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Aliases for EMC10 Gene

Aliases for EMC10 Gene

  • ER Membrane Protein Complex Subunit 10 2 3 3 5
  • Hematopoietic Signal Peptide-Containing Membrane Domain-Containing 1 2 3
  • Hematopoietic Signal Peptide-Containing Secreted 1 2 3
  • C19orf63 3 4
  • HSM1 3 4
  • Hematopoietic Signal Peptide-Containing Membrane Domain-Containing Protein 1 4
  • Chromosome 19 Open Reading Frame 63 2
  • UPF0510 Protein INM02 3
  • INM02 4
  • HSS1 3

External Ids for EMC10 Gene

Previous HGNC Symbols for EMC10 Gene

  • C19orf63

Previous GeneCards Identifiers for EMC10 Gene

  • GC19P050980

Summaries for EMC10 Gene

GeneCards Summary for EMC10 Gene

EMC10 (ER Membrane Protein Complex Subunit 10) is a Protein Coding gene.

Additional gene information for EMC10 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EMC10 Gene

Genomics for EMC10 Gene

GeneHancer (GH) Regulatory Elements for EMC10 Gene

Promoters and enhancers for EMC10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J050475 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.1 62 2.2 HDGF PKNOX1 SMAD1 SIN3A ZNF2 YY1 POLR2B ZNF213 E2F8 ZNF207 FAM71E1 EMC10 ASPDH
GH19J050720 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 5.8 +247.0 246956 5.7 HDGF SIN3A ZNF2 ZBTB7B POLR2B CBX5 E2F8 FOS KLF13 SP3 CLEC11A NUP62 ZNF175 CTU1 C19orf48 GPR32 ENSG00000268047 AKT1S1 SNORD88C SNORD88B
GH19J050346 Enhancer 1.1 Ensembl ENCODE 11.1 -128.4 -128371 3.9 PKNOX1 FOXA2 SMAD1 ARID4B DMAP1 IRF4 ZNF48 ZNF143 ATF7 RUNX3 NAPSB KCNC3 NAPSA POLD1 JOSD2 ASPDH EMC10 FAM71E1 KLK2 LOC105372437
GH19J050410 Enhancer 0.6 ENCODE 11.7 -65.5 -65450 1.3 ZMYM3 ZNF384 POLR2A ZFP36 ZNF580 ZBTB33 NR2F6 KDM1A NAPSB NAPSA NR1H2 EMC10 FAM71E1 ENSG00000142539 GC19P050397 POLD1
GH19J050479 Enhancer 1 ENCODE dbSUPER 0.7 +3.1 3111 0.7 ELF3 HDGF PKNOX1 RB1 ARID4B SIN3A ZNF2 RAD21 ZNF48 CBX5 GC19P050481 NAPSA NR1H2 CLEC11A LOC100506114 EMC10 FAM71E1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EMC10 on UCSC Golden Path with GeneCards custom track

Genomic Locations for EMC10 Gene

Genomic Locations for EMC10 Gene
29,510 bases
Plus strand
6,952 bases
Plus strand

Genomic View for EMC10 Gene

Genes around EMC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EMC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EMC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EMC10 Gene

Proteins for EMC10 Gene

  • Protein details for EMC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ER membrane protein complex subunit 10
    Protein Accession:
    Secondary Accessions:
    • Q5UCC6
    • Q69YT5
    • Q6UWP3
    • Q86YL4
    • Q8N541

    Protein attributes for EMC10 Gene

    262 amino acids
    Molecular mass:
    27347 Da
    Quaternary structure:
    • Component of the ER membrane protein complex (EMC).
    • Sequence=AAQ89073.1; Type=Miscellaneous discrepancy; Note=Intron retention at the C-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for EMC10 Gene


neXtProt entry for EMC10 Gene

Post-translational modifications for EMC10 Gene

No data available for DME Specific Peptides for EMC10 Gene

Domains & Families for EMC10 Gene

Gene Families for EMC10 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for EMC10 Gene


Suggested Antigen Peptide Sequences for EMC10 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the EMC10 family.
  • Belongs to the EMC10 family.
genes like me logo Genes that share domains with EMC10: view

Function for EMC10 Gene

Phenotypes From GWAS Catalog for EMC10 Gene

genes like me logo Genes that share phenotypes with EMC10: view

Animal Models for EMC10 Gene

MGI Knock Outs for EMC10:
  • Emc10 Emc10<tm1b(EUCOMM)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for EMC10

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EMC10 Gene

Localization for EMC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EMC10 Gene

Isoform 1: Membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EMC10 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 4
nucleus 3
plasma membrane 2
cytosol 2
mitochondrion 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for EMC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IDA,IEA 22119785
GO:0072546 ER membrane protein complex IDA 22119785
genes like me logo Genes that share ontologies with EMC10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for EMC10 Gene

Pathways & Interactions for EMC10 Gene

SuperPathways for EMC10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EMC10 Gene


No data available for Pathways by source and SIGNOR curated interactions for EMC10 Gene

Drugs & Compounds for EMC10 Gene

No Compound Related Data Available

Transcripts for EMC10 Gene

mRNA/cDNA for EMC10 Gene

Unigene Clusters for EMC10 Gene

ER membrane protein complex subunit 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EMC10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: - -
SP3: -

Relevant External Links for EMC10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EMC10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EMC10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EMC10 Gene

This gene is overexpressed in Frontal cortex (17.8) and Skin (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EMC10 Gene

Protein tissue co-expression partners for EMC10 Gene

NURSA nuclear receptor signaling pathways regulating expression of EMC10 Gene:


SOURCE GeneReport for Unigene cluster for EMC10 Gene:


mRNA Expression by UniProt/SwissProt for EMC10 Gene:

Tissue specificity: Present in serum (at protein level). Expressed in the pituitary gland; very low levels in other brain regions.

Evidence on tissue expression from TISSUES for EMC10 Gene

  • Nervous system(4.7)
  • Liver(4.4)
  • Lung(2.1)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with EMC10: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EMC10 Gene

Orthologs for EMC10 Gene

This gene was present in the common ancestor of animals.

Orthologs for EMC10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EMC10 34 33
  • 98.98 (n)
(Bos Taurus)
Mammalia EMC10 34 33
  • 88.39 (n)
(Canis familiaris)
Mammalia EMC10 34 33
  • 88.25 (n)
(Mus musculus)
Mammalia Emc10 16 34 33
  • 83.74 (n)
(Rattus norvegicus)
Mammalia Emc10 33
  • 82.51 (n)
(Ornithorhynchus anatinus)
Mammalia EMC10 34
  • 70 (a)
(Anolis carolinensis)
Reptilia EMC10 34
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia emc10 33
  • 67.18 (n)
MGC76288 33
African clawed frog
(Xenopus laevis)
Amphibia LOC398481 33
(Danio rerio)
Actinopterygii emc10 34 33
  • 61.2 (n)
wufa97d10 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10700 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011346 33
  • 49.65 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32441 34 33
  • 48.8 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11152 34
  • 31 (a)
Species where no ortholog for EMC10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EMC10 Gene

Gene Tree for EMC10 (if available)
Gene Tree for EMC10 (if available)
Evolutionary constrained regions (ECRs) for EMC10: view image

Paralogs for EMC10 Gene

(1) SIMAP similar genes for EMC10 Gene using alignment to 5 proteins:

  • M0R030_HUMAN
  • M0R1B7_HUMAN
  • M0R2A0_HUMAN
genes like me logo Genes that share paralogs with EMC10: view

No data available for Paralogs for EMC10 Gene

Variants for EMC10 Gene

Sequence variations from dbSNP and Humsavar for EMC10 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000152888 -- 50,492,054(+) G/C genic_downstream_transcript_variant, intron_variant
rs1000206290 -- 50,491,333(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000255206 -- 50,479,648(+) G/T intron_variant
rs1000281651 -- 50,491,719(+) GAGAGA/GA genic_downstream_transcript_variant, intron_variant
rs1000357024 -- 50,491,805(+) GAGAGAGAGA/GAGAGAGA genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for EMC10 Gene

Variant ID Type Subtype PubMed ID
nsv1133010 OTHER inversion 24896259
nsv1140251 OTHER inversion 24896259
nsv1152956 OTHER inversion 26484159
nsv509750 CNV insertion 20534489

Variation tolerance for EMC10 Gene

Residual Variation Intolerance Score: 84.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.89; 48.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EMC10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EMC10 Gene

Disorders for EMC10 Gene

Additional Disease Information for EMC10

No disorders were found for EMC10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EMC10 Gene

Publications for EMC10 Gene

  1. Defining human ERAD networks through an integrative mapping strategy. (PMID: 22119785) Christianson JC … Kopito RR (Nature cell biology 2011) 2 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  3. hHSS1: a novel secreted factor and suppressor of glioma growth located at chromosome 19q13.33. (PMID: 20680400) Junes-Gill KS … Basile LA (Journal of neuro-oncology 2011) 3 4 58
  4. Molecular cloning of a novel secreted peptide, INM02, and regulation of its expression by glucose. (PMID: 19570817) Wang X … Hu R (The Journal of endocrinology 2009) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for EMC10 Gene

Sources for EMC10 Gene

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