This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has b... See more...

Aliases for ENO1 Gene

Aliases for ENO1 Gene

  • Enolase 1 2 3 4 5
  • Alpha-Enolase 2 3 4
  • 2-Phospho-D-Glycerate Hydro-Lyase 3 4
  • Plasminogen-Binding Protein 3 4
  • Phosphopyruvate Hydratase 3 4
  • Non-Neural Enolase 3 4
  • Enolase 1, (Alpha) 2 3
  • EC 4.2.1.11 4 52
  • ENO1L1 3 4
  • MPB1 3 4
  • NNE 3 4
  • Epididymis Secretory Protein Li 17 3
  • C-Myc Promoter-Binding Protein-1 3
  • MYC Promoter-Binding Protein 1 3
  • C-Myc Promoter-Binding Protein 4
  • Alpha Enolase Like 1 3
  • Tau-Crystallin 3
  • Enolase-Alpha 3
  • HEL-S-17 3
  • EC 4.2.1 52
  • MBP-1 4
  • MBPB1 4
  • MPB-1 4
  • PPH 3

External Ids for ENO1 Gene

Previous HGNC Symbols for ENO1 Gene

  • ENO1L1
  • MPB1

Previous GeneCards Identifiers for ENO1 Gene

  • GC01M008541
  • GC01M008732
  • GC01M008517
  • GC01M008630
  • GC01M008855
  • GC01M008843
  • GC01M008921
  • GC01M008070

Summaries for ENO1 Gene

Entrez Gene Summary for ENO1 Gene

  • This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011]

GeneCards Summary for ENO1 Gene

ENO1 (Enolase 1) is a Protein Coding gene. Diseases associated with ENO1 include Hashimoto Encephalopathy and Cancer-Associated Retinopathy. Among its related pathways are Carbon metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity. An important paralog of this gene is ENO3.

UniProtKB/Swiss-Prot Summary for ENO1 Gene

  • Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:29775581, PubMed:1369209). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:2005901, PubMed:10802057, PubMed:12666133, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209).
  • MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor.

Gene Wiki entry for ENO1 Gene

Additional gene information for ENO1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ENO1 Gene

Genomics for ENO1 Gene

GeneHancer (GH) Regulatory Elements for ENO1 Gene

Promoters and enhancers for ENO1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J008869 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 521.6 +3.4 3400 11.8 RXRA HNRNPK ZBTB40 EP300 CTCF ZSCAN5C SIN3A MYC NRF1 POLR2G ENO1 RERE GPR157 RERE-AS1 CLSTN1 PIK3CD-AS2 MIR34AHG SLC45A1 H6PD ENO1-AS1
GH01J008856 Enhancer 1.3 Ensembl ENCODE dbSUPER 34.1 +20.1 20105 5.4 CTCF ZSCAN5C NRF1 POLR2G ZNF10 KDM6A POLR2A AFF1 REST HES1 piR-32214-007 ENO1 RNU6-304P RERE RERE-AS1 MIR6728
GH01J008700 Promoter/Enhancer 2.1 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.5 +176.3 176278 5.3 HNRNPK ZBTB40 ZNF217 EP300 ZSCAN5C SIN3A TCF12 MYC POLR2G SP1 PER3 ENO1 RERE-AS1 piR-34822-001 piR-42694-002 lnc-RERE-3 RERE
GH01J008847 Enhancer 1.3 ENCODE CraniofacialAtlas dbSUPER 15.1 +30.7 30677 2.1 CTCF ZSCAN5C GABPA ZBTB26 REST ZBTB25 MYC CTBP1 EP300 RAD21 RERE ENO1 piR-57133-003
GH01J008864 Enhancer 1 Ensembl ENCODE dbSUPER 19 +13.3 13315 2.7 POLR2G POLR2A KDM5B MYNN U2AF1 RBM22 SRSF4 ZGPAT POU2F2 SUPT5H MIR6728 H6PD ENO1 RERE-AS1 PIK3CD-AS2 piR-32214-007
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ENO1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ENO1

Top Transcription factor binding sites by QIAGEN in the ENO1 gene promoter:
  • AML1a
  • c-Ets-1
  • CUTL1
  • GATA-1
  • PPAR-gamma1
  • PPAR-gamma2
  • RFX1
  • Sox5

Genomic Locations for ENO1 Gene

Genomic Locations for ENO1 Gene
chr1:8,861,000-8,879,190
(GRCh38/hg38)
Size:
18,191 bases
Orientation:
Minus strand
chr1:8,921,059-8,939,308
(GRCh37/hg19)
Size:
18,250 bases
Orientation:
Minus strand

Genomic View for ENO1 Gene

Genes around ENO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENO1 Gene

Proteins for ENO1 Gene

  • Protein details for ENO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06733-ENOA_HUMAN
    Recommended name:
    Alpha-enolase
    Protein Accession:
    P06733
    Secondary Accessions:
    • B2RD59
    • P22712
    • Q16704
    • Q4TUS4
    • Q53FT9
    • Q53HR3
    • Q658M5
    • Q6GMP2
    • Q71V37
    • Q7Z3V6
    • Q8WU71
    • Q96GV1
    • Q9BT62
    • Q9UCH6
    • Q9UM55

    Protein attributes for ENO1 Gene

    Size:
    434 amino acids
    Molecular mass:
    47169 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Mammalian enolase is composed of 3 isozyme subunits, alpha, beta and gamma, which can form homodimers or heterodimers which are cell-type and development-specific (PubMed:18560153). ENO1 interacts with PLG in the neuronal plasma membrane and promotes its activation. The C-terminal lysine is required for this binding (PubMed:9308760). Isoform MBP-1 interacts with TRAPPC2B (PubMed:11134351). Interacts with ENO4 and PGAM2 (By similarity). Interacts with CMTM6 (PubMed:28813417).
    Miscellaneous:
    • Used as a diagnostic marker for many tumors and, in the heterodimeric form, alpha/gamma, as a marker for hypoxic brain injury after cardiac arrest. Also marker for endometriosis. Antibodies against alpha-enolase are present in sera from patients with cancer-associated retinopathy syndrome (CAR), a progressive blinding disease which occurs in the presence of systemic tumor growth, primarily small-cell carcinoma of the lung and other malignancies. Is identified as an autoantigen in Hashimoto encephalopathy (HE) a rare autoimmune disease associated with Hashimoto thyroiditis (HT). HT is a disorder in which destructive processes overcome the potential capacity of thyroid replacement leading to hypothyroidism.
    • [Isoform MBP-1]: It is uncertain whether the alternative initiation site is at Met-94 or at Met-97.
    SequenceCaution:
    • Sequence=AAA35698.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAA35698.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ENO1 Gene

    Alternative splice isoforms for ENO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ENO1 Gene

Selected DME Specific Peptides for ENO1 Gene

P06733:
  • TGQIKTG
  • LLLKVNQIG
  • ELLKTAI
  • YPVVSIEDPFDQD
  • VGDDLTV
  • DDLTVTNP
  • DSRGNPT
  • QLADLYK
  • VSLAVCKAGA
  • NKTIAPA
  • PDQLADLY
  • KAKFAGR
  • EVYHNLK
  • RYMGKGV
  • KTGAPCR
  • GDEGGFAP
  • GQIKTGAP
  • DVAASEF
  • LRIEEEL
  • PSGASTG
  • SRGNPTVE
  • EKGVPLY
  • FIADLVVGL
  • IGMDVAAS
  • FAGRNFRNP
  • QEFMILP
  • RSGETED
  • EVILPVPAFNVINGGSHAGNKLAMQEFMI
  • GKGVSKAV
  • FGANAIL
  • GANAILGVS
  • KYNQLLRI
  • GKYDLDFKSPDD
  • EAMRIGAEVYH
  • SHRSGET
  • VTNPKRI
  • NVGDEGG
  • DGTENKS
  • KYGKDATNVG
  • GVPLYRH
  • LELLKTAI
  • RSERLAK

Post-translational modifications for ENO1 Gene

  • ISGylated.
  • Lysine 2-hydroxyisobutyrylation (Khib) by p300/EP300 activates the phosphopyruvate hydratase activity.
  • Ubiquitination at Lys5, Lys120, Lys28, Lys126, Lys54, Lys60, Lys64, Lys71, Lys81, Lys89, Lys193, Lys202, Lys221, Lys228, Lys233, Lys256, Lys262, Lys281, Lys285, Lys326, Lys335, Lys343, Lys358, Lys406, and Lys420
  • Modification sites at PhosphoSitePlus

Domains & Families for ENO1 Gene

Gene Families for ENO1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ENO1 Gene

Suggested Antigen Peptide Sequences for ENO1 Gene

GenScript: Design optimal peptide antigens:
  • Enolase (A4QMW8_HUMAN)
  • Plasminogen-binding protein (ENOA_HUMAN)
  • Enolase (Q96GV1_HUMAN)
  • Enolase (Q9BT62_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P06733

UniProtKB/Swiss-Prot:

ENOA_HUMAN :
  • Belongs to the enolase family.
Family:
  • Belongs to the enolase family.
genes like me logo Genes that share domains with ENO1: view

Function for ENO1 Gene

Molecular function for ENO1 Gene

UniProtKB/Swiss-Prot Function:
Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:29775581, PubMed:1369209). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:2005901, PubMed:10802057, PubMed:12666133, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209).
UniProtKB/Swiss-Prot Function:
MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate; Xref=Rhea:RHEA:10164, ChEBI:CHEBI:15377, ChEBI:CHEBI:58289, ChEBI:CHEBI:58702; EC=4.2.1.11; Evidence={ECO:0000269 PubMed:1369209, ECO:0000269 PubMed:29775581};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Enolase activity is lost above pH 9.0. Immunoglobulin production stimulating activity is retained at pH 13.0. {ECO:0000269 PubMed:1369209};
UniProtKB/Swiss-Prot Induction:
Induced in diffuse large cell lymphoma (DLCL) after treatment with the natural biological agent, Bryo1. Up-regulated in response to enterovirus 71 (EV71) infection (at protein level).
GENATLAS Biochemistry:
enolase 1,alpha subunit,ubiquitous and embryonic precocious type (2-phospho-D-glycerate hydratase),glycolysis,energy pathway

Enzyme Numbers (IUBMB) for ENO1 Gene

Phenotypes From GWAS Catalog for ENO1 Gene

Gene Ontology (GO) - Molecular Function for ENO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 2005901
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IDA 2005901
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding HDA 22658674
genes like me logo Genes that share ontologies with ENO1: view
genes like me logo Genes that share phenotypes with ENO1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ENO1

Clone Products

  • Addgene plasmids for ENO1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ENO1 Gene

Localization for ENO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENO1 Gene

Cytoplasm. Cell membrane. Cytoplasm, myofibril, sarcomere, M line. Note=Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form. ENO1 is localized to the M line.
[Isoform MBP-1]: Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ENO1 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
lysosome 2
peroxisome 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ENO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000015 phosphopyruvate hydratase complex IDA 3529090
GO:0005615 extracellular space HDA 16502470
GO:0005634 nucleus IEA,IC 2005901
GO:0005737 cytoplasm IEA,IDA 15459207
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ENO1: view

Pathways & Interactions for ENO1 Gene

genes like me logo Genes that share pathways with ENO1: view

Pathways by source for ENO1 Gene

1 GeneGo (Thomson Reuters) pathway for ENO1 Gene
  • Glycolysis and gluconeogenesis (short map)
1 Cell Signaling Technology pathway for ENO1 Gene

UniProtKB/Swiss-Prot P06733-ENOA_HUMAN

  • Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.

SIGNOR curated interactions for ENO1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ENO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 2005901
GO:0006094 gluconeogenesis TAS --
GO:0006096 glycolytic process IEA --
GO:0009615 response to virus IEP 16548883
GO:0010756 positive regulation of plasminogen activation IMP 12666133
genes like me logo Genes that share ontologies with ENO1: view

Drugs & Compounds for ENO1 Gene

(23) Drugs for ENO1 Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 236
Zinc Approved, Investigational Pharma Target 2822
zinc acetate Approved, Investigational Pharma Target 0
Zinc chloride Approved, Investigational Pharma Target 0
Magnesium Approved, Experimental, Investigational Pharma 0

(20) Additional Compounds for ENO1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Dehydroquinate
  • 5-Dehydroquinic acid
  • 5-Dehydroquinate
  • 3-Dehydroquinic acid
  • Cyclohexan-1,4,5-triol-3-one-1-carboxylic acid

(1) ApexBio Compounds for ENO1 Gene

Compound Action Cas Number
AP-III-a4 1177827-73-4
genes like me logo Genes that share compounds with ENO1: view

Transcripts for ENO1 Gene

mRNA/cDNA for ENO1 Gene

3 REFSEQ mRNAs :
31 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ENO1

Clone Products

  • Addgene plasmids for ENO1

Alternative Splicing Database (ASD) splice patterns (SP) for ENO1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - -
SP2: - - - - - -
SP3: -
SP4: -
SP5:
SP6:

Relevant External Links for ENO1 Gene

GeneLoc Exon Structure for
ENO1

Expression for ENO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ENO1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ENO1 Gene



Protein tissue co-expression partners for ENO1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ENO1

SOURCE GeneReport for Unigene cluster for ENO1 Gene:

Hs.517145

mRNA Expression by UniProt/SwissProt for ENO1 Gene:

P06733-ENOA_HUMAN
Tissue specificity: The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.

Evidence on tissue expression from TISSUES for ENO1 Gene

  • Blood(5)
  • Eye(5)
  • Kidney(5)
  • Liver(5)
  • Lung(5)
  • Skin(5)
  • Nervous system(5)
  • Intestine(4.9)
  • Pancreas(4.9)
  • Stomach(4.9)
  • Bone(4.5)
  • Muscle(4.5)
  • Thyroid gland(4.5)
  • Heart(3.8)
  • Spleen(2.9)
  • Lymph node(2.7)
  • Bone marrow(2.4)
  • Gall bladder(2.3)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with ENO1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENO1 Gene

Orthologs for ENO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ENO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ENO1 31 30
  • 99.39 (n)
OneToOne
cow
(Bos Taurus)
Mammalia -- 31
  • 96 (a)
OneToMany
ENO1 30
  • 90.32 (n)
-- 31
  • 63 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Eno1 31
  • 95 (a)
OneToMany
Gm5506 31 30
  • 88.25 (n)
OneToMany
Eno1b 17
platypus
(Ornithorhynchus anatinus)
Mammalia ENO1 31
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 90 (a)
OneToMany
-- 31
  • 82 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Eno1 30
  • 88.33 (n)
dog
(Canis familiaris)
Mammalia ENO1 31
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves ENO1 31 30
  • 83.45 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ENO1 31
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eno1 30
  • 77.7 (n)
MGC75746 30
African clawed frog
(Xenopus laevis)
Amphibia eno1-prov 30
zebrafish
(Danio rerio)
Actinopterygii eno1a 31 30
  • 81.71 (n)
OneToOne
wufi32b03 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007827 30
  • 70.53 (n)
fruit fly
(Drosophila melanogaster)
Insecta Eno 31 32 30
  • 69.53 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea enol-1 31 30
  • 69.84 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENO1 31
  • 63 (a)
ManyToMany
ENO2 33 31
  • 62 (a)
ERR3 31
  • 59 (a)
ManyToMany
ERR2 31
  • 59 (a)
ManyToMany
ERR1 31 30
  • 58.14 (n)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ENO1 30
  • 62.88 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7421 30
corn
(Zea mays)
Liliopsida Zm.410 30
barley
(Hordeum vulgare)
Liliopsida Hv.12462 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10219 31
  • 74 (a)
OneToMany
Cin.4682 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4682 30
Species where no ortholog for ENO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ENO1 Gene

ENSEMBL:
Gene Tree for ENO1 (if available)
TreeFam:
Gene Tree for ENO1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ENO1: view image

Paralogs for ENO1 Gene

Paralogs for ENO1 Gene

(4) SIMAP similar genes for ENO1 Gene using alignment to 4 proteins:

  • ENOA_HUMAN
  • A4QMW8_HUMAN
  • K7EM90_HUMAN
  • K7ERS8_HUMAN

Pseudogenes.org Pseudogenes for ENO1 Gene

genes like me logo Genes that share paralogs with ENO1: view

Variants for ENO1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ENO1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs11544513 - p.Asn177Lys
rs11544514 - p.Pro325Gln

Additional dbSNP identifiers (rs#s) for ENO1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ENO1 Gene

Variant ID Type Subtype PubMed ID
esv3585154 CNV loss 21293372
nsv1001865 CNV gain 25217958
nsv545345 CNV gain 21841781

Variation tolerance for ENO1 Gene

Residual Variation Intolerance Score: 18.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ENO1 Gene

Human Gene Mutation Database (HGMD)
ENO1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ENO1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENO1 Gene

Disorders for ENO1 Gene

MalaCards: The human disease database

(35) MalaCards diseases for ENO1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hashimoto encephalopathy
  • hashimoto's encephalopathy
cancer-associated retinopathy
  • car syndrome
autoimmune disease
  • autoimmune hypersensitivity disease
non-herpetic acute limbic encephalitis
lymphocytic hypophysitis
  • autoimmune hypophysitis
- elite association - COSMIC cancer census association via MalaCards
Search ENO1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ENO1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
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No data available for UniProtKB/Swiss-Prot and Genatlas for ENO1 Gene

Publications for ENO1 Gene

  1. Molecular cloning and expression analysis of five novel genes in chromosome 1p36. (PMID: 9653645) Onyango P … Weith A (Genomics 1998) 2 3 4 23 54
  2. Structure of human alpha-enolase (hENO1), a multifunctional glycolytic enzyme. (PMID: 18560153) Kang HJ … Chung SJ (Acta crystallographica. Section D, Biological crystallography 2008) 3 4 23 54
  3. Inhibition of cell surface mediated plasminogen activation by a monoclonal antibody against alpha-Enolase. (PMID: 12666133) López-Alemany R … Félez J (American journal of hematology 2003) 3 4 23 54
  4. Proteomic analysis of human brain identifies alpha-enolase as a novel autoantigen in Hashimoto's encephalopathy. (PMID: 12297304) Ochi H … Kira J (FEBS letters 2002) 3 4 23 54
  5. A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1. (PMID: 11134351) Ghosh AK … Ray RB (Molecular and cellular biology 2001) 3 4 23 54

Products for ENO1 Gene

Sources for ENO1 Gene