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Aliases for ELOVL3 Gene

Aliases for ELOVL3 Gene

  • ELOVL Fatty Acid Elongase 3 2 3 4 5
  • Elongation Of Very Long Chain Fatty Acids (FEN1/Elo2, SUR4/Elo3, Yeast)-Like 3 2 3
  • Very Long Chain 3-Ketoacyl-CoA Synthase 3 3 4
  • Very Long Chain 3-Oxoacyl-CoA Synthase 3 3 4
  • Cold-Inducible Glycoprotein Of 30 KDa 3 4
  • 3-Keto Acyl-CoA Synthase ELOVL3 3 4
  • ELOVL FA Elongase 3 3 4
  • CIG30 3 4
  • Elongation Of Very Long Chain Fatty Acids Protein 3 3
  • EC 2.3.1.199 4
  • CIG-30 3

External Ids for ELOVL3 Gene

Previous GeneCards Identifiers for ELOVL3 Gene

  • GC10U990120
  • GC10P103219
  • GC10P104117
  • GC10P103650
  • GC10P103976
  • GC10P097618

Summaries for ELOVL3 Gene

Entrez Gene Summary for ELOVL3 Gene

  • This gene encodes a protein that belongs to the GNS1/SUR4 family. Members of this family play a role in elongation of long chain fatty acids to provide precursors for synthesis of sphingolipids and ceramides. [provided by RefSeq, Jul 2013]

GeneCards Summary for ELOVL3 Gene

ELOVL3 (ELOVL Fatty Acid Elongase 3) is a Protein Coding gene. Among its related pathways are alpha-linolenic (omega3) and linoleic (omega6) acid metabolism and Fatty Acyl-CoA Biosynthesis. Gene Ontology (GO) annotations related to this gene include transferase activity. An important paralog of this gene is ELOVL6.

UniProtKB/Swiss-Prot for ELOVL3 Gene

  • Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

Additional gene information for ELOVL3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELOVL3 Gene

Genomics for ELOVL3 Gene

GeneHancer (GH) Regulatory Elements for ELOVL3 Gene

Promoters and enhancers for ELOVL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J102225 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.9 921 2.2 HDGF PKNOX1 ATF1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 SLC30A9 FOS ELOVL3 HPS6 PITX3
GH10J102393 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.6 +170.4 170418 4.7 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF213 E2F8 NFKB2 PPRC1 GBF1 SFXN2 C10orf95 MFSD13A ELOVL3 TAF5 PITX3 RPARP-AS1
GH10J102169 Enhancer 1.1 Ensembl ENCODE 11.6 -55.7 -55661 1 ATF1 ARID4B SIN3A ZNF2 ZNF121 ZNF143 ATF7 RUNX3 DEK REST GBF1 NOLC1 ELOVL3 HPS6 PITX3 PPRC1 NFKB2 PSD FBXL15
GH10J102279 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.8 +55.2 55190 2.8 HDAC1 MEIS2 PKNOX1 FEZF1 ZNF664 POLR2A FOXK2 ATF7 PRDM10 GFI1B NFKB2 PPRC1 LDB1 PITX3 GBF1 ELOVL3 C10orf95 MFSD13A HPS6 KCNIP2
GH10J102309 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.6 +85.6 85606 1.9 ELF3 PKNOX1 FOXA2 SAP130 ZNF133 MZF1 ETS1 TEAD3 ZNF664 GATA3 PITX3 GBF1 ELOVL3 FBXL15 GC10P102289 NFKB2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ELOVL3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ELOVL3 gene promoter:

Genomic Locations for ELOVL3 Gene

Genomic Locations for ELOVL3 Gene
chr10:102,225,358-102,229,589
(GRCh38/hg38)
Size:
4,232 bases
Orientation:
Plus strand
chr10:103,986,085-103,989,346
(GRCh37/hg19)

Genomic View for ELOVL3 Gene

Genes around ELOVL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELOVL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELOVL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELOVL3 Gene

Proteins for ELOVL3 Gene

  • Protein details for ELOVL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HB03-ELOV3_HUMAN
    Recommended name:
    Elongation of very long chain fatty acids protein 3
    Protein Accession:
    Q9HB03
    Secondary Accessions:
    • Q5VZL3
    • Q8N180

    Protein attributes for ELOVL3 Gene

    Size:
    270 amino acids
    Molecular mass:
    31500 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ELOVL3 Gene

Post-translational modifications for ELOVL3 Gene

Other Protein References for ELOVL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ELOVL3 Gene

Domains & Families for ELOVL3 Gene

Gene Families for ELOVL3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for ELOVL3 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ELOVL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HB03

UniProtKB/Swiss-Prot:

ELOV3_HUMAN :
  • The C-terminal di-lysine motif may confer endoplasmic reticulum localization.
  • Belongs to the ELO family. ELOVL3 subfamily.
Domain:
  • The C-terminal di-lysine motif may confer endoplasmic reticulum localization.
Family:
  • Belongs to the ELO family. ELOVL3 subfamily.
genes like me logo Genes that share domains with ELOVL3: view

Function for ELOVL3 Gene

Molecular function for ELOVL3 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
UniProtKB/Swiss-Prot CatalyticActivity:
A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2).

Enzyme Numbers (IUBMB) for ELOVL3 Gene

Phenotypes From GWAS Catalog for ELOVL3 Gene

Gene Ontology (GO) - Molecular Function for ELOVL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20937905
GO:0009922 fatty acid elongase activity TAS --
GO:0016740 transferase activity IEA --
GO:0102336 3-oxo-arachidoyl-CoA synthase activity IEA --
GO:0102337 3-oxo-cerotoyl-CoA synthase activity IEA --
genes like me logo Genes that share ontologies with ELOVL3: view
genes like me logo Genes that share phenotypes with ELOVL3: view

Animal Models for ELOVL3 Gene

MGI Knock Outs for ELOVL3:

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ELOVL3 Gene

Localization for ELOVL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELOVL3 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ELOVL3 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ELOVL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 20937905
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030176 integral component of endoplasmic reticulum membrane IBA --
genes like me logo Genes that share ontologies with ELOVL3: view

Pathways & Interactions for ELOVL3 Gene

genes like me logo Genes that share pathways with ELOVL3: view

UniProtKB/Swiss-Prot Q9HB03-ELOV3_HUMAN

  • Pathway: Lipid metabolism; polyunsaturated fatty acid biosynthesis.

Gene Ontology (GO) - Biological Process for ELOVL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IEA --
GO:0006636 unsaturated fatty acid biosynthetic process IEA --
GO:0019367 fatty acid elongation, saturated fatty acid IDA 20937905
genes like me logo Genes that share ontologies with ELOVL3: view

No data available for SIGNOR curated interactions for ELOVL3 Gene

Drugs & Compounds for ELOVL3 Gene

(3) Drugs for ELOVL3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carbon dioxide Approved, Investigational, Vet_approved Pharma 0
Malonyl-CoA Experimental Pharma 0
Coenzyme A Investigational Nutra 0
genes like me logo Genes that share compounds with ELOVL3: view

Transcripts for ELOVL3 Gene

mRNA/cDNA for ELOVL3 Gene

(28) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ELOVL3 Gene

ELOVL fatty acid elongase 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ELOVL3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1:
SP2: -

Relevant External Links for ELOVL3 Gene

GeneLoc Exon Structure for
ELOVL3
ECgene alternative splicing isoforms for
ELOVL3

Expression for ELOVL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ELOVL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ELOVL3 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x22.4) and Skin - Sun Exposed (Lower leg) (x8.2).

NURSA nuclear receptor signaling pathways regulating expression of ELOVL3 Gene:

ELOVL3

SOURCE GeneReport for Unigene cluster for ELOVL3 Gene:

Hs.302130

mRNA Expression by UniProt/SwissProt for ELOVL3 Gene:

Q9HB03-ELOV3_HUMAN
Tissue specificity: Testis.

Evidence on tissue expression from TISSUES for ELOVL3 Gene

  • Skin(4.5)
genes like me logo Genes that share expression patterns with ELOVL3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ELOVL3 Gene

Orthologs for ELOVL3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ELOVL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ELOVL3 34 33
  • 98.89 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ELOVL3 34 33
  • 85.96 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ELOVL3 34 33
  • 84.81 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Elovl3 33
  • 81.11 (n)
mouse
(Mus musculus)
Mammalia Elovl3 16 34 33
  • 79.63 (n)
oppossum
(Monodelphis domestica)
Mammalia ELOVL3 34
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 56 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 34
  • 42 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii elovl6l 34
  • 44 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea elo-4 34
  • 35 (a)
ManyToMany
elo-6 34
  • 31 (a)
ManyToMany
elo-9 34
  • 31 (a)
ManyToMany
elo-2 34
  • 31 (a)
ManyToMany
elo-5 34
  • 28 (a)
ManyToMany
elo-1 34
  • 27 (a)
ManyToMany
elo-7 34
  • 27 (a)
ManyToMany
elo-3 34
  • 24 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ELO1 34
  • 18 (a)
ManyToMany
SUR4 34
  • 17 (a)
ManyToMany
FEN1 34
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10330 34
  • 38 (a)
ManyToMany
-- 34
  • 34 (a)
ManyToMany
-- 34
  • 33 (a)
ManyToMany
Species where no ortholog for ELOVL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ELOVL3 Gene

ENSEMBL:
Gene Tree for ELOVL3 (if available)
TreeFam:
Gene Tree for ELOVL3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ELOVL3: view image

Paralogs for ELOVL3 Gene

Paralogs for ELOVL3 Gene

(1) SIMAP similar genes for ELOVL3 Gene using alignment to 1 proteins:

  • ELOV3_HUMAN
genes like me logo Genes that share paralogs with ELOVL3: view

Variants for ELOVL3 Gene

Sequence variations from dbSNP and Humsavar for ELOVL3 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000237780 -- 102,225,940(+) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001237297 -- 102,224,638(+) C/T upstream_transcript_variant
rs1001335132 -- 102,226,167(+) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1002125245 -- 102,223,420(+) A/G upstream_transcript_variant
rs1002234427 -- 102,226,739(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ELOVL3 Gene

Variant ID Type Subtype PubMed ID
esv997610 CNV loss 20482838

Variation tolerance for ELOVL3 Gene

Residual Variation Intolerance Score: 25.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ELOVL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ELOVL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELOVL3 Gene

Disorders for ELOVL3 Gene

Additional Disease Information for ELOVL3

No disorders were found for ELOVL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ELOVL3 Gene

Publications for ELOVL3 Gene

  1. ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis. (PMID: 20937905) Ohno Y … Kihara A (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3 58
  4. ELOVL2 overexpression enhances triacylglycerol synthesis in 3T3-L1 and F442A cells. (PMID: 17583696) Kobayashi T … Jacobsson A (FEBS letters 2007) 3 58
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58

Products for ELOVL3 Gene

Sources for ELOVL3 Gene

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