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Aliases for ELP5 Gene

Aliases for ELP5 Gene

  • Elongator Acetyltransferase Complex Subunit 5 2 3 5
  • S-Phase 2 Protein 2 3 4
  • Dermal Papilla Derived Protein 6 2 3
  • C17orf81 3 4
  • DERP6 3 4
  • Chromosome 17 Open Reading Frame 81 2
  • Dermal Papilla-Derived Protein 6 4
  • Elongator Complex Protein 5 3
  • HSPC002 3
  • MSTP071 3
  • MST071 3

External Ids for ELP5 Gene

Previous HGNC Symbols for ELP5 Gene

  • C17orf81

Previous GeneCards Identifiers for ELP5 Gene

  • GC17P007154

Summaries for ELP5 Gene

GeneCards Summary for ELP5 Gene

ELP5 (Elongator Acetyltransferase Complex Subunit 5) is a Protein Coding gene. Among its related pathways are Chromatin organization.

UniProtKB/Swiss-Prot for ELP5 Gene

  • Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (By similarity). May be involved in TP53-mediated transcriptional regulation.

Gene Wiki entry for ELP5 Gene

Additional gene information for ELP5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELP5 Gene

Genomics for ELP5 Gene

GeneHancer (GH) Regulatory Elements for ELP5 Gene

Promoters and enhancers for ELP5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J007247 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 688.1 -0.7 -738 6 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ELP5 CTDNEP1 PIR48144 YBX2 DVL2 CTC1 ENSG00000262089 CNTROB WRAP53 PFAS
GH17J007256 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 37.8 +9.4 9382 8.7 HDGF FOXA2 MLX ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 CLDN7 ENSG00000262302 GC17M007249 PIR33341 CTDNEP1 ELP5 YBX2 WRAP53 POLR2A CNTROB
GH17J007233 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 37.8 -12.8 -12757 11.3 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 DVL2 GABARAP PHF23 CNTROB SNORD10 WRAP53 NEURL4 POLR2A KIAA0753 KCTD11
GH17J007213 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 29.2 -32.7 -32726 10.6 HDGF FOXA2 PKNOX1 ARID4B NEUROD1 SIN3A ZNF2 YY1 ZNF766 ZNF207 DLG4 ACADVL GC17M007214 GC17P007220 ELP5 CLDN7 GPS2 PER1 LOC100996842 SLC35G6
GH17J007279 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 31.2 +29.9 29922 4.3 HDGF FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 SLC2A4 YBX2 ELP5 PFAS DVL2 CTC1 ENSG00000262089 CNTROB WRAP53 SNORD10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ELP5 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ELP5 Gene

Genomic Locations for ELP5 Gene
chr17:7,251,416-7,259,940
(GRCh38/hg38)
Size:
8,525 bases
Orientation:
Plus strand
chr17:7,154,735-7,163,259
(GRCh37/hg19)
Size:
8,525 bases
Orientation:
Plus strand

Genomic View for ELP5 Gene

Genes around ELP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELP5 Gene

Proteins for ELP5 Gene

  • Protein details for ELP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TE02-ELP5_HUMAN
    Recommended name:
    Elongator complex protein 5
    Protein Accession:
    Q8TE02
    Secondary Accessions:
    • A8K1M5
    • D3DTN9
    • Q659B6
    • Q7Z2T4
    • Q8TDR9
    • Q9BUB2
    • Q9Y2Q4

    Protein attributes for ELP5 Gene

    Size:
    316 amino acids
    Molecular mass:
    34841 Da
    Quaternary structure:
    • Component of the RNA polymerase II elongator complex (Elongator), which consists of ELP1, STIP1/ELP2, ELP3, ELP4, ELP5 and ELP6; in the complex, is required for optimal binding of ELP3 to ELP4.
    SequenceCaution:
    • Sequence=AAD20964.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAQ13591.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ELP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELP5 Gene

Post-translational modifications for ELP5 Gene

  • Ubiquitination at isoforms=2, 3, 494 and Lys43
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ELP5 Gene

Domains & Families for ELP5 Gene

Gene Families for ELP5 Gene

Protein Domains for ELP5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ELP5 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TE02

UniProtKB/Swiss-Prot:

ELP5_HUMAN :
  • Belongs to the ELP5 family.
Family:
  • Belongs to the ELP5 family.
genes like me logo Genes that share domains with ELP5: view

Function for ELP5 Gene

Molecular function for ELP5 Gene

UniProtKB/Swiss-Prot Function:
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (By similarity). May be involved in TP53-mediated transcriptional regulation.

Phenotypes From GWAS Catalog for ELP5 Gene

Gene Ontology (GO) - Molecular Function for ELP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16713569
genes like me logo Genes that share ontologies with ELP5: view
genes like me logo Genes that share phenotypes with ELP5: view

Animal Model Products

CRISPR Products

miRNA for ELP5 Gene

miRTarBase miRNAs that target ELP5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ELP5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ELP5 Gene

Localization for ELP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELP5 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ELP5 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ELP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 22854966
GO:0005737 cytoplasm IDA,IEA 22854966
GO:0005829 cytosol IDA --
GO:0033588 Elongator holoenzyme complex IDA 22854966
genes like me logo Genes that share ontologies with ELP5: view

Pathways & Interactions for ELP5 Gene

genes like me logo Genes that share pathways with ELP5: view

Pathways by source for ELP5 Gene

Gene Ontology (GO) - Biological Process for ELP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002098 tRNA wobble uridine modification IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030335 positive regulation of cell migration ISS --
genes like me logo Genes that share ontologies with ELP5: view

No data available for SIGNOR curated interactions for ELP5 Gene

Drugs & Compounds for ELP5 Gene

(1) Drugs for ELP5 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methylphenidate Approved, Investigational Pharma 387
genes like me logo Genes that share compounds with ELP5: view

Transcripts for ELP5 Gene

Unigene Clusters for ELP5 Gene

Elongator acetyltransferase complex subunit 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ELP5

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ELP5 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b
SP1: - - -
SP2: - - - -
SP3: - -
SP4:
SP5: - - - - - - - - - -
SP6:
SP7:
SP8: - - - -
SP9: -

Relevant External Links for ELP5 Gene

GeneLoc Exon Structure for
ELP5
ECgene alternative splicing isoforms for
ELP5

Expression for ELP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ELP5 Gene

mRNA differential expression in normal tissues according to GTEx for ELP5 Gene

This gene is overexpressed in Testis (x4.8).

Protein differential expression in normal tissues from HIPED for ELP5 Gene

This gene is overexpressed in Breast (29.6), Bone (13.7), Cerebrospinal fluid (13.1), and Pancreas (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ELP5 Gene



NURSA nuclear receptor signaling pathways regulating expression of ELP5 Gene:

ELP5

SOURCE GeneReport for Unigene cluster for ELP5 Gene:

Hs.417029

mRNA Expression by UniProt/SwissProt for ELP5 Gene:

Q8TE02-ELP5_HUMAN
Tissue specificity: Ubiquitously expressed with high levels in heart, brain, liver, skeletal muscle and testis.

Evidence on tissue expression from TISSUES for ELP5 Gene

  • Nervous system(4.3)
  • Skin(4.2)
  • Blood(4.1)
  • Muscle(2.6)
genes like me logo Genes that share expression patterns with ELP5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ELP5 Gene

Orthologs for ELP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ELP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC455799 33
  • 99.26 (n)
-- 34
  • 99 (a)
OneToMany
-- 34
  • 98 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ELP5 34 33
  • 85.78 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ELP5 34 33
  • 84.44 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Elp5 16 34 33
  • 78.55 (n)
rat
(Rattus norvegicus)
Mammalia Elp5 33
  • 78.4 (n)
oppossum
(Monodelphis domestica)
Mammalia ELP5 34
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ELP5 34
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ELP5 34
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii elp5 34 33
  • 46.43 (n)
OneToOne
Species where no ortholog for ELP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ELP5 Gene

ENSEMBL:
Gene Tree for ELP5 (if available)
TreeFam:
Gene Tree for ELP5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ELP5: view image

Paralogs for ELP5 Gene

No data available for Paralogs for ELP5 Gene

Variants for ELP5 Gene

Sequence variations from dbSNP and Humsavar for ELP5 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000038770 -- 7,256,064(+) AAAAA/AA intron_variant
rs1000925641 -- 7,250,300(+) T/C upstream_transcript_variant
rs1001008709 -- 7,260,316(+) C/T downstream_transcript_variant
rs1001609662 -- 7,259,081(+) C/A 3_prime_UTR_variant, intron_variant
rs1001815552 -- 7,253,480(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ELP5 Gene

Variant ID Type Subtype PubMed ID
dgv885e212 CNV loss 25503493
esv2422288 CNV deletion 17116639
esv2665200 CNV deletion 23128226
esv3639861 CNV loss 21293372
nsv1963 CNV deletion 18451855
nsv457659 CNV loss 19166990
nsv574322 CNV loss 21841781
nsv952118 CNV deletion 24416366

Variation tolerance for ELP5 Gene

Residual Variation Intolerance Score: 70.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ELP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ELP5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELP5 Gene

Disorders for ELP5 Gene

Additional Disease Information for ELP5

No disorders were found for ELP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ELP5 Gene

Publications for ELP5 Gene

  1. DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator. (PMID: 22854966) Close P … Chariot A (The Journal of biological chemistry 2012) 2 3 4 58
  2. Cloning and characterization of the human gene DERP6, which activates transcriptional activities of p53. (PMID: 16850183) Yuan J … Yu L (Molecular biology reports 2006) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ELP5 Gene

Sources for ELP5 Gene

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