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Aliases for ELOB Gene

Aliases for ELOB Gene

  • Elongin B 2 3 5
  • Transcription Elongation Factor B (SIII), Polypeptide 2 (18kDa, Elongin B) 2 3
  • RNA Polymerase II Transcription Factor SIII Subunit B 3 4
  • Transcription Elongation Factor B Polypeptide 2 3 4
  • Transcription Elongation Factor B Subunit 2 2 3
  • Elongin 18 KDa Subunit 3 4
  • SIII P18 3 4
  • TCEB2 3 4
  • RNA Polymerase II Transcription Factor SIII P18 Subunit 3
  • Elongin, 18-KD Subunit 3
  • Elongin-B 3
  • SIII 3
  • EloB 4

External Ids for ELOB Gene

Previous HGNC Symbols for ELOB Gene

  • TCEB2

Summaries for ELOB Gene

Entrez Gene Summary for ELOB Gene

  • This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, Aug 2008]

GeneCards Summary for ELOB Gene

ELOB (Elongin B) is a Protein Coding gene. Diseases associated with ELOB include Von Hippel-Lindau Syndrome and Renal Cell Carcinoma, Nonpapillary. Among its related pathways are Gene Expression and Class I MHC mediated antigen processing and presentation.

UniProtKB/Swiss-Prot for ELOB Gene

  • SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7638163). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity).

  • The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.

Gene Wiki entry for ELOB Gene

Additional gene information for ELOB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELOB Gene

Genomics for ELOB Gene

GeneHancer (GH) Regulatory Elements for ELOB Gene

Promoters and enhancers for ELOB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J002774 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.0 16 4.6 CLOCK SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 POLR2B ZNF766 ELOB PIR54527 GC16P003522 ENSG00000276791 MTCO1P28 ZNF597 SRRM2 TBL3 SRRM2-AS1 TIGD7
GH16J002750 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.5 +24.2 24225 4.7 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 SRRM2 GC16P003532 SRRM2-AS1 ZNF75A ZNF263 TSC2 ERVK13-1 ZNF213-AS1 E4F1 ENSG00000261938
GH16J002867 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 11.4 -91.2 -91179 2 MLX DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D ZNF610 GLIS1 LOC101929566 GC16P003535 ENSG00000200059 ENSG00000261240 FLYWCH2 ZG16B FLYWCH1 PRSS41 SNORA3C PRSS33
GH16J002427 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 3.1 +348.0 348049 2.8 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZBTB7B POLR2B E2F8 ZNF207 CCNF TBL3 AMDHD2 CRAMP1 ENSG00000260051 ZNF263 TELO2 ZNF200 E4F1 ZNF75A
GH16J002756 Enhancer 0.5 ENCODE 12.5 +20.8 20773 0.1 HDGF ZFHX2 ZNF473 POLR2A RBM22 ZBTB33 EGR2 ELOB PRSS33 PRSS41 SNORA3C ZNF200 PRSS27 RNF151 PRSS22 ENSG00000260447 ENSG00000263235
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ELOB on UCSC Golden Path with GeneCards custom track

Genomic Locations for ELOB Gene

Genomic Locations for ELOB Gene
chr16:2,771,414-2,777,297
(GRCh38/hg38)
Size:
5,884 bases
Orientation:
Minus strand
chr16:2,821,415-2,827,298
(GRCh37/hg19)
Size:
5,884 bases
Orientation:
Minus strand

Genomic View for ELOB Gene

Genes around ELOB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELOB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELOB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELOB Gene

Proteins for ELOB Gene

  • Protein details for ELOB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15370-ELOB_HUMAN
    Recommended name:
    Elongin-B
    Protein Accession:
    Q15370
    Secondary Accessions:
    • B7WPD3

    Protein attributes for ELOB Gene

    Size:
    118 amino acids
    Molecular mass:
    13133 Da
    Quaternary structure:
    • Heterotrimer of an A (ELOA, ELOA2 or ELOA3), ELOB and ELOC subunit (PubMed:10205047, PubMed:17997974). The elongin BC complex interacts with EPOP; leading to recruit the elongin BC complex to Polycomb group (PcG) target genes, thereby restricting excessive activity of the PRC2/EED-EZH2 complex (By similarity). Part of E3 ubiquitin ligase complexes with CUL5 or CUL2, RBX1 and a substrate adapter protein that can be either SOCS1, SOCS5, ELOA, VHL or WSB1 (PubMed:15590694, PubMed:22286099). Interacts with VHL (PubMed:10205047, PubMed:11006129). Found in a complex composed of LIMD1, VHL, EGLN1/PHD2, ELOB and CUL2. Interacts with SPSB1 (PubMed:17189197). Interacts with KLHDC10; which may be an E3 ubiquitin ligase complex substrate recognition component (PubMed:23102700).
    • (Microbial infection) Substrate adapter protein can be a viral protein such as HIV Vif.
    SequenceCaution:
    • Sequence=AAC08452.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ELOB Gene

    Alternative splice isoforms for ELOB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELOB Gene

Post-translational modifications for ELOB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ELOB Gene

No data available for DME Specific Peptides for ELOB Gene

Domains & Families for ELOB Gene

Gene Families for ELOB Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ELOB Gene

Suggested Antigen Peptide Sequences for ELOB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ELOB: view

No data available for UniProtKB/Swiss-Prot for ELOB Gene

Function for ELOB Gene

Molecular function for ELOB Gene

UniProtKB/Swiss-Prot Function:
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7638163). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity).
UniProtKB/Swiss-Prot Function:
The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.

Phenotypes From GWAS Catalog for ELOB Gene

Gene Ontology (GO) - Molecular Function for ELOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 10205047
GO:0031625 ubiquitin protein ligase binding IDA 17636018
genes like me logo Genes that share ontologies with ELOB: view
genes like me logo Genes that share phenotypes with ELOB: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ELOB

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ELOB Gene

Localization for ELOB Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELOB Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ELOB gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for ELOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0030891 VCB complex IBA --
GO:0031462 Cul2-RING ubiquitin ligase complex IDA 17636018
genes like me logo Genes that share ontologies with ELOB: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ELOB Gene

Pathways & Interactions for ELOB Gene

genes like me logo Genes that share pathways with ELOB: view

UniProtKB/Swiss-Prot Q15370-ELOB_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ELOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
GO:0006414 translational elongation IEA --
genes like me logo Genes that share ontologies with ELOB: view

No data available for SIGNOR curated interactions for ELOB Gene

Drugs & Compounds for ELOB Gene

(1) Drugs for ELOB Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ELOB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ELOB: view

Transcripts for ELOB Gene

mRNA/cDNA for ELOB Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ELOB

Alternative Splicing Database (ASD) splice patterns (SP) for ELOB Gene

No ASD Table

Relevant External Links for ELOB Gene

GeneLoc Exon Structure for
ELOB
ECgene alternative splicing isoforms for
ELOB

Expression for ELOB Gene

NURSA nuclear receptor signaling pathways regulating expression of ELOB Gene:

ELOB

Evidence on tissue expression from TISSUES for ELOB Gene

  • Liver(4.4)
  • Pancreas(4.4)
  • Nervous system(3.5)
  • Muscle(2.9)
  • Kidney(2.4)
  • Heart(2.3)
  • Gall bladder(2.1)
  • Lymph node(2.1)
  • Thyroid gland(2.1)
  • Adrenal gland(2)
  • Bone marrow(2)
  • Skin(2)
  • Stomach(2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ELOB Gene

Orthologs for ELOB Gene

This gene was present in the common ancestor of animals.

Orthologs for ELOB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCEB2 33
  • 99.38 (n)
-- 34
  • 98 (a)
OneToMany
-- 34
  • 97 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tceb2 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 34
  • 96 (a)
OneToMany
-- 34
  • 91 (a)
OneToMany
TCEB2 34 33
  • 88.42 (n)
OneToMany
-- 34
  • 84 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TCEB2 34
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 92 (a)
OneToMany
-- 34
  • 72 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC479873 33
  • 89.77 (n)
TCEB2 34
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100909963 33
  • 88.03 (n)
lizard
(Anolis carolinensis)
Reptilia TCEB2 34
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia tceb2-prov 33
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76322 33
zebrafish
(Danio rerio)
Actinopterygii tceb2 34 33
  • 85 (a)
OneToMany
TCEB2 (2 of 2) 34
  • 64 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13460 33
fruit fly
(Drosophila melanogaster)
Insecta Elongin-B 34
  • 53 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea elb-1 34
  • 36 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4437 34
  • 55 (a)
OneToOne
Species where no ortholog for ELOB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ELOB Gene

ENSEMBL:
Gene Tree for ELOB (if available)
TreeFam:
Gene Tree for ELOB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ELOB: view image

Paralogs for ELOB Gene

Pseudogenes.org Pseudogenes for ELOB Gene

genes like me logo Genes that share paralogs with ELOB: view

No data available for Paralogs for ELOB Gene

Variants for ELOB Gene

Sequence variations from dbSNP and Humsavar for ELOB Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000338801 -- 2,772,363(-) C/T intron_variant
rs1000375926 -- 2,777,447(-) T/A/C upstream_transcript_variant
rs1000705525 -- 2,771,078(-) G/C downstream_transcript_variant
rs1000721371 -- 2,774,875(-) G/A intron_variant
rs1001265857 -- 2,773,008(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ELOB Gene

Variant ID Type Subtype PubMed ID
esv2760067 CNV gain+loss 17122850
nsv471073 CNV loss 18288195
nsv827523 CNV gain 20364138

Variation tolerance for ELOB Gene

Residual Variation Intolerance Score: 86.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.98; 84.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ELOB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ELOB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELOB Gene

Disorders for ELOB Gene

MalaCards: The human disease database

(4) MalaCards diseases for ELOB Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
von hippel-lindau syndrome
  • vhl
renal cell carcinoma, nonpapillary
  • rcc
clear cell renal cell carcinoma
  • clear cell carcinoma of kidney
familial renal papillary carcinoma
  • hereditary papillary renal carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search ELOB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ELOB

genes like me logo Genes that share disorders with ELOB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ELOB Gene

Publications for ELOB Gene

  1. Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation. (PMID: 15574592) Mehle A … Gabuzda D (Genes & development 2004) 3 4 22 58
  2. Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity. (PMID: 11006129) Aso T … Kitajima S (Biochemical and biophysical research communications 2000) 3 4 22 58
  3. Positive regulation of general transcription factor SIII by a tailed ubiquitin homolog. (PMID: 7638163) Garrett KP … Conaway JW (Proceedings of the National Academy of Sciences of the United States of America 1995) 2 3 4 58
  4. The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. (PMID: 22286099) Foxler DE … Sharp TV (Nature cell biology 2012) 3 4 58
  5. NEDD8 acts as a 'molecular switch' defining the functional selectivity of VHL. (PMID: 18323857) Russell RC … Ohh M (EMBO reports 2008) 3 22 58

Products for ELOB Gene

Sources for ELOB Gene

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