Aliases for ENDOV Gene
External Ids for ENDOV Gene
Previous GeneCards Identifiers for ENDOV Gene
GeneCards Summary for ENDOV Gene
ENDOV (Endonuclease V) is a Protein Coding gene. Diseases associated with ENDOV include Robinow Syndrome, Autosomal Recessive 1 and Uv-Sensitive Syndrome. Gene Ontology (GO) annotations related to this gene include magnesium ion binding and single-stranded RNA binding.
UniProtKB/Swiss-Prot Summary for ENDOV Gene
Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures.