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Aliases for EMC4 Gene

Aliases for EMC4 Gene

  • ER Membrane Protein Complex Subunit 4 2 3 4 5
  • Transmembrane Protein 85 2 3 4
  • Cell Proliferation-Inducing Gene 17 Protein 3 4
  • TMEM85 3 4
  • PIG17 3

External Ids for EMC4 Gene

Previous HGNC Symbols for EMC4 Gene

  • TMEM85

Previous GeneCards Identifiers for EMC4 Gene

  • GC15P034519

Summaries for EMC4 Gene

GeneCards Summary for EMC4 Gene

EMC4 (ER Membrane Protein Complex Subunit 4) is a Protein Coding gene. Diseases associated with EMC4 include Ogden Syndrome.

UniProtKB/Swiss-Prot for EMC4 Gene

Additional gene information for EMC4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EMC4 Gene

Genomics for EMC4 Gene

GeneHancer (GH) Regulatory Elements for EMC4 Gene

Promoters and enhancers for EMC4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J034223 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 600.7 -0.1 -96 2.6 CC2D1A ZFX ZKSCAN8 SIX5 NKRF POLR2A MLLT1 GTF2F1 CSDE1 ZNF384 EMC4 NOP10 NUTM1 AQR HNRNPLP2 SLC12A6 ENSG00000259287 ENSG00000259336 KATNBL1
GH15J034100 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.7 -123.5 -123496 3.4 SP1 ZNF652 ZFX CC2D1A ELF3 MNT SIX5 NKRF POLR2A MLLT1 PGBD4 EMC7 AVEN ENSG00000259287 GOLGA8A ENSG00000259408 KATNBL1 HNRNPLP2 EMC4 CHRM5
GH15J034317 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 8.8 +93.8 93775 3.9 CBFA2T2 NKRF CEBPG GTF2F1 ZSCAN21 TFE3 SP7 ELF1 SP1 SP5 SLC12A6 NOP10 GOLGA8A AQR ENSG00000259287 ENSG00000259408 EMC4 ENSG00000207091
GH15J034208 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 9.1 -15.5 -15497 2.6 CC2D1A SP1 ZFX CTCF NKRF POLR2A GTF2F1 ZNF687 AHR ZNF24 KATNBL1 NOP10 EMC4 PIR44117
GH15J034248 Enhancer 0.7 Ensembl 12.5 +24.1 24104 1.4 BACH1 MAFK SMARCA4 NFE2L2 ZNF316 MGA EGR1 NFE2 NFRKB MAFG NOP10 EMC4 SLC12A6 NUTM1 LPCAT4 KATNBL1 ENSG00000259468
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EMC4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for EMC4 Gene

Genomic Locations for EMC4 Gene
5,169 bases
Plus strand
5,158 bases
Plus strand

Genomic View for EMC4 Gene

Genes around EMC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EMC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EMC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EMC4 Gene

Proteins for EMC4 Gene

  • Protein details for EMC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ER membrane protein complex subunit 4
    Protein Accession:
    Secondary Accessions:
    • A8K3A9
    • B4DJQ4
    • Q96KX9
    • Q9BUI5
    • Q9P0T9

    Protein attributes for EMC4 Gene

    183 amino acids
    Molecular mass:
    20087 Da
    Quaternary structure:
    • Component of the ER membrane protein complex (EMC).

    Alternative splice isoforms for EMC4 Gene


neXtProt entry for EMC4 Gene

Post-translational modifications for EMC4 Gene

  • Ubiquitination at posLast=5050 and isoforms=2, 316
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EMC4 Gene

Domains & Families for EMC4 Gene

Gene Families for EMC4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for EMC4 Gene


Suggested Antigen Peptide Sequences for EMC4 Gene

GenScript: Design optimal peptide antigens:
  • Cell proliferation-inducing gene 17 protein (TMM85_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the EMC4 family.
  • Belongs to the EMC4 family.
genes like me logo Genes that share domains with EMC4: view

Function for EMC4 Gene

Molecular function for EMC4 Gene

UniProtKB/Swiss-Prot Function:
May mediate anti-apoptotic activity.

Phenotypes From GWAS Catalog for EMC4 Gene

genes like me logo Genes that share phenotypes with EMC4: view

Animal Models for EMC4 Gene

MGI Knock Outs for EMC4:
  • Emc4 Emc4<tm1(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for EMC4 - Now 50% OFF >
  • * EMC4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * EMC4 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for EMC4 Gene

Localization for EMC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EMC4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EMC4 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 2
mitochondrion 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Focal adhesion sites (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EMC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IDA,IEA 22119785
GO:0072546 ER membrane protein complex IDA 22119785
genes like me logo Genes that share ontologies with EMC4: view

Pathways & Interactions for EMC4 Gene

PathCards logo

SuperPathways for EMC4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EMC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0034975 protein folding in endoplasmic reticulum IBA 21873635
genes like me logo Genes that share ontologies with EMC4: view

No data available for Pathways by source and SIGNOR curated interactions for EMC4 Gene

Drugs & Compounds for EMC4 Gene

No Compound Related Data Available

Transcripts for EMC4 Gene

Unigene Clusters for EMC4 Gene

ER membrane protein complex subunit 4:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for EMC4 - Now 50% OFF >
  • * EMC4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * EMC4 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for EMC4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - - - - - - -
SP6: - - - -
SP7: - - - - - - - - - -
SP8: - - - - - - - - - -
SP10: - -

Relevant External Links for EMC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EMC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EMC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EMC4 Gene

This gene is overexpressed in Bone (25.1) and Peripheral blood mononuclear cells (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EMC4 Gene

Protein tissue co-expression partners for EMC4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EMC4 Gene:


SOURCE GeneReport for Unigene cluster for EMC4 Gene:


mRNA Expression by UniProt/SwissProt for EMC4 Gene:

Tissue specificity: Isoform 1 is expressed in brain and heart. Isoform 2 is expressed in heart.

Evidence on tissue expression from TISSUES for EMC4 Gene

  • Liver(4.3)
  • Nervous system(4.3)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with EMC4: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EMC4 Gene

Orthologs for EMC4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EMC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia EMC4 35
  • 98 (a)
(Pan troglodytes)
Mammalia EMC4 35 34
  • 96.36 (n)
(Bos Taurus)
Mammalia EMC4 35 34
  • 94.72 (n)
(Canis familiaris)
Mammalia EMC4 34 35
  • 94.17 (n)
(Rattus norvegicus)
Mammalia Emc4 34
  • 93.62 (n)
(Mus musculus)
Mammalia Emc4 35 17 34
  • 93.44 (n)
(Ornithorhynchus anatinus)
Mammalia EMC4 35
  • 91 (a)
(Gallus gallus)
Aves EMC4 35 34
  • 65.69 (n)
(Anolis carolinensis)
Reptilia EMC4 35
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia emc4 34
  • 75.56 (n)
MGC75691 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8318 34
(Danio rerio)
Actinopterygii emc4 34 35 35
  • 70.81 (n)
Dr.11020 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11082 34
fruit fly
(Drosophila melanogaster)
Insecta CG11137 35 34
  • 56.84 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010558 34
  • 55.76 (n)
(Caenorhabditis elegans)
Secernentea perm-3 35 34
  • 51.74 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EMC4 35 37
  • 26 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G10780 34
  • 45.29 (n)
(Oryza sativa)
Liliopsida Os03g0360500 34
  • 45.86 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3102 35
  • 54 (a)
Cin.1875 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1875 34
Species where no ortholog for EMC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EMC4 Gene

Gene Tree for EMC4 (if available)
Gene Tree for EMC4 (if available)
Evolutionary constrained regions (ECRs) for EMC4: view image

Paralogs for EMC4 Gene

No data available for Paralogs for EMC4 Gene

Variants for EMC4 Gene

Sequence variations from dbSNP and Humsavar for EMC4 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1133154 likely-benign, Andermann syndrome 34,230,356(+) G/A downstream_transcript_variant
rs11544435 likely-benign, Andermann syndrome 34,230,213(+) A/T downstream_transcript_variant
rs189231487 uncertain-significance, Andermann syndrome 34,230,493(+) C/A/G downstream_transcript_variant
rs4530104 benign, Andermann syndrome 34,230,478(+) C/T downstream_transcript_variant
rs549855456 uncertain-significance, Andermann syndrome 34,230,301(+) C/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for EMC4 Gene

Variant ID Type Subtype PubMed ID
dgv4456n54 CNV gain 21841781
esv33337 CNV gain+loss 17666407
esv3569431 CNV gain 25503493
nsv1052620 CNV gain 25217958

Variation tolerance for EMC4 Gene

Residual Variation Intolerance Score: 37.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EMC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Human Gene Mutation Database (HGMD)

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EMC4 Gene

Disorders for EMC4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for EMC4 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
ogden syndrome
  • ogdns
- elite association - COSMIC cancer census association via MalaCards
Search EMC4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for EMC4

genes like me logo Genes that share disorders with EMC4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EMC4 Gene

Publications for EMC4 Gene

  1. Transmembrane protein 85 from both human (TMEM85) and yeast (YGL231c) inhibit hydrogen peroxide mediated cell death in yeast. (PMID: 18586032) Ring G … Greenwood MT (FEBS letters 2008) 2 3 4 23 58
  2. Defining human ERAD networks through an integrative mapping strategy. (PMID: 22119785) Christianson JC … Kopito RR (Nature cell biology 2011) 2 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 3 4 58

Products for EMC4 Gene

Sources for EMC4 Gene

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