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This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has b... See more...
Aliases for ENO1 Gene
Aliases for ENO1 Gene
External Ids for ENO1 Gene
- HGNC: 3350
- Entrez Gene: 2023
- Ensembl: ENSG00000074800
- OMIM: 172430
- UniProtKB: P06733
Previous HGNC Symbols for ENO1 Gene
- ENO1L1
- MPB1
Previous GeneCards Identifiers for ENO1 Gene
- GC01M008541
- GC01M008732
- GC01M008517
- GC01M008630
- GC01M008855
- GC01M008843
- GC01M008921
- GC01M008070
Summaries for ENO1 Gene
-
This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011]
GeneCards Summary for ENO1 Gene
ENO1 (Enolase 1) is a Protein Coding gene. Diseases associated with ENO1 include Hashimoto Encephalopathy and Cancer-Associated Retinopathy. Among its related pathways are Glucose metabolism and Validated targets of C-MYC transcriptional activation. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity. An important paralog of this gene is ENO3.
UniProtKB/Swiss-Prot Summary for ENO1 Gene
-
Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:29775581, PubMed:1369209). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:2005901, PubMed:10802057, PubMed:12666133, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209).
-
MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor.
Additional gene information for ENO1 Gene
- HGNC(3350)
- Entrez Gene(2023)
- Ensembl(ENSG00000074800)
- OMIM(172430)
- UniProtKB(P06733)
- Open Targets Platform(ENSG00000074800)
- Monarch Initiative
- Search for ENO1 at DataMed
- Search for ENO1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ENO1 Gene
Genomics for ENO1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ENO1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ENO1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ENO1
- Top Transcription factor binding sites by QIAGEN in the ENO1 gene promoter:
-
- AML1a
- c-Ets-1
- CUTL1
- GATA-1
- PPAR-gamma1
- PPAR-gamma2
- RFX1
- Sox5
Genomic Locations for ENO1 Gene
Genomic Locations for ENO1 Gene
- chr1:8,861,000-8,879,190
- (GRCh38/hg38)
- Size:
- 18,191 bases
- Orientation:
- Minus strand
- chr1:8,921,059-8,939,308
- (GRCh37/hg19)
- Size:
- 18,250 bases
- Orientation:
- Minus strand
Genomic View for ENO1 Gene
Genes around ENO1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.23 by HGNC
- 1p36.23 by Entrez Gene
- 1p36.23 by Ensembl
ENO1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ENO1 Gene
Proteins for ENO1 Gene
-
Protein details for ENO1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P06733-ENOA_HUMAN
- Recommended name:
- Alpha-enolase
- Protein Accession:
- P06733
- B2RD59
- P22712
- Q16704
- Q4TUS4
- Q53FT9
- Q53HR3
- Q658M5
- Q6GMP2
- Q71V37
- Q7Z3V6
- Q8WU71
- Q96GV1
- Q9BT62
- Q9UCH6
- Q9UM55
Protein attributes for ENO1 Gene
- Size:
- 434 amino acids
- Molecular mass:
- 47169 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Mammalian enolase is composed of 3 isozyme subunits, alpha, beta and gamma, which can form homodimers or heterodimers which are cell-type and development-specific (PubMed:18560153). ENO1 interacts with PLG in the neuronal plasma membrane and promotes its activation. The C-terminal lysine is required for this binding (PubMed:9308760). Isoform MBP-1 interacts with TRAPPC2B (PubMed:11134351). Interacts with ENO4 and PGAM2 (By similarity). Interacts with CMTM6 (PubMed:28813417).
- SequenceCaution:
-
- Sequence=AAA35698.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAA35698.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
- Miscellaneous:
-
- Used as a diagnostic marker for many tumors and, in the heterodimeric form, alpha/gamma, as a marker for hypoxic brain injury after cardiac arrest. Also marker for endometriosis. Antibodies against alpha-enolase are present in sera from patients with cancer-associated retinopathy syndrome (CAR), a progressive blinding disease which occurs in the presence of systemic tumor growth, primarily small-cell carcinoma of the lung and other malignancies. Is identified as an autoantigen in Hashimoto encephalopathy (HE) a rare autoimmune disease associated with Hashimoto thyroiditis (HT). HT is a disorder in which destructive processes overcome the potential capacity of thyroid replacement leading to hypothyroidism.
- [Isoform MBP-1]: It is uncertain whether the alternative initiation site is at Met-94 or at Met-97.
Three dimensional structures from OCA and Proteopedia for ENO1 Gene
Protein Expression for ENO1 Gene
Selected DME Specific Peptides for ENO1 Gene
- P06733:
-
- TGQIKTG
- LLLKVNQIG
- ELLKTAI
- YPVVSIEDPFDQD
- VGDDLTV
- DDLTVTNP
- DSRGNPT
- QLADLYK
- VSLAVCKAGA
- NKTIAPA
- PDQLADLY
- KAKFAGR
- EVYHNLK
- RYMGKGV
- KTGAPCR
- GDEGGFAP
- GQIKTGAP
- DVAASEF
- LRIEEEL
- PSGASTG
- SRGNPTVE
- EKGVPLY
- FIADLVVGL
- IGMDVAAS
- FAGRNFRNP
- QEFMILP
- RSGETED
- EVILPVPAFNVINGGSHAGNKLAMQEFMI
- GKGVSKAV
- FGANAIL
- GANAILGVS
- KYNQLLRI
- GKYDLDFKSPDD
- EAMRIGAEVYH
- SHRSGET
- VTNPKRI
- NVGDEGG
- DGTENKS
- KYGKDATNVG
- GVPLYRH
- LELLKTAI
- RSERLAK
Post-translational modifications for ENO1 Gene
- ISGylated.
- Lysine 2-hydroxyisobutyrylation (Khib) by p300/EP300 activates the phosphopyruvate hydratase activity.
-
Ubiquitination at Lys5, Lys120, Lys28, Lys126, Lys54, Lys60, Lys64, Lys71, Lys81, Lys89, Lys193, Lys202, Lys221, Lys228, Lys233, Lys256, Lys262, Lys281, Lys285, Lys326, Lys335, Lys343, Lys358, Lys406, and Lys420
- NX_P06733 (NX_P06733-1)
- Modification sites at PhosphoSitePlus
Other Protein References for ENO1 Gene
Antibody Products
- LifeSpan BioSciences ENO1 / Alpha Enolase Monoclonal Antibody and ENO1 / Alpha Enolase Antibody
- GeneTex Anti-ENO1 antibody and Anti-ENO1 antibody [N3C3]
- NSJ Bioreagents Alpha Enolase Antibody / ENO1 (Rabbit Monoclonal)
- Creative Diagnostics Anti-ENO1 monoclonal antibody, clone 10G8
-
Creative Biolabs
- Recombinant Anti-Human ENO1 Antibody
- Afuco™ Anti-Human ENO1 ADCC Therapeutic Antibody, ADCC Enhanced
- Anti-Human ENO1 Therapeutic Antibody (A3)
- Recombinant Humanized Anti-ENO1 Antibody Fab Fragment (IMGT)
- Mouse Anti-ENO1 Recombinant Antibody (CBFYE-0084)
- Mouse Anti-ENO1 (AA 1-434) Recombinant Antibody (CBFYE-0874)
- Recombinant Humanized Anti-ENO1 Antibody (IMGT)
- Recombinant Human Anti-ENO1 Antibody (C4)
-
Custom Antibody ServicesOriGene Antibodies for ENO1
- Novus Biologicals Antibodies for ENO1
-
Abcam antibodies for ENO1
- Invitrogen Antibodies for ENO1 (AFLGC-ENO1)
- antibodies-online: Show 88 available ENO1 Antibodies ranked by validation data
-
Santa Cruz Biotechnology (SCBT) Antibodies for ENO1
- Sino Biological Antibodies for ENO1
Protein Products
- G Biosciences Human Enolase 1/ENO1/Alpha-enolase/MPB-1/NNE, Liquid
- Creative Biomart Recombinant Human Enolase 1, (Alpha)
-
OriGene Purified Proteins for ENO1
- Search Origene for MassSpec and Protein Over-expression Lysates for ENO1
- Origene Custom Protein Services for ENO1
- Sino Biological Recombinant Proteins for ENO1
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for ENO1
- antibodies-online: Search results for available ENO1 related products ranked by validation data
-
Abcam proteins for ENO1
Assay Products
- antibodies-online: Search results for available ENO1 related products ranked by validation data
Domains & Families for ENO1 Gene
Gene Families for ENO1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for ENO1 Gene
- InterPro:
- Blocks:
-
- Enolase
- ProtoNet:
Suggested Antigen Peptide Sequences for ENO1 Gene
- GenScript: Design optimal peptide antigens:
-
- Enolase (A4QMW8_HUMAN)
- Plasminogen-binding protein (ENOA_HUMAN)
- Enolase (Q96GV1_HUMAN)
- Enolase (Q9BT62_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P06733- Family:
-
- Belongs to the enolase family.
Function for ENO1 Gene
Molecular function for ENO1 Gene
- UniProtKB/Swiss-Prot Function:
- Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:29775581, PubMed:1369209). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:2005901, PubMed:10802057, PubMed:12666133, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209).
- UniProtKB/Swiss-Prot Function:
- MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate; Xref=Rhea:RHEA:10164, ChEBI:CHEBI:15377, ChEBI:CHEBI:58289, ChEBI:CHEBI:58702; EC=4.2.1.11; Evidence={ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:29775581};.
- UniProtKB/Swiss-Prot Induction:
- Induced in diffuse large cell lymphoma (DLCL) after treatment with the natural biological agent, Bryo1. Up-regulated in response to enterovirus 71 (EV71) infection (at protein level).
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- pH dependence: Enolase activity is lost above pH 9.0. Immunoglobulin production stimulating activity is retained at pH 13.0. {ECO:0000269|PubMed:1369209};
- GENATLAS Biochemistry:
- enolase 1,alpha subunit,ubiquitous and embryonic precocious type (2-phospho-D-glycerate hydratase),glycolysis,energy pathway
Enzyme Numbers (IUBMB) for ENO1 Gene
Phenotypes From GWAS Catalog for ENO1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000287 | magnesium ion binding | IEA | -- |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 2005901 |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IDA | 2005901 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003723 | RNA binding | HDA | 22658674 |
Phenotypes for ENO1 Gene
- MGI mutant phenotypes for ENO1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ENO1:
-
- Increased vaccinia virus (VACV) infection
- no effect
- shRNA abundance <= 50%
- Decreased shRNA abundance (Z-score < -2)
- shRNA abundance <= 25%
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance
- Increased hepcidin::fluc mRNA expression
- Decreased viability in esophageal squamous lineage; decreased viability in non-small-cell lung cancer (NSCLC) lineage
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ENO1 - Select products 50% OFF >
- * ENO1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ENO1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ENO1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ENO1
miRNA for ENO1 Gene
- miRTarBase miRNAs that target ENO1
-
- hsa-miR-744-5p (MIRT037729)
- hsa-miR-615-3p (MIRT039693)
- hsa-miR-18a-3p (MIRT040892)
- hsa-miR-181d-5p (MIRT041167)
- hsa-miR-484 (MIRT041760)
- hsa-miR-378a-3p (MIRT043896)
- hsa-miR-125a-5p (MIRT045746)
- hsa-miR-222-3p (MIRT046821)
- hsa-miR-204-5p (MIRT047021)
- hsa-miR-92a-3p (MIRT049082)
- hsa-miR-1260b (MIRT052701)
- hsa-miR-3177-3p (MIRT052801)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ENO1
- Browse OriGene Inhibitory RNA Products For ENO1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ENO1
Clone Products
- Applied Biological Materials (abm): Clones for ENO1 - Select products 50% OFF >
- * ENO1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ENO1
- Addgene plasmids for ENO1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ENO1
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ENO1 Gene
Localization for ENO1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ENO1 Gene
- Cytoplasm. Cell membrane. Cytoplasm, myofibril, sarcomere, M line. Note=Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form. ENO1 is localized to the M line.
- [Isoform MBP-1]: Nucleus.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 3 |
| mitochondrion | 3 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| golgi apparatus | 1 |
- Cytosol (4)
- Plasma membrane (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000015 | phosphopyruvate hydratase complex | IEA,IDA | 3529090 |
| GO:0005615 | extracellular space | HDA | 16502470 |
| GO:0005634 | nucleus | IEA,IC | 2005901 |
| GO:0005737 | cytoplasm | IEA,IDA | 15459207 |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for ENO1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glucose metabolism |
Glycolysis and gluconeogenesis (short map)
.58
.52
|
.46
|
| 2 | Carbon metabolism | ||
| 3 | Metabolism |
.40
|
|
| 4 | Glucose / Energy Metabolism | ||
| 5 | HIF-1 signaling pathway | ||
Pathways by source for ENO1 Gene
4 BioSystems pathways for ENO1 Gene
5 Reactome pathways for ENO1 Gene
6 KEGG pathways for ENO1 Gene
1 GeneGo (Thomson Reuters) pathway for ENO1 Gene
- Glycolysis and gluconeogenesis (short map)
1 Cell Signaling Technology pathway for ENO1 Gene
UniProtKB/Swiss-Prot P06733-ENOA_HUMAN
- Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.
Interacting Proteins for ENO1 Gene
Selected Interacting proteins:
P06733-ENOA_HUMAN
ENSP00000234590
for ENO1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ENO1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 2005901 |
| GO:0006094 | gluconeogenesis | TAS | -- |
| GO:0006096 | glycolytic process | IEA,IBA | 21873635 |
| GO:0009615 | response to virus | IEP | 16548883 |
| GO:0010756 | positive regulation of plasminogen activation | IMP | 12666133 |
Drugs & Compounds for ENO1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Copper | Approved, Investigational | Pharma | Target | 249 | ||
| Zinc | Approved, Investigational | Pharma | Target | 1594 | ||
| zinc acetate | Approved, Investigational | Pharma | Target | 0 | ||
| Zinc chloride | Approved, Investigational | Pharma | Target, binder | 0 | ||
| Zinc sulfate, unspecified form | Approved, Experimental | Pharma | Target, binder | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 3-Dehydroquinate |
|
|
(1) ApexBio Compounds for ENO1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| AP-III-a4 | 1177827-73-4 |
Drug Products
- G Biosciences Human Enolase 1/ENO1/Alpha-enolase/MPB-1/NNE, Liquid
- Creative Biomart Recombinant Human Enolase 1, (Alpha)
- ApexBio compounds for ENO1
Transcripts for ENO1 Gene
mRNA/cDNA for ENO1 Gene
- 3 REFSEQ mRNAs :
- 31 NCBI additional mRNA sequence :
- 16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000234590 1781 nts (view in UCSC)
- ENST00000464920 2548 nts (view in UCSC)
- ENST00000647408 1782 nts (view in UCSC)
- ENST00000646370 1837 nts (view in UCSC)
- ENST00000645609 1819 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ENO1 - Select products 50% OFF >
- * ENO1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ENO1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ENO1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ENO1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ENO1
- Browse OriGene Inhibitory RNA Products For ENO1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ENO1
Clone Products
- Applied Biological Materials (abm): Clones for ENO1 - Select products 50% OFF >
- * ENO1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ENO1
- Addgene plasmids for ENO1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ENO1
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||
| SP6: |
Relevant External Links for ENO1 Gene
- GeneLoc Exon Structure for
- ENO1
Expression for ENO1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ENO1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ENO1
SOURCE GeneReport for Unigene cluster for ENO1 Gene:
Hs.517145mRNA Expression by UniProt/SwissProt for ENO1 Gene:
P06733-ENOA_HUMAN
Tissue specificity:
The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.
Evidence on tissue expression from TISSUES for ENO1 Gene
- Nervous system(5)
- Skin(5)
- Kidney(5)
- Lung(5)
- Liver(5)
- Eye(5)
- Blood(5)
- Intestine(4.9)
- Stomach(4.9)
- Pancreas(4.9)
- Bone(4.6)
- Muscle(4.6)
- Thyroid gland(4.6)
- Heart(4.1)
- Spleen(3.6)
- Lymph node(3.4)
- Bone marrow(3.3)
- Adrenal gland(2.9)
- Gall bladder(2.3)
Primer Products
-
OriGene qPCR primer pairs for ENO1
-
OriGene qPCR primer pairs and template standards for ENO1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENO1 Gene
Orthologs for ENO1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ENO1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | -- 31 |
|
OneToMany | |
| ENO1 30 |
|
||||
| -- 31 |
|
OneToMany | |||
| Mouse (Mus musculus) |
Mammalia | Eno1 17 31 |
|
OneToMany | |
| Gm5506 30 31 |
|
OneToMany | |||
| Eno1b 17 |
|
||||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ENO1 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Rat (Rattus norvegicus) |
Mammalia | Eno1 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | ENO1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ENO1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ENO1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | eno1 30 |
|
||
| MGC75746 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | eno1-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | eno1a 30 31 |
|
OneToOne | |
| wufi32b03 30 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007827 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Eno 30 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | enol-1 30 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ENO1 31 |
|
ManyToMany | |
| ENO2 31 33 |
|
ManyToMany | |||
| ERR3 31 |
|
ManyToMany | |||
| ERR2 31 |
|
ManyToMany | |||
| ERR1 30 31 |
|
ManyToMany | |||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | ENO1 30 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.7421 30 |
|
||
| Barley (Hordeum vulgare) |
Liliopsida | Hv.12462 30 |
|
||
| Corn (Zea mays) |
Liliopsida | Zm.410 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10219 31 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.4682 30 |
|
- Species where no ortholog for ENO1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for ENO1 Gene
- ENSEMBL:
- Gene Tree for ENO1 (if available)
- TreeFam:
- Gene Tree for ENO1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ENO1: view image
Paralogs for ENO1 Gene
(4) SIMAP similar genes for ENO1 Gene using alignment to 4 proteins:
- ENOA_HUMAN
- A4QMW8_HUMAN
- K7EM90_HUMAN
- K7ERS8_HUMAN
Pseudogenes.org Pseudogenes for ENO1 Gene
Variants for ENO1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ENO1 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 722451 | Benign: not provided | 8,861,360(-) | T/C | SYNONYMOUS_VARIANT | |
| 731576 | Likely Benign: not provided | 8,871,910(-) | C/T | SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT | |
| 751845 | Likely Benign: not provided | 8,865,492(-) | G/A | INTRON_VARIANT | |
| 775127 | Benign: not provided | 8,865,415(-) | G/A | SYNONYMOUS_VARIANT | |
| rs11544513 | - | p.Asn177Lys |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3585154 | CNV | loss | 21293372 |
| nsv1001865 | CNV | gain | 25217958 |
| nsv545345 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
18.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.94;
19.50% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ENO1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENO1 Gene
Disorders for ENO1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hashimoto encephalopathy |
|
|
| cancer-associated retinopathy |
|
|
| autoimmune disease |
|
|
| non-herpetic acute limbic encephalitis |
|
|
| lymphocytic hypophysitis |
|
|
Search ENO1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ENO1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ENO1 Gene
Publications for ENO1 Gene
- Molecular cloning and expression analysis of five novel genes in chromosome 1p36. (PMID: 9653645) Onyango P … Weith A (Genomics 1998) 2 3 4 23
- Structure of human alpha-enolase (hENO1), a multifunctional glycolytic enzyme. (PMID: 18560153) Kang HJ … Chung SJ (Acta crystallographica. Section D, Biological crystallography 2008) 3 4 23
- Inhibition of cell surface mediated plasminogen activation by a monoclonal antibody against alpha-Enolase. (PMID: 12666133) López-Alemany R … Félez J (American journal of hematology 2003) 3 4 23
- Proteomic analysis of human brain identifies alpha-enolase as a novel autoantigen in Hashimoto's encephalopathy. (PMID: 12297304) Ochi H … Kira J (FEBS letters 2002) 3 4 23
- A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1. (PMID: 11134351) Ghosh AK … Ray RB (Molecular and cellular biology 2001) 3 4 23
ExternalLinks
Products for ENO1 Gene
- Custom Antibody ServicesOriGene Antibodies for ENO1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ENO1
- Search Origene for MassSpec and Protein Over-expression Lysates for ENO1
- Origene Custom Protein Services for ENO1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ENO1
- Browse OriGene Inhibitory RNA Products For ENO1
- OriGene qPCR primer pairs for ENO1
- OriGene qPCR primer pairs and template standards for ENO1
- OriGene CRISPR knockouts for ENO1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ENO1
- Sino Biological Human cDNA Clone for ENO1
- Sino Biological Recombinant Proteins for ENO1
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for ENO1
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ENO1
- Novus Biologicals proteins and lysates for ENO1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for ENO1
- Abcam proteins for ENO1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ApexBio compounds for ENO1
- VectorBuilder Custom and pre-made DNA vectors for ENO1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ENO1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ENO1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ENO1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ENO1
- Addgene plasmids for ENO1
- antibodies-online: Show 88 available ENO1 Antibodies ranked by validation data
- antibodies-online: Search results for available ENO1 related products ranked by validation data
- antibodies-online: Search results for available ENO1 related products ranked by validation data
- Santa Cruz Biotechnology (SCBT) Antibodies for ENO1
- Search Santa Cruz Biotechnology (SCBT) for ENO1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ENO1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ENO1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ENO1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ENO1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ENO1
Sources for ENO1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB