Aliases for ELK4 Gene
External Ids for ELK4 Gene
Previous GeneCards Identifiers for ELK4 Gene
This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ELK4 Gene
ELK4 (ETS Transcription Factor ELK4) is a Protein Coding gene. Diseases associated with ELK4 include Lung Acinar Adenocarcinoma. Among its related pathways are Transcriptional misregulation in cancer and NGF Pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is ELK3.
UniProtKB/Swiss-Prot Summary for ELK4 Gene
Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously.