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Aliases for EML2 Gene

Aliases for EML2 Gene

  • Echinoderm Microtubule Associated Protein Like 2 2 3 5
  • Echinoderm MT-Associated Protein (EMAP)-Like Protein 70 2 3
  • Microtubule-Associated Protein Like Echinoderm EMAP 2 3
  • EMAP-2 3 4
  • EMAP2 3 4
  • Echinoderm Microtubule-Associated Protein-Like 2 3
  • HuEMAP-2 4
  • EMAPL2 4
  • ELP70 3

External Ids for EML2 Gene

Previous GeneCards Identifiers for EML2 Gene

  • GC19M046756
  • GC19M046503
  • GC19M050788
  • GC19M050804
  • GC19M046112
  • GC19M042541

Summaries for EML2 Gene

GeneCards Summary for EML2 Gene

EML2 (Echinoderm Microtubule Associated Protein Like 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include receptor binding and protein C-terminus binding. An important paralog of this gene is EML1.

UniProtKB/Swiss-Prot for EML2 Gene

  • Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules.

Additional gene information for EML2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EML2 Gene

Genomics for EML2 Gene

GeneHancer (GH) Regulatory Elements for EML2 Gene

Promoters and enhancers for EML2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I045637 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 564.1 +4.7 4650 6.2 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B IRF4 EML2-AS1 EML2 GC19M045643 MIR330 CCDC61 ENSG00000268810 IRF2BP1 ENSG00000267114 SYMPK CLASRP
GH19I045645 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -0.3 -269 1.6 PKNOX1 SMAD1 ARNT SIN3A ZNF2 IRF4 E2F8 ZNF143 ZNF207 FOS EML2 GIPR EML2-AS1 RN7SL836P
GH19I045401 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.8 +241.1 241057 6.2 CLOCK FEZF1 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D GLIS1 RCOR2 CD3EAP PPP1R13L CCDC61 ZNF180 CLASRP FBXO46 ENSG00000269148 IRF2BP1 ERCC1 ENSG00000268810
GH19I045690 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11 -46.8 -46843 3.2 HDGF FOXA2 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B QPCTL SNRPD2 CCDC61 ENSG00000268810 SYMPK FBXO46 CLASRP ENSG00000269148 ENSG00000267114 IRF2BP1
GH19I045477 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11 +167.3 167329 2.4 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A ZNF2 ZBTB7B IRF4 ERCC1 PIR58452 TRU-TCA1-1 ZNF180 CCDC61 CD3EAP IRF2BP1 CLASRP PPP1R37 ENSG00000268810
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around EML2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EML2 gene promoter:

Genomic Locations for EML2 Gene

Genomic Locations for EML2 Gene
chr19:45,606,994-45,645,629
(GRCh38/hg38)
Size:
38,636 bases
Orientation:
Minus strand
chr19:46,110,252-46,148,887
(GRCh37/hg19)

Genomic View for EML2 Gene

Genes around EML2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EML2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EML2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EML2 Gene

Proteins for EML2 Gene

  • Protein details for EML2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95834-EMAL2_HUMAN
    Recommended name:
    Echinoderm microtubule-associated protein-like 2
    Protein Accession:
    O95834
    Secondary Accessions:
    • B7Z3I2
    • B7Z3Q9
    • K7ERL7
    • Q59EN8
    • Q8N5A2
    • Q9UG50

    Protein attributes for EML2 Gene

    Size:
    649 amino acids
    Molecular mass:
    70679 Da
    Quaternary structure:
    • Interacts with GRID2 and may also interact with GRID1 (By similarity). Binds unpolymerized tubulins via its WD repeat region.

    Three dimensional structures from OCA and Proteopedia for EML2 Gene

    Alternative splice isoforms for EML2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EML2 Gene

Post-translational modifications for EML2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for EML2 Gene

Domains & Families for EML2 Gene

Gene Families for EML2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

O95834

UniProtKB/Swiss-Prot:

EMAL2_HUMAN :
  • Contains a tandem atypical propeller in EMLs (TAPE) domain. The N-terminal beta-propeller is formed by canonical WD repeats; in contrast, the second beta-propeller contains one blade that is formed by discontinuous parts of the polypeptide chain (By similarity).
  • Belongs to the WD repeat EMAP family.
Domain:
  • Contains a tandem atypical propeller in EMLs (TAPE) domain. The N-terminal beta-propeller is formed by canonical WD repeats; in contrast, the second beta-propeller contains one blade that is formed by discontinuous parts of the polypeptide chain (By similarity).
Family:
  • Belongs to the WD repeat EMAP family.
genes like me logo Genes that share domains with EML2: view

Function for EML2 Gene

Molecular function for EML2 Gene

UniProtKB/Swiss-Prot Function:
Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules.

Phenotypes From GWAS Catalog for EML2 Gene

Gene Ontology (GO) - Molecular Function for EML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008017 microtubule binding IDA 11694528
GO:0008022 protein C-terminus binding IEA --
GO:0015631 tubulin binding IDA 24706829
genes like me logo Genes that share ontologies with EML2: view
genes like me logo Genes that share phenotypes with EML2: view

Animal Models for EML2 Gene

MGI Knock Outs for EML2:
  • Eml2 tm1b(EUCOMM)Wtsi

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for EML2 Gene

Localization for EML2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EML2 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Note=Colocalizes with the microtubule cytoskeleton. Colocalizes with the mitotic spindle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EML2 gene
Compartment Confidence
cytoskeleton 4
plasma membrane 2
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005819 spindle IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0005875 microtubule associated complex TAS 10521658
genes like me logo Genes that share ontologies with EML2: view

Pathways & Interactions for EML2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007601 visual perception TAS 10521658
GO:0007605 sensory perception of sound TAS 10521658
GO:0010968 regulation of microtubule nucleation IDA 11694528
GO:0031115 negative regulation of microtubule polymerization IDA 11694528
genes like me logo Genes that share ontologies with EML2: view

No data available for Pathways by source and SIGNOR curated interactions for EML2 Gene

Drugs & Compounds for EML2 Gene

No Compound Related Data Available

Transcripts for EML2 Gene

Unigene Clusters for EML2 Gene

Echinoderm microtubule associated protein like 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EML2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: -
SP5: - -
SP6: - -
SP7: -
SP8:

ExUns: 21 ^ 22a · 22b · 22c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for EML2 Gene

GeneLoc Exon Structure for
EML2
ECgene alternative splicing isoforms for
EML2

Expression for EML2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EML2 Gene

Protein differential expression in normal tissues from HIPED for EML2 Gene

This gene is overexpressed in Salivary gland (9.1) and Peripheral blood mononuclear cells (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EML2 Gene



Protein tissue co-expression partners for EML2 Gene

NURSA nuclear receptor signaling pathways regulating expression of EML2 Gene:

EML2

SOURCE GeneReport for Unigene cluster for EML2 Gene:

Hs.24178

mRNA Expression by UniProt/SwissProt for EML2 Gene:

O95834-EMAL2_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for EML2 Gene

  • Nervous system(4.7)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with EML2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EML2 Gene

Orthologs for EML2 Gene

This gene was present in the common ancestor of animals.

Orthologs for EML2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EML2 33 34
  • 92.16 (n)
dog
(Canis familiaris)
Mammalia EML2 33 34
  • 92.07 (n)
mouse
(Mus musculus)
Mammalia Eml2 33 16 34
  • 88.27 (n)
rat
(Rattus norvegicus)
Mammalia Eml2 33
  • 88.15 (n)
oppossum
(Monodelphis domestica)
Mammalia EML2 34
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EML2 34
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EML2 34
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8866 33
zebrafish
(Danio rerio)
Actinopterygii eml2 33 34
  • 65.83 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.206 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012350 33
  • 57.25 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13466 35
  • 36 (a)
DCX-EMAP 34
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea elp-1 35 33 34
  • 41.29 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10048 34
  • 50 (a)
OneToMany
Species where no ortholog for EML2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for EML2 Gene

ENSEMBL:
Gene Tree for EML2 (if available)
TreeFam:
Gene Tree for EML2 (if available)

Paralogs for EML2 Gene

Variants for EML2 Gene

Sequence variations from dbSNP and Humsavar for EML2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
VAR_035879 A colorectal cancer sample p.Val484Leu
rs1000027988 -- 45,646,796(-) TGT/T upstream_transcript_variant
rs1000190817 -- 45,625,385(-) C/T intron_variant
rs1000320840 -- 45,619,343(-) C/A 3_prime_UTR_variant, intron_variant
rs1000433873 -- 45,624,754(-) C/G coding_sequence_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for EML2 Gene

Variant ID Type Subtype PubMed ID
nsv833848 CNV loss 17160897

Variation tolerance for EML2 Gene

Residual Variation Intolerance Score: 15.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.82; 91.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EML2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EML2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EML2 Gene

Disorders for EML2 Gene

Additional Disease Information for EML2

No disorders were found for EML2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EML2 Gene

Publications for EML2 Gene

  1. The human EMAP-like protein-70 (ELP70) is a microtubule destabilizer that localizes to the mitotic apparatus. (PMID: 11694528) Eichenmuller B … Suprenant KA (The Journal of biological chemistry 2002) 2 3 4 22 58
  2. Sequence and expression patterns of a human EMAP-related protein-2 (HuEMAP-2). (PMID: 10521658) Lepley DM … Suprenant KA (Gene 1999) 2 3 4 22 58
  3. Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical β-propeller domain. (PMID: 24706829) Richards MW … Bayliss R (Proceedings of the National Academy of Sciences of the United States of America 2014) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for EML2 Gene

Sources for EML2 Gene

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