Aliases for ENHO Gene

Aliases for ENHO Gene

  • Energy Homeostasis Associated 2 3 5
  • Adropin 2 3 4
  • Energy Homeostasis-Associated Protein 3 4
  • C9orf165 3 4
  • Chromosome 9 Open Reading Frame 165 2
  • GAAI470 3
  • UNQ470 3

External Ids for ENHO Gene

Previous HGNC Symbols for ENHO Gene

  • C9orf165

Summaries for ENHO Gene

GeneCards Summary for ENHO Gene

ENHO (Energy Homeostasis Associated) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for ENHO Gene

  • Involved in the regulation of glucose homeostasis and lipid metabolism.

Additional gene information for ENHO Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ENHO Gene

Genomics for ENHO Gene

GeneHancer (GH) Regulatory Elements for ENHO Gene

Promoters and enhancers for ENHO Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J034522 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas 500.7 -0.1 -62 1.4 NRF1 FOS ZIC2 ZBTB26 CTBP1 RBM25 POLR2A EZH2 DEAF1 SMC3 ENHO ENSG00000230729 lnc-CNTFR-2 piR-55823
GH09J034521 Promoter/Enhancer 0.5 Ensembl CraniofacialAtlas 500.7 +1.0 1037 0.4 ENHO ENSG00000230729 lnc-CNTFR-2 piR-43407 ENSG00000230074
GH09J034575 Enhancer 1 FANTOM5 ENCODE CraniofacialAtlas 15.5 -55.3 -55264 5.4 JUND REST ZNF341 EZH2 POLR2A ZFHX2 CTCF RNF2 PAX5 ZNF366 GALT RPP25L ENSG00000230074 ENHO FAM219A CNTFR-AS1 ENSG00000232983 ARID3C CNTFR ENSG00000230729
GH09J034500 Enhancer 0.9 Ensembl ENCODE 12 +20.9 20938 3.4 CTCF ZIC2 REST RAD21 TRIM22 SMC3 TCF12 ZFHX2 BATF IRF4 FAM219A ENSG00000232983 CNTFR-AS1 ENHO DNAI1 RPP25L ARID3C GALT SIGMAR1 NUDT2
GH09J034430 Enhancer 0.9 Ensembl ENCODE 10.8 +92.6 92638 4 ZIC2 REST MXI1 FOXA2 MIER1 NR2F2 SIN3A JUND EHMT2 RCOR1 FAM219A DNAI1 NUDT2 C9orf24 ENSG00000207032 ENSG00000230729 RPP25L ENHO ARID3C GALT
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ENHO on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ENHO

Top Transcription factor binding sites by QIAGEN in the ENHO gene promoter:
  • Elk-1
  • Evi-1
  • FOXJ2
  • FOXJ2 (long isoform)
  • MyoD
  • NF-kappaB1
  • Pax-2
  • Pax-2a
  • Pax-4a
  • SEF-1 (1)

Genomic Locations for ENHO Gene

Genomic Locations for ENHO Gene
1,998 bases
Minus strand
2,002 bases
Minus strand

Genomic View for ENHO Gene

Genes around ENHO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENHO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENHO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENHO Gene

Proteins for ENHO Gene

  • Protein details for ENHO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q8N666

    Protein attributes for ENHO Gene

    76 amino acids
    Molecular mass:
    7927 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ89021.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for ENHO Gene


neXtProt entry for ENHO Gene

Post-translational modifications for ENHO Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ENHO Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ENHO Gene

Domains & Families for ENHO Gene

Gene Families for ENHO Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for ENHO Gene


Suggested Antigen Peptide Sequences for ENHO Gene

GenScript: Design optimal peptide antigens:
  • Energy homeostasis-associated protein (ENHO_HUMAN)
genes like me logo Genes that share domains with ENHO: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ENHO Gene

Function for ENHO Gene

Molecular function for ENHO Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of glucose homeostasis and lipid metabolism.

Gene Ontology (GO) - Molecular Function for ENHO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IEA --
genes like me logo Genes that share ontologies with ENHO: view
genes like me logo Genes that share phenotypes with ENHO: view

Animal Models for ENHO Gene

MGI Knock Outs for ENHO:
  • Enho Enho<tm1.1Butl>
  • Enho Enho<tm1Cmwo>

Animal Model Products

CRISPR Products

miRNA for ENHO Gene

miRTarBase miRNAs that target ENHO

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ENHO

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ENHO Gene

Localization for ENHO Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENHO Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ENHO gene
Compartment Confidence
extracellular 4
plasma membrane 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ENHO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with ENHO: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ENHO Gene

Pathways & Interactions for ENHO Gene

PathCards logo

SuperPathways for ENHO Gene

No Data Available

Interacting Proteins for ENHO Gene


Gene Ontology (GO) - Biological Process for ENHO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0045747 positive regulation of Notch signaling pathway IEA --
GO:0046627 negative regulation of insulin receptor signaling pathway IEA --
GO:0046676 negative regulation of insulin secretion IEA --
GO:0051055 negative regulation of lipid biosynthetic process IEA --
genes like me logo Genes that share ontologies with ENHO: view

No data available for Pathways by source and SIGNOR curated interactions for ENHO Gene

Drugs & Compounds for ENHO Gene

No Compound Related Data Available

Transcripts for ENHO Gene

mRNA/cDNA for ENHO Gene

5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ENHO

Alternative Splicing Database (ASD) splice patterns (SP) for ENHO Gene

No ASD Table

Relevant External Links for ENHO Gene

GeneLoc Exon Structure for

Expression for ENHO Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ENHO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ENHO Gene

This gene is overexpressed in Brain - Amygdala (x5.7), Brain - Putamen (basal ganglia) (x5.7), Brain - Caudate (basal ganglia) (x5.6), Brain - Nucleus accumbens (basal ganglia) (x5.1), Brain - Hippocampus (x4.4), and Brain - Substantia nigra (x4.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ENHO

SOURCE GeneReport for Unigene cluster for ENHO Gene:


mRNA Expression by UniProt/SwissProt for ENHO Gene:

Tissue specificity: Expressed in liver and brain.

Evidence on tissue expression from TISSUES for ENHO Gene

  • Skin(4.1)
  • Nervous system(3)
genes like me logo Genes that share expression patterns with ENHO: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENHO Gene

Orthologs for ENHO Gene

This gene was present in the common ancestor of mammals.

Orthologs for ENHO Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ENHO 31 30
  • 100 (n)
(Bos Taurus)
Mammalia ENHO 31
  • 95 (a)
(Mus musculus)
Mammalia Enho 17 31 30
  • 94.3 (n)
(Rattus norvegicus)
Mammalia LOC100912292 30
  • 92.54 (n)
(Canis familiaris)
Mammalia ENHO 30
  • 92.54 (n)
Species where no ortholog for ENHO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ENHO Gene

Gene Tree for ENHO (if available)
Gene Tree for ENHO (if available)
Evolutionary constrained regions (ECRs) for ENHO: view image

Paralogs for ENHO Gene

No data available for Paralogs for ENHO Gene

Variants for ENHO Gene

Additional dbSNP identifiers (rs#s) for ENHO Gene

Structural Variations from Database of Genomic Variants (DGV) for ENHO Gene

Variant ID Type Subtype PubMed ID
esv3620335 CNV gain 21293372
nsv1125318 OTHER inversion 24896259
nsv519946 CNV loss 19592680
nsv831543 CNV loss 17160897

Variation tolerance for ENHO Gene

Residual Variation Intolerance Score: 43.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.06; 1.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ENHO Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ENHO Gene

Disorders for ENHO Gene

Additional Disease Information for ENHO

No disorders were found for ENHO Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ENHO Gene

Publications for ENHO Gene

  1. Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism. (PMID: 19041763) Kumar KG … Butler AA (Cell metabolism 2008) 2 3 4 54
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 54
  3. Afamin and adropin in patients with alcohol-induced liver cirrhosis. (PMID: 30260179) Prystupa A … Załuska W (Annals of agricultural and environmental medicine : AAEM 2018) 3 54
  4. Adropin: An endocrine link between the biological clock and cholesterol homeostasis. (PMID: 29331507) Ghoshal S … Butler AA (Molecular metabolism 2018) 3 54
  5. The Glycosyltransferase EOGT Regulates Adropin Expression in Decidualizing Human Endometrium. (PMID: 29244071) Muter J … Brosens JJ (Endocrinology 2018) 3 54

Products for ENHO Gene

  • Signalway ELISA kits for ENHO
  • Signalway Proteins for ENHO

Sources for ENHO Gene