Aliases for ELF5 Gene
External Ids for ELF5 Gene
Previous GeneCards Identifiers for ELF5 Gene
The protein encoded by this gene is a member of an epithelium-specific subclass of the Ets transcritpion factor family. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]
GeneCards Summary for ELF5 Gene
ELF5 (E74 Like ETS Transcription Factor 5) is a Protein Coding gene. Diseases associated with ELF5 include Luminal Breast Carcinoma and Isolated Growth Hormone Deficiency, Type Ii. Among its related pathways are Prolactin Signaling Pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is EHF.
UniProtKB/Swiss-Prot for ELF5 Gene
Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation.
Isoform 2 binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates SPRR2A and the parotid gland-specific PSP promoters.