Aliases for EML5 Gene

Aliases for EML5 Gene

  • EMAP Like 5 2 3 5
  • Echinoderm Microtubule-Associated Protein-Like 5 3 4
  • Echinoderm Microtubule Associated Protein Like 5 2 3
  • EMAP-5 3 4
  • EMAP-2 3

External Ids for EML5 Gene

Previous GeneCards Identifiers for EML5 Gene

  • GC14M082988
  • GC14M087161
  • GC14M087072
  • GC14M087070
  • GC14M088150
  • GC14M089081
  • GC14M069251
  • GC14M089159
  • GC14M089582
  • GC14M089881
  • GC14M090292
  • GC14M089147
  • GC14M089257
  • GC14M092338
  • GC14M092432
  • GC14M092455
  • GC14M089317
  • GC14M090498
  • GC14M090830
  • GC14M091103
  • GC14M091401
  • GC14M091688
  • GC14M091979
  • GC14M092237

Summaries for EML5 Gene

GeneCards Summary for EML5 Gene

EML5 (EMAP Like 5) is a Protein Coding gene. An important paralog of this gene is EML6.

UniProtKB/Swiss-Prot Summary for EML5 Gene

  • May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.

Additional gene information for EML5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EML5 Gene

Genomics for EML5 Gene

GeneHancer (GH) Regulatory Elements for EML5 Gene

Promoters and enhancers for EML5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EML5 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EML5

Top Transcription factor binding sites by QIAGEN in the EML5 gene promoter:
  • C/EBPalpha
  • Evi-1
  • IRF-1
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • S8
  • YY1

Genomic Locations for EML5 Gene

Genomic Locations for EML5 Gene
chr14:88,612,431-88,792,752
(GRCh38/hg38)
Size:
180,322 bases
Orientation:
Minus strand
chr14:89,078,775-89,259,096
(GRCh37/hg19)
Size:
180,322 bases
Orientation:
Minus strand

Genomic View for EML5 Gene

Genes around EML5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EML5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EML5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EML5 Gene

Proteins for EML5 Gene

  • Protein details for EML5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05BV3-EMAL5_HUMAN
    Recommended name:
    Echinoderm microtubule-associated protein-like 5
    Protein Accession:
    Q05BV3
    Secondary Accessions:
    • B9EK59
    • Q5H9N6
    • Q6UYC9
    • Q6ZRP3
    • Q6ZT03

    Protein attributes for EML5 Gene

    Size:
    1969 amino acids
    Molecular mass:
    219427 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    • [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    SequenceCaution:
    • Sequence=AAH32685.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAC86793.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAC87266.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=CAI46257.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown in N-terminus because it seems to be derived from a pre-mRNA.; Evidence={ECO:0000305};

    Alternative splice isoforms for EML5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EML5 Gene

Post-translational modifications for EML5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for EML5 Gene

Domains & Families for EML5 Gene

Gene Families for EML5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for EML5 Gene

GenScript: Design optimal peptide antigens:
  • Echinoderm microtubule-associated protein-like 5 (EMAL5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q05BV3

UniProtKB/Swiss-Prot:

EMAL5_HUMAN :
  • Belongs to the WD repeat EMAP family.
Family:
  • Belongs to the WD repeat EMAP family.
genes like me logo Genes that share domains with EML5: view

Function for EML5 Gene

Molecular function for EML5 Gene

UniProtKB/Swiss-Prot Function:
May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.

Phenotypes From GWAS Catalog for EML5 Gene

Gene Ontology (GO) - Molecular Function for EML5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003824 catalytic activity IEA --
GO:0005515 protein binding IEA --
GO:0008017 microtubule binding IBA 21873635
genes like me logo Genes that share ontologies with EML5: view
genes like me logo Genes that share phenotypes with EML5: view

Animal Model Products

CRISPR Products

miRNA for EML5 Gene

miRTarBase miRNAs that target EML5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EML5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EML5 Gene

Localization for EML5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EML5 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EML5 gene
Compartment Confidence
cytoskeleton 4
nucleus 2
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for EML5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with EML5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for EML5 Gene

Pathways & Interactions for EML5 Gene

PathCards logo

SuperPathways for EML5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EML5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with EML5: view

No data available for Pathways by source and SIGNOR curated interactions for EML5 Gene

Drugs & Compounds for EML5 Gene

No Compound Related Data Available

Transcripts for EML5 Gene

mRNA/cDNA for EML5 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EML5

Alternative Splicing Database (ASD) splice patterns (SP) for EML5 Gene

No ASD Table

Relevant External Links for EML5 Gene

GeneLoc Exon Structure for
EML5

Expression for EML5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EML5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EML5 Gene

This gene is overexpressed in Ovary (x7.0), Brain - Cerebellar Hemisphere (x6.5), and Brain - Cerebellum (x6.4).

Protein differential expression in normal tissues from HIPED for EML5 Gene

This gene is overexpressed in Pancreas (22.3), Monocytes (11.6), Heart (9.4), and Breast (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EML5 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EML5

SOURCE GeneReport for Unigene cluster for EML5 Gene:

Hs.325846

Evidence on tissue expression from TISSUES for EML5 Gene

  • Eye(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with EML5: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EML5 Gene

Orthologs for EML5 Gene

This gene was present in the common ancestor of animals.

Orthologs for EML5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EML5 31 30
  • 99.54 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 94 (a)
OneToMany
-- 31
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia EML5 31 30
  • 93.76 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EML5 31
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EML5 31 30
  • 91.74 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Eml5 17 31 30
  • 90.73 (n)
rat
(Rattus norvegicus)
Mammalia Eml5 30
  • 90.41 (n)
chicken
(Gallus gallus)
Aves EML5 31 30
  • 83.41 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 87 (a)
OneToMany
-- 31
  • 79 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia eml5 30
  • 78.01 (n)
zebrafish
(Danio rerio)
Actinopterygii EML5 31
  • 85 (a)
OneToOne
si:dkey-1f12.3 30
  • 74.6 (n)
wufb77g05 30
fruit fly
(Drosophila melanogaster)
Insecta DCX-EMAP 31
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea elp-1 31
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 60 (a)
OneToMany
Species where no ortholog for EML5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EML5 Gene

ENSEMBL:
Gene Tree for EML5 (if available)
TreeFam:
Gene Tree for EML5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EML5: view image

Paralogs for EML5 Gene

Paralogs for EML5 Gene

(5) SIMAP similar genes for EML5 Gene using alignment to 6 proteins:

  • EMAL5_HUMAN
  • H0YJ79_HUMAN
  • H0YJS1_HUMAN
  • H0YJX1_HUMAN
  • J3KNC1_HUMAN
  • L8EBH5_HUMAN
genes like me logo Genes that share paralogs with EML5: view

Variants for EML5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EML5 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
709293 Benign: not provided 88,620,769(-) G/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT
770998 Benign: not provided 88,740,517(-) G/A MISSENSE_VARIANT
773724 Benign: not provided 88,644,457(-) T/C SYNONYMOUS_VARIANT
rs35953031 Benign: not specified 88,620,934(-) T/TA THREE_PRIME_UTR_VARIANT,INTRON_VARIANT
rs17188228 - p.Ile269Val

Additional dbSNP identifiers (rs#s) for EML5 Gene

Structural Variations from Database of Genomic Variants (DGV) for EML5 Gene

Variant ID Type Subtype PubMed ID
dgv1955n100 CNV gain 25217958
esv1000040 CNV deletion 20482838
esv1437722 CNV insertion 17803354
esv1552947 CNV insertion 17803354
esv2671135 CNV deletion 23128226
esv2678445 CNV deletion 23128226
esv2748998 CNV deletion 23290073
esv3304540 CNV mobile element insertion 20981092
esv3371598 CNV insertion 20981092
esv3635277 CNV gain 21293372
esv3635281 CNV loss 21293372
esv6674 CNV gain 19470904
esv998149 CNV insertion 20482838
nsv1110906 OTHER inversion 24896259
nsv1125589 CNV tandem duplication 24896259
nsv1390 CNV insertion 18451855
nsv1391 CNV insertion 18451855
nsv475884 CNV novel sequence insertion 20440878
nsv479211 CNV novel sequence insertion 20440878
nsv509543 CNV insertion 20534489
nsv85511 CNV deletion 16902084
nsv983848 CNV duplication 23825009

Variation tolerance for EML5 Gene

Residual Variation Intolerance Score: 0.898% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.95; 87.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EML5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EML5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EML5 Gene

Disorders for EML5 Gene

Additional Disease Information for EML5

No disorders were found for EML5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EML5 Gene

Publications for EML5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  3. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 54
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal KB … Olsen JV (Science signaling 2015) 3 54
  5. Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim TY … Major MB (Molecular and cellular biology 2015) 3 54

Products for EML5 Gene

Sources for EML5 Gene