Aliases for ELP2 Gene
External Ids for ELP2 Gene
Previous HGNC Symbols for ELP2 Gene
Previous GeneCards Identifiers for ELP2 Gene
The protein encoded by this gene is a core subunit of the elongator complex, a histone acetyltransferase complex that associates with RNA polymerase II. In addition to histone acetylation, the encoded protein effects transcriptional elongation and may help remodel chromatin. [provided by RefSeq, May 2016]
GeneCards Summary for ELP2 Gene
ELP2 (Elongator Acetyltransferase Complex Subunit 2) is a Protein Coding gene. Diseases associated with ELP2 include Mental Retardation, Autosomal Recessive 58 and Neuropathy, Hereditary Sensory And Autonomic, Type Iii. Among its related pathways are Chromatin organization and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include protein kinase binding and RNA polymerase II complex binding.
UniProtKB/Swiss-Prot Summary for ELP2 Gene
Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation (PubMed:11714725, PubMed:11818576). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244).