Aliases for ELF1 Gene
Aliases for ELF1 Gene
External Ids for ELF1 Gene
- HGNC: 3316
- Entrez Gene: 1997
- Ensembl: ENSG00000120690
- OMIM: 189973
- UniProtKB: P32519
Previous GeneCards Identifiers for ELF1 Gene
- GC13M039492
- GC13M035492
- GC13M040442
- GC13M039304
- GC13M040404
- GC13M041506
- GC13M022305
Summaries for ELF1 Gene
-
This gene encodes an E26 transformation-specific related transcription factor. The encoded protein is primarily expressed in lymphoid cells and acts as both an enhancer and a repressor to regulate transcription of various genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]
GeneCards Summary for ELF1 Gene
ELF1 (E74 Like ETS Transcription Factor 1) is a Protein Coding gene. Diseases associated with ELF1 include T-Cell Leukemia. Among its related pathways are Immune response IL-23 signaling pathway and Immune response IL-2 activation and signaling pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is ELF4.
UniProtKB/Swiss-Prot for ELF1 Gene
-
Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer.
Additional gene information for ELF1 Gene
- Monarch Initiative
- Search for ELF1 at DataMed
- Search for ELF1 at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELF1 Gene
Genomics for ELF1 Gene
GeneHancer (GH) Regulatory Elements for ELF1 Gene
Promoters and enhancers for ELF1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ELF1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ELF1 gene promoter:
-
- GATA-1
- AREB6
- AML1a
- GCNF-2
- GCNF-1
- GCNF
- p53
- C/EBPbeta
- AP-1
- FAC1
Regulatory Element Products
Genomic Locations for ELF1 Gene
Genomic Locations for ELF1 Gene
- chr13:40,931,919-41,061,440
- (GRCh38/hg38)
- Size:
- 129,522 bases
- Orientation:
- Minus strand
- chr13:41,506,055-41,635,576
- (GRCh37/hg19)
- Size:
- 129,522 bases
- Orientation:
- Minus strand
Genomic View for ELF1 Gene
Genes around ELF1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 13q14.11 by Entrez Gene
- 13q14.11 by HGNC
- 13q14.11 by Ensembl
ELF1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ELF1 Gene
Proteins for ELF1 Gene
-
Protein details for ELF1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P32519-ELF1_HUMAN
- Recommended name:
- ETS-related transcription factor Elf-1
- Protein Accession:
- P32519
- B4E2I5
- E9PDQ9
- Q8N6F6
- Q9UDE1
Protein attributes for ELF1 Gene
- Size:
- 619 amino acids
- Molecular mass:
- 67498 Da
- Quaternary structure:
-
- Binds to the underphosphorylated form of RB. May interact with other transcription factors in order to regulate specific genes. Interacts with RUNX1.
Protein Expression for ELF1 Gene
Post-translational modifications for ELF1 Gene
Other Protein References for ELF1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ELF1
- Invitrogen Antibodies for ELF1
- GeneTex ELF1 Antibody for ELF1
-
Santa Cruz Biotechnology (SCBT) Antibodies for ELF1
Protein Products
-
OriGene Purified Proteins for ELF1
- Search Origene for MassSpec and Protein Over-expression Lysates for ELF1
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- antibodies-online: Search results for 5 available ELF1 Proteins ranked by validation data
- Compare Top ELF1 Proteins
-
Quality Products:
- Search GeneTex for Proteins for ELF1
Assay Products
- antibodies-online: Search results for 2 available ELF1 Elisa Kits ranked by validation data
- Compare Top ELF1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for ELF1 Gene
Domains & Families for ELF1 Gene
Gene Families for ELF1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ELF1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ELF1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P32519- Family:
-
- Belongs to the ETS family.
Function for ELF1 Gene
Molecular function for ELF1 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer.
- GENATLAS Biochemistry:
- E74-like factor 1,ETS transcription regulator family,expressed in lymphoid and myeloid cells,binding to both the Ets binding sites (EBS1,EBS2) of IL2 enhancer,also binding to RB1 in resting normal T cells
Phenotypes From GWAS Catalog for ELF1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 8756667 |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAS | 19274049 |
| GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 8756667 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA binding transcription factor activity | IEA,IDA | 14970218 |
Phenotypes for ELF1 Gene
- MGI mutant phenotypes for ELF1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ELF1:
Animal Models for ELF1 Gene
- MGI Knock Outs for ELF1:
-
- Elf1 Elf1<tm1Jml>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ELF1
-
CRISPR Products
-
OriGene CRISPR knockouts for ELF1
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- genomics-online: gRNA clones - Search results for 101 available ELF1 gene related products
- Overview of 101 available ELF1 gene related products
- Applied Biological Materials CRISPR for ELF1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ELF1
- GenScript: Design CRISPR guide RNA sequences for ELF1
miRNA for ELF1 Gene
- miRTarBase miRNAs that target ELF1
Targeted motifs for ELF1 Gene
HOMER Transcription Factor Regulatory Elements motif ELF1
- Consensus sequence: AACCGGAAGT Submotif: canonical Cell Type: Jurkat GEO ID: SRA014231
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ELF1
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- genomics-online: shRNA clones - Search results for 101 available ELF1 gene related products
- Overview of 101 available ELF1 gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for ELF1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ELF1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ELF1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ELF1
- Applied Biological Materials Clones for ELF1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ELF1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for ELF1 Gene
Localization for ELF1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ELF1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 19674970 |
| GO:0005654 | nucleoplasm | TAS | -- |
Pathways & Interactions for ELF1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Immune response IL-2 activation and signaling pathway | ||
| 2 | Immune response IL-23 signaling pathway | ||
| 3 | IL2 signaling events mediated by PI3K | ||
| 4 | Regulation of retinoblastoma protein | ||
Pathways by source for ELF1 Gene
3 BioSystems pathways for ELF1 Gene
2 GeneGo (Thomson Reuters) pathways for ELF1 Gene
Interacting Proteins for ELF1 Gene
Selected Interacting proteins:
P32519-ELF1_HUMAN
ENSP00000239882
for ELF1 Gene via
IID
UniProtKB
STRING
GPS-Prot Interaction Network for ELF1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001817 | regulation of cytokine production | IEA | -- |
| GO:0001959 | regulation of cytokine-mediated signaling pathway | TAS | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IBA | -- |
No data available for SIGNOR curated interactions for ELF1 Gene
Transcripts for ELF1 Gene
mRNA/cDNA for ELF1 Gene
- (6) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (305) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000239882 3566 bps (uc001uxs.4)
- ENST00000405737 903 bps (uc058wpi.1)
- ENST00000498824 3563 bps (uc058wph.1)
- ENST00000625359 2032 bps (uc010tfc.3)
- ENST00000635415 2116 bps (uc284njs.1)
Unigene Clusters for ELF1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ELF1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ELF1
- genomics-online: gRNA clones - Search results for 101 available ELF1 gene related products
- Overview of 101 available ELF1 gene related products
- Applied Biological Materials CRISPR for ELF1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ELF1
- GenScript: Design CRISPR guide RNA sequences for ELF1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ELF1
- Browse OriGene Inhibitory RNA Products For ELF1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ELF1
- genomics-online: shRNA clones - Search results for 101 available ELF1 gene related products
- Overview of 101 available ELF1 gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for ELF1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ELF1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ELF1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ELF1
- Applied Biological Materials Clones for ELF1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c |
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| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||
| SP7: | - |
Expression for ELF1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in CD8 Tcells (25.1), Peripheral blood mononuclear cells (11.8), Blymphocyte (9.9), and NK cells (9.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ELF1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ELF1 Gene:
ELF1SOURCE GeneReport for Unigene cluster for ELF1 Gene:
Hs.135646mRNA Expression by UniProt/SwissProt for ELF1 Gene:
P32519-ELF1_HUMAN
Tissue specificity:
In fetal tissues, it is highly expressed in heart, lung liver and kidney, and weakly expressed in brain. In adult, it is highly expressed in pancreas, spleen, thymus and peripheral blood leukocytes, expressed at moderate levels in heart, placenta, lung, liver, skeletal muscle, kidney, prostate, ovary, small intestine and colon, and weakly expressed in brain and testis.
Evidence on tissue expression from TISSUES for ELF1 Gene
- Liver(4.3)
- Nervous system(2.5)
- Spleen(2.2)
- Blood(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for ELF1
-
OriGene qPCR primer pairs for ELF1
- genomics-online: primer clones - Search results for 101 available ELF1 gene related products
- Overview of 101 available ELF1 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ELF1 Gene
Orthologs for ELF1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ELF1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ELF1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Elf1 16 34 33 |
|
||
| cow (Bos Taurus) |
Mammalia | ELF1 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Elf1 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ELF1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ELF1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ELF1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ELF1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | elf1 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | elf-1-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ef1 33 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1074 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Eip74EF 35 |
|
|
|
| worm (Caenorhabditis elegans) |
Secernentea | C24A1.2 35 |
|
|
|
| ets-8 34 |
|
ManyToMany | |||
| elf-1 34 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for ELF1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for ELF1 Gene
- ENSEMBL:
- Gene Tree for ELF1 (if available)
- TreeFam:
- Gene Tree for ELF1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ELF1: view image
Paralogs for ELF1 Gene
Variants for ELF1 Gene
| SNP ID | Clin | Chr 13 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000010532 | -- | 41,034,609(-) | AA/ | genic_upstream_transcript_variant, intron_variant | |
| rs1000031246 | -- | 41,058,727(-) | C/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000037688 | -- | 40,966,715(-) | A/T | intron_variant | |
| rs1000038690 | -- | 40,946,570(-) | C/T | intron_variant | |
| rs1000039882 | -- | 41,015,262(-) | G/A | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv952542 | CNV | duplication | 24416366 |
| nsv64500 | CNV | deletion | 16902084 |
| nsv561538 | CNV | loss | 21841781 |
| esv3373421 | CNV | duplication | 20981092 |
| esv2747298 | CNV | deletion | 23290073 |
| esv2747296 | CNV | deletion | 23290073 |
| esv2672182 | CNV | deletion | 23128226 |
| esv1709140 | CNV | deletion | 17803354 |
| dgv986e59 | CNV | tandem duplication | 20981092 |
Residual Variation Intolerance Score:
67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
16.00;
97.49% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ELF1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ELF1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELF1 Gene
Disorders for ELF1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| t-cell leukemia |
|
Search ELF1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ELF1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ELF1 Gene
Publications for ELF1 Gene
- cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1. (PMID: 1545787) Thompson CB … Karpinski B (Molecular and cellular biology 1992) 2 3 4 22 58
- Cloning of a novel human ELF-1-related ETS transcription factor, ELFR, its characterization and chromosomal assignment relative to ELF-1. (PMID: 9524226) Aryee DN … Kovar H (Gene 1998) 3 4 22 58
- Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1. (PMID: 8756667) Oettgen P … Libermann TA (Molecular and cellular biology 1996) 3 4 22 58
- Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein. (PMID: 8493578) Wang CY … Leiden JM (Science (New York, N.Y.) 1993) 3 4 22 58
- A novel Ets-related transcription factor, Elf-1, binds to human immunodeficiency virus type 2 regulatory elements that are required for inducible trans activation in T cells. (PMID: 1527846) Leiden JM … Thompson CB (Journal of virology 1992) 3 4 22 58
Products for ELF1 Gene
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- VectorBuilder custom plasmid, inducible vectors for ELF1
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ELF1
- antibodies-online: Search results for 90 available ELF1 Antibodies ranked by validation data
- Compare Top ELF1 Antibodies
- antibodies-online: Search results for 2 available ELF1 Elisa Kits ranked by validation data
- Compare Top ELF1 Elisa Kits
- Quality Products:
- antibodies-online: Search results for 5 available ELF1 Proteins ranked by validation data
- Compare Top ELF1 Proteins
- Quality Products:
- GeneTex ELF1 Antibody for ELF1
- Search GeneTex for Proteins for ELF1
- Santa Cruz Biotechnology (SCBT) Antibodies for ELF1
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- genomics-online: cdna clones - Search results for 101 available ELF1 gene related products
- Overview of 101 available ELF1 gene related products
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- Overview of 101 available ELF1 gene related products
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- Overview of 101 available ELF1 gene related products
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Sources for ELF1 Gene
- (1) GeneCards
- (2) HGNC
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