Aliases for ENO1 Gene
Aliases for ENO1 Gene
- Enolase 1 2 3 4 5
- Alpha-Enolase 2 3 4
- 2-Phospho-D-Glycerate Hydro-Lyase 3 4
- Plasminogen-Binding Protein 3 4
- Phosphopyruvate Hydratase 3 4
- Non-Neural Enolase 3 4
- Enolase 1, (Alpha) 2 3
- EC 4.2.1.11 4 56
- ENO1L1 3 4
- MPB1 3 4
- NNE 3 4
- Epididymis Secretory Protein Li 17 3
- C-Myc Promoter-Binding Protein-1 3
External Ids for ENO1 Gene
- HGNC: 3350
- Entrez Gene: 2023
- Ensembl: ENSG00000074800
- OMIM: 172430
- UniProtKB: P06733
Previous HGNC Symbols for ENO1 Gene
- ENO1L1
- MPB1
Previous GeneCards Identifiers for ENO1 Gene
- GC01M008541
- GC01M008732
- GC01M008517
- GC01M008630
- GC01M008855
- GC01M008843
- GC01M008921
- GC01M008070
Summaries for ENO1 Gene
-
This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011]
GeneCards Summary for ENO1 Gene
ENO1 (Enolase 1) is a Protein Coding gene. Diseases associated with ENO1 include Hashimoto Encephalopathy and Cancer-Associated Retinopathy. Among its related pathways are Notch signaling pathway (KEGG) and HIF-1-alpha transcription factor network. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity. An important paralog of this gene is ENO2.
UniProtKB/Swiss-Prot for ENO1 Gene
-
Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production.
-
MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor.
Additional gene information for ENO1 Gene
- Monarch Initiative
- Search for ENO1 at DataMed
- Search for ENO1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENO1 Gene
Genomics for ENO1 Gene
GeneHancer (GH) Regulatory Elements for ENO1 Gene
Promoters and enhancers for ENO1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ENO1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ENO1 gene promoter:
-
- AML1a
- c-Ets-1
- CUTL1
- GATA-1
- PPAR-gamma1
- PPAR-gamma2
- RFX1
- Sox5
Genomic Locations for ENO1 Gene
Genomic Locations for ENO1 Gene
- chr1:8,861,000-8,879,250
- (GRCh38/hg38)
- Size:
- 18,251 bases
- Orientation:
- Minus strand
- chr1:8,921,059-8,939,308
- (GRCh37/hg19)
- Size:
- 18,250 bases
- Orientation:
- Minus strand
Genomic View for ENO1 Gene
Genes around ENO1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.23 by HGNC
- 1p36.23 by Entrez Gene
- 1p36.23 by Ensembl
ENO1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ENO1 Gene
Proteins for ENO1 Gene
-
Protein details for ENO1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P06733-ENOA_HUMAN
- Recommended name:
- Alpha-enolase
- Protein Accession:
- P06733
- B2RD59
- P22712
- Q16704
- Q4TUS4
- Q53FT9
- Q53HR3
- Q658M5
- Q6GMP2
- Q71V37
- Q7Z3V6
- Q8WU71
- Q96GV1
- Q9BT62
- Q9UCH6
- Q9UM55
Protein attributes for ENO1 Gene
- Size:
- 434 amino acids
- Molecular mass:
- 47169 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Mammalian enolase is composed of 3 isozyme subunits, alpha, beta and gamma, which can form homodimers or heterodimers which are cell-type and development-specific (PubMed:18560153). ENO1 interacts with PLG in the neuronal plasma membrane and promotes its activation. The C-terminal lysine is required for this binding (PubMed:9308760). Isoform MBP-1 interacts with TRAPPC2B (PubMed:11134351). Interacts with ENO4 and PGAM2 (By similarity). Interacts with CMTM6 (PubMed:28813417).
- Miscellaneous:
-
- Used as a diagnostic marker for many tumors and, in the heterodimeric form, alpha/gamma, as a marker for hypoxic brain injury after cardiac arrest. Also marker for endometriosis. Antibodies against alpha-enolase are present in sera from patients with cancer-associated retinopathy syndrome (CAR), a progressive blinding disease which occurs in the presence of systemic tumor growth, primarily small-cell carcinoma of the lung and other malignancies. Is identified as an autoantigen in Hashimoto encephalopathy (HE) a rare autoimmune disease associated with Hashimoto thyroiditis (HT). HT is a disorder in which destructive processes overcome the potential capacity of thyroid replacement leading to hypothyroidism.
- SequenceCaution:
-
- Sequence=AAA35698.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAA35698.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for ENO1 Gene
Protein Expression for ENO1 Gene
Selected DME Specific Peptides for ENO1 Gene
- P06733:
-
- TGQIKTG
- LLLKVNQIG
- ELLKTAI
- YPVVSIEDPFDQD
- VGDDLTV
- DDLTVTNP
- DSRGNPT
- QLADLYK
- VSLAVCKAGA
- NKTIAPA
- PDQLADLY
- KAKFAGR
- EVYHNLK
- RYMGKGV
- KTGAPCR
- GDEGGFAP
- GQIKTGAP
- DVAASEF
- LRIEEEL
- PSGASTG
- SRGNPTVE
- EKGVPLY
- FIADLVVGL
- IGMDVAAS
- FAGRNFRNP
- QEFMILP
- RSGETED
- EVILPVPAFNVINGGSHAGNKLAMQEFMI
- GKGVSKAV
- FGANAIL
- GANAILGVS
- KYNQLLRI
- GKYDLDFKSPDD
- EAMRIGAEVYH
- SHRSGET
- VTNPKRI
- NVGDEGG
- DGTENKS
- KYGKDATNVG
- GVPLYRH
- LELLKTAI
- RSERLAK
Post-translational modifications for ENO1 Gene
- ISGylated.
- Ubiquitination at isoforms=2221, isoforms=2120, isoforms=2228, isoforms=60, isoforms=2358, posLast=6464, isoforms=2326, isoforms=2202, isoforms=2285, isoforms=2256, posLast=8989, and posLast=8181
- Modification sites at PhosphoSitePlus
Other Protein References for ENO1 Gene
Antibody Products
- NSJ Bioreagents Alpha Enolase Antibody / ENO1 (Rabbit Monoclonal)
- Atlas Antibodies Anti-ENO1 Antibody
- GeneTex Anti-ENO1 antibody and Anti-ENO1 antibody [N3C3]
-
Custom Antibody ServicesOriGene Antibodies for ENO1
- Novus Biologicals Antibodies for ENO1
-
Abcam antibodies for ENO1
- Invitrogen Antibodies for ENO1 (AFLGC-ENO1)
- antibodies-online: Search results for available ENO1 related products ranked by validation data
-
Custom Antibody ServicesProSci Antibodies for ENO1
-
Santa Cruz Biotechnology (SCBT) Antibodies for ENO1
- Sino Biological Antibodies for ENO1
Protein Products
- G Biosciences Human Enolase 1/ENO1/Alpha-enolase/MPB-1/NNE, Liquid
- Atlas Antibodies PrEST Antigen ENO1
-
OriGene Purified Proteins for ENO1
- Search Origene for MassSpec and Protein Over-expression Lysates for ENO1
- Origene Custom Protein Services for ENO1
- Sino Biological Recombinant Proteins for ENO1
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for ENO1
- antibodies-online: Search results for available ENO1 related products ranked by validation data
-
Abcam proteins for ENO1
Assay Products
- antibodies-online: Search results for 1 available ENO1 Elisa Kits ranked by validation data
- Compare Top ENO1 Elisa Kits
-
Quality Products:
Domains & Families for ENO1 Gene
Gene Families for ENO1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for ENO1 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ENO1 Gene
- GenScript: Design optimal peptide antigens:
-
- Enolase (A4QMW8_HUMAN)
- Plasminogen-binding protein (ENOA_HUMAN)
- Enolase (Q96GV1_HUMAN)
- Enolase (Q9BT62_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P06733- Family:
-
- Belongs to the enolase family.
Function for ENO1 Gene
Molecular function for ENO1 Gene
- UniProtKB/Swiss-Prot Function:
- Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production.
- UniProtKB/Swiss-Prot Function:
- MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate; Xref=Rhea:RHEA:10164, ChEBI:CHEBI:15377, ChEBI:CHEBI:58289, ChEBI:CHEBI:58702; EC=4.2.1.11; Evidence=. ;.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- pH dependence: Enolase activity is lost above pH 9.0. Immunoglobulin production stimulating activity is retained at pH 13.0. {ECO:0000269 PubMed:1369209};
- UniProtKB/Swiss-Prot Induction:
- Induced in diffuse large cell lymphoma (DLCL) after treatment with the natural biological agent, Bryo1. Up-regulated in response to enterovirus 71 (EV71) infection (at protein level).
- GENATLAS Biochemistry:
- enolase 1,alpha subunit,ubiquitous and embryonic precocious type (2-phospho-D-glycerate hydratase),glycolysis,energy pathway
Enzyme Numbers (IUBMB) for ENO1 Gene
Phenotypes From GWAS Catalog for ENO1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000287 | magnesium ion binding | IEA | -- |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 2005901 |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IDA | 2005901 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003723 | RNA binding | HDA | 22658674 |
Phenotypes for ENO1 Gene
- GenomeRNAi human phenotypes for ENO1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ENO1
-
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ENO1 - Now 50% OFF >
- * ENO1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * ENO1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for ENO1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ENO1
- genomics-online: gRNA clones - Search results for available ENO1 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for ENO1
miRNA for ENO1 Gene
- miRTarBase miRNAs that target ENO1
-
- hsa-mir-744-5p (MIRT037729)
- hsa-mir-615-3p (MIRT039693)
- hsa-mir-18a-3p (MIRT040892)
- hsa-mir-181d-5p (MIRT041167)
- hsa-mir-484 (MIRT041760)
- hsa-mir-378a-3p (MIRT043896)
- hsa-mir-125a-5p (MIRT045746)
- hsa-mir-222-3p (MIRT046821)
- hsa-mir-204-5p (MIRT047021)
- hsa-mir-92a-3p (MIRT049082)
- hsa-mir-1260b (MIRT052701)
- hsa-mir-3177-3p (MIRT052801)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ENO1
- Browse OriGene Inhibitory RNA Products For ENO1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ENO1
- genomics-online: shRNA clones - Search results for available ENO1 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for ENO1 - Now 50% OFF >
- * ENO1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * ENO1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG206913
- MG227149
- MR227149
- MR227149L1
- MR227149L1V
- MR227149L2
- MR227149L2V
- MR227149L3
- MR227149L3V
- MR227149L4
- MR227149L4V
- RC205494
- RC205494L1
- RC205494L1V
- RC205494L2
- RC205494L2V
- RC205494L3
- RC205494L3V
- RC205494L4
- RC205494L4V
- RC232529
- RC505494
- RG205494
- RG232529
- RR200517
- RR200517L1
- RR200517L1V
- RR200517L2
- RR200517L2V
- RR200517L3
- RR200517L3V
- RR200517L4
- RR200517L4V
- RR216663
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ENO1
- Addgene plasmids for ENO1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ENO1
- genomics-online: cdna clones - Search results for available ENO1 gene related products
- orf clones - Search results for available ENO1 gene related products
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ENO1 Gene
Localization for ENO1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ENO1 Gene
- Cytoplasm. Cell membrane. Cytoplasm, myofibril, sarcomere, M line. Note=Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form. ENO1 is localized to the M line.
- Isoform MBP-1: Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 4 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 1 |
- Cytosol (4)
- Plasma membrane (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000015 | phosphopyruvate hydratase complex | IDA | 3529090 |
| GO:0005615 | extracellular space | HDA | 16502470 |
| GO:0005634 | nucleus | IC,IEA | 2005901 |
| GO:0005737 | cytoplasm | IEA,IDA | 15459207 |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for ENO1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glucose metabolism |
.52
|
.46
|
| 2 | Carbon metabolism | ||
| 3 | Metabolism |
.40
|
|
| 4 | Glucose / Energy Metabolism | ||
| 5 | HIF-1 signaling pathway | ||
Pathways by source for ENO1 Gene
4 BioSystems pathways for ENO1 Gene
5 Reactome pathways for ENO1 Gene
6 KEGG pathways for ENO1 Gene
1 GeneGo (Thomson Reuters) pathway for ENO1 Gene
1 Cell Signaling Technology pathway for ENO1 Gene
UniProtKB/Swiss-Prot P06733-ENOA_HUMAN
- Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.
Interacting Proteins for ENO1 Gene
Selected Interacting proteins:
P06733-ENOA_HUMAN
ENSP00000234590
for ENO1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ENO1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 2005901 |
| GO:0006094 | gluconeogenesis | TAS | -- |
| GO:0006096 | glycolytic process | IEA | -- |
| GO:0009615 | response to virus | IEP | 16548883 |
| GO:0010756 | positive regulation of plasminogen activation | IMP | 12666133 |
Drugs & Compounds for ENO1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Copper | Approved, Investigational | Pharma | Target | 226 | ||
| Zinc | Approved, Investigational | Pharma | Target | 2681 | ||
| zinc acetate | Approved, Investigational | Pharma | Target | 0 | ||
| Zinc chloride | Approved, Investigational | Pharma | Target | 0 | ||
| Magnesium | Approved, Experimental, Investigational | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 3-Dehydroquinate |
|
|
(1) ApexBio Compounds for ENO1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| AP-III-a4 | 1177827-73-4 |
Drug Products
- G Biosciences Human Enolase 1/ENO1/Alpha-enolase/MPB-1/NNE, Liquid
- Atlas Antibodies PrEST Antigen ENO1
- ApexBio compounds for ENO1
Transcripts for ENO1 Gene
mRNA/cDNA for ENO1 Gene
- (3) REFSEQ mRNAs :
- (32) Additional mRNA sequences :
- (148) Selected AceView cDNA sequences:
- (17) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000234590 1781 bps (ENST00000234590.10)
- ENST00000414948 744 bps (ENST00000414948.1)
- ENST00000464920 2548 bps (ENST00000464920.2)
- ENST00000486051 536 bps (ENST00000486051.5)
- ENST00000489867 637 bps (ENST00000489867.2)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ENO1 - Now 50% OFF >
- * ENO1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * ENO1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for ENO1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ENO1
- genomics-online: gRNA clones - Search results for available ENO1 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for ENO1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ENO1
- Browse OriGene Inhibitory RNA Products For ENO1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ENO1
- genomics-online: shRNA clones - Search results for available ENO1 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for ENO1 - Now 50% OFF >
- * ENO1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * ENO1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG206913
- MG227149
- MR227149
- MR227149L1
- MR227149L1V
- MR227149L2
- MR227149L2V
- MR227149L3
- MR227149L3V
- MR227149L4
- MR227149L4V
- RC205494
- RC205494L1
- RC205494L1V
- RC205494L2
- RC205494L2V
- RC205494L3
- RC205494L3V
- RC205494L4
- RC205494L4V
- RC232529
- RC505494
- RG205494
- RG232529
- RR200517
- RR200517L1
- RR200517L1V
- RR200517L2
- RR200517L2V
- RR200517L3
- RR200517L3V
- RR200517L4
- RR200517L4V
- RR216663
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ENO1
- Addgene plasmids for ENO1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ENO1
- genomics-online: cdna clones - Search results for available ENO1 gene related products
- orf clones - Search results for available ENO1 gene related products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||
| SP6: |
Expression for ENO1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ENO1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ENO1 Gene:
ENO1SOURCE GeneReport for Unigene cluster for ENO1 Gene:
Hs.517145mRNA Expression by UniProt/SwissProt for ENO1 Gene:
P06733-ENOA_HUMAN
Tissue specificity:
The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.
Evidence on tissue expression from TISSUES for ENO1 Gene
- Blood(5)
- Eye(5)
- Kidney(5)
- Liver(5)
- Lung(5)
- Skin(5)
- Nervous system(5)
- Intestine(4.9)
- Pancreas(4.9)
- Stomach(4.9)
- Bone(4.5)
- Muscle(4.5)
- Thyroid gland(4.5)
- Heart(3.8)
- Spleen(2.9)
- Lymph node(2.7)
- Bone marrow(2.4)
- Gall bladder(2.3)
- Adrenal gland(2.1)
Primer Products
-
OriGene qPCR primer pairs for ENO1
-
OriGene qPCR primer pairs and template standards for ENO1
- genomics-online: primer clones - Search results for available ENO1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENO1 Gene
Orthologs for ENO1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ENO1 35 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | -- 35 |
|
OneToMany | |
| ENO1 34 |
|
||||
| -- 35 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Eno1 35 |
|
OneToMany | |
| Gm5506 35 34 |
|
OneToMany | |||
| Eno1b 17 |
|
||||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ENO1 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Eno1 34 |
|
||
| dog (Canis familiaris) |
Mammalia | ENO1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ENO1 35 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ENO1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | eno1 34 |
|
||
| MGC75746 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | eno1-prov 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | eno1a 35 34 |
|
OneToOne | |
| wufi32b03 34 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007827 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Eno 35 36 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | enol-1 35 34 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ENO1 35 |
|
ManyToMany | |
| ENO2 37 35 |
|
||||
| ERR3 35 |
|
ManyToMany | |||
| ERR2 35 |
|
ManyToMany | |||
| ERR1 35 34 |
|
ManyToMany | |||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | ENO1 34 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.7421 34 |
|
||
| corn (Zea mays) |
Liliopsida | Zm.410 34 |
|
||
| barley (Hordeum vulgare) |
Liliopsida | Hv.12462 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10219 35 |
|
OneToMany | |
| Cin.4682 34 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4682 34 |
|
- Species where no ortholog for ENO1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for ENO1 Gene
- ENSEMBL:
- Gene Tree for ENO1 (if available)
- TreeFam:
- Gene Tree for ENO1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ENO1: view image
Paralogs for ENO1 Gene
(4) SIMAP similar genes for ENO1 Gene using alignment to 4 proteins:
- ENOA_HUMAN
- A4QMW8_HUMAN
- K7EM90_HUMAN
- K7ERS8_HUMAN
Pseudogenes.org Pseudogenes for ENO1 Gene
Variants for ENO1 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000039412 | -- | 8,864,779(-) | C/A | intron_variant | |
| rs1000224184 | -- | 8,880,218(-) | A/G | upstream_transcript_variant | |
| rs1000296452 | -- | 8,880,428(-) | G/A | upstream_transcript_variant | |
| rs1000533487 | -- | 8,861,566(-) | T/G | intron_variant | |
| rs1000744012 | -- | 8,874,996(-) | G/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3585154 | CNV | loss | 21293372 |
| nsv1001865 | CNV | gain | 25217958 |
| nsv545345 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
18.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.94;
19.50% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ENO1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENO1 Gene
Disorders for ENO1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hashimoto encephalopathy |
|
|
| cancer-associated retinopathy |
|
|
| non-herpetic acute limbic encephalitis |
|
|
| lymphocytic hypophysitis |
|
|
| autoimmune retinopathy |
|
|
Search ENO1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ENO1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ENO1 Gene
Publications for ENO1 Gene
- Molecular cloning and expression analysis of five novel genes in chromosome 1p36. (PMID: 9653645) Onyango P … Weith A (Genomics 1998) 2 3 4 23 58
- Structure of human alpha-enolase (hENO1), a multifunctional glycolytic enzyme. (PMID: 18560153) Kang HJ … Chung SJ (Acta crystallographica. Section D, Biological crystallography 2008) 3 4 23 58
- Inhibition of cell surface mediated plasminogen activation by a monoclonal antibody against alpha-Enolase. (PMID: 12666133) López-Alemany R … Félez J (American journal of hematology 2003) 3 4 23 58
- Proteomic analysis of human brain identifies alpha-enolase as a novel autoantigen in Hashimoto's encephalopathy. (PMID: 12297304) Ochi H … Kira J (FEBS letters 2002) 3 4 23 58
- A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1. (PMID: 11134351) Ghosh AK … Ray RB (Molecular and cellular biology 2001) 3 4 23 58
ExternalLinks
Products for ENO1 Gene
- Custom Antibody ServicesOriGene Antibodies for ENO1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ENO1
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- Browse OriGene Inhibitory RNA Products For ENO1
- OriGene qPCR primer pairs for ENO1
- OriGene qPCR primer pairs and template standards for ENO1
- OriGene CRISPR knockouts for ENO1
- MG206913
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- RC205494
- RC205494L1
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- RC205494L3
- RC205494L3V
- RC205494L4
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- RC232529
- RC505494
- RG205494
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- RR200517
- RR200517L1
- RR200517L1V
- RR200517L2
- RR200517L2V
- RR200517L3
- RR200517L3V
- RR200517L4
- RR200517L4V
- RR216663
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ENO1
- Sino Biological Human cDNA Clone for ENO1
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- Sino Biological Antibodies for ENO1
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for ENO1
- Novus Biologicals proteins and lysates for ENO1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for ENO1
- Abcam proteins for ENO1
- Find your target
- Browse Primary Antibodies
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- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ApexBio compounds for ENO1
- Cyagen custom Knockout/knockin (KOKI) mouse models for ENO1
- Addgene plasmids for ENO1
- antibodies-online: Search results for available ENO1 related products ranked by validation data
- antibodies-online: Search results for 1 available ENO1 Elisa Kits ranked by validation data
- Compare Top ENO1 Elisa Kits
- Quality Products:
- antibodies-online: Search results for available ENO1 related products ranked by validation data
- Santa Cruz Biotechnology (SCBT) Antibodies for ENO1
- Search Santa Cruz Biotechnology (SCBT) for ENO1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ENO1
- Custom Antibody ServicesProSci Antibodies for ENO1
- Search for ENO1 Proteins at ProSci
- genomics-online: cdna clones - Search results for available ENO1 gene related products
- orf clones - Search results for available ENO1 gene related products
- genomics-online: gRNA clones - Search results for available ENO1 gene related products
- genomics-online: primer clones - Search results for available ENO1 gene related products
- genomics-online: shRNA clones - Search results for available ENO1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ENO1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ENO1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ENO1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ENO1
Sources for ENO1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) HGMD
- (45) GAD
- (46) BGMUT
- (47) HuGE
- (48) Atlas
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) OCA
- (69) Proteopedia
- (70) MOPED
- (71) neXtProt
- (72) Reactome
- (73) GeneGo (Thomson Reuters)
- (74) fRNAdb
- (75) DISEASES
- (76) SIMAP
- (77) GenomeRNAi
- (78) LifeMap
- (79) miRTarBase
- (80) MalaCards
- (81) Invitrogen
- (82) BitterDB
- (83) ESI-BIO
- (84) RefSeq
- (85) BioSystems
- (86) MaxQB
- (87) IUPHAR
- (88) BioGPS
- (89) Illumina
- (90) COMPARTMENTS
- (91) HOMER
- (92) PaxDb
- (93) ApexBio
- (94) Addgene
- (95) antibodies-online
- (96) CYP
- (97) NONCODE
- (98) SwitchGear Genomics
- (99) TreeFam
- (100) PathCards
- (101) GeneReviews
- (102) GeneTex
- (103) Taconic Biosciences
- (104) GTEx
- (105) ProteomicsDB
- (106) SCBT
- (107) DGIdb
- (108) ClinicalTrials
- (109) FDA Approved Drugs
- (110) RVIS
- (111) SIGNOR
- (112) diseasecard
- (113) NIH Rare Diseases
- (114) Orphanet
- (115) UMLS
- (116) GTR
- (117) Disease Ontology
- (118) Genetics Home Reference
- (119) MeSH
- (120) MedlinePlus
- (121) CDC
- (122) NINDS
- (123) NCBI Bookshelf
- (124) ClinVar
- (125) Gene Damage Index
- (126) ViGene Biosciences
- (127) HPO
- (128) UDN
- (129) VISTA
- (130) FANTOM5
- (131) ENCODE
- (132) ProSci
- (133) Horizon
- (134) NURSA
- (135) IID
- (136) Cyagen
- (137) VectorBuilder
- (138) SNPedia
- (139) BRCA Exchange
- (140) St John's Lab
- (141) CIViC
- (142) ProteoGenix
- (143) dbSUPER
- (144) TISSUES
- (145) Gene ORGANizer
- (146) abm
- (147) CrownBio
- (148) Human Protein Atlas
- (149) GWAS Catalog
- (150) Monarch Initiative
- (151) DataMed
- (152) HumanCyc
- (153) genomics-online
- (154) UCNEbase
- (155) EPDnew
- (156) Applied Biosystems
- (157) GlyConnect
- (158) Aminode
- (159) GeneCopoeia
- (160) GPS-Prot
- (161) RNACentral
- (162) LncRNADisease
- (163) LOVD
- (164) miR2Disease
- (165) DiseaseEnhancer
- (166) Boster Bio
- (167) Biorbyt
- (168) Biocompare
- (169) Mastermind