Aliases for EME1 Gene
External Ids for EME1 Gene
Previous GeneCards Identifiers for EME1 Gene
This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. This protein may be involved in repairing DNA damage and in maintaining genomic stability. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
GeneCards Summary for EME1 Gene
EME1 (Essential Meiotic Structure-Specific Endonuclease 1) is a Protein Coding gene. Diseases associated with EME1 include Xeroderma Pigmentosum, Complementation Group F and Xeroderma Pigmentosum, Variant Type. Among its related pathways are DNA Double-Strand Break Repair and Resolution of D-loop Structures through Holliday Junction Intermediates. Gene Ontology (GO) annotations related to this gene include endonuclease activity and nuclease activity. An important paralog of this gene is EME2.
UniProtKB/Swiss-Prot Summary for EME1 Gene
Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.