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This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011]
ENO1 (Enolase 1) is a Protein Coding gene. Diseases associated with ENO1 include Hashimoto Encephalopathy and Cancer-Associated Retinopathy. Among its related pathways are Glucose metabolism and Carbon metabolism. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity. An important paralog of this gene is ENO2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000287 | magnesium ion binding | IEA | -- |
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 2005901 |
GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IDA | 2005901 |
GO:0003677 | DNA binding | IEA | -- |
GO:0003723 | RNA binding | HDA | 22658674 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000015 | phosphopyruvate hydratase complex | IEA,IDA | 3529090 |
GO:0005615 | extracellular space | HDA | 16502470 |
GO:0005634 | nucleus | IEA,IC | 2005901 |
GO:0005737 | cytoplasm | IEA,IDA | 15459207 |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Glucose metabolism |
Glycolysis and gluconeogenesis (short map)
.58
.52
|
.46
|
2 | Carbon metabolism | ||
3 | Metabolism |
.40
|
|
4 | Glucose / Energy Metabolism | ||
5 | HIF-1 signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 2005901 |
GO:0006094 | gluconeogenesis | TAS | -- |
GO:0006096 | glycolytic process | IEA,IBA | 21873635 |
GO:0009615 | response to virus | IEP | 16548883 |
GO:0010756 | positive regulation of plasminogen activation | IMP | 12666133 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Copper | Approved, Investigational | Pharma | Target | 271 | ||
Zinc | Approved, Investigational | Pharma | Target | 1687 | ||
zinc acetate | Approved, Investigational | Pharma | Target | 0 | ||
Zinc chloride | Approved, Investigational | Pharma | Target, binder | 0 | ||
Zinc sulfate, unspecified form | Approved, Experimental | Pharma | Target, binder | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
AP-III-a4 | 1177827-73-4 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||||||||
SP6: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ENO1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
OneToMany | |
ENO1 30 |
|
||||
-- 31 |
|
OneToMany | |||
Mouse (Mus musculus) |
Mammalia | Eno1 17 31 |
|
OneToMany | |
Gm5506 30 31 |
|
OneToMany | |||
Eno1b 17 |
|
||||
Platypus (Ornithorhynchus anatinus) |
Mammalia | ENO1 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Rat (Rattus norvegicus) |
Mammalia | Eno1 30 |
|
||
Dog (Canis familiaris) |
Mammalia | ENO1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ENO1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ENO1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | eno1 30 |
|
||
MGC75746 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | eno1-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | eno1a 30 31 |
|
OneToOne | |
wufi32b03 30 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007827 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Eno 30 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | enol-1 30 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ENO1 31 |
|
ManyToMany | |
ENO2 31 33 |
|
ManyToMany | |||
ERR3 31 |
|
ManyToMany | |||
ERR2 31 |
|
ManyToMany | |||
ERR1 30 31 |
|
ManyToMany | |||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | ENO1 30 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.7421 30 |
|
||
Barley (Hordeum vulgare) |
Liliopsida | Hv.12462 30 |
|
||
Corn (Zea mays) |
Liliopsida | Zm.410 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10219 31 |
|
OneToMany | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.4682 30 |
|
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1306980664 | Likely Benign: not provided | 8,871,910(-) |
C/T NM_001428.5(ENO1):c.162G>A (p.Lys54=) |
SYNONYMOUS_VARIANT,FIVE_PRIME_UTR | |
rs1356620931 | Likely Benign: not provided | 8,865,492(-) |
G/A NM_001428.5(ENO1):c.668-10C>T |
INTRON | |
rs138375821 | Benign: not provided | 8,861,360(-) |
T/C NM_001428.5(ENO1):c.1305A>G (p.Ter435=) |
SYNONYMOUS | |
rs2230874 | Benign: not provided | 8,865,415(-) |
G/A NM_001428.5(ENO1):c.735C>T (p.Asp245=) |
SYNONYMOUS | |
rs11544513 | - |
p.Asn177Lys |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3585154 | CNV | loss | 21293372 |
nsv1001865 | CNV | gain | 25217958 |
nsv545345 | CNV | gain | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
hashimoto encephalopathy |
|
|
cancer-associated retinopathy |
|
|
autoimmune disease |
|
|
lymphocytic hypophysitis |
|
|
non-herpetic acute limbic encephalitis |
|
|