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Aliases for EMC10 Gene

Aliases for EMC10 Gene

  • ER Membrane Protein Complex Subunit 10 2 3 4 5
  • Hematopoietic Signal Peptide-Containing Membrane Domain-Containing 1 2 3
  • Hematopoietic Signal Peptide-Containing Secreted 1 2 3
  • C19orf63 3 4
  • HSM1 3 4
  • Hematopoietic Signal Peptide-Containing Membrane Domain-Containing Protein 1 4
  • Chromosome 19 Open Reading Frame 63 2
  • UPF0510 Protein INM02 3
  • INM02 4
  • HSS1 3

External Ids for EMC10 Gene

Previous HGNC Symbols for EMC10 Gene

  • C19orf63

Previous GeneCards Identifiers for EMC10 Gene

  • GC19P050980

Summaries for EMC10 Gene

GeneCards Summary for EMC10 Gene

EMC10 (ER Membrane Protein Complex Subunit 10) is a Protein Coding gene. Diseases associated with EMC10 include Myocardial Infarction.

UniProtKB/Swiss-Prot for EMC10 Gene

  • Promotes angiogenesis and tissue repair in the heart after myocardial infarction. Stimulates cardiac endothelial cell migration and outgrowth via the activation of p38 MAPK, PAK and MAPK2 signaling pathways.

Additional gene information for EMC10 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EMC10 Gene

Genomics for EMC10 Gene

GeneHancer (GH) Regulatory Elements for EMC10 Gene

Promoters and enhancers for EMC10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J050475 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 600.7 +0.3 293 2.6 MTA3 SP1 ZFX NKRF POLR2A GTF2F1 CSDE1 ZNF687 ZSCAN21 MAFK FAM71E1 EMC10 ASPDH
GH19J050346 Promoter/Enhancer 1.4 Ensembl ENCODE 11.1 -128.4 -128371 3.9 SP1 ELF3 NKRF CEBPG ZNF687 MAFK TFE3 RELA CREM PRDM1 NAPSB KCNC3 NAPSA POLD1 JOSD2 ASPDH EMC10 FAM71E1 KLK2 NR1H2
GH19J050720 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 5.8 +247.1 247145 6.1 SP1 ZFX CTCF CC2D1A MLLT1 GTF2F1 ZNF687 ZSCAN21 MYC TRIM24 CLEC11A NUP62 ZNF175 CTU1 C19orf48 GPR32 ENSG00000268047 AKT1S1 SNORD88A SNORD88B
GH19J050410 Enhancer 0.5 ENCODE 11.7 -65.5 -65450 1.3 ZNF384 ZNF580 POLR2A ZBTB33 KDM1A ZMYM3 NR2F6 NAPSB NAPSA NR1H2 FAM71E1 EMC10 ENSG00000142539 GC19P050397 POLD1
GH19J051101 Enhancer 0.3 Ensembl 5.6 +625.3 625301 1 ZNF148 EMC10 PIR34748 CTU1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EMC10 on UCSC Golden Path with GeneCards custom track

Genomic Locations for EMC10 Gene

Genomic Locations for EMC10 Gene
chr19:50,476,400-50,505,909
(GRCh38/hg38)
Size:
29,510 bases
Orientation:
Plus strand
chr19:50,979,657-50,986,608
(GRCh37/hg19)
Size:
6,952 bases
Orientation:
Plus strand

Genomic View for EMC10 Gene

Genes around EMC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EMC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EMC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EMC10 Gene

Proteins for EMC10 Gene

  • Protein details for EMC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5UCC4-EMC10_HUMAN
    Recommended name:
    ER membrane protein complex subunit 10
    Protein Accession:
    Q5UCC4
    Secondary Accessions:
    • Q5UCC6
    • Q69YT5
    • Q6UWP3
    • Q86YL4
    • Q8N541

    Protein attributes for EMC10 Gene

    Size:
    262 amino acids
    Molecular mass:
    27347 Da
    Quaternary structure:
    • Component of the ER membrane protein complex (EMC).
    SequenceCaution:
    • Sequence=AAQ89073.1; Type=Miscellaneous discrepancy; Note=Intron retention at the C-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for EMC10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EMC10 Gene

Post-translational modifications for EMC10 Gene

No data available for DME Specific Peptides for EMC10 Gene

Domains & Families for EMC10 Gene

Gene Families for EMC10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for EMC10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EMC10 Gene

GenScript: Design optimal peptide antigens:
  • Hematopoietic signal peptide-containing membrane domain-containing protein 1 (INM02_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5UCC4

UniProtKB/Swiss-Prot:

EMC10_HUMAN :
  • Belongs to the EMC10 family.
Family:
  • Belongs to the EMC10 family.
genes like me logo Genes that share domains with EMC10: view

Function for EMC10 Gene

Molecular function for EMC10 Gene

UniProtKB/Swiss-Prot Function:
Promotes angiogenesis and tissue repair in the heart after myocardial infarction. Stimulates cardiac endothelial cell migration and outgrowth via the activation of p38 MAPK, PAK and MAPK2 signaling pathways.

Phenotypes From GWAS Catalog for EMC10 Gene

genes like me logo Genes that share phenotypes with EMC10: view

Animal Models for EMC10 Gene

MGI Knock Outs for EMC10:
  • Emc10 Emc10<tm1b(EUCOMM)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for EMC10

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for EMC10 - Now 50% OFF >
  • * EMC10 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * EMC10 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EMC10 Gene

Localization for EMC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EMC10 Gene

Isoform 1: Membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EMC10 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
nucleus 2
cytosol 2
plasma membrane 1
mitochondrion 0
lysosome 0
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for EMC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IDA,IEA 22119785
GO:0072546 ER membrane protein complex IDA 22119785
genes like me logo Genes that share ontologies with EMC10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for EMC10 Gene

Pathways & Interactions for EMC10 Gene

PathCards logo

SuperPathways for EMC10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EMC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001938 positive regulation of endothelial cell proliferation IDA 28931551
GO:0010595 positive regulation of endothelial cell migration ISS --
GO:0045766 positive regulation of angiogenesis IMP 28931551
GO:1900745 positive regulation of p38MAPK cascade ISS --
genes like me logo Genes that share ontologies with EMC10: view

No data available for Pathways by source and SIGNOR curated interactions for EMC10 Gene

Drugs & Compounds for EMC10 Gene

No Compound Related Data Available

Transcripts for EMC10 Gene

mRNA/cDNA for EMC10 Gene

Unigene Clusters for EMC10 Gene

ER membrane protein complex subunit 10:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for EMC10 - Now 50% OFF >
  • * EMC10 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * EMC10 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for EMC10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for EMC10 Gene

GeneLoc Exon Structure for
EMC10
ECgene alternative splicing isoforms for
EMC10

Expression for EMC10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EMC10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EMC10 Gene

This gene is overexpressed in Frontal cortex (17.8) and Skin (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EMC10 Gene



Protein tissue co-expression partners for EMC10 Gene

NURSA nuclear receptor signaling pathways regulating expression of EMC10 Gene:

EMC10

SOURCE GeneReport for Unigene cluster for EMC10 Gene:

Hs.515550

mRNA Expression by UniProt/SwissProt for EMC10 Gene:

Q5UCC4-EMC10_HUMAN
Tissue specificity: Present in serum (at protein level). Increased expression seen in the left ventrice after myocardial infarction (at protein level). Expressed in the pituitary gland; very low levels in other brain regions.

Evidence on tissue expression from TISSUES for EMC10 Gene

  • Nervous system(4.7)
  • Liver(4.4)
  • Lung(2.1)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with EMC10: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EMC10 Gene

Orthologs for EMC10 Gene

This gene was present in the common ancestor of animals.

Orthologs for EMC10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EMC10 35 34
  • 98.98 (n)
OneToOne
cow
(Bos Taurus)
Mammalia EMC10 35 34
  • 88.39 (n)
OneToOne
dog
(Canis familiaris)
Mammalia EMC10 35 34
  • 88.25 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Emc10 17 35 34
  • 83.74 (n)
rat
(Rattus norvegicus)
Mammalia Emc10 34
  • 82.51 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EMC10 35
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EMC10 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia emc10 34
  • 67.18 (n)
MGC76288 34
African clawed frog
(Xenopus laevis)
Amphibia LOC398481 34
zebrafish
(Danio rerio)
Actinopterygii emc10 35 34
  • 61.2 (n)
OneToOne
wufa97d10 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10700 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011346 34
  • 49.65 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32441 35 34
  • 48.8 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11152 35
  • 31 (a)
OneToOne
Species where no ortholog for EMC10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EMC10 Gene

ENSEMBL:
Gene Tree for EMC10 (if available)
TreeFam:
Gene Tree for EMC10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EMC10: view image

Paralogs for EMC10 Gene

(1) SIMAP similar genes for EMC10 Gene using alignment to 5 proteins:

  • EMC10_HUMAN
  • M0QYY4_HUMAN
  • M0R030_HUMAN
  • M0R1B7_HUMAN
  • M0R2A0_HUMAN
genes like me logo Genes that share paralogs with EMC10: view

No data available for Paralogs for EMC10 Gene

Variants for EMC10 Gene

Sequence variations from dbSNP and Humsavar for EMC10 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000152888 -- 50,492,054(+) G/C genic_downstream_transcript_variant, intron_variant
rs1000206290 -- 50,491,333(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000255206 -- 50,479,648(+) G/T intron_variant
rs1000281651 -- 50,491,719(+) GAGAGA/GA genic_downstream_transcript_variant, intron_variant
rs1000357024 -- 50,491,805(+) GAGAGAGAGA/GAGAGAGA genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for EMC10 Gene

Variant ID Type Subtype PubMed ID
nsv1133010 OTHER inversion 24896259
nsv1140251 OTHER inversion 24896259
nsv1152956 OTHER inversion 26484159
nsv509750 CNV insertion 20534489

Variation tolerance for EMC10 Gene

Residual Variation Intolerance Score: 84.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.89; 48.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EMC10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EMC10

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EMC10 Gene

Disorders for EMC10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for EMC10 Gene - From: GeneCards

Disorder Aliases PubMed IDs
myocardial infarction
  • myocardial infarction, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search EMC10 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for EMC10

genes like me logo Genes that share disorders with EMC10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EMC10 Gene

Publications for EMC10 Gene

  1. Defining human ERAD networks through an integrative mapping strategy. (PMID: 22119785) Christianson JC … Kopito RR (Nature cell biology 2011) 2 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  3. EMC10 (Endoplasmic Reticulum Membrane Protein Complex Subunit 10) Is a Bone Marrow-Derived Angiogenic Growth Factor Promoting Tissue Repair After Myocardial Infarction. (PMID: 28931551) Reboll MR … Wollert KC (Circulation 2017) 3 4 58
  4. hHSS1: a novel secreted factor and suppressor of glioma growth located at chromosome 19q13.33. (PMID: 20680400) Junes-Gill KS … Basile LA (Journal of neuro-oncology 2011) 3 4 58
  5. Molecular cloning of a novel secreted peptide, INM02, and regulation of its expression by glucose. (PMID: 19570817) Wang X … Hu R (The Journal of endocrinology 2009) 3 4 58

Products for EMC10 Gene

Sources for EMC10 Gene

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