Aliases for ENAH Gene
External Ids for ENAH Gene
Previous GeneCards Identifiers for ENAH Gene
This gene encodes a member of the enabled/ vasodilator-stimulated phosphoprotein. Members of this gene family are involved in actin-based motility. This protein is involved in regulating the assembly of actin filaments and modulates cell adhesion and motility. Alternate splice variants of this gene have been correlated with tumor invasiveness in certain tissues and these variants may serve as prognostic markers. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2016]
GeneCards Summary for ENAH Gene
ENAH (ENAH Actin Regulator) is a Protein Coding gene. Diseases associated with ENAH include Gastric Papillary Adenocarcinoma and Gastric Tubular Adenocarcinoma. Among its related pathways are Signaling by Robo receptor and Signaling by Slit. Gene Ontology (GO) annotations related to this gene include actin binding and WW domain binding. An important paralog of this gene is EVL.
UniProtKB/Swiss-Prot Summary for ENAH Gene
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity).