Aliases for ELOVL1 Gene
- ELOVL Fatty Acid Elongase 1 2 3 4 5
- Elongation Of Very Long Chain Fatty Acids (FEN1/Elo2, SUR4/Elo3, Yeast)-Like 1 2 3
- Elongation Of Very Long Chain Fatty Acids Protein 1 3 4
- Very Long Chain 3-Ketoacyl-CoA Synthase 1 3 4
- Very Long Chain 3-Oxoacyl-CoA Synthase 1 3 4
- 3-Keto Acyl-CoA Synthase ELOVL1 3 4
External Ids for ELOVL1 Gene
Previous GeneCards Identifiers for ELOVL1 Gene
GeneCards Summary for ELOVL1 Gene
ELOVL1 (ELOVL Fatty Acid Elongase 1) is a Protein Coding gene. Diseases associated with ELOVL1 include Ichthyotic Keratoderma, Spasticity, Hypomyelination, And Dysmorphic Facial Features and Spasticity. Among its related pathways are alpha-linolenic (omega3) and linoleic (omega6) acid metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include fatty acid elongase activity. An important paralog of this gene is ELOVL7.
UniProtKB/Swiss-Prot Summary for ELOVL1 Gene
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle (PubMed:29496980, PubMed:30487246). This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and monounsaturated acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis (PubMed:20937905). Indirectly inhibits RPE65 via production of VLCFAs.