Aliases for EML2 Gene

Aliases for EML2 Gene

  • EMAP Like 2 2 3 5
  • EMAP-2 2 3 4
  • EMAP2 2 3 4
  • Echinoderm MT-Associated Protein (EMAP)-Like Protein 70 2 3
  • Microtubule-Associated Protein Like Echinoderm EMAP 2 3
  • Echinoderm Microtubule Associated Protein Like 2 2 3
  • Echinoderm Microtubule-Associated Protein-Like 2 3 4
  • ELP70 2 3
  • HuEMAP-2 4
  • EMAPL2 4
  • EML2 5

External Ids for EML2 Gene

Previous GeneCards Identifiers for EML2 Gene

  • GC19M046756
  • GC19M046503
  • GC19M050788
  • GC19M050804
  • GC19M046112
  • GC19M042541

Summaries for EML2 Gene

GeneCards Summary for EML2 Gene

EML2 (EMAP Like 2) is a Protein Coding gene. Diseases associated with EML2 include Sulfonamide Allergy. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and protein C-terminus binding. An important paralog of this gene is EML1.

UniProtKB/Swiss-Prot Summary for EML2 Gene

  • Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EML2 Gene

Genomics for EML2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for EML2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EML2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EML2

Top Transcription factor binding sites by QIAGEN in the EML2 gene promoter:
  • AhR
  • AML1a
  • AP-4
  • Arnt
  • c-Myc
  • C/EBPalpha
  • CREB
  • deltaCREB
  • GATA-2
  • Max1

Genomic Locations for EML2 Gene

Genomic Locations for EML2 Gene
chr19:45,606,994-45,645,629
(GRCh38/hg38)
Size:
38,636 bases
Orientation:
Minus strand
chr19:46,110,252-46,148,887
(GRCh37/hg19)
Size:
38,636 bases
Orientation:
Minus strand

Genomic View for EML2 Gene

Genes around EML2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EML2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EML2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EML2 Gene

Proteins for EML2 Gene

  • Protein details for EML2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95834-EMAL2_HUMAN
    Recommended name:
    Echinoderm microtubule-associated protein-like 2
    Protein Accession:
    O95834
    Secondary Accessions:
    • B7Z3I2
    • B7Z3Q9
    • K7ERL7
    • Q59EN8
    • Q8N5A2
    • Q9UG50

    Protein attributes for EML2 Gene

    Size:
    649 amino acids
    Molecular mass:
    70679 Da
    Quaternary structure:
    • Interacts with GRID2 and may also interact with GRID1 (By similarity). Binds unpolymerized tubulins via its WD repeat region.

    Three dimensional structures from OCA and Proteopedia for EML2 Gene

    Alternative splice isoforms for EML2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EML2 Gene

Post-translational modifications for EML2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for EML2 Gene

Domains & Families for EML2 Gene

Gene Families for EML2 Gene

Protein Domains for EML2 Gene

Suggested Antigen Peptide Sequences for EML2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ59545, highly similar to Echinoderm microtubule-associated protein-like 2 (B7Z3I2_HUMAN)
  • Echinoderm microtubule-associated protein-like 2 (EMAL2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95834

UniProtKB/Swiss-Prot:

EMAL2_HUMAN :
  • Contains a tandem atypical propeller in EMLs (TAPE) domain. The N-terminal beta-propeller is formed by canonical WD repeats; in contrast, the second beta-propeller contains one blade that is formed by discontinuous parts of the polypeptide chain (By similarity).
  • Belongs to the WD repeat EMAP family.
Domain:
  • Contains a tandem atypical propeller in EMLs (TAPE) domain. The N-terminal beta-propeller is formed by canonical WD repeats; in contrast, the second beta-propeller contains one blade that is formed by discontinuous parts of the polypeptide chain (By similarity).
Family:
  • Belongs to the WD repeat EMAP family.
genes like me logo Genes that share domains with EML2: view

Function for EML2 Gene

Molecular function for EML2 Gene

UniProtKB/Swiss-Prot Function:
Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules.

Phenotypes From GWAS Catalog for EML2 Gene

Gene Ontology (GO) - Molecular Function for EML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IEA --
GO:0005515 protein binding IEA,IPI 25416956
GO:0008017 microtubule binding IBA,IDA 11694528
GO:0008022 protein C-terminus binding IEA --
GO:0015631 tubulin binding IDA 24706829
genes like me logo Genes that share ontologies with EML2: view
genes like me logo Genes that share phenotypes with EML2: view

Animal Models for EML2 Gene

MGI Knock Outs for EML2:
  • Eml2 Eml2<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EML2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for EML2 Gene

Localization for EML2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EML2 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Note=Colocalizes with the microtubule cytoskeleton. Colocalizes with the mitotic spindle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EML2 gene
Compartment Confidence
cytoskeleton 4
plasma membrane 2
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005819 spindle IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0005875 microtubule associated complex TAS 10521658
genes like me logo Genes that share ontologies with EML2: view

Pathways & Interactions for EML2 Gene

PathCards logo

SuperPathways for EML2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IBA 21873635
GO:0007601 visual perception TAS 10521658
GO:0007605 sensory perception of sound TAS 10521658
GO:0010968 regulation of microtubule nucleation IDA 11694528
GO:0031115 negative regulation of microtubule polymerization IDA 11694528
genes like me logo Genes that share ontologies with EML2: view

No data available for Pathways by source and SIGNOR curated interactions for EML2 Gene

Drugs & Compounds for EML2 Gene

No Compound Related Data Available

Transcripts for EML2 Gene

mRNA/cDNA for EML2 Gene

7 REFSEQ mRNAs :
22 NCBI additional mRNA sequence :
31 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EML2

Alternative Splicing Database (ASD) splice patterns (SP) for EML2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: -
SP5: - -
SP6: - -
SP7: -
SP8:

ExUns: 21 ^ 22a · 22b · 22c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for EML2 Gene

GeneLoc Exon Structure for
EML2

Expression for EML2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EML2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Lymph (Hematopoietic System)

Protein differential expression in normal tissues from HIPED for EML2 Gene

This gene is overexpressed in Salivary gland (9.1) and Peripheral blood mononuclear cells (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EML2 Gene



Protein tissue co-expression partners for EML2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EML2

SOURCE GeneReport for Unigene cluster for EML2 Gene:

Hs.24178

mRNA Expression by UniProt/SwissProt for EML2 Gene:

O95834-EMAL2_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for EML2 Gene

  • Nervous system(4.8)
  • Liver(4.3)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with EML2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EML2 Gene

Orthologs for EML2 Gene

This gene was present in the common ancestor of animals.

Orthologs for EML2 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia EML2 30 31
  • 92.16 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia EML2 30 31
  • 92.07 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Eml2 30 17 31
  • 88.27 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Eml2 30
  • 88.15 (n)
Oppossum
(Monodelphis domestica)
Mammalia EML2 31
  • 84 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia EML2 31
  • 80 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia EML2 31
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8866 30
Zebrafish
(Danio rerio)
Actinopterygii eml2 30 31
  • 65.83 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.206 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012350 30
  • 57.25 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG13466 32
  • 36 (a)
DCX-EMAP 31
  • 25 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea elp-1 30 31 32
  • 41.29 (n)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10048 31
  • 50 (a)
OneToMany
Species where no ortholog for EML2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for EML2 Gene

ENSEMBL:
Gene Tree for EML2 (if available)
TreeFam:
Gene Tree for EML2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EML2: view image

Paralogs for EML2 Gene

Paralogs for EML2 Gene

(37) SIMAP similar genes for EML2 Gene using alignment to 17 proteins:

  • EMAL2_HUMAN
  • C9JRL6_HUMAN
  • K7EII6_HUMAN
  • K7EIK7_HUMAN
  • K7EIM1_HUMAN
  • K7EIZ0_HUMAN
  • K7EJV6_HUMAN
  • K7EKG3_HUMAN
  • K7EKU5_HUMAN
  • K7EL23_HUMAN
  • K7ELB2_HUMAN
  • K7ELI8_HUMAN
  • K7EQR0_HUMAN
  • K7ERR2_HUMAN
  • K7ERR9_HUMAN
  • K7ERY9_HUMAN
  • K7ESL7_HUMAN
genes like me logo Genes that share paralogs with EML2: view

Variants for EML2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EML2 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs1270442107 A colorectal cancer sample p.Val484Leu
rs12151009 - p.Met33Val
rs1545040 - p.Glu235Asp
rs3816045 - p.Arg357His
rs7252175 - p.Leu187Phe

Additional dbSNP identifiers (rs#s) for EML2 Gene

Structural Variations from Database of Genomic Variants (DGV) for EML2 Gene

Variant ID Type Subtype PubMed ID
nsv833848 CNV loss 17160897

Variation tolerance for EML2 Gene

Residual Variation Intolerance Score: 15.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.82; 91.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EML2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EML2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EML2 Gene

Disorders for EML2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for EML2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
sulfonamide allergy
- elite association - COSMIC cancer census association via MalaCards
Search EML2 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with EML2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EML2 Gene

Publications for EML2 Gene

  1. The human EMAP-like protein-70 (ELP70) is a microtubule destabilizer that localizes to the mitotic apparatus. (PMID: 11694528) Eichenmuller B … Suprenant KA (The Journal of biological chemistry 2002) 2 3 4 23
  2. Sequence and expression patterns of a human EMAP-related protein-2 (HuEMAP-2). (PMID: 10521658) Lepley DM … Suprenant KA (Gene 1999) 2 3 4 23
  3. Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical β-propeller domain. (PMID: 24706829) Richards MW … Bayliss R (Proceedings of the National Academy of Sciences of the United States of America 2014) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for EML2 Gene

  • Signalway ELISA kits for EML2
  • Signalway Proteins for EML2

Sources for EML2 Gene