This gene encodes a protein that belongs to the GNS1/SUR4 family. Members of this family play a role in elongation of long chain fatty acids to provide precursors for synthesis of sphingolipids and ceramides. [provided by RefSeq, Jul 2013] See more...

Aliases for ELOVL3 Gene

Aliases for ELOVL3 Gene

  • ELOVL Fatty Acid Elongase 3 2 3 4 5
  • Elongation Of Very Long Chain Fatty Acids (FEN1/Elo2, SUR4/Elo3, Yeast)-Like 3 2 3
  • Elongation Of Very Long Chain Fatty Acids Protein 3 3 4
  • Very Long Chain 3-Ketoacyl-CoA Synthase 3 3 4
  • Very Long Chain 3-Oxoacyl-CoA Synthase 3 3 4
  • Cold-Inducible Glycoprotein Of 30 KDa 3 4
  • 3-Keto Acyl-CoA Synthase ELOVL3 3 4
  • ELOVL FA Elongase 3 3 4
  • CIG-30 2 3
  • CIG30 3 4
  • EC 2.3.1.199 4
  • ELOVL3 5

External Ids for ELOVL3 Gene

Previous GeneCards Identifiers for ELOVL3 Gene

  • GC10U990120
  • GC10P103219
  • GC10P104117
  • GC10P103650
  • GC10P103976
  • GC10P097618

Summaries for ELOVL3 Gene

Entrez Gene Summary for ELOVL3 Gene

  • This gene encodes a protein that belongs to the GNS1/SUR4 family. Members of this family play a role in elongation of long chain fatty acids to provide precursors for synthesis of sphingolipids and ceramides. [provided by RefSeq, Jul 2013]

GeneCards Summary for ELOVL3 Gene

ELOVL3 (ELOVL Fatty Acid Elongase 3) is a Protein Coding gene. Diseases associated with ELOVL3 include Fetal Akinesia Deformation Sequence 1. Among its related pathways are alpha-linolenic (omega3) and linoleic (omega6) acid metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include transferase activity. An important paralog of this gene is ELOVL6.

UniProtKB/Swiss-Prot Summary for ELOVL3 Gene

  • Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and unsaturated acyl-CoA substrates with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

Additional gene information for ELOVL3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ELOVL3 Gene

Genomics for ELOVL3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ELOVL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J102225 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +1.5 1533 2.2 SP1 GATAD2A TFE3 NFKBIZ KDM1A ZSCAN4 PKNOX1 POLR2A RXRB IRF2 ELOVL3 HPS6 lnc-ELOVL3-1 PITX3 lnc-C10orf95-2
GH10J102393 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.6 +170.8 170795 5.1 SP1 CREB1 CTCF TEAD4 PRDM10 REST ZNF629 IKZF1 KDM1A ZNF692 NFKB2 lnc-PSD-2 lnc-NFKB2-1 SFXN2 C10orf95 MFSD13A ELOVL3 PITX3 RPARP-AS1 BORCS7
GH10J102169 Promoter/Enhancer 1.2 ENCODE CraniofacialAtlas 11.6 -55.0 -54997 0.8 SP1 GATAD2A CTCF PRDM10 ZNF629 KDM1A FOXA1 PRDM1 ZNF143 ZNF24 GBF1 NOLC1 ELOVL3 HPS6 PITX3 PPRC1 NFKB2 FBXL15 PSD MN309200
GH10J102462 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 9.7 +238.7 238740 1.7 LEF1 IKZF1 ZIC2 MTA1 SP1 HDAC1 SOX6 FOXK2 SCRT2 MGA MFSD13A MIR146B CUEDC2 FBXL15 PSD SUFU RNU6-43P NFKB2 ELOVL3 lnc-SUFU-1
GH10J102309 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.2 +86.7 86734 5 ZNF692 FOXA1 PRDM1 ZBTB20 ETS1 JUND FOXA2 MAFF MAFK TEAD1 PITX3 FBXL15 GBF1 ELOVL3 PSD POLL piR-42700-020 LOC107984263 NFKB2 lnc-C10orf95-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ELOVL3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ELOVL3

Top Transcription factor binding sites by QIAGEN in the ELOVL3 gene promoter:
  • AML1a
  • CREB
  • deltaCREB
  • POU3F1
  • PPAR-alpha
  • PPAR-gamma1
  • PPAR-gamma2
  • YY1

Genomic Locations for ELOVL3 Gene

Genomic Locations for ELOVL3 Gene
chr10:102,224,767-102,229,589
(GRCh38/hg38)
Size:
4,823 bases
Orientation:
Plus strand
chr10:103,986,085-103,989,346
(GRCh37/hg19)
Size:
3,262 bases
Orientation:
Plus strand

Genomic View for ELOVL3 Gene

Genes around ELOVL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELOVL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELOVL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELOVL3 Gene

Proteins for ELOVL3 Gene

  • Protein details for ELOVL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HB03-ELOV3_HUMAN
    Recommended name:
    Elongation of very long chain fatty acids protein 3
    Protein Accession:
    Q9HB03
    Secondary Accessions:
    • Q5VZL3
    • Q8N180

    Protein attributes for ELOVL3 Gene

    Size:
    270 amino acids
    Molecular mass:
    31500 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ELOVL3 Gene

Post-translational modifications for ELOVL3 Gene

Other Protein References for ELOVL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ELOVL3 Gene

Domains & Families for ELOVL3 Gene

Gene Families for ELOVL3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for ELOVL3 Gene

InterPro:
Blocks:
  • GNS1/SUR4 membrane protein
ProtoNet:

Suggested Antigen Peptide Sequences for ELOVL3 Gene

GenScript: Design optimal peptide antigens:
  • Cold-inducible glycoprotein of 30 kDa (ELOV3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9HB03

UniProtKB/Swiss-Prot:

ELOV3_HUMAN :
  • The C-terminal di-lysine motif may confer endoplasmic reticulum localization.
  • Belongs to the ELO family. ELOVL3 subfamily.
Domain:
  • The C-terminal di-lysine motif may confer endoplasmic reticulum localization.
Family:
  • Belongs to the ELO family. ELOVL3 subfamily.
genes like me logo Genes that share domains with ELOVL3: view

Function for ELOVL3 Gene

Molecular function for ELOVL3 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and unsaturated acyl-CoA substrates with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:32727, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:90725, ChEBI:CHEBI:90736; EC=2.3.1.199; Evidence={ECO:0000255|HAMAP-Rule:MF_03203, ECO:0000269|PubMed:19575253, ECO:0000269|PubMed:20937905};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=eicosanoyl-CoA + H(+) + malonyl-CoA = 3-oxodocosanoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:35327, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57380, ChEBI:CHEBI:57384, ChEBI:CHEBI:71451; Evidence={ECO:0000269|PubMed:19575253, ECO:0000269|PubMed:20937905};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H(+) + hexadecanoyl-CoA + malonyl-CoA = 3-oxooctadecanoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:35315, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:57384, ChEBI:CHEBI:71407; Evidence={ECO:0000269|PubMed:19575253, ECO:0000269|PubMed:20937905};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H(+) + malonyl-CoA + octadecanoyl-CoA = 3-oxoeicosanoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:35319, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:57394, ChEBI:CHEBI:65115; Evidence={ECO:0000269|PubMed:19575253, ECO:0000269|PubMed:20937905};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA = (11Z)-3-oxoicosenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36511, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:57387, ChEBI:CHEBI:74011; Evidence={ECO:0000269|PubMed:20937905};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA = (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36503, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:57384, ChEBI:CHEBI:74012; Evidence={ECO:0000269|PubMed:20937905};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA = (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36523, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74034, ChEBI:CHEBI:74054; Evidence={ECO:0000269|PubMed:20937905};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=docosanoyl-CoA + H(+) + malonyl-CoA = 3-oxotetracosanoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36507, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:65059, ChEBI:CHEBI:73977; Evidence={ECO:0000269|PubMed:20937905};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H(+) + malonyl-CoA + tetradecanoyl-CoA = 3-oxohexadecanoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:39167, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57349, ChEBI:CHEBI:57384, ChEBI:CHEBI:57385; Evidence={ECO:0000269|PubMed:19575253};.

Enzyme Numbers (IUBMB) for ELOVL3 Gene

Phenotypes From GWAS Catalog for ELOVL3 Gene

Gene Ontology (GO) - Molecular Function for ELOVL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20937905
GO:0009922 fatty acid elongase activity IBA 21873635
GO:0016740 transferase activity IEA --
GO:0102336 3-oxo-arachidoyl-CoA synthase activity IEA --
GO:0102337 3-oxo-cerotoyl-CoA synthase activity IEA --
genes like me logo Genes that share ontologies with ELOVL3: view
genes like me logo Genes that share phenotypes with ELOVL3: view

Animal Models for ELOVL3 Gene

MGI Knock Outs for ELOVL3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ELOVL3

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ELOVL3 Gene

Localization for ELOVL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELOVL3 Gene

Endoplasmic reticulum membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ELOVL3 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
extracellular 2
mitochondrion 2
peroxisome 2
nucleus 2
cytoskeleton 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ELOVL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 20937905
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030176 integral component of endoplasmic reticulum membrane IBA 21873635
genes like me logo Genes that share ontologies with ELOVL3: view

Pathways & Interactions for ELOVL3 Gene

genes like me logo Genes that share pathways with ELOVL3: view

UniProtKB/Swiss-Prot Q9HB03-ELOV3_HUMAN

  • Pathway: Lipid metabolism; polyunsaturated fatty acid biosynthesis.

Interacting Proteins for ELOVL3 Gene

Gene Ontology (GO) - Biological Process for ELOVL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IEA --
GO:0006636 unsaturated fatty acid biosynthetic process IEA --
GO:0019367 fatty acid elongation, saturated fatty acid IBA,IDA 20937905
genes like me logo Genes that share ontologies with ELOVL3: view

No data available for SIGNOR curated interactions for ELOVL3 Gene

Drugs & Compounds for ELOVL3 Gene

(3) Drugs for ELOVL3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carbon dioxide Approved, Investigational, Vet_approved Pharma 0
Malonyl-CoA Experimental Pharma 0
Coenzyme A Investigational Nutra 0
genes like me logo Genes that share compounds with ELOVL3: view

Transcripts for ELOVL3 Gene

mRNA/cDNA for ELOVL3 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ELOVL3

Alternative Splicing Database (ASD) splice patterns (SP) for ELOVL3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1:
SP2: -

Relevant External Links for ELOVL3 Gene

GeneLoc Exon Structure for
ELOVL3

Expression for ELOVL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ELOVL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ELOVL3 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x22.4) and Skin - Sun Exposed (Lower leg) (x8.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ELOVL3

SOURCE GeneReport for Unigene cluster for ELOVL3 Gene:

Hs.302130

mRNA Expression by UniProt/SwissProt for ELOVL3 Gene:

Q9HB03-ELOV3_HUMAN
Tissue specificity: Testis.

Evidence on tissue expression from TISSUES for ELOVL3 Gene

  • Skin(4.5)
  • Liver(2.3)
  • Muscle(2)
genes like me logo Genes that share expression patterns with ELOVL3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ELOVL3 Gene

Orthologs for ELOVL3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ELOVL3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ELOVL3 30 31
  • 98.89 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ELOVL3 30 31
  • 85.96 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ELOVL3 30 31
  • 84.81 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Elovl3 30
  • 81.11 (n)
Mouse
(Mus musculus)
Mammalia Elovl3 30 17 31
  • 79.63 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ELOVL3 31
  • 59 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 56 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 42 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii elovl6l 31
  • 44 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea elo-4 31
  • 35 (a)
ManyToMany
elo-6 31
  • 31 (a)
ManyToMany
elo-9 31
  • 31 (a)
ManyToMany
elo-2 31
  • 31 (a)
ManyToMany
elo-5 31
  • 28 (a)
ManyToMany
elo-1 31
  • 27 (a)
ManyToMany
elo-7 31
  • 27 (a)
ManyToMany
elo-3 31
  • 24 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ELO1 31
  • 18 (a)
ManyToMany
SUR4 31
  • 17 (a)
ManyToMany
FEN1 31
  • 17 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10330 31
  • 38 (a)
ManyToMany
-- 31
  • 34 (a)
ManyToMany
-- 31
  • 33 (a)
ManyToMany
Species where no ortholog for ELOVL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for ELOVL3 Gene

ENSEMBL:
Gene Tree for ELOVL3 (if available)
TreeFam:
Gene Tree for ELOVL3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ELOVL3: view image

Paralogs for ELOVL3 Gene

Paralogs for ELOVL3 Gene

(1) SIMAP similar genes for ELOVL3 Gene using alignment to 1 proteins:

  • ELOV3_HUMAN
genes like me logo Genes that share paralogs with ELOVL3: view

Variants for ELOVL3 Gene

Additional dbSNP identifiers (rs#s) for ELOVL3 Gene

Structural Variations from Database of Genomic Variants (DGV) for ELOVL3 Gene

Variant ID Type Subtype PubMed ID
esv997610 CNV loss 20482838

Variation tolerance for ELOVL3 Gene

Residual Variation Intolerance Score: 25.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ELOVL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ELOVL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ELOVL3 Gene

Disorders for ELOVL3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ELOVL3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
fetal akinesia deformation sequence 1
  • fads1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ELOVL3

genes like me logo Genes that share disorders with ELOVL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ELOVL3 Gene

Publications for ELOVL3 Gene

  1. ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis. (PMID: 20937905) Ohno Y … Kihara A (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. The chromatin remodeling protein BRG1 links ELOVL3 trans-activation to prostate cancer metastasis. (PMID: 31154107) Yang Y … Xu Y (Biochimica et biophysica acta. Gene regulatory mechanisms 2019) 3
  4. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3

Products for ELOVL3 Gene

Sources for ELOVL3 Gene