External Ids for ENDOG Gene
Previous GeneCards Identifiers for ENDOG Gene
The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. [provided by RefSeq, Jul 2008]
GeneCards Summary for ENDOG Gene
ENDOG (Endonuclease G) is a Protein Coding gene. Diseases associated with ENDOG include Leber Hereditary Optic Neuropathy. Among its related pathways are Apoptosis Modulation and Signaling and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and endonuclease activity. An important paralog of this gene is EXOG.
UniProtKB/Swiss-Prot for ENDOG Gene
Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity).