Aliases for ELMO3 Gene
External Ids for ELMO3 Gene
Previous GeneCards Identifiers for ELMO3 Gene
The protein encoded by this gene is similar to a C. elegans protein that functions in phagocytosis of apoptotic cells and in cell migration. Other members of this small family of engulfment and cell motility (ELMO) proteins have been shown to interact with the dedicator of cyto-kinesis 1 protein to promote phagocytosis and effect cell shape changes. [provided by RefSeq, Jul 2008]
GeneCards Summary for ELMO3 Gene
ELMO3 (Engulfment And Cell Motility 3) is a Protein Coding gene. Diseases associated with ELMO3 include Salivary Gland Carcinoma and Hemophagocytic Lymphohistiocytosis, Familial, 2. Among its related pathways are Bacterial invasion of epithelial cells. Gene Ontology (GO) annotations related to this gene include binding and SH3 domain binding. An important paralog of this gene is ELMO1.
UniProtKB/Swiss-Prot Summary for ELMO3 Gene
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity).