This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII comple... See more...

Aliases for ELOC Gene

Aliases for ELOC Gene

  • Elongin C 2 3 5
  • Transcription Elongation Factor B (SIII), Polypeptide 1 (15kDa, Elongin C) 2 3
  • RNA Polymerase II Transcription Factor SIII Subunit C 3 4
  • Transcription Elongation Factor B Polypeptide 1 3 4
  • Transcription Elongation Factor B Subunit 1 2 3
  • Elongin 15 KDa Subunit 3 4
  • Elongin-C 3 4
  • SIII P15 3 4
  • TCEB1 3 4
  • SIII 2 3
  • Transcription Elongation Factor B (SIII), Polypeptide 1 (15kD, Elongin C) 2
  • ELOC 5
  • EloC 4

External Ids for ELOC Gene

Previous HGNC Symbols for ELOC Gene

  • TCEB1

Summaries for ELOC Gene

Entrez Gene Summary for ELOC Gene

  • This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

GeneCards Summary for ELOC Gene

ELOC (Elongin C) is a Protein Coding gene. Diseases associated with ELOC include Molluscum Contagiosum and Renal Cell Carcinoma, Papillary, 1. Among its related pathways are HIF1Alpha Pathway and HIV Transcription Elongation.

UniProtKB/Swiss-Prot Summary for ELOC Gene

  • SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7821821). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity).
  • The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.

Gene Wiki entry for ELOC Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ELOC Gene

Genomics for ELOC Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ELOC Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J073970 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 -2.2 -2214 9 SP1 CREB1 HNRNPL ATF7 PRDM10 REST ZNF629 TFE3 SIX5 IKZF1 TMEM70 ELOC NONHSAG050528.2 RPL7 UBE2W LY96
GH08J073876 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 10.4 +93.8 93786 4.2 SP1 HNRNPL CREB1 GATAD2A ATF7 PRDM10 REST ZNF629 ZNF512 RFX1 UBE2W ENSG00000258677 ENSG00000286113 LINC01617 ELOC TMEM70 piR-54764-614 STAU2
GH08J073990 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 11.9 -20.2 -20209 3.8 SP1 GATAD2A TFE3 JUND RELA TCF12 IKZF2 TRIM22 HDAC1 GABPA LY96 TMEM70 ELOC piR-60140-024 GDAP1
GH08J073892 Enhancer 0.9 FANTOM5 Ensembl ENCODE 10.9 +78.9 78887 1.2 CREB1 HDAC1 CTBP1 USF1 ZNF318 MYNN ATF4 BHLHE40 VEZF1 RAD51 TMEM70 ELOC STAU2 ENSG00000253596 GDAP1 UBE2W ENSG00000286113 LINC01617 piR-57757-006
GH08J073672 Enhancer 0.6 Ensembl 10.8 +299.4 299371 1 CTCF REST RAD21 TRIM22 SMC3 RFX5 ZNF335 ZNF384 ZNF654 ZFP91 RDH10 STAU2 ELOC TMEM70 RPL7 ENSG00000254538 piR-41195-089 lnc-UBE2W-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ELOC on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ELOC

Genomic Locations for ELOC Gene

Genomic Locations for ELOC Gene
chr8:73,939,169-73,972,287
(GRCh38/hg38)
Size:
33,119 bases
Orientation:
Minus strand
chr8:74,851,404-74,884,522
(GRCh37/hg19)
Size:
33,119 bases
Orientation:
Minus strand

Genomic View for ELOC Gene

Genes around ELOC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELOC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELOC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELOC Gene

Proteins for ELOC Gene

  • Protein details for ELOC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15369-ELOC_HUMAN
    Recommended name:
    Elongin-C
    Protein Accession:
    Q15369
    Secondary Accessions:
    • E5RGD9
    • Q567Q6

    Protein attributes for ELOC Gene

    Size:
    112 amino acids
    Molecular mass:
    12473 Da
    Quaternary structure:
    • Heterotrimer of an A (ELOA, ELOA2 or ELOA3), ELOB and ELOC subunit (PubMed:17997974). The elongin BC complex interacts with EPOP; leading to recruit the elongin BC complex to Polycomb group (PcG) target genes, thereby restricting excessive activity of the PRC2/EED-EZH2 complex (By similarity). Part of E3 ubiquitin ligase complexes with CUL5 or CUL2, RBX1 and a substrate adapter protein that can be either SOCS1, SOCS5, ELOA, VHL or WSB1 (PubMed:15590694). The elongin BC complex is part of a complex with VHL and hydroxylated HIF1A (PubMed:12050673, PubMed:12004076). Part of an E3 ubiquitin-protein ligase complex including ZYG11B, CUL2 and Elongin BC. Part of an E3 ubiquitin-protein ligase complex including ZER1, CUL2 and Elongin BC (PubMed:17304241). Interacts with VHL (PubMed:10205047, PubMed:12050673, PubMed:11006129). Interacts with TMF1 (PubMed:15467733). Interacts with SPSB1 (PubMed:17189197). Interacts with SPSB1. Interacts with KLHDC10; which may be an E3 ubiquitin ligase complex substrate recognition component (PubMed:23102700). Interacts with NOS2 in the presence of SPSB1 or SPSB2 or SPSB4 (PubMed:21199876).
    • (Microbial infection) Substrate adapter protein can be a viral protein such as HIV Vif.
    • (Microbial infection) Interacts with human respiratory syncytial virus (HRSV) protein NS1.
    • (Microbial infection) Interacts with molluscum contagiosum virus MC132.
    • (Microbial infection) Interacts with herpes virus 8 virus protein LANA1.

    Three dimensional structures from OCA and Proteopedia for ELOC Gene

    Alternative splice isoforms for ELOC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELOC Gene

Post-translational modifications for ELOC Gene

  • Ubiquitination at Lys6, Lys32, and Lys43
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ELOC Gene

Domains & Families for ELOC Gene

Gene Families for ELOC Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ELOC Gene

Suggested Antigen Peptide Sequences for ELOC Gene

GenScript: Design optimal peptide antigens:
  • SIII p15 (ELOC_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15369

UniProtKB/Swiss-Prot:

ELOC_HUMAN :
  • Belongs to the SKP1 family.
Family:
  • Belongs to the SKP1 family.
genes like me logo Genes that share domains with ELOC: view

Function for ELOC Gene

Molecular function for ELOC Gene

UniProtKB/Swiss-Prot Function:
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7821821). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity).
UniProtKB/Swiss-Prot Function:
The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.

Phenotypes From GWAS Catalog for ELOC Gene

Gene Ontology (GO) - Molecular Function for ELOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003746 translation elongation factor activity IEA --
GO:0005515 protein binding IPI 10205047
genes like me logo Genes that share ontologies with ELOC: view
genes like me logo Genes that share phenotypes with ELOC: view

Animal Model Products

CRISPR Products

miRNA for ELOC Gene

miRTarBase miRNAs that target ELOC

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ELOC

Clone Products

  • Addgene plasmids for ELOC

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ELOC Gene

Localization for ELOC Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELOC Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ELOC gene
Compartment Confidence
cytosol 5
nucleus 4
extracellular 2
cytoskeleton 2
mitochondrion 2
plasma membrane 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nucleoli (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ELOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0070449 elongin complex IBA 21873635
genes like me logo Genes that share ontologies with ELOC: view

Pathways & Interactions for ELOC Gene

genes like me logo Genes that share pathways with ELOC: view

SIGNOR curated interactions for ELOC Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for ELOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II TAS 7660129
GO:0006366 transcription by RNA polymerase II TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
GO:0006414 translational elongation IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IBA 21873635
genes like me logo Genes that share ontologies with ELOC: view

Drugs & Compounds for ELOC Gene

(1) Drugs for ELOC Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ELOC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ELOC: view

Transcripts for ELOC Gene

mRNA/cDNA for ELOC Gene

9 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ELOC

Clone Products

  • Addgene plasmids for ELOC

Alternative Splicing Database (ASD) splice patterns (SP) for ELOC Gene

No ASD Table

Relevant External Links for ELOC Gene

GeneLoc Exon Structure for
ELOC

Expression for ELOC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ELOC

mRNA Expression by UniProt/SwissProt for ELOC Gene:

Q15369-ELOC_HUMAN
Tissue specificity: Overexpressed in prostate cancer cell line PC-3 and breast cancer cell line SK-BR-3.

Evidence on tissue expression from TISSUES for ELOC Gene

  • Liver(4.6)
  • Skin(4.6)
  • Nervous system(4.5)
  • Intestine(4.5)
  • Blood(4.5)
  • Lung(3.2)
  • Kidney(3.1)
  • Heart(3)
  • Muscle(2.7)
  • Spleen(2.6)
  • Adrenal gland(2.4)
  • Lymph node(2.2)
  • Bone marrow(2.1)
genes like me logo Genes that share expression patterns with ELOC: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ELOC Gene

Orthologs for ELOC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ELOC Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TCEB1 30 31
  • 99.4 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TCEB1 30 31
  • 94.64 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TCEB1 30 31
  • 94.05 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TCEB1 31
  • 94 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tceb1 30
  • 93.75 (n)
Mouse
(Mus musculus)
Mammalia Tceb1 30 31
  • 92.56 (n)
OneToOne
Eloc 17
Oppossum
(Monodelphis domestica)
Mammalia TCEB1 31
  • 84 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TCEB1 30 31
  • 88.99 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TCEB1 31
  • 99 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tceb1 30
  • 85.42 (n)
Str.2774 30
African clawed frog
(Xenopus laevis)
Amphibia tceb1-prov 30
Zebrafish
(Danio rerio)
Actinopterygii tceb1b 30 31
  • 80.95 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2905 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011535 30
  • 74.24 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Elongin-C 30 31
  • 72.22 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea elc-1 30 31
  • 63.03 (n)
OneToMany
elc-2 31
  • 31 (a)
OneToMany
F54F7.10 31
  • 30 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ELC1 31 33
  • 37 (a)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT5G59140 30
  • 50.74 (n)
Rice
(Oryza sativa)
Liliopsida Os11g0707700 30
  • 51.06 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2870 31
  • 82 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.14780 30
Species where no ortholog for ELOC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ELOC Gene

ENSEMBL:
Gene Tree for ELOC (if available)
TreeFam:
Gene Tree for ELOC (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ELOC: view image

Paralogs for ELOC Gene

No data available for Paralogs for ELOC Gene

Variants for ELOC Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ELOC Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs1057519973 Likely Pathogenic: Renal cell carcinoma, papillary, 1. Likely Pathogenic: Renal cell carcinoma, papillary, 1 73,946,733(-) T/AT/G MISSENSE_VARIANT
rs1057519974 Likely Pathogenic: Renal cell carcinoma, papillary, 1 73,946,734(-) A/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ELOC Gene

Structural Variations from Database of Genomic Variants (DGV) for ELOC Gene

Variant ID Type Subtype PubMed ID
esv1009583 OTHER inversion 20482838
nsv510151 OTHER sequence alteration 20534489
nsv831355 CNV loss 17160897

Variation tolerance for ELOC Gene

Residual Variation Intolerance Score: 53.1% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ELOC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ELOC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELOC Gene

Disorders for ELOC Gene

MalaCards: The human disease database

(15) MalaCards diseases for ELOC Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search ELOC in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with ELOC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ELOC Gene

Publications for ELOC Gene

  1. Amplification and overexpression of Elongin C gene discovered in prostate cancer by cDNA microarrays. (PMID: 12004003) Porkka K … Visakorpi T (Laboratory investigation; a journal of technical methods and pathology 2002) 3 4 23
  2. Inhibition of transcription elongation by the VHL tumor suppressor protein. (PMID: 7660122) Duan DR … Klausner RD (Science (New York, N.Y.) 1995) 2 3 23
  3. A human cDNA encoding the small subunit of RNA polymerase II transcription factor SIII. (PMID: 7821821) Garrett KP … Conaway JW (Gene 1994) 2 3 4
  4. Regulation of inducible nitric-oxide synthase by the SPRY domain- and SOCS box-containing proteins. (PMID: 21199876) Nishiya T … Miwa S (The Journal of biological chemistry 2011) 3 4
  5. Mammalian SWI/SNF--a subunit BAF250/ARID1 is an E3 ubiquitin ligase that targets histone H2B. (PMID: 20086098) Li XS … Tanese N (Molecular and cellular biology 2010) 3 23

Products for ELOC Gene

Sources for ELOC Gene