Aliases for ELF3 Gene

Aliases for ELF3 Gene

  • E74 Like ETS Transcription Factor 3 2 3 5
  • ESE-1 2 3 4
  • ERT 2 3 4
  • E74-Like Factor 3 (Ets Domain Transcription Factor, Epithelial-Specific ) 2 3
  • Epithelium-Specific Ets Transcription Factor 1 3 4
  • ETS-Related Transcription Factor Elf-3 3 4
  • Epithelial-Restricted With Serine Box 3 4
  • Epithelium-Restricted Ets Protein ESX 3 4
  • EPR-1 2 3
  • ESX 3 4
  • E74-Like Factor 3 (ETS Domain Transcription Factor, Serine Box, Epithelial-Specific) 3
  • Ets Domain Transcription Factor, Serine Box (Epithelial-Specific) 3
  • E74-Like Factor 3 (Ets Domain Transcription Factor) 3
  • E74-Like Factor 3 4
  • ELF3 5
  • JEN 4

External Ids for ELF3 Gene

Previous HGNC Symbols for ELF3 Gene

  • ESX

Previous GeneCards Identifiers for ELF3 Gene

  • GC01P199635
  • GC01P197413
  • GC01P198446
  • GC01P199265
  • GC01P198708
  • GC01P200243
  • GC01P201977
  • GC01P173145

Summaries for ELF3 Gene

GeneCards Summary for ELF3 Gene

ELF3 (E74 Like ETS Transcription Factor 3) is a Protein Coding gene. Diseases associated with ELF3 include Sarcoma, Synovial and Ampulla Of Vater Cancer. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is EHF.

UniProtKB/Swiss-Prot Summary for ELF3 Gene

  • Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity).

Additional gene information for ELF3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ELF3 Gene

Genomics for ELF3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ELF3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ELF3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ELF3

Top Transcription factor binding sites by QIAGEN in the ELF3 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • E2F-1
  • E2F-2
  • Sp1

Genomic Locations for ELF3 Gene

Genomic Locations for ELF3 Gene
chr1:202,007,945-202,017,183
(GRCh38/hg38)
Size:
9,239 bases
Orientation:
Plus strand
chr1:201,977,073-201,986,316
(GRCh37/hg19)
Size:
9,244 bases
Orientation:
Plus strand

Genomic View for ELF3 Gene

Genes around ELF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELF3 Gene

Proteins for ELF3 Gene

  • Protein details for ELF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78545-ELF3_HUMAN
    Recommended name:
    ETS-related transcription factor Elf-3
    Protein Accession:
    P78545
    Secondary Accessions:
    • B2R5Q6
    • Q6IAP8
    • Q7RU03
    • Q7Z3X2
    • Q8NFG2
    • Q99718

    Protein attributes for ELF3 Gene

    Size:
    371 amino acids
    Molecular mass:
    41454 Da
    Quaternary structure:
    • Interacts with TBP. Interacts with CREBBP and EP300; these act as transcriptional coactivators of ELF3 and positively modulate its function. Interacts with XRCC5/KU86 and XRCC6/KU70; these inhibit the ability of ELF3 to bind DNA and negatively modulate its transcriptional activity. Associated with CLND7 and POU2F3.

    Three dimensional structures from OCA and Proteopedia for ELF3 Gene

    Alternative splice isoforms for ELF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELF3 Gene

Post-translational modifications for ELF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ELF3 Gene

No data available for DME Specific Peptides for ELF3 Gene

Domains & Families for ELF3 Gene

Gene Families for ELF3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ELF3 Gene

InterPro:
Blocks:
  • Sterile alpha motif (SAM)/Pointed domain
ProtoNet:

Suggested Antigen Peptide Sequences for ELF3 Gene

GenScript: Design optimal peptide antigens:
  • Epithelium-specific Ets transcription factor 1 (ELF3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P78545

UniProtKB/Swiss-Prot:

ELF3_HUMAN :
  • the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
  • Belongs to the ETS family.
Domain:
  • the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ELF3: view

Function for ELF3 Gene

Molecular function for ELF3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity).
UniProtKB/Swiss-Prot Induction:
Transcriptionally regulated by ERBB2 receptor signaling in breast cancer epithelial cells. Up-regulated by phorbol 12-myristate 13-acetate (PMA) in bronchial epithelial cells. By retinoic acid in MCF-7 mammary epithelial cells (at protein level).
GENATLAS Biochemistry:
E74-like factor 3,transcription regulator family,expressed in the majority of epithelial cell types,targetting SPR2A during keratinocyte differentiation,putative regulation of epithelial cell differentiation,overexpressed in breast tumorigenesis

Phenotypes From GWAS Catalog for ELF3 Gene

Gene Ontology (GO) - Molecular Function for ELF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA,NAS 9234700
genes like me logo Genes that share ontologies with ELF3: view
genes like me logo Genes that share phenotypes with ELF3: view

Animal Models for ELF3 Gene

MGI Knock Outs for ELF3:
  • Elf3 Elf3<tm1Pjh>
  • Elf3 Elf3<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ELF3

Clone Products

  • Addgene plasmids for ELF3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ELF3 Gene

Localization for ELF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELF3 Gene

Cytoplasm. Nucleus. Note=Localizes to the cytoplasm where it has been shown to transform MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A and MCF-12A via a transcription-dependent mechanism. {ECO:0000269 PubMed:10391676, ECO:0000269 PubMed:15169914, ECO:0000269 PubMed:17060315}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ELF3 gene
Compartment Confidence
nucleus 5
cytosol 4
golgi apparatus 4
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ELF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA,NAS 9234700
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with ELF3: view

Pathways & Interactions for ELF3 Gene

PathCards logo

SuperPathways for ELF3 Gene

No Data Available

SIGNOR curated interactions for ELF3 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for ELF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001824 blastocyst development IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0006366 transcription by RNA polymerase II IEA --
GO:0006954 inflammatory response IEA,IEP 14715662
genes like me logo Genes that share ontologies with ELF3: view

No data available for Pathways by source for ELF3 Gene

Drugs & Compounds for ELF3 Gene

(2) Drugs for ELF3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for ELF3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ELF3: view

Transcripts for ELF3 Gene

mRNA/cDNA for ELF3 Gene

2 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ELF3

Clone Products

  • Addgene plasmids for ELF3

Alternative Splicing Database (ASD) splice patterns (SP) for ELF3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d · 9e ^ 10a ·
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - - -
SP8: - - -
SP9: - - -
SP10: - -
SP11: - - - -
SP12: -
SP13: - - - - - - - - - - - - - - - -
SP14: -
SP15:
SP16:

ExUns: 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - - - -
SP14:
SP15:
SP16: -

Relevant External Links for ELF3 Gene

GeneLoc Exon Structure for
ELF3

Expression for ELF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ELF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ELF3 Gene

This gene is overexpressed in Bladder (x6.6), Esophagus - Mucosa (x6.2), Colon - Transverse (x6.1), and Minor Salivary Gland (x5.6).

Protein differential expression in normal tissues from HIPED for ELF3 Gene

This gene is overexpressed in Cervix (35.3), Tlymphocyte (21.4), and Monocytes (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ELF3 Gene



Protein tissue co-expression partners for ELF3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ELF3

SOURCE GeneReport for Unigene cluster for ELF3 Gene:

Hs.603657

mRNA Expression by UniProt/SwissProt for ELF3 Gene:

P78545-ELF3_HUMAN
Tissue specificity: Expressed exclusively in tissues containing a high content of terminally differentiated epithelial cells including mammary gland, colon, trachea, kidney, prostate, uterus, stomach and skin.

Evidence on tissue expression from TISSUES for ELF3 Gene

  • Intestine(4.7)
  • Lung(4.4)
  • Eye(4.2)
  • Pancreas(3.1)
  • Stomach(3.1)
  • Kidney(3)
  • Liver(2.7)
  • Gall bladder(2.4)
  • Skin(2.4)
  • Heart(2.1)
  • Blood(2.1)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with ELF3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ELF3 Gene

Orthologs for ELF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ELF3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ELF3 30 31
  • 99.55 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ELF3 30 31
  • 87.08 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Elf3 30 17 31
  • 85.14 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Elf3 30
  • 85.14 (n)
Cow
(Bos Taurus)
Mammalia ELF3 30 31
  • 83.47 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ELF3 31
  • 81 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ELF3 31
  • 71 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ELF3 30 31
  • 72.87 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ELF3 31
  • 59 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia elf3 30
  • 56.76 (n)
Zebrafish
(Danio rerio)
Actinopterygii elf3 30 31
  • 52.91 (n)
OneToOne
wufb06f04 30
Fruit Fly
(Drosophila melanogaster)
Insecta aop 31
  • 12 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea tag-97 31
  • 19 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 12 (a)
OneToMany
Species where no ortholog for ELF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ELF3 Gene

ENSEMBL:
Gene Tree for ELF3 (if available)
TreeFam:
Gene Tree for ELF3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ELF3: view image

Paralogs for ELF3 Gene

(2) SIMAP similar genes for ELF3 Gene using alignment to 2 proteins:

  • ELF3_HUMAN
  • Q5SR36_HUMAN
genes like me logo Genes that share paralogs with ELF3: view

Variants for ELF3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ELF3 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
775154 Benign: not provided 202,012,105(+) T/C SYNONYMOUS_VARIANT
rs1135542 - p.Gln317Lys

Additional dbSNP identifiers (rs#s) for ELF3 Gene

Structural Variations from Database of Genomic Variants (DGV) for ELF3 Gene

Variant ID Type Subtype PubMed ID
nsv516812 CNV loss 19592680

Variation tolerance for ELF3 Gene

Residual Variation Intolerance Score: 59.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.86; 67.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ELF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ELF3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELF3 Gene

Disorders for ELF3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ELF3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
sarcoma, synovial
  • synovial sarcoma
ampulla of vater cancer
  • malignant tumour of ampulla of vater
gastrointestinal anthrax
isolated growth hormone deficiency, type ii
  • ighd2
breast cancer
  • breast lobular carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search ELF3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ELF3

genes like me logo Genes that share disorders with ELF3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ELF3 Gene

Publications for ELF3 Gene

  1. A novel epithelial-expressed ETS gene, ELF3: human and murine cDNA sequences, murine genomic organization, human mapping to 1q32.2 and expression in tissues and cancer. (PMID: 9395241) Tymms MJ … Kola I (Oncogene 1997) 2 3 4 23
  2. Expression of claudin7 is tightly associated with epithelial structures in synovial sarcomas and regulated by an Ets family transcription factor, ELF3. (PMID: 17060315) Kohno Y … Toguchida J (The Journal of biological chemistry 2006) 3 4 23
  3. Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86. (PMID: 15075319) Wang H … Oettgen P (The Journal of biological chemistry 2004) 3 4 23
  4. ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation. (PMID: 14715662) Brown C … Oettgen P (The Journal of biological chemistry 2004) 3 4 23
  5. ESX induces transformation and functional epithelial to mesenchymal transition in MCF-12A mammary epithelial cells. (PMID: 14767472) Schedin PJ … Gutierrez-Hartmann A (Oncogene 2004) 3 4 23

Products for ELF3 Gene

  • Signalway Proteins for ELF3

Sources for ELF3 Gene