Aliases for EML4 Gene
External Ids for EML4 Gene
Previous HGNC Symbols for EML4 Gene
Previous GeneCards Identifiers for EML4 Gene
This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq, Jan 2015]
GeneCards Summary for EML4 Gene
EML4 (EMAP Like 4) is a Protein Coding gene. Diseases associated with EML4 include Signet Ring Lung Adenocarcinoma and Inflammatory Myofibroblastic Tumor. Among its related pathways are Cytoskeletal Signaling and Glioma. An important paralog of this gene is EML1.
UniProtKB/Swiss-Prot Summary for EML4 Gene
May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.