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Aliases for ELF1 Gene

Aliases for ELF1 Gene

  • E74 Like ETS Transcription Factor 1 2 3 5
  • E74-Like Factor 1 (Ets Domain Transcription Factor) 2 3
  • ETS-Related Transcription Factor Elf-1 3
  • E74-Like Factor 1 4
  • EFTUD1 3
  • RIA1 3

External Ids for ELF1 Gene

Previous GeneCards Identifiers for ELF1 Gene

  • GC13M039492
  • GC13M035492
  • GC13M040442
  • GC13M039304
  • GC13M040404
  • GC13M041506
  • GC13M022305

Summaries for ELF1 Gene

Entrez Gene Summary for ELF1 Gene

  • This gene encodes an E26 transformation-specific related transcription factor. The encoded protein is primarily expressed in lymphoid cells and acts as both an enhancer and a repressor to regulate transcription of various genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]

GeneCards Summary for ELF1 Gene

ELF1 (E74 Like ETS Transcription Factor 1) is a Protein Coding gene. Among its related pathways are Immune response IL-2 activation and signaling pathway and Regulation of retinoblastoma protein. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is ELF4.

UniProtKB/Swiss-Prot for ELF1 Gene

  • Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer.

Additional gene information for ELF1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELF1 Gene

Genomics for ELF1 Gene

GeneHancer (GH) Regulatory Elements for ELF1 Gene

Promoters and enhancers for ELF1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I040972 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 569.8 +81.7 81716 15.1 PKNOX1 ATF1 FOXA2 ARNT FEZF1 YY1 TCF12 ZNF143 ATF7 RUNX3 ELF1 WBP4 CYCSP34 SUGT1P3 RGCC NAA16 FOXO1 RGS17P1 PIR56183
GH13I041014 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 565.2 +43.3 43310 8.2 ATF1 FOXA2 SMAD1 ARNT ZNF2 IRF4 YY1 POLR2B E2F8 FOS ELF1 WBP4 SLC25A15 RGCC NAA16 GC13M041020 GC13M041021 GC13M041022 GC13M041023 GC13M041024
GH13I041056 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.1 147 9.7 MLX FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC WBP4 ELF1 TRE-TTC1-2 NAA16 TPTE2P5 MTRF1 RNU6-57P CYCSP34
GH13I040770 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12 +290.3 290343 1.9 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC MRPS31 KBTBD6 LINC00548 ELF1 FOXO1 SUGT1P3 NAA16 SLC25A15 ENSG00000277794
GH13I041001 Enhancer 1.4 Ensembl ENCODE dbSUPER 12.5 +56.1 56098 8.1 PKNOX1 FOXA2 MLX ARID4B DMAP1 IRF4 YY1 SLC30A9 FOS JUNB WBP4 ELF1 NAA16 CYCSP34 SLC25A15 RGS17P1 GC13M041023
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ELF1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ELF1 gene promoter:

Genomic Locations for ELF1 Gene

Genomic Locations for ELF1 Gene
chr13:40,931,919-41,061,440
(GRCh38/hg38)
Size:
129,522 bases
Orientation:
Minus strand
chr13:41,506,055-41,635,576
(GRCh37/hg19)

Genomic View for ELF1 Gene

Genes around ELF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELF1 Gene

Proteins for ELF1 Gene

  • Protein details for ELF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32519-ELF1_HUMAN
    Recommended name:
    ETS-related transcription factor Elf-1
    Protein Accession:
    P32519
    Secondary Accessions:
    • B4E2I5
    • E9PDQ9
    • Q8N6F6
    • Q9UDE1

    Protein attributes for ELF1 Gene

    Size:
    619 amino acids
    Molecular mass:
    67498 Da
    Quaternary structure:
    • Binds to the underphosphorylated form of RB. May interact with other transcription factors in order to regulate specific genes. Interacts with RUNX1.

    Alternative splice isoforms for ELF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELF1 Gene

Post-translational modifications for ELF1 Gene

  • Ubiquitination at Lys571
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ELF1 Gene

Domains & Families for ELF1 Gene

Gene Families for ELF1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ELF1 Gene

Suggested Antigen Peptide Sequences for ELF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P32519

UniProtKB/Swiss-Prot:

ELF1_HUMAN :
  • Belongs to the ETS family.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ELF1: view

Function for ELF1 Gene

Molecular function for ELF1 Gene

GENATLAS Biochemistry:
E74-like factor 1,ETS transcription regulator family,expressed in lymphoid and myeloid cells,binding to both the Ets binding sites (EBS1,EBS2) of IL2 enhancer,also binding to RB1 in resting normal T cells
UniProtKB/Swiss-Prot Function:
Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer.

Phenotypes From GWAS Catalog for ELF1 Gene

Gene Ontology (GO) - Molecular Function for ELF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 8756667
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA 8756667
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IDA,IEA 14970218
GO:0005515 protein binding IPI 10207087
genes like me logo Genes that share ontologies with ELF1: view
genes like me logo Genes that share phenotypes with ELF1: view

Animal Models for ELF1 Gene

MGI Knock Outs for ELF1:

Animal Model Products

miRNA for ELF1 Gene

miRTarBase miRNAs that target ELF1
Targeted motifs for ELF1 Gene
HOMER Transcription Factor Regulatory Elements motif ELF1
  • Consensus sequence: AACCGGAAGT Submotif: canonical Cell Type: Jurkat GEO ID: SRA014231

Clone Products

  • Addgene plasmids for ELF1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for ELF1 Gene

Localization for ELF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ELF1 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ELF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 19674970
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with ELF1: view

Pathways & Interactions for ELF1 Gene

genes like me logo Genes that share pathways with ELF1: view

Gene Ontology (GO) - Biological Process for ELF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001817 regulation of cytokine production IEA --
GO:0001959 regulation of cytokine-mediated signaling pathway TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ELF1: view

No data available for SIGNOR curated interactions for ELF1 Gene

Drugs & Compounds for ELF1 Gene

(1) Additional Compounds for ELF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ELF1: view

Transcripts for ELF1 Gene

Unigene Clusters for ELF1 Gene

E74-like factor 1 (ets domain transcription factor):
Representative Sequences:

Clone Products

  • Addgene plasmids for ELF1

Alternative Splicing Database (ASD) splice patterns (SP) for ELF1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4:
SP5: - - -
SP6: -
SP7: -

Relevant External Links for ELF1 Gene

GeneLoc Exon Structure for
ELF1
ECgene alternative splicing isoforms for
ELF1

Expression for ELF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ELF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ELF1 Gene

This gene is overexpressed in CD8 Tcells (25.1), Peripheral blood mononuclear cells (11.8), Blymphocyte (9.9), and NK cells (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ELF1 Gene



Protein tissue co-expression partners for ELF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ELF1 Gene:

ELF1

SOURCE GeneReport for Unigene cluster for ELF1 Gene:

Hs.135646

mRNA Expression by UniProt/SwissProt for ELF1 Gene:

P32519-ELF1_HUMAN
Tissue specificity: In fetal tissues, it is highly expressed in heart, lung liver and kidney, and weakly expressed in brain. In adult, it is highly expressed in pancreas, spleen, thymus and peripheral blood leukocytes, expressed at moderate levels in heart, placenta, lung, liver, skeletal muscle, kidney, prostate, ovary, small intestine and colon, and weakly expressed in brain and testis.

Evidence on tissue expression from TISSUES for ELF1 Gene

  • Liver(4.3)
  • Nervous system(2.5)
  • Spleen(2.2)
  • Blood(2)
genes like me logo Genes that share expression patterns with ELF1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ELF1 Gene

Orthologs for ELF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ELF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ELF1 33 34
  • 99.78 (n)
dog
(Canis familiaris)
Mammalia ELF1 33 34
  • 91.87 (n)
mouse
(Mus musculus)
Mammalia Elf1 33 16 34
  • 87.67 (n)
cow
(Bos Taurus)
Mammalia ELF1 33 34
  • 87.62 (n)
rat
(Rattus norvegicus)
Mammalia Elf1 33
  • 86.29 (n)
oppossum
(Monodelphis domestica)
Mammalia ELF1 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ELF1 34
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves ELF1 33 34
  • 76.44 (n)
lizard
(Anolis carolinensis)
Reptilia ELF1 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia elf1 33
  • 70.31 (n)
African clawed frog
(Xenopus laevis)
Amphibia elf-1-prov 33
zebrafish
(Danio rerio)
Actinopterygii ef1 33
  • 62.1 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1074 33
fruit fly
(Drosophila melanogaster)
Insecta Eip74EF 35
  • 76 (a)
worm
(Caenorhabditis elegans)
Secernentea C24A1.2 35
  • 69 (a)
ets-8 34
  • 34 (a)
ManyToMany
elf-1 34
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 27 (a)
OneToMany
Species where no ortholog for ELF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ELF1 Gene

ENSEMBL:
Gene Tree for ELF1 (if available)
TreeFam:
Gene Tree for ELF1 (if available)

Paralogs for ELF1 Gene

Paralogs for ELF1 Gene

(4) SIMAP similar genes for ELF1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ELF1: view

Variants for ELF1 Gene

Sequence variations from dbSNP and Humsavar for ELF1 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000010532 -- 41,034,609(-) AA/ genic_upstream_transcript_variant, intron_variant
rs1000031246 -- 41,058,727(-) C/A genic_upstream_transcript_variant, intron_variant
rs1000037688 -- 40,966,715(-) A/T intron_variant
rs1000038690 -- 40,946,570(-) C/T intron_variant
rs1000039882 -- 41,015,262(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ELF1 Gene

Variant ID Type Subtype PubMed ID
dgv986e59 CNV tandem duplication 20981092
esv1709140 CNV deletion 17803354
esv2672182 CNV deletion 23128226
esv2747296 CNV deletion 23290073
esv2747298 CNV deletion 23290073
esv3373421 CNV duplication 20981092
nsv561538 CNV loss 21841781
nsv64500 CNV deletion 16902084
nsv952542 CNV duplication 24416366

Variation tolerance for ELF1 Gene

Residual Variation Intolerance Score: 67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.00; 97.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ELF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ELF1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELF1 Gene

Disorders for ELF1 Gene

Additional Disease Information for ELF1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ELF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ELF1 Gene

Publications for ELF1 Gene

  1. cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1. (PMID: 1545787) Thompson CB … Karpinski B (Molecular and cellular biology 1992) 2 3 4 22 58
  2. Cloning of a novel human ELF-1-related ETS transcription factor, ELFR, its characterization and chromosomal assignment relative to ELF-1. (PMID: 9524226) Aryee DN … Kovar H (Gene 1998) 3 4 22 58
  3. Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1. (PMID: 8756667) Oettgen P … Libermann TA (Molecular and cellular biology 1996) 3 4 22 58
  4. Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein. (PMID: 8493578) Wang CY … Leiden JM (Science (New York, N.Y.) 1993) 3 4 22 58
  5. A novel Ets-related transcription factor, Elf-1, binds to human immunodeficiency virus type 2 regulatory elements that are required for inducible trans activation in T cells. (PMID: 1527846) Leiden JM … Thompson CB (Journal of virology 1992) 3 4 22 58

Products for ELF1 Gene

  • Addgene plasmids for ELF1

Sources for ELF1 Gene

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