Aliases for EML4 Gene
External Ids for EML4 Gene
Previous HGNC Symbols for EML4 Gene
Previous GeneCards Identifiers for EML4 Gene
This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq, Jan 2015]
GeneCards Summary for EML4 Gene
EML4 (EMAP Like 4) is a Protein Coding gene. Diseases associated with EML4 include Signet Ring Lung Adenocarcinoma and Inflammatory Myofibroblastic Tumor. Among its related pathways are Cytoskeletal Signaling and Crizotinib Pathway, Pharmacokinetics/Pharmacodynamics. An important paralog of this gene is EML1.
UniProtKB/Swiss-Prot Summary for EML4 Gene
Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526).