSIEDPFDQD
- VGDDLTV
- DDLTVTNP
- DSRGNPT
- VSLAVCKAGA
- KTGAPCR
- GDEGGFAP
- AGHNFRNP
- GQIKTGAP
- AKYNQLMRIE
- DVAASEF
- EALELRDGD
- PSGASTG
- REILDSRG
- SRGNPTVE
- FIADLVVGL
- IGMDVAAS
- GKGVLKA
- QEFMILP
- LDGTENK
- RSGETED
- FGANAIL
- GANAILGVS
- RYLGKGV
- SHRSGET
- QIVGDDL
- VTNPKRI
- NVGDEGG
- DGTENKS
- ELRDGDK
- KYGKDATNVG
- PVGAESF
- RSERLAK
Post-translational modifications for ENO2 Gene
Other Protein References for ENO2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences ENO2 / NSE Monoclonal Antibody and ENO2 / NSE Antibody
- GeneTex Anti-NSE antibody [N1C1] and Anti-NSE antibody [C1C3]
- NSJ Bioreagents NSE Antibody / Neuron Specific Enolase (Mouse Monoclonal)
-
BioLegend
- Purified anti-NSE (804501)
- Purified anti-NSE (804901)
- Alexa Fluor(R) 594 anti-NSE (804903)
- Alexa Fluor(R) 594 anti-NSE (804902)
- Alexa Fluor(R) 647 anti-NSE (804907)
- Alexa Fluor(R) 647 anti-NSE (804906)
- Alexa Fluor(R) 488 anti-NSE (804905)
- Alexa Fluor(R) 488 anti-NSE (804904)
- Purified anti-NSE (804908)
-
Custom Antibody ServicesOriGene Antibodies for ENO2
- 4N6-1C1
- 4N6-2F1
- 4N6-5A4
- 4N6-5E2
- 4N6-5G10
- 4N6-H11
- AM00578SU-N
- AM09272PU-N
- AM09273PU-N
- AM09274PU-N
- AM31841PU-N
- AM50058PU-N
- AM50058PU-S
- AP06253PU-N
- AP12426PU-N
- AP12427PU-N
- AP12999PU-N
- AP23266PU-N
- AP31758PU-N
- AP31816PU-N
- BM021
- BM150
- TA309202
- TA311937
- TA321414
- TA327525
- TA336531
- TA347441
- TA353161L
- TA353162L
- TA590105
- Novus Biologicals Antibodies for ENO2
-
Abcam antibodies for ENO2
- Invitrogen Antibodies for ENO2 (AFLGC-ENO2)
-
Custom Antibody ServicesProSci Antibodies for ENO2
-
Santa Cruz Biotechnology (SCBT) Antibodies for ENO2
- Sino Biological Antibodies for ENO2
Protein products for research
- G Biosciences Human Enolase 2/ENO2/Gamma-enolase, Lyophilized
- Search Origene for MassSpec and Protein Over-expression Lysates for ENO2
- Origene Custom Protein Services for ENO2
- Sino Biological Recombinant Proteins for ENO2
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for ENO2
-
Abcam proteins for ENO2
Domains & Families for ENO2 Gene
Gene Families for ENO2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for ENO2 Gene
- InterPro:
- Blocks:
-
- Enolase
- ProtoNet:
Suggested Antigen Peptide Sequences for ENO2 Gene
- GenScript: Design optimal peptide antigens:
-
- Enolase (B7Z2X9_HUMAN)
- Neuron-specific enolase (ENOG_HUMAN)
- Enolase (F5H0C8_HUMAN)
- Enolase (Q6FHV6_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P09104- Family:
-
- Belongs to the enolase family.
Function for ENO2 Gene
Molecular function for ENO2 Gene
- UniProtKB/Swiss-Prot Function:
- Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate; Xref=Rhea:RHEA:10164, ChEBI:CHEBI:15377, ChEBI:CHEBI:58289, ChEBI:CHEBI:58702; EC=4.2.1.11;.
- UniProtKB/Swiss-Prot Induction:
- Levels of ENO2 increase dramatically in cardiovascular accidents, cerebral trauma, brain tumors and Creutzfeldt-Jakob disease.
- GENATLAS Biochemistry:
- enolase 2,gamma subunit,neuronal (2-phospho-D-glycerate hydrolase),glycolysis,energy pathway
Enzyme Numbers (IUBMB) for ENO2 Gene
Phenotypes From GWAS Catalog for ENO2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000287 | magnesium ion binding | IEA | -- |
| GO:0004634 | phosphopyruvate hydratase activity | IEA,ISS | 22087329 |
| GO:0005515 | protein binding | IPI | 21044950 |
| GO:0016829 | lyase activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ENO2 Gene
- MGI mutant phenotypes for ENO2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ENO2:
Animal Models for research
-
Taconic Biosciences Mouse Models for ENO2
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ENO2 - Starting at $85 >
- * ENO2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ENO2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ENO2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ENO2
miRNA for ENO2 Gene
- miRTarBase miRNAs that target ENO2
-
- mmu-miR-301b-3p (MIRT008006)
- mmu-miR-30e-5p (MIRT013470)
- mmu-miR-24-3p (MIRT013968)
- hsa-miR-93-3p (MIRT038722)
- hsa-miR-99b-5p (MIRT044208)
- hsa-miR-382-3p (MIRT440723)
- mmu-miR-539-5p (MIRT583773)
- mmu-miR-495-3p (MIRT583774)
- mmu-miR-1192 (MIRT583775)
- mmu-miR-466l-3p (MIRT583776)
- mmu-miR-804 (MIRT590147)
- mmu-miR-3089-5p (MIRT590148)
- mmu-miR-1195 (MIRT590149)
- mmu-miR-665-3p (MIRT590150)
- mmu-miR-1190 (MIRT590151)
- mmu-miR-883a-5p (MIRT590152)
- mmu-miR-706 (MIRT590153)
- mmu-miR-218-5p (MIRT590154)
- mmu-miR-3967 (MIRT590155)
- mmu-miR-5121 (MIRT590156)
- mmu-miR-669d-5p (MIRT590157)
- mmu-miR-297b-5p (MIRT590158)
- mmu-miR-297a-5p (MIRT590159)
- mmu-miR-297c-5p (MIRT590160)
- mmu-miR-30a-5p (MIRT590161)
- mmu-miR-30c-5p (MIRT590162)
- mmu-miR-30d-5p (MIRT590163)
- mmu-miR-384-5p (MIRT590164)
- mmu-miR-30b-5p (MIRT590165)
- mmu-miR-466m-3p (MIRT590166)
- mmu-miR-466o-3p (MIRT590167)
- mmu-miR-208a-5p (MIRT604065)
- mmu-miR-709 (MIRT604066)
- mmu-miR-10b-5p (MIRT606448)
- mmu-miR-10a-5p (MIRT606449)
- mmu-miR-339-5p (MIRT606450)
- mmu-miR-669e-5p (MIRT606451)
- mmu-miR-431-5p (MIRT606453)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ENO2
- Browse OriGene Inhibitory RNA Products For ENO2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ENO2
Clone products for research
- Applied Biological Materials (abm): Clones for ENO2 - Starting at $45 >
- * ENO2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ENO2
- Addgene plasmids for ENO2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ENO2
Cell Lines for research
-
Horizon Cell Lines for ENO2
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ENO2 Gene
Localization for ENO2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ENO2 Gene
- Cytoplasm. Cell membrane. Note=Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| plasma membrane | 4 |
| cytoskeleton | 3 |
| mitochondrion | 3 |
| nucleus | 3 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
| endosome | 1 |
- Cytosol (3)
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000015 | phosphopyruvate hydratase complex | IEA,IBA | 21873635 |
| GO:0001917 | photoreceptor inner segment | IEA | -- |
| GO:0005615 | extracellular space | HDA | 22664934 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for ENO2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glucose metabolism |
Glycolysis and gluconeogenesis (short map)
.58
.52
.46
|
.35
.01
|
| 2 | Carbon metabolism | ||
| 3 | Metabolism |
.40
|
|
| 4 | Glucose / Energy Metabolism | ||
| 5 | Neuroscience | ||
Pathways by source for ENO2 Gene
4 BioSystems pathways for ENO2 Gene
5 Reactome pathways for ENO2 Gene
6 KEGG pathways for ENO2 Gene
1 GeneGo (Thomson Reuters) pathway for ENO2 Gene
- Glycolysis and gluconeogenesis (short map)
2 Cell Signaling Technology pathways for ENO2 Gene
UniProtKB/Swiss-Prot P09104-ENOG_HUMAN
- Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.
Interacting Proteins for ENO2 Gene
Selected Interacting proteins:
P09104-ENOG_HUMAN
ENSP00000437402
for ENO2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for ENO2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006094 | gluconeogenesis | TAS | -- |
| GO:0006096 | glycolytic process | IEA,ISS | 22087329 |
| GO:0032889 | regulation of vacuole fusion, non-autophagic | IBA | 21873635 |
| GO:0061621 | canonical glycolysis | TAS | -- |
No data available for SIGNOR curated interactions for ENO2 Gene
Drugs & Compounds for ENO2 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for ENO2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| AP-III-a4 | 1177827-73-4 |
Drug products for research
- G Biosciences Human Enolase 2/ENO2/Gamma-enolase, Lyophilized
- ApexBio compounds for ENO2
Transcripts for ENO2 Gene
mRNA/cDNA for ENO2 Gene
- 1 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000229277 2294 nts (view in UCSC)
- ENST00000441285 597 nts (view in UCSC)
- ENST00000534977 351 nts (view in UCSC)
- ENST00000535275 724 nts (view in UCSC)
- ENST00000535366 2827 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ENO2 - Starting at $85 >
- * ENO2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ENO2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ENO2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ENO2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ENO2
- Browse OriGene Inhibitory RNA Products For ENO2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ENO2
Clone products for research
- Applied Biological Materials (abm): Clones for ENO2 - Starting at $45 >
- * ENO2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ENO2
- Addgene plasmids for ENO2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ENO2
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - |
| ExUns: | 12b |
|---|---|
| SP1: | |
| SP2: | |
| SP3: | |
| SP4: | |
| SP5: | |
| SP6: | |
| SP7: | |
| SP8: | |
| SP9: | |
| SP10: | |
| SP11: | |
| SP12: | |
| SP13: |
Relevant External Links for ENO2 Gene
- GeneLoc Exon Structure for
- ENO2
Expression for ENO2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
- NULL (Uncategorized)
- Inner Cell Mass (Early Embryonic Tissues)
- Bone (Muscoskeletal System)
- Mesenchymal Stem Cells
-
Gonad (Reproductive System)
- Testis Somatic Cells Primitive Gonad
-
Testis (Reproductive System)
- Testis Somatic Cells Primitive Gonad
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Pancreas (Endocrine System)
- Motor Neurons (Nervous System)
- Spinal Cord (Nervous System)
mRNA differential expression in normal tissues according to GTEx for ENO2 Gene
This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.0), Brain - Cerebellum (x5.5), Brain - Frontal Cortex (BA9) (x4.6), and Brain - Cortex (x4.3).
This gene is overexpressed in Retina (17.2), Brain (13.9), and Saliva (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ENO2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ENO2
SOURCE GeneReport for Unigene cluster for ENO2 Gene:
Hs.511915mRNA Expression by UniProt/SwissProt for ENO2 Gene:
P09104-ENOG_HUMAN
Tissue specificity:
The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.
Evidence on tissue expression from TISSUES for ENO2 Gene
- Nervous system(5)
- Eye(4.9)
- Blood(4.6)
- Liver(4.6)
- Kidney(4.1)
- Lung(3.1)
- Adrenal gland(3.1)
- Lymph node(3)
- Intestine(3)
- Muscle(3)
- Pancreas(2.9)
- Heart(2.9)
- Skin(2.9)
- Thyroid gland(2.8)
- Stomach(2.6)
- Gall bladder(2.5)
- Bone marrow(2.4)
- Spleen(2.3)
- Bone(2.1)
- Urine(2)
Primer products for research
-
OriGene qPCR primer pairs for ENO2
-
OriGene qPCR primer pairs and template standards for ENO2
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ENO2 Gene
Orthologs for ENO2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Dog (Canis familiaris) |
Mammalia | ENO2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ENO2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Eno2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | LOC100911625 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ENO2 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ENO2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ENO2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ENO2 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | eno2 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Eno 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | enol-1 31 |
|
OneToMany | |
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AER294C 30 |
|
||
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0A09185g 30 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ENO1 30 31 |
|
ManyToMany | |
| ENO2 31 |
|
ManyToMany | |||
| ERR2 31 |
|
ManyToMany | |||
| ERR1 31 |
|
ManyToMany | |||
| ERR3 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10219 31 |
|
OneToMany | |
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU10042 30 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | eno101 30 |
|
- Species where no ortholog for ENO2 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for ENO2 Gene
- ENSEMBL:
- Gene Tree for ENO2 (if available)
- TreeFam:
- Gene Tree for ENO2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ENO2: view image
Paralogs for ENO2 Gene
Variants for ENO2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ENO2 Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs141344525 | Benign: not provided | 6,917,572(+) |
A/C NM_001975.3(ENO2):c.311-9A>C |
INTRON | |
| VAR_002354 | - |
p.Pro264Ala |
|||
| VAR_002355 | - |
p.Thr395Ala |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1035811 | CNV | gain | 25217958 |
| nsv1047373 | CNV | gain | 25217958 |
| nsv1129363 | OTHER | inversion | 24896259 |
| nsv509453 | CNV | insertion | 20534489 |
| nsv557261 | CNV | loss | 21841781 |
| nsv832324 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
14.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.56;
12.09% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ENO2 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENO2 Gene
Disorders for ENO2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| granular cell tumor |
|
|
| creutzfeldt-jakob disease |
|
|
| bronchus cancer |
|
|
| olfactory neuroblastoma |
|
|
| neuroendocrine carcinoma |
|
|
Search ENO2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ENO2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ENO2 Gene
Publications for ENO2 Gene
- The estrogen hypothesis of schizophrenia implicates glucose metabolism: association study in three independent samples. (PMID: 18460190) Olsen L ā¦ Werge T (BMC medical genetics 2008) 3 23 41
- Serum levels of S100B and NSE proteins in Alzheimer's disease patients. (PMID: 20105309) Chaves ML ā¦ Portela LV (Journal of neuroinflammation 2010) 3 23
- [Changes in plasma S-100 beta and neuron-specific enolase in peri-operative period of orthotopic liver transplantation and its relationship with encephalopathy after operation]. (PMID: 19220958) Sun HY ā¦ Li SR (Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 2009) 3 23
- Serum concentrations of s100b and NSE in migraine. (PMID: 18783450) Teepker M ā¦ Schepelmann K (Headache 2009) 3 23
- Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PMID: 19204726) Chapuis J ā¦ Lambert JC (Molecular psychiatry 2009) 3 41
ExternalLinks
Products for ENO2 Gene
- View all 10 R&D Systems ENO2 (Enolase 2/Neuron-specific Enolase) Products
- View all R&D Systems ENO2 (Enolase 2/Neuron-specific Enolase) Proteins and Enzymes
- View all 3 R&D Systems ENO2 (Enolase 2/Neuron-specific Enolase) Primary Antibodies
- View all 3 R&D Systems ENO2 (Enolase 2/Neuron-specific Enolase) ELISAs
- View all R&D Systems ENO2 (Enolase 2/Neuron-specific Enolase) Luminex Assays
- View all R&D Systems ENO2 (Enolase 2/Neuron-specific Enolase) Proteome Profiler Antibody Arrays
- View all R&D Systems ENO2 (Enolase 2/Neuron-specific Enolase) cDNA Clones
- Learn more about R&D Systems custom ENO2 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for ENO2
- 4N6-1C1
- 4N6-2F1
- 4N6-5A4
- 4N6-5E2
- 4N6-5G10
- 4N6-H11
- AM00578SU-N
- AM09272PU-N
- AM09273PU-N
- AM09274PU-N
- AM31841PU-N
- AM50058PU-N
- AM50058PU-S
- AP06253PU-N
- AP12426PU-N
- AP12427PU-N
- AP12999PU-N
- AP23266PU-N
- AP31758PU-N
- AP31816PU-N
- BM021
- BM150
- TA309202
- TA311937
- TA321414
- TA327525
- TA336531
- TA347441
- TA353161L
- TA353162L
- TA590105
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for ENO2
- Origene Custom Protein Services for ENO2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ENO2
- Browse OriGene Inhibitory RNA Products For ENO2
- OriGene qPCR primer pairs for ENO2
- OriGene qPCR primer pairs and template standards for ENO2
- OriGene CRISPR knockouts for ENO2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ENO2
- Sino Biological Human cDNA Clone for ENO2
- Sino Biological Recombinant Proteins for ENO2
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for ENO2
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ENO2
- Novus Biologicals proteins and lysates for ENO2
- Novus Biologicals ELISA Kits for ENO2
- Browse Antibodies
- Browse Peptides and Proteins
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- Abcam antibodies for ENO2
- Abcam proteins for ENO2
- Abcam assays for ENO2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
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- ProSpec Recombinant Proteins for ENO2
- Taconic Biosciences Mouse Models for ENO2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for ENO2 (AFLGC-ENO2)
- ApexBio compounds for ENO2
- VectorBuilder Custom and pre-made DNA vectors for ENO2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ENO2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ENO2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ENO2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ENO2
- Addgene plasmids for ENO2
- antibodies-online: Show 196 available ENO2 Antibodies ranked by validation data
- Compare Top ENO2 Antibodies
- antibodies-online: Show 86 available ENO2 Elisa Kits ranked by validation data
- Compare Top ENO2 Elisa Kits
- antibodies-online: Show 45 available ENO2 Proteins ranked by validation data
- Compare Top ENO2 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for ENO2
- Search Santa Cruz Biotechnology (SCBT) for ENO2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ENO2
- Custom Antibody ServicesProSci Antibodies for ENO2
- Search for ENO2 Proteins at ProSci
- Horizon Cell Lines for ENO2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ENO2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ENO2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ENO2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ENO2
Sources for ENO2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152)