This gene encodes a protein with protease activity and is expressed in the placenta. The protein may be useful as a tumor marker. Multiple alternatively spliced transcript variants have been found for this protein. [provided by RefSeq, Feb 2010] See more...

Aliases for ENDOU Gene

Aliases for ENDOU Gene

  • Endonuclease, Poly(U) Specific 2 3 5
  • PP11 2 3 4
  • Uridylate-Specific Endoribonuclease 3 4
  • Poly(U)-Specific Endoribonuclease 3 4
  • Endonuclease, PolyU-Specific 2 3
  • Placental Protein 11 3 4
  • Protein EndoU 3 4
  • PRSS26 2 3
  • P11 2 3
  • 22 Serine Protease 3
  • 26 Serine Protease 3
  • EC 3.1.-.- 4
  • ENDOU 5

External Ids for ENDOU Gene

Previous GeneCards Identifiers for ENDOU Gene

  • GC12M048103
  • GC12M045134

Summaries for ENDOU Gene

Entrez Gene Summary for ENDOU Gene

  • This gene encodes a protein with protease activity and is expressed in the placenta. The protein may be useful as a tumor marker. Multiple alternatively spliced transcript variants have been found for this protein. [provided by RefSeq, Feb 2010]

GeneCards Summary for ENDOU Gene

ENDOU (Endonuclease, Poly(U) Specific) is a Protein Coding gene. Diseases associated with ENDOU include Non-Gestational Choriocarcinoma and Rapp-Hodgkin Syndrome. Gene Ontology (GO) annotations related to this gene include RNA binding and serine-type peptidase activity.

UniProtKB/Swiss-Prot Summary for ENDOU Gene

  • Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2'-3'-cyclic phosphate termini.

Additional gene information for ENDOU Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ENDOU Gene

Genomics for ENDOU Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ENDOU Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ENDOU on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ENDOU

Genomic Locations for ENDOU Gene

Genomic Locations for ENDOU Gene
chr12:47,709,734-47,725,567
(GRCh38/hg38)
Size:
15,834 bases
Orientation:
Minus strand
chr12:48,103,517-48,119,355
(GRCh37/hg19)
Size:
15,839 bases
Orientation:
Minus strand

Genomic View for ENDOU Gene

Genes around ENDOU on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENDOU Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENDOU Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENDOU Gene

Proteins for ENDOU Gene

  • Protein details for ENDOU Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21128-ENDOU_HUMAN
    Recommended name:
    Poly(U)-specific endoribonuclease
    Protein Accession:
    P21128
    Secondary Accessions:
    • B2RBJ3
    • B3KQS7
    • B7Z6E1
    • Q2NKJ4

    Protein attributes for ENDOU Gene

    Size:
    410 amino acids
    Molecular mass:
    46872 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for ENDOU Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ENDOU Gene

Post-translational modifications for ENDOU Gene

  • It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ENDOU Gene

No data available for DME Specific Peptides for ENDOU Gene

Domains & Families for ENDOU Gene

Gene Families for ENDOU Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for ENDOU Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ56948, moderately similar to Placental protein 11 (EC 3.4.21.-) (B7Z7N4_HUMAN)
  • Uridylate-specific endoribonuclease (ENDOU_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P21128

UniProtKB/Swiss-Prot:

ENDOU_HUMAN :
  • Belongs to the ENDOU family.
Family:
  • Belongs to the ENDOU family.
genes like me logo Genes that share domains with ENDOU: view

Function for ENDOU Gene

Molecular function for ENDOU Gene

UniProtKB/Swiss-Prot Function:
Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2'-3'-cyclic phosphate termini.

Enzyme Numbers (IUBMB) for ENDOU Gene

Phenotypes From GWAS Catalog for ENDOU Gene

Gene Ontology (GO) - Molecular Function for ENDOU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,IDA 18936097
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IEA --
GO:0004521 endoribonuclease activity IBA,IDA 18936097
GO:0005044 scavenger receptor activity IEA --
genes like me logo Genes that share ontologies with ENDOU: view
genes like me logo Genes that share phenotypes with ENDOU: view

Animal Models for ENDOU Gene

MGI Knock Outs for ENDOU:
  • Endou Endou<tm1Tft>
  • Endou Endou<tm1(KOMP)Vlcg>
  • Endou Endou<tm1.1(KOMP)Vlcg>

Animal Model Products

  • Taconic Biosciences Mouse Models for ENDOU

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ENDOU

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ENDOU Gene

Localization for ENDOU Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENDOU Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ENDOU gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ENDOU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 1710108
GO:0005615 extracellular space TAS 2350438
GO:0005737 cytoplasm TAS 2350438
GO:0005886 plasma membrane TAS 1710108
genes like me logo Genes that share ontologies with ENDOU: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ENDOU Gene

Pathways & Interactions for ENDOU Gene

PathCards logo

SuperPathways for ENDOU Gene

No Data Available

Interacting Proteins for ENDOU Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000397679 P21128-ENDOU_HUMAN for ENDOU Gene via STRING IID

Gene Ontology (GO) - Biological Process for ENDOU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA 2350438
GO:0006897 endocytosis IEA --
GO:0006955 immune response IEA --
GO:0007165 signal transduction IEA --
GO:0007565 female pregnancy IEP 2350438
genes like me logo Genes that share ontologies with ENDOU: view

No data available for Pathways by source and SIGNOR curated interactions for ENDOU Gene

Drugs & Compounds for ENDOU Gene

(1) Drugs for ENDOU Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ENDOU: view

Transcripts for ENDOU Gene

mRNA/cDNA for ENDOU Gene

3 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ENDOU

Alternative Splicing Database (ASD) splice patterns (SP) for ENDOU Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10
SP1:
SP2:
SP3: -
SP4: - -
SP5:

Relevant External Links for ENDOU Gene

GeneLoc Exon Structure for
ENDOU

Expression for ENDOU Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ENDOU Gene

mRNA differential expression in normal tissues according to GTEx for ENDOU Gene

This gene is overexpressed in Esophagus - Mucosa (x18.4), Vagina (x6.1), Minor Salivary Gland (x4.6), Skin - Not Sun Exposed (Suprapubic) (x4.5), Cervix - Ectocervix (x4.4), and Skin - Sun Exposed (Lower leg) (x4.1).

Protein differential expression in normal tissues from HIPED for ENDOU Gene

This gene is overexpressed in Placenta (45.9) and Cervix (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ENDOU Gene



Protein tissue co-expression partners for ENDOU Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ENDOU

SOURCE GeneReport for Unigene cluster for ENDOU Gene:

Hs.997

mRNA Expression by UniProt/SwissProt for ENDOU Gene:

P21128-ENDOU_HUMAN
Tissue specificity: Placental-specific, but also associated with various malignant neoplasms.

Evidence on tissue expression from TISSUES for ENDOU Gene

  • Nervous system(4.2)
  • Skin(2.4)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with ENDOU: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENDOU Gene

Orthologs for ENDOU Gene

This gene was present in the common ancestor of animals.

Orthologs for ENDOU Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ENDOU 30 31
  • 99.84 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ENDOU 30 31
  • 86.59 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ENDOU 30 31
  • 85.37 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Endou 30
  • 83.05 (n)
Mouse
(Mus musculus)
Mammalia Endou 30 17 31
  • 82.72 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ENDOU 31
  • 74 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ENDOU 31
  • 61 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ENDOU 30 31
  • 68.38 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 73 (a)
OneToMany
-- 31
  • 59 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100490819 30
  • 60.66 (n)
Zebrafish
(Danio rerio)
Actinopterygii endou 30 31
  • 60.9 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1715 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG2145 30
  • 48.06 (n)
CG3303 31
  • 23 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea K02A11.3 30 31
  • 46.92 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 38 (a)
OneToMany
CSA.5199 31
  • 33 (a)
OneToMany
Species where no ortholog for ENDOU was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ENDOU Gene

ENSEMBL:
Gene Tree for ENDOU (if available)
TreeFam:
Gene Tree for ENDOU (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ENDOU: view image

Paralogs for ENDOU Gene

No data available for Paralogs for ENDOU Gene

Variants for ENDOU Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ENDOU Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
720453 Benign: not provided 47,712,537(-) G/A SYNONYMOUS_VARIANT
784236 Benign: not provided 47,716,367(-) G/A SYNONYMOUS_VARIANT
787924 Benign: not provided 47,716,419(-) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ENDOU Gene

Structural Variations from Database of Genomic Variants (DGV) for ENDOU Gene

Variant ID Type Subtype PubMed ID
esv2751101 CNV gain 17911159
nsv470289 CNV gain 18288195
nsv696 CNV insertion 18451855

Variation tolerance for ENDOU Gene

Residual Variation Intolerance Score: 89.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.11; 51.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ENDOU Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ENDOU

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENDOU Gene

Disorders for ENDOU Gene

MalaCards: The human disease database

(2) MalaCards diseases for ENDOU Gene - From: DISEASES

Disorder Aliases PubMed IDs
non-gestational choriocarcinoma
  • choriocarcinoma, non-gestational
rapp-hodgkin syndrome
  • rhs
- elite association - COSMIC cancer census association via MalaCards
Search ENDOU in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ENDOU

genes like me logo Genes that share disorders with ENDOU: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ENDOU Gene

Publications for ENDOU Gene

  1. The tumor marker human placental protein 11 is an endoribonuclease. (PMID: 18936097) Laneve P … Caffarelli E (The Journal of biological chemistry 2008) 2 3 4 23
  2. Cloning and expression of a cDNA encoding human placental protein 11, a putative serine protease with diagnostic significance as a tumor marker. (PMID: 2350438) Grundmann U … Amann E (DNA and cell biology 1990) 2 3 4 23
  3. Homology of placental protein 11 and pea seed albumin 2 with vitronectin. (PMID: 1710108) Jenne D (Biochemical and biophysical research communications 1991) 2 3 4
  4. Functional characterization of XendoU, the endoribonuclease involved in small nucleolar RNA biosynthesis. (PMID: 15755742) Gioia U … Caffarelli E (The Journal of biological chemistry 2005) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for ENDOU Gene

  • Signalway Proteins for ENDOU

Sources for ENDOU Gene