Aliases for ELOVL3 Gene
External Ids for ELOVL3 Gene
Previous GeneCards Identifiers for ELOVL3 Gene
This gene encodes a protein that belongs to the GNS1/SUR4 family. Members of this family play a role in elongation of long chain fatty acids to provide precursors for synthesis of sphingolipids and ceramides. [provided by RefSeq, Jul 2013]
GeneCards Summary for ELOVL3 Gene
ELOVL3 (ELOVL Fatty Acid Elongase 3) is a Protein Coding gene. Among its related pathways are Fatty Acyl-CoA Biosynthesis and alpha-linolenic (omega3) and linoleic (omega6) acid metabolism. Gene Ontology (GO) annotations related to this gene include transferase activity. An important paralog of this gene is ELOVL6.
UniProtKB/Swiss-Prot Summary for ELOVL3 Gene
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and unsaturated acyl-CoA substrates with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.