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Aliases for ENDOD1 Gene

Aliases for ENDOD1 Gene

  • Endonuclease Domain Containing 1 2 3 5
  • EC 3.1.30.- 4
  • KIAA0830 4

External Ids for ENDOD1 Gene

Previous GeneCards Identifiers for ENDOD1 Gene

  • GC11P094463
  • GC11P094823
  • GC11P090887

Summaries for ENDOD1 Gene

GeneCards Summary for ENDOD1 Gene

ENDOD1 (Endonuclease Domain Containing 1) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and endonuclease activity.

UniProtKB/Swiss-Prot for ENDOD1 Gene

  • May act as a DNase and a RNase.

Additional gene information for ENDOD1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENDOD1 Gene

Genomics for ENDOD1 Gene

GeneHancer (GH) Regulatory Elements for ENDOD1 Gene

Promoters and enhancers for ENDOD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I095088 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 558.5 +0.1 59 2.9 HDGF ATF1 ARID4B SIN3A ZNF48 YY1 ZNF207 ZNF143 ATF7 RUNX3 ENDOD1 GC11P095088 SRSF8 LOC101929295 KDM4E GC11P095093 GC11M095076
GH11I095066 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 17.1 -21.7 -21698 3.7 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SRSF8 GC11P095067 GC11M095066 ENDOD1 LOC101929295 KDM4E CWC15 KDM4D MTMR2 GC11P095083
GH11I095133 Enhancer 1 Ensembl ENCODE dbSUPER 23.8 +44.7 44723 2.9 MAFG OSR2 ZFHX2 ZNF316 JUND POLR2A PRDM10 ZNF600 MAFK EMSY ENDOD1 BUD13P1 ENSG00000270578 KDM4D CWC15 KDM4E SRSF8 LOC105369435 GC11P095138 GC11M095076
GH11I095076 Enhancer 0.9 ENCODE dbSUPER 19.8 -13.3 -13259 0.7 MEIS2 SRF PKNOX1 MAX CEBPB CEBPG EP300 NR2F2 PRDM6 ELK1 ENDOD1 LOC101929295 GC11P095083 GC11P095067 GC11M095076
GH11I095140 Enhancer 0.8 ENCODE 19.3 +51.1 51107 1.1 ATF1 MZF1 CEBPG FEZF1 ZIC2 HIC1 ZFHX2 EGR1 ZSCAN5C CBFA2T2 ENDOD1 KDM4E GC11P095138 BUD13P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ENDOD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ENDOD1 gene promoter:

Genomic Locations for ENDOD1 Gene

Genomic Locations for ENDOD1 Gene
chr11:95,089,810-95,132,651
(GRCh38/hg38)
Size:
42,842 bases
Orientation:
Plus strand
chr11:94,822,974-94,865,815
(GRCh37/hg19)

Genomic View for ENDOD1 Gene

Genes around ENDOD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENDOD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENDOD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENDOD1 Gene

Proteins for ENDOD1 Gene

  • Protein details for ENDOD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94919-ENDD1_HUMAN
    Recommended name:
    Endonuclease domain-containing 1 protein
    Protein Accession:
    O94919
    Secondary Accessions:
    • A8K6K8
    • Q6GQY5
    • Q8TAQ8

    Protein attributes for ENDOD1 Gene

    Size:
    500 amino acids
    Molecular mass:
    55017 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA74853.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ENDOD1 Gene

Post-translational modifications for ENDOD1 Gene

No Post-translational modifications

Other Protein References for ENDOD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ENDOD1 Gene

Domains & Families for ENDOD1 Gene

Gene Families for ENDOD1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for ENDOD1 Gene

Suggested Antigen Peptide Sequences for ENDOD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94919

UniProtKB/Swiss-Prot:

ENDD1_HUMAN :
  • Belongs to the DNA/RNA non-specific endonuclease family.
Family:
  • Belongs to the DNA/RNA non-specific endonuclease family.
genes like me logo Genes that share domains with ENDOD1: view

Function for ENDOD1 Gene

Molecular function for ENDOD1 Gene

UniProtKB/Swiss-Prot Function:
May act as a DNase and a RNase.

Enzyme Numbers (IUBMB) for ENDOD1 Gene

Phenotypes From GWAS Catalog for ENDOD1 Gene

Gene Ontology (GO) - Molecular Function for ENDOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ENDOD1: view

Phenotypes for ENDOD1 Gene

GenomeRNAi human phenotypes for ENDOD1:
genes like me logo Genes that share phenotypes with ENDOD1: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ENDOD1 Gene

Localization for ENDOD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENDOD1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ENDOD1 gene
Compartment Confidence
extracellular 5
cytosol 4
plasma membrane 3
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ENDOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA,HDA 19946888
GO:0070062 extracellular exosome HDA,IDA 23376485
genes like me logo Genes that share ontologies with ENDOD1: view

Pathways & Interactions for ENDOD1 Gene

genes like me logo Genes that share pathways with ENDOD1: view

Interacting Proteins for ENDOD1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000278505%0d%0a9606.ENSP00000381148%0d%0a9606.ENSP00000286713%0d%0a
Selected Interacting proteins: O94919-ENDD1_HUMAN ENSP00000278505 for ENDOD1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for ENDOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with ENDOD1: view

No data available for SIGNOR curated interactions for ENDOD1 Gene

Drugs & Compounds for ENDOD1 Gene

No Compound Related Data Available

Transcripts for ENDOD1 Gene

mRNA/cDNA for ENDOD1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(214) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ENDOD1 Gene

Endonuclease domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ENDOD1 Gene

No ASD Table

Relevant External Links for ENDOD1 Gene

GeneLoc Exon Structure for
ENDOD1
ECgene alternative splicing isoforms for
ENDOD1

Expression for ENDOD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ENDOD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ENDOD1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.4), Urine (9.7), Cervix (9.6), and Platelet (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ENDOD1 Gene



Protein tissue co-expression partners for ENDOD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ENDOD1 Gene:

ENDOD1

SOURCE GeneReport for Unigene cluster for ENDOD1 Gene:

Hs.167115

Evidence on tissue expression from TISSUES for ENDOD1 Gene

  • Nervous system(4.8)
  • Blood(4.2)
  • Liver(2.3)
genes like me logo Genes that share expression patterns with ENDOD1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENDOD1 Gene

Orthologs for ENDOD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ENDOD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ENDOD1 34 33
  • 98.75 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ENDOD1 33 34
  • 82.89 (n)
cow
(Bos Taurus)
Mammalia ENDOD1 33 34
  • 81.6 (n)
mouse
(Mus musculus)
Mammalia Endod1 33 16 34
  • 80.4 (n)
rat
(Rattus norvegicus)
Mammalia Endod1 33
  • 80.16 (n)
oppossum
(Monodelphis domestica)
Mammalia ENDOD1 34
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 59 (a)
OneToMany
-- 34
  • 59 (a)
OneToMany
-- 34
  • 27 (a)
OneToMany
chicken
(Gallus gallus)
Aves ENDOD1 33 34
  • 57.87 (n)
lizard
(Anolis carolinensis)
Reptilia ENDOD1 34
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia endod1 33
  • 54.04 (n)
zebrafish
(Danio rerio)
Actinopterygii ENDOD1 (12 of 15) 34
  • 32 (a)
OneToMany
ENDOD1 (1 of 15) 34
  • 29 (a)
OneToMany
ENDOD1 (15 of 15) 34
  • 29 (a)
OneToMany
ENDOD1 (4 of 15) 34
  • 27 (a)
OneToMany
ENDOD1 (9 of 15) 34
  • 27 (a)
OneToMany
ENDOD1 (5 of 15) 34
  • 26 (a)
OneToMany
ENDOD1 (11 of 15) 34
  • 25 (a)
OneToMany
ENDOD1 (8 of 15) 34
  • 25 (a)
OneToMany
ENDOD1 (3 of 15) 34
  • 24 (a)
OneToMany
ENDOD1 (7 of 15) 34
  • 24 (a)
OneToMany
ENDOD1 (10 of 15) 34
  • 23 (a)
OneToMany
CT573337.1 34
  • 22 (a)
OneToMany
ENDOD1 (2 of 15) 34
  • 21 (a)
OneToMany
ENDOD1 (13 of 15) 34
  • 17 (a)
OneToMany
ENDOD1 (6 of 15) 34
  • 4 (a)
OneToMany
Species where no ortholog for ENDOD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ENDOD1 Gene

ENSEMBL:
Gene Tree for ENDOD1 (if available)
TreeFam:
Gene Tree for ENDOD1 (if available)

Paralogs for ENDOD1 Gene

Pseudogenes.org Pseudogenes for ENDOD1 Gene

genes like me logo Genes that share paralogs with ENDOD1: view

No data available for Paralogs for ENDOD1 Gene

Variants for ENDOD1 Gene

Sequence variations from dbSNP and Humsavar for ENDOD1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000026675 -- 95,096,586(+) T/C intron_variant
rs1000198742 -- 95,102,912(+) A/G intron_variant
rs1000243705 -- 95,109,273(+) G/A intron_variant
rs1000369317 -- 95,090,245(+) C/A/T intron_variant
rs1000540025 -- 95,114,526(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ENDOD1 Gene

Variant ID Type Subtype PubMed ID
nsv1138065 CNV deletion 24896259
esv992223 CNV insertion 20482838
esv3413248 CNV duplication 20981092
esv1343006 CNV insertion 17803354

Variation tolerance for ENDOD1 Gene

Residual Variation Intolerance Score: 54.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.33; 88.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ENDOD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ENDOD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENDOD1 Gene

Disorders for ENDOD1 Gene

Additional Disease Information for ENDOD1

No disorders were found for ENDOD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ENDOD1 Gene

Publications for ENDOD1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Towards complete analysis of the platelet proteome. (PMID: 11921445) O'Neill EE … Hebestreit HF (Proteomics 2002) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58

Products for ENDOD1 Gene

Sources for ENDOD1 Gene

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