Aliases for ELF4 Gene
External Ids for ELF4 Gene
Previous GeneCards Identifiers for ELF4 Gene
The protein encoded by this gene is a transcriptional activator that binds and activates the promoters of the CSF2, IL3, IL8, and PRF1 genes. The encoded protein is involved in natural killer cell development and function, innate immunity, and induction of cell cycle arrest in naive CD8+ cells. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010]
GeneCards Summary for ELF4 Gene
ELF4 (E74 Like ETS Transcription Factor 4) is a Protein Coding gene. Diseases associated with ELF4 include Isolated Growth Hormone Deficiency, Type Iii, With Agammaglobulinemia and Myeloid Leukemia. Among its related pathways are AMP-activated Protein Kinase (AMPK) Signaling. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is ELF1.
UniProtKB/Swiss-Prot Summary for ELF4 Gene
Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway.