Aliases for EME1 Gene
- Essential Meiotic Structure-Specific Endonuclease 1 2 3 5
- MMS4 Homolog 3 4
- HMMS4 3 4
- SLX2 Structure-Specific Endonuclease Subunit Homolog A (S. Cerevisiae) 2
- SLX2 Structure-Specific Endonuclease Subunit Homolog A 3
- Essential Meiotic Endonuclease 1 Homolog 1 (S. Pombe) 2
- Essential Meiotic Endonuclease 1 Homolog 1 3
- Essential Meiotic Endonuclease 1 Homolog 2 3
External Ids for EME1 Gene
Previous GeneCards Identifiers for EME1 Gene
This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. This protein may be involved in repairing DNA damage and in maintaining genomic stability. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
GeneCards Summary for EME1 Gene
EME1 (Essential Meiotic Structure-Specific Endonuclease 1) is a Protein Coding gene. Diseases associated with EME1 include Xeroderma Pigmentosum, Complementation Group F. Among its related pathways are Fanconi anemia pathway and Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA). Gene Ontology (GO) annotations related to this gene include endonuclease activity and nuclease activity. An important paralog of this gene is EME2.
UniProtKB/Swiss-Prot for EME1 Gene
Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5-end at the branch nick. Typical substrates include 3-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.