This gene encodes a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the... See more...

Aliases for ELK3 Gene

Aliases for ELK3 Gene

  • ETS Transcription Factor ELK3 2 3 5
  • SRF Accessory Protein 2 2 3 4
  • SAP2 2 3 4
  • NET 2 3 4
  • ELK3, ETS-Domain Protein (SRF Accessory Protein 2) 2 3
  • Serum Response Factor Accessory Protein 2 3 4
  • ETS Domain-Containing Protein Elk-3 3 4
  • ETS-Related Protein ERP 3 4
  • ETS-Related Protein NET 3 4
  • SAP-2 3 4
  • ERP 2 3
  • ELK3, ETS Transcription Factor 3
  • ELK3 5

External Ids for ELK3 Gene

Previous GeneCards Identifiers for ELK3 Gene

  • GC12P096023
  • GC12P096951
  • GC12P096521
  • GC12P095090
  • GC12P093649

Summaries for ELK3 Gene

Entrez Gene Summary for ELK3 Gene

  • This gene encodes a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for ELK3 Gene

ELK3 (ETS Transcription Factor ELK3) is a Protein Coding gene. Diseases associated with ELK3 include Yellow Nail Syndrome and Liver Sarcoma. Among its related pathways are NGF Pathway and Beta-Adrenergic Signaling. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is ELK4.

UniProtKB/Swiss-Prot Summary for ELK3 Gene

  • May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.

Gene Wiki entry for ELK3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ELK3 Gene

Genomics for ELK3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ELK3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J096192 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 612.3 +2.2 2209 7.7 SP1 PRDM10 JUND FOXA1 LARP7 STAT3 RELA ZIC2 ZSCAN4 PKNOX1 ELK3 LTA4H piR-54132 CDK17
GH12J096206 Promoter/Enhancer 0.7 EPDnew ENCODE dbSUPER 600.4 +11.7 11742 0.2 ELK3 piR-54132 CDK17
GH12J096419 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 31.7 +231.5 231504 12.6 CREB1 ATF7 ZNF629 PRDM1 IKZF2 ZNF501 ZNF341 PKNOX1 CEBPA MNT CDK17 RF00017-1216 RF00100-031 RN7SKP11 lnc-CDK17-6 ELK3 METAP2 USP44 CFAP54 SNRPF
GH12J095941 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 31 -251.3 -251303 2.5 HNRNPL PRDM10 ZNF629 TFE3 CTCF ZNF692 POLR2A RCOR2 GABPA PRDM1 AMDHD1 CCDC38 RF00017-1212 lnc-HAL-2 NR2C1 ELK3 METAP2 SNRPF USP44 LTA4H
GH12J095652 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 31.8 -540.6 -540643 2.4 CEBPG CREB1 GATAD2A TFE3 IKZF1 RFX1 RXRB REST IKZF2 ZNF331 NR2C1 ELK3 METAP2 SNRPF NTN4 USP44 VEZT LTA4H piR-34822-070 lnc-USP44-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ELK3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ELK3

Top Transcription factor binding sites by QIAGEN in the ELK3 gene promoter:
  • C/EBPbeta
  • COMP1
  • CUTL1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • RORalpha2

Genomic Locations for ELK3 Gene

Genomic Locations for ELK3 Gene
chr12:96,194,375-96,269,824
(GRCh38/hg38)
Size:
75,450 bases
Orientation:
Plus strand
chr12:96,588,160-96,663,613
(GRCh37/hg19)
Size:
75,454 bases
Orientation:
Plus strand

Genomic View for ELK3 Gene

Genes around ELK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELK3 Gene

Proteins for ELK3 Gene

  • Protein details for ELK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41970-ELK3_HUMAN
    Recommended name:
    ETS domain-containing protein Elk-3
    Protein Accession:
    P41970
    Secondary Accessions:
    • B2R6S6
    • Q6FG57
    • Q6GU29
    • Q9UD17

    Protein attributes for ELK3 Gene

    Size:
    407 amino acids
    Molecular mass:
    44240 Da
    Quaternary structure:
    • Interacts with CTBP1.

neXtProt entry for ELK3 Gene

Post-translational modifications for ELK3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ELK3 Gene

No data available for DME Specific Peptides for ELK3 Gene

Domains & Families for ELK3 Gene

Gene Families for ELK3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ELK3 Gene

Suggested Antigen Peptide Sequences for ELK3 Gene

GenScript: Design optimal peptide antigens:
  • Serum response factor accessory protein 2 (ELK3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P41970

UniProtKB/Swiss-Prot:

ELK3_HUMAN :
  • Belongs to the ETS family.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ELK3: view

Function for ELK3 Gene

Molecular function for ELK3 Gene

UniProtKB/Swiss-Prot Function:
May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.
GENATLAS Biochemistry:
ets related protooncogene 3,homologous to murine Net (Erp),ubiquitous but expressed primarily at early stages of B-lymphocyte development with a drastic decline,upon B-cell maturation,activated by RAS,divergent member of the winged helix-turn-helix superfamily

Phenotypes From GWAS Catalog for ELK3 Gene

Gene Ontology (GO) - Molecular Function for ELK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 12788937
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IDA 12933792
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 12788937
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with ELK3: view
genes like me logo Genes that share phenotypes with ELK3: view

Animal Models for ELK3 Gene

MGI Knock Outs for ELK3:
  • Elk3 Elk3<tm1Wlyk>
  • Elk3 Elk3<tm1.2Ics>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ELK3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ELK3 Gene

Localization for ELK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELK3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ELK3 gene
Compartment Confidence
nucleus 5
mitochondrion 4
plasma membrane 1
extracellular 1
cytoskeleton 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ELK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA,IC 12933792
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with ELK3: view

Pathways & Interactions for ELK3 Gene

PathCards logo

SuperPathways for ELK3 Gene

SuperPathway Contained pathways
1 ERK Signaling
.61
.51
2 CNTF Signaling
.50
3 Beta-Adrenergic Signaling
.37
4 NGF Pathway
.75
5 ID signaling pathway
genes like me logo Genes that share pathways with ELK3: view

Pathways by source for ELK3 Gene

1 BioSystems pathway for ELK3 Gene
5 Qiagen pathways for ELK3 Gene
  • ERK Signaling
  • FLT3 Signaling
  • Insulin Receptor Pathway
  • Molecular Mechanisms of Cancer
  • TRKA Signaling

SIGNOR curated interactions for ELK3 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ELK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0001525 angiogenesis IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0007165 signal transduction TAS 7958835
genes like me logo Genes that share ontologies with ELK3: view

Drugs & Compounds for ELK3 Gene

No Compound Related Data Available

Transcripts for ELK3 Gene

mRNA/cDNA for ELK3 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ELK3

Alternative Splicing Database (ASD) splice patterns (SP) for ELK3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - - - -
SP2: -
SP3: - -
SP4: -
SP5:

Relevant External Links for ELK3 Gene

GeneLoc Exon Structure for
ELK3

Expression for ELK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ELK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ELK3 Gene

This gene is overexpressed in Liver (61.9) and Platelet (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ELK3 Gene



Protein tissue co-expression partners for ELK3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ELK3

SOURCE GeneReport for Unigene cluster for ELK3 Gene:

Hs.46523

Evidence on tissue expression from TISSUES for ELK3 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ELK3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ELK3 Gene

Orthologs for ELK3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ELK3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ELK3 30 31
  • 99.59 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ELK3 30 31
  • 92.7 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ELK3 30 31
  • 92.37 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ELK3 31
  • 90 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Elk3 30 17 31
  • 88.86 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Elk3 30
  • 88.86 (n)
Oppossum
(Monodelphis domestica)
Mammalia ELK3 31
  • 88 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ELK3 30 31
  • 81.9 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ELK3 31
  • 88 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia elk3 30
  • 72.54 (n)
African clawed frog
(Xenopus laevis)
Amphibia elk3-prov 30
Zebrafish
(Danio rerio)
Actinopterygii elk3 30 31
  • 70.81 (n)
OneToOne
Species where no ortholog for ELK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ELK3 Gene

ENSEMBL:
Gene Tree for ELK3 (if available)
TreeFam:
Gene Tree for ELK3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ELK3: view image

Paralogs for ELK3 Gene

(16) SIMAP similar genes for ELK3 Gene using alignment to 5 proteins:

  • ELK3_HUMAN
  • F8VUJ0_HUMAN
  • F8VZQ0_HUMAN
  • G3V1Z7_HUMAN
  • H0YIH6_HUMAN
genes like me logo Genes that share paralogs with ELK3: view

Variants for ELK3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ELK3 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
709509 Likely Benign: not provided 96,247,410(+) G/A MISSENSE_VARIANT
728966 Benign: not provided 96,259,860(+) G/A INTRON_VARIANT
773263 Likely Benign: not provided 96,247,343(+) C/T MISSENSE_VARIANT
778645 Benign: not provided 96,247,566(+) G/A SYNONYMOUS_VARIANT
779607 Benign: not provided 96,259,757(+) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ELK3 Gene

Structural Variations from Database of Genomic Variants (DGV) for ELK3 Gene

Variant ID Type Subtype PubMed ID
dgv2805n54 CNV loss 21841781
dgv2806n54 CNV gain 21841781
dgv2807n54 CNV loss 21841781
dgv858n106 CNV tandem duplication 24896259
esv26105 CNV loss 19812545
esv3549624 CNV deletion 23714750
esv3630447 CNV loss 21293372
nsv1035411 CNV gain 25217958
nsv1113511 CNV deletion 24896259
nsv559837 CNV loss 21841781
nsv559841 CNV loss 21841781
nsv559842 CNV gain 21841781
nsv559846 CNV loss 21841781
nsv559848 CNV gain 21841781
nsv7234 OTHER inversion 18451855
nsv836 CNV insertion 18451855

Variation tolerance for ELK3 Gene

Residual Variation Intolerance Score: 59.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.90; 48.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ELK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ELK3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELK3 Gene

Disorders for ELK3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ELK3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
yellow nail syndrome
  • yns
liver sarcoma
  • hepatic sarcoma
peho syndrome
  • peho
- elite association - COSMIC cancer census association via MalaCards
Search ELK3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ELK3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ELK3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ELK3 Gene

Publications for ELK3 Gene

  1. Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET). (PMID: 7540136) Price MA … Treisman R (The EMBO journal 1995) 3 4 23
  2. Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively. (PMID: 7851904) Shipley J … Patel K (Genomics 1994) 2 3 23
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif. (PMID: 8918463) Maira SM … Wasylyk B (The EMBO journal 1996) 3 23

Products for ELK3 Gene

Sources for ELK3 Gene