Aliases for EMC8 Gene

Aliases for EMC8 Gene

  • ER Membrane Protein Complex Subunit 8 2 3 4 5
  • Neighbor Of COX4 2 3 4
  • FAM158B 2 3 4
  • Family With Sequence Similarity 158, Member B 2 3
  • COX4 Neighbor 2 3
  • C16orf2 3 4
  • C16orf4 3 4
  • COX4NB 3 4
  • NOC4 3 4
  • Chromosome 16 Open Reading Frame 4 2
  • Chromosome 16 Open Reading Frame 2 2
  • Protein FAM158B 4
  • COX4AL 4
  • EMC8 5

External Ids for EMC8 Gene

Previous HGNC Symbols for EMC8 Gene

  • C16orf4
  • NOC4
  • C16orf2
  • COX4NB

Previous GeneCards Identifiers for EMC8 Gene

  • GC16M085813

Summaries for EMC8 Gene

GeneCards Summary for EMC8 Gene

EMC8 (ER Membrane Protein Complex Subunit 8) is a Protein Coding gene. An important paralog of this gene is EMC9.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EMC8 Gene

Genomics for EMC8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for EMC8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EMC8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EMC8

Genomic Locations for EMC8 Gene

Genomic Locations for EMC8 Gene
27,851 bases
Minus strand
27,851 bases
Minus strand

Genomic View for EMC8 Gene

Genes around EMC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EMC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EMC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EMC8 Gene

Proteins for EMC8 Gene

  • Protein details for EMC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ER membrane protein complex subunit 8
    Protein Accession:
    Secondary Accessions:
    • C9JB21

    Protein attributes for EMC8 Gene

    210 amino acids
    Molecular mass:
    23773 Da
    Quaternary structure:
    • Component of the ER membrane protein complex (EMC).

    Alternative splice isoforms for EMC8 Gene


neXtProt entry for EMC8 Gene

Post-translational modifications for EMC8 Gene

  • Ubiquitination at Lys100 and Lys110
  • Modification sites at PhosphoSitePlus

Other Protein References for EMC8 Gene

No data available for DME Specific Peptides for EMC8 Gene

Domains & Families for EMC8 Gene

Gene Families for EMC8 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for EMC8 Gene

  • Protein of unknown function UPF0172

Suggested Antigen Peptide Sequences for EMC8 Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM158B (CX4NB_HUMAN)
  • cDNA, FLJ94626, Homo sapiens neighbor of COX4 (NOC4), mRNA (Q53Y03_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the EMC8/EMC9 family.
  • Belongs to the EMC8/EMC9 family.
genes like me logo Genes that share domains with EMC8: view

Function for EMC8 Gene

Phenotypes From GWAS Catalog for EMC8 Gene

Gene Ontology (GO) - Molecular Function for EMC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with EMC8: view
genes like me logo Genes that share phenotypes with EMC8: view

Animal Models for EMC8 Gene

MGI Knock Outs for EMC8:
  • Emc8 Emc8<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EMC8

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EMC8 Gene

Localization for EMC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EMC8 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EMC8 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 5
mitochondrion 4
nucleus 4
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EMC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10337626
GO:0005737 cytoplasm TAS,IDA 22119785
GO:0005739 mitochondrion TAS 10337626
GO:0005829 cytosol IDA --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with EMC8: view

Pathways & Interactions for EMC8 Gene

PathCards logo

SuperPathways for EMC8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EMC8 Gene


No data available for Pathways by source and SIGNOR curated interactions for EMC8 Gene

Drugs & Compounds for EMC8 Gene

No Compound Related Data Available

Transcripts for EMC8 Gene

mRNA/cDNA for EMC8 Gene

9 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EMC8

Alternative Splicing Database (ASD) splice patterns (SP) for EMC8 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6
SP1: -
SP3: - - -
SP4: -
SP5: - -

Relevant External Links for EMC8 Gene

GeneLoc Exon Structure for

Expression for EMC8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EMC8 Gene

Protein differential expression in normal tissues from HIPED for EMC8 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.1), Bone (7.3), and Bone marrow stromal cell (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EMC8 Gene

Protein tissue co-expression partners for EMC8 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EMC8

SOURCE GeneReport for Unigene cluster for EMC8 Gene:


mRNA Expression by UniProt/SwissProt for EMC8 Gene:

Tissue specificity: Expressed in liver, pancreas, heart, lung, kidney, brain, skeletal muscle, and placenta. Expression levels are highest in pancreas and moderate in heart, skeletal muscle, and placenta.

Evidence on tissue expression from TISSUES for EMC8 Gene

  • Eye(4.4)
  • Muscle(4.2)
  • Nervous system(3.3)
  • Lung(2.7)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with EMC8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EMC8 Gene

Orthologs for EMC8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EMC8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia COX4NB 30 31
  • 98.73 (n)
(Canis familiaris)
Mammalia EMC8 30 31
  • 93.33 (n)
(Bos Taurus)
Mammalia EMC8 30 31
  • 92.7 (n)
(Monodelphis domestica)
Mammalia -- 31
  • 92 (a)
-- 31
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia EMC8 31
  • 90 (a)
(Mus musculus)
Mammalia Emc8 30 17 31
  • 87.6 (n)
(Rattus norvegicus)
Mammalia Emc8 30
  • 87.28 (n)
(Gallus gallus)
Aves EMC8 30 31
  • 79.97 (n)
(Anolis carolinensis)
Reptilia EMC8 31
  • 77 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia emc8 30
  • 71.45 (n)
MGC75783 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.4449 30
(Danio rerio)
Actinopterygii emc8 30 31
  • 72.14 (n)
Dr.3514 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG3501 31
  • 38 (a)
(Caenorhabditis elegans)
Secernentea F25H2.4 31
  • 27 (a)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons emb2731 30
  • 43.26 (n)
(Oryza sativa)
Liliopsida Os04g0270200 30
  • 51.97 (n)
Species where no ortholog for EMC8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for EMC8 Gene

Gene Tree for EMC8 (if available)
Gene Tree for EMC8 (if available)
Evolutionary constrained regions (ECRs) for EMC8: view image

Paralogs for EMC8 Gene

Paralogs for EMC8 Gene

(2) SIMAP similar genes for EMC8 Gene using alignment to 2 proteins:

  • M0R1B0_HUMAN
genes like me logo Genes that share paralogs with EMC8: view

Variants for EMC8 Gene

Additional dbSNP identifiers (rs#s) for EMC8 Gene

Structural Variations from Database of Genomic Variants (DGV) for EMC8 Gene

Variant ID Type Subtype PubMed ID
esv4262 OTHER complex 18987735
nsv483044 CNV gain 15286789
nsv833316 CNV loss 17160897

Variation tolerance for EMC8 Gene

Residual Variation Intolerance Score: 31.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EMC8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EMC8 Gene

Disorders for EMC8 Gene

No disorders were found for EMC8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EMC8 Gene

Publications for EMC8 Gene

  1. The 5' region of the COX4 gene contains a novel overlapping gene, NOC4. (PMID: 10337626) Bachman NJ … Lomax MI (Mammalian genome : official journal of the International Mammalian Genome Society 1999) 2 3 4 23
  2. Defining human ERAD networks through an integrative mapping strategy. (PMID: 22119785) Christianson JC … Kopito RR (Nature cell biology 2011) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling. (PMID: 31073040) Choi JH … Beutler B (Science (New York, N.Y.) 2019) 3

Products for EMC8 Gene

  • Signalway Proteins for EMC8

Sources for EMC8 Gene