Aliases for ENDOD1 Gene

Aliases for ENDOD1 Gene

  • Endonuclease Domain Containing 1 2 3 5
  • Endonuclease Domain-Containing 1 Protein 3 4
  • KIAA0830 2 4
  • EC 3.1.30.- 4
  • ENDOD1 5

External Ids for ENDOD1 Gene

Previous GeneCards Identifiers for ENDOD1 Gene

  • GC11P094463
  • GC11P094823
  • GC11P090887

Summaries for ENDOD1 Gene

GeneCards Summary for ENDOD1 Gene

ENDOD1 (Endonuclease Domain Containing 1) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and endonuclease activity.

UniProtKB/Swiss-Prot Summary for ENDOD1 Gene

Additional gene information for ENDOD1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ENDOD1 Gene

Genomics for ENDOD1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ENDOD1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ENDOD1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ENDOD1

Top Transcription factor binding sites by QIAGEN in the ENDOD1 gene promoter:
  • AREB6
  • Bach2
  • N-Myc
  • Pax-4a
  • Pax-6
  • RP58
  • STAT5B
  • USF-1
  • USF1

Genomic Locations for ENDOD1 Gene

Genomic Locations for ENDOD1 Gene
chr11:95,089,846-95,132,645
(GRCh38/hg38)
Size:
42,800 bases
Orientation:
Plus strand
chr11:94,822,974-94,865,815
(GRCh37/hg19)
Size:
42,842 bases
Orientation:
Plus strand

Genomic View for ENDOD1 Gene

Genes around ENDOD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENDOD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENDOD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENDOD1 Gene

Proteins for ENDOD1 Gene

  • Protein details for ENDOD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94919-ENDD1_HUMAN
    Recommended name:
    Endonuclease domain-containing 1 protein
    Protein Accession:
    O94919
    Secondary Accessions:
    • A8K6K8
    • Q6GQY5
    • Q8TAQ8

    Protein attributes for ENDOD1 Gene

    Size:
    500 amino acids
    Molecular mass:
    55017 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA74853.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ENDOD1 Gene

Post-translational modifications for ENDOD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ENDOD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Boster Bio Antibodies for ENDOD1
  • Santa Cruz Biotechnology (SCBT) Antibodies for ENDOD1

No data available for DME Specific Peptides for ENDOD1 Gene

Domains & Families for ENDOD1 Gene

Gene Families for ENDOD1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for ENDOD1 Gene

Suggested Antigen Peptide Sequences for ENDOD1 Gene

GenScript: Design optimal peptide antigens:
  • Endonuclease domain-containing 1 protein (ENDD1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O94919

UniProtKB/Swiss-Prot:

ENDD1_HUMAN :
  • Belongs to the DNA/RNA non-specific endonuclease family.
Family:
  • Belongs to the DNA/RNA non-specific endonuclease family.
genes like me logo Genes that share domains with ENDOD1: view

Function for ENDOD1 Gene

Molecular function for ENDOD1 Gene

UniProtKB/Swiss-Prot Function:
May act as a DNase and a RNase.

Enzyme Numbers (IUBMB) for ENDOD1 Gene

Phenotypes From GWAS Catalog for ENDOD1 Gene

Gene Ontology (GO) - Molecular Function for ENDOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ENDOD1: view

Phenotypes for ENDOD1 Gene

genes like me logo Genes that share phenotypes with ENDOD1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ENDOD1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ENDOD1 Gene

Localization for ENDOD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENDOD1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ENDOD1 gene
Compartment Confidence
extracellular 4
cytosol 4
plasma membrane 3
nucleus 1
endoplasmic reticulum 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ENDOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005829 cytosol TAS --
GO:0016020 membrane HDA 19946888
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with ENDOD1: view

Pathways & Interactions for ENDOD1 Gene

genes like me logo Genes that share pathways with ENDOD1: view

Gene Ontology (GO) - Biological Process for ENDOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with ENDOD1: view

No data available for SIGNOR curated interactions for ENDOD1 Gene

Drugs & Compounds for ENDOD1 Gene

No Compound Related Data Available

Transcripts for ENDOD1 Gene

mRNA/cDNA for ENDOD1 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ENDOD1

Alternative Splicing Database (ASD) splice patterns (SP) for ENDOD1 Gene

No ASD Table

Relevant External Links for ENDOD1 Gene

GeneLoc Exon Structure for
ENDOD1

Expression for ENDOD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ENDOD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ENDOD1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.4), Urine (9.7), Cervix (9.6), and Platelet (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ENDOD1 Gene



Protein tissue co-expression partners for ENDOD1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ENDOD1

SOURCE GeneReport for Unigene cluster for ENDOD1 Gene:

Hs.167115

Evidence on tissue expression from TISSUES for ENDOD1 Gene

  • Nervous system(4.8)
  • Blood(4.3)
  • Liver(2.6)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with ENDOD1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENDOD1 Gene

Orthologs for ENDOD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ENDOD1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ENDOD1 30 31
  • 98.75 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ENDOD1 30 31
  • 82.89 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ENDOD1 30 31
  • 81.6 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Endod1 30 17 31
  • 80.4 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Endod1 30
  • 80.16 (n)
Oppossum
(Monodelphis domestica)
Mammalia ENDOD1 31
  • 66 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 59 (a)
OneToMany
-- 31
  • 59 (a)
OneToMany
-- 31
  • 27 (a)
OneToMany
Chicken
(Gallus gallus)
Aves ENDOD1 30 31
  • 57.87 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ENDOD1 31
  • 38 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia endod1 30
  • 54.04 (n)
Zebrafish
(Danio rerio)
Actinopterygii ENDOD1 (12 of 15) 31
  • 32 (a)
OneToMany
ENDOD1 (1 of 15) 31
  • 29 (a)
OneToMany
ENDOD1 (15 of 15) 31
  • 29 (a)
OneToMany
ENDOD1 (9 of 15) 31
  • 27 (a)
OneToMany
ENDOD1 (4 of 15) 31
  • 27 (a)
OneToMany
ENDOD1 (5 of 15) 31
  • 26 (a)
OneToMany
ENDOD1 (8 of 15) 31
  • 25 (a)
OneToMany
ENDOD1 (11 of 15) 31
  • 25 (a)
OneToMany
ENDOD1 (7 of 15) 31
  • 24 (a)
OneToMany
ENDOD1 (3 of 15) 31
  • 24 (a)
OneToMany
ENDOD1 (10 of 15) 31
  • 23 (a)
OneToMany
CT573337.1 31
  • 22 (a)
OneToMany
ENDOD1 (2 of 15) 31
  • 21 (a)
OneToMany
ENDOD1 (13 of 15) 31
  • 17 (a)
OneToMany
ENDOD1 (6 of 15) 31
  • 4 (a)
OneToMany
Species where no ortholog for ENDOD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ENDOD1 Gene

ENSEMBL:
Gene Tree for ENDOD1 (if available)
TreeFam:
Gene Tree for ENDOD1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ENDOD1: view image

Paralogs for ENDOD1 Gene

Pseudogenes.org Pseudogenes for ENDOD1 Gene

genes like me logo Genes that share paralogs with ENDOD1: view

No data available for Paralogs for ENDOD1 Gene

Variants for ENDOD1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ENDOD1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs3740861 - p.Gly446Val
rs3740862 - p.Val350Met

Additional dbSNP identifiers (rs#s) for ENDOD1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ENDOD1 Gene

Variant ID Type Subtype PubMed ID
esv1343006 CNV insertion 17803354
esv3413248 CNV duplication 20981092
esv992223 CNV insertion 20482838
nsv1138065 CNV deletion 24896259

Variation tolerance for ENDOD1 Gene

Residual Variation Intolerance Score: 54.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.33; 88.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ENDOD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ENDOD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENDOD1 Gene

Disorders for ENDOD1 Gene

Additional Disease Information for ENDOD1

No disorders were found for ENDOD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ENDOD1 Gene

Publications for ENDOD1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Towards complete analysis of the platelet proteome. (PMID: 11921445) O'Neill EE … Hebestreit HF (Proteomics 2002) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling. (PMID: 31073040) Choi JH … Beutler B (Science (New York, N.Y.) 2019) 3

Products for ENDOD1 Gene

Sources for ENDOD1 Gene