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Aliases for ELOF1 Gene

Aliases for ELOF1 Gene

  • Elongation Factor 1 Homolog 2 3 5
  • Elongation Factor 1 Homolog (ELF1, S. Cerevisiae) 2 3
  • Transcription Elongation Factor 1 Homolog 3 4
  • Elongation Factor 1 Homolog (S. Cerevisiae) 2
  • ELF1 Homolog, Elongation Factor 1 3
  • ELF1 3

External Ids for ELOF1 Gene

Previous GeneCards Identifiers for ELOF1 Gene

  • GC19M011663
  • GC19M011238

Summaries for ELOF1 Gene

GeneCards Summary for ELOF1 Gene

ELOF1 (Elongation Factor 1 Homolog) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include translation elongation factor activity.

UniProtKB/Swiss-Prot for ELOF1 Gene

  • Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

Additional gene information for ELOF1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELOF1 Gene

Genomics for ELOF1 Gene

GeneHancer (GH) Regulatory Elements for ELOF1 Gene

Promoters and enhancers for ELOF1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J011557 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE 606.4 -0.3 -265 3.4 CC2D1A ELF3 CTCF CBFA2T2 ZNF148 NKRF POLR2A MLLT1 ZNF121 GTF2F1 ELOF1 ZNF627 CCDC159 ACP5 LDLR GC19P011561 GC19M011558
GH19J011558 Promoter 0.6 Ensembl 600.7 +1.7 1735 0.2 MNT ZNF627 ELOF1 CNN1
GH19J010834 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 17.5 +722.8 722828 3.2 ZNF473 MTA3 SP1 CC2D1A ZFX CBFA2T2 ZNF148 NKRF MLLT1 ZNF121 C19orf38 TMED1 ILF3 KRI1 RAVER1 ZNF627 ZNF491 ZNF441 DNMT1 PRKCSH
GH19J010624 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 17.5 +933.4 933362 3.1 ZNF473 SP1 ZNF121 ZBTB7A SP7 POLR2A GLIS2 ZBTB8A PRDM10 ZIC2 SLC44A2 ELOF1 ILF3-DT DNMT1 PIR56383
GH19J011465 Enhancer 0.9 Ensembl ENCODE 17.6 +93.3 93341 1.4 ZNF473 SP1 CDC5L ZSCAN4 ZNF148 MNT ZNF23 ZNF248 ZNF266 POLR2A GC19P011467 GC19M011464 ILF3 ZNF136 KRI1 ZNF627 ZNF441 ZNF44 ZNF442 ZNF700
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ELOF1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ELOF1 gene promoter:
  • CUTL1
  • Meis-1
  • Meis-1a
  • Meis-1b
  • p53
  • Pax-5
  • PPAR-gamma1
  • PPAR-gamma2
  • RREB-1
  • ZIC2

Genomic Locations for ELOF1 Gene

Genomic Locations for ELOF1 Gene
chr19:11,551,147-11,559,236
(GRCh38/hg38)
Size:
8,090 bases
Orientation:
Minus strand
chr19:11,661,962-11,670,051
(GRCh37/hg19)
Size:
8,090 bases
Orientation:
Minus strand

Genomic View for ELOF1 Gene

Genes around ELOF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELOF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELOF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELOF1 Gene

Proteins for ELOF1 Gene

  • Protein details for ELOF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60002-ELOF1_HUMAN
    Recommended name:
    Transcription elongation factor 1 homolog
    Protein Accession:
    P60002
    Secondary Accessions:
    • Q8R1J7
    • Q96II4

    Protein attributes for ELOF1 Gene

    Size:
    83 amino acids
    Molecular mass:
    9462 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ELOF1 Gene

Post-translational modifications for ELOF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ELOF1 Gene

Domains & Families for ELOF1 Gene

Gene Families for ELOF1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ELOF1 Gene

Suggested Antigen Peptide Sequences for ELOF1 Gene

GenScript: Design optimal peptide antigens:
  • Transcription elongation factor 1 homolog (ELOF1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P60002

UniProtKB/Swiss-Prot:

ELOF1_HUMAN :
  • Belongs to the ELOF1 family.
Family:
  • Belongs to the ELOF1 family.
genes like me logo Genes that share domains with ELOF1: view

Function for ELOF1 Gene

Molecular function for ELOF1 Gene

UniProtKB/Swiss-Prot Function:
Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

Phenotypes From GWAS Catalog for ELOF1 Gene

Gene Ontology (GO) - Molecular Function for ELOF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II complex binding IBA 21873635
GO:0003746 translation elongation factor activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ELOF1: view
genes like me logo Genes that share phenotypes with ELOF1: view

Animal Models for ELOF1 Gene

MGI Knock Outs for ELOF1:
  • Elof1 Elof1<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for ELOF1 - Now 50% OFF >
  • * ELOF1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ELOF1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ELOF1 Gene

Localization for ELOF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELOF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ELOF1 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ELOF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0008023 transcription elongation factor complex IBA 21873635
genes like me logo Genes that share ontologies with ELOF1: view

Pathways & Interactions for ELOF1 Gene

PathCards logo

SuperPathways for ELOF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ELOF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006368 transcription elongation from RNA polymerase II promoter IBA 21873635
GO:0006414 translational elongation IEA --
GO:0048096 chromatin-mediated maintenance of transcription IBA 21873635
genes like me logo Genes that share ontologies with ELOF1: view

No data available for Pathways by source and SIGNOR curated interactions for ELOF1 Gene

Drugs & Compounds for ELOF1 Gene

(1) Drugs for ELOF1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ELOF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ELOF1: view

Transcripts for ELOF1 Gene

Unigene Clusters for ELOF1 Gene

Elongation factor 1 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for ELOF1 - Now 50% OFF >
  • * ELOF1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ELOF1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for ELOF1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1: - -
SP2: - - - -
SP3: -
SP4:
SP5: - - -
SP6: - -

Relevant External Links for ELOF1 Gene

GeneLoc Exon Structure for
ELOF1
ECgene alternative splicing isoforms for
ELOF1

Expression for ELOF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ELOF1 Gene

Protein differential expression in normal tissues from HIPED for ELOF1 Gene

This gene is overexpressed in Retina (13.6), Pancreas (12.1), CD8 Tcells (9.3), and Testis (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ELOF1 Gene



Protein tissue co-expression partners for ELOF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ELOF1 Gene:

ELOF1

SOURCE GeneReport for Unigene cluster for ELOF1 Gene:

Hs.631633

Evidence on tissue expression from TISSUES for ELOF1 Gene

  • Muscle(4.2)
genes like me logo Genes that share expression patterns with ELOF1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ELOF1 Gene

Orthologs for ELOF1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ELOF1 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia ELOF1 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ELOF1 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ELOF1 35 34
  • 98.8 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ELOF1 35 34
  • 93.98 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ELOF1 35 34
  • 91.97 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Elof1 34
  • 90.36 (n)
mouse
(Mus musculus)
Mammalia Elof1 17 35 34
  • 89.96 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia elof1 34
  • 82.33 (n)
MGC75802 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.25747 34
zebrafish
(Danio rerio)
Actinopterygii elof1 35 34
  • 81.93 (n)
OneToOne
zgc64163 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8356 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003707 34
  • 67.48 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG40228 35 34
  • 67.1 (n)
OneToMany
CG6244 35
  • 60 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y54G11A.11 35
  • 68 (a)
OneToOne
CELE_Y54G11A.11 34
  • 63.01 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ELF1 37 35 34
  • 56.08 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F21868g 34
  • 55.21 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER237W 34
  • 53.92 (n)
rice
(Oryza sativa)
Liliopsida Os02g0134300 34
  • 52.08 (n)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.1067 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1067 34
Species where no ortholog for ELOF1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ELOF1 Gene

ENSEMBL:
Gene Tree for ELOF1 (if available)
TreeFam:
Gene Tree for ELOF1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ELOF1: view image

Paralogs for ELOF1 Gene

No data available for Paralogs for ELOF1 Gene

Variants for ELOF1 Gene

Sequence variations from dbSNP and Humsavar for ELOF1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000435653 -- 11,553,497(-) G/C 3_prime_UTR_variant
rs1000975716 -- 11,556,036(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001111561 -- 11,555,867(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001559874 -- 11,559,009(-) A/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1001742119 -- 11,552,903(-) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ELOF1 Gene

Variant ID Type Subtype PubMed ID
nsv509721 CNV insertion 20534489
nsv519802 CNV loss 19592680

Variation tolerance for ELOF1 Gene

Residual Variation Intolerance Score: 41.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.34; 63.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ELOF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ELOF1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELOF1 Gene

Disorders for ELOF1 Gene

Additional Disease Information for ELOF1

No disorders were found for ELOF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ELOF1 Gene

Publications for ELOF1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M … Stelzl U (Nature methods 2013) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 58

Products for ELOF1 Gene

Sources for ELOF1 Gene

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