Aliases for ENO1 Gene
- Enolase 1 2 3 4 5
- Alpha-Enolase 2 3 4
- 2-Phospho-D-Glycerate Hydro-Lyase 3 4
- Plasminogen-Binding Protein 3 4
- Phosphopyruvate Hydratase 3 4
- Non-Neural Enolase 3 4
- Enolase 1, (Alpha) 2 3
- EC 126.96.36.199 4 56
- ENO1L1 3 4
- MPB1 3 4
- NNE 3 4
- Epididymis Secretory Protein Li 17 3
- C-Myc Promoter-Binding Protein-1 3
External Ids for ENO1 Gene
Previous HGNC Symbols for ENO1 Gene
Previous GeneCards Identifiers for ENO1 Gene
This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011]
GeneCards Summary for ENO1 Gene
ENO1 (Enolase 1) is a Protein Coding gene. Diseases associated with ENO1 include Hashimoto Encephalopathy and Cancer-Associated Retinopathy. Among its related pathways are Notch signaling pathway (KEGG) and HIF-1-alpha transcription factor network. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity. An important paralog of this gene is ENO2.
UniProtKB/Swiss-Prot for ENO1 Gene
Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production.
MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor.