Aliases for ELAVL4 Gene

Aliases for ELAVL4 Gene

  • ELAV Like RNA Binding Protein 4 2 3 5
  • ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 4 (Hu Antigen D) 2 3
  • ELAV Like Neuron-Specific RNA Binding Protein 4 2 3
  • Paraneoplastic Encephalomyelitis Antigen HuD 3 4
  • ELAV-Like Protein 4 3 4
  • Hu Antigen D 2 3
  • PNEM 3 4
  • HUD 3 4
  • ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 4 2
  • Hu-Antigen D 4
  • HuD 4

External Ids for ELAVL4 Gene

Previous HGNC Symbols for ELAVL4 Gene

  • HUD

Previous GeneCards Identifiers for ELAVL4 Gene

  • GC01P050199
  • GC01P049460
  • GC01P049928
  • GC01P049941
  • GC01P050283
  • GC01P050347
  • GC01P050513
  • GC01P048632
  • GC01P050048

Summaries for ELAVL4 Gene

GeneCards Summary for ELAVL4 Gene

ELAVL4 (ELAV Like RNA Binding Protein 4) is a Protein Coding gene. Diseases associated with ELAVL4 include Lambert-Eaton Myasthenic Syndrome and Sensory Peripheral Neuropathy. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is ELAVL2.

UniProtKB/Swiss-Prot Summary for ELAVL4 Gene

  • RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs (PubMed:7898713, PubMed:10710437, PubMed:12034726, PubMed:12468554, PubMed:17035636, PubMed:17234598). Plays a role in the regulation of mRNA stability, alternative splicing and translation (PubMed:7898713, PubMed:10710437, PubMed:12034726, PubMed:12468554, PubMed:17035636, PubMed:17234598). Binds to AU-rich element (ARE) sequences in the 3' untranslated region (UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA (PubMed:7898713, PubMed:10710437, PubMed:12034726, PubMed:12468554). Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function (By similarity). By binding to the mRNA 3'UTR, decreases mRNA deadenylation and thereby contributes to the stabilization of mRNA molecules and their protection from decay (PubMed:12034726). Also binds to the polyadenylated (poly(A)) tail in the 3'UTR of mRNA, thereby increasing its affinity for mRNA binding (PubMed:12034726). Mainly plays a role in neuron-specific RNA processing by stabilization of mRNAs such as GAP43, ACHE and mRNAs of other neuronal proteins, thereby contributing to the differentiation of neural progenitor cells, nervous system development, learning and memory mechanisms (PubMed:12034726, PubMed:12468554, PubMed:17234598, PubMed:18218628). Involved in the negative regulation of the proliferative activity of neuronal stem cells and in the positive regulation of neuronal differentiation of neural progenitor cells (By similarity). Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone of the hippocampus by binding to and stabilizing SATB1 mRNA (By similarity). Binds and stabilizes MSI1 mRNA in neural stem cells (By similarity). Exhibits increased binding to ACHE mRNA during neuronal differentiation, thereby stabilizing ACHE mRNA and enhancing its expression (PubMed:12468554, PubMed:17234598). Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity). May bind to APP and BACE1 mRNAS and the BACE1AS lncRNA and enhance their stabilization (PubMed:24857657). Plays a role in neurite outgrowth and in the establishment and maturation of dendritic arbors, thereby contributing to neocortical and hippocampal circuitry function (By similarity). Stabilizes GAP43 mRNA and protects it from decay during postembryonic development in the brain (PubMed:12034726). By promoting the stabilization of GAP43 mRNA, plays a role in NGF-mediated neurite outgrowth (By similarity). Binds to BDNF long 3'UTR mRNA, thereby leading to its stabilization and increased dendritic translation after activation of PKC (By similarity). By increasing translation of BDNF after nerve injury, may contribute to nerve regeneration (By similarity). Acts as a stabilizing factor by binding to the 3'UTR of NOVA1 mRNA, thereby increasing its translation and enhancing its functional activity in neuron-specific splicing (PubMed:18218628). Stimulates translation of mRNA in a poly(A)- and cap-dependent manner, possibly by associating with the EIF4F cap-binding complex (By similarity). May also negatively regulate translation by binding to the 5'UTR of Ins2 mRNA, thereby repressing its translation (By similarity). Upon glucose stimulation, Ins2 mRNA is released from ELAVL4 and translational inhibition is abolished (By similarity). Also plays a role in the regulation of alternative splicing (PubMed:17035636). May regulate alternative splicing of CALCA pre-mRNA into Calcitonin and Calcitonin gene-related peptide 1 (CGRP) by competing with splicing regulator TIAR for binding to U-rich intronic sequences of CALCA pre-mRNA (PubMed:17035636).

Gene Wiki entry for ELAVL4 Gene

Additional gene information for ELAVL4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ELAVL4 Gene

Genomics for ELAVL4 Gene

GeneHancer (GH) Regulatory Elements for ELAVL4 Gene

Promoters and enhancers for ELAVL4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J050108 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 510.6 +86.6 86571 3.6 EZH2 MXI1 POLR2A RCOR1 SMARCA4 SPI1 GATA2 CEBPB ELAVL4 HQ292121 ENSG00000237337 ENSG00000230828 lnc-CDKN2C-32
GH01J050023 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 -0.1 -64 1.3 ZBTB26 RFX1 MXI1 BCL11A ZNF76 YY1 ZFHX2 E2F6 ZBTB48 ZNF335 AGBL4 ELAVL4 LOC105378708
GH01J050103 Promoter/Enhancer 0.8 EPDnew dbSUPER 509.8 +79.9 79861 0.1 POLR2A RCOR1 REST CHD2 GATA2 EZH2 RAD21 ELAVL4 piR-55985-012 ENSG00000237337 HQ292121
GH01J050334 Promoter/Enhancer 1.2 ENCODE CraniofacialAtlas 9.8 +309.4 309405 0.2 EP300 CTCF NRF1 USF1 ZBTB10 ZBTB11 ZBTB26 TARDBP MYC HDAC2 ENSG00000234080 CDKN2C ENSG00000237337 ELAVL4 lnc-ELAVL4-6 piR-30927-001
GH01J050336 Promoter 1 CraniofacialAtlas 9.8 +309.0 309000 0.2 HNRNPK EP300 CTCF ZBTB10 ZBTB11 ZBTB26 TARDBP REST MYC RAD21 ENSG00000237337 ELAVL4 lnc-ELAVL4-6 piR-30927-001
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ELAVL4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ELAVL4

Top Transcription factor binding sites by QIAGEN in the ELAVL4 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a

Genomic Locations for ELAVL4 Gene

Genomic Locations for ELAVL4 Gene
chr1:50,024,029-50,203,786
(GRCh38/hg38)
Size:
179,758 bases
Orientation:
Plus strand
chr1:50,513,686-50,669,458
(GRCh37/hg19)
Size:
155,773 bases
Orientation:
Plus strand

Genomic View for ELAVL4 Gene

Genes around ELAVL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELAVL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELAVL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELAVL4 Gene

Proteins for ELAVL4 Gene

  • Protein details for ELAVL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26378-ELAV4_HUMAN
    Recommended name:
    ELAV-like protein 4
    Protein Accession:
    P26378
    Secondary Accessions:
    • B1APY6
    • B1APY7
    • B1APY8
    • B7Z4G7
    • Q8IYD4
    • Q96J74
    • Q96J75
    • Q9UD24

    Protein attributes for ELAVL4 Gene

    Size:
    385 amino acids
    Molecular mass:
    42398 Da
    Quaternary structure:
    • Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP (By similarity). Associates with the EIF4F cap-binding complex, composed of EIF4G, EIF4A, EIF4E and PABP (By similarity). Within the EIF4F cap-binding complex, interacts with EIF4A (By similarity). Interacts with SMN (via Tudor domain) in an RNA-independent manner; the interaction is required for localization of ELAVL4 to RNA granules (PubMed:21088113, PubMed:21389246, PubMed:29061699). Interacts with MAP1 light chain LC1 (via C-terminus); the interaction contributes to the association of ELAVL4 with microtubules (By similarity). Interacts with MAP1 light chain LC2 (By similarity).

    Three dimensional structures from OCA and Proteopedia for ELAVL4 Gene

    Alternative splice isoforms for ELAVL4 Gene

neXtProt entry for ELAVL4 Gene

Post-translational modifications for ELAVL4 Gene

  • Methylated by CARM1, which leads to reduced RNA-binding activity and enhanced interaction with SMN (PubMed:21088113). Methylation at Arg-248 by CARM1 weakens protective binding to the 3'UTR of CDKN1A mRNA and down-regulates CDKN1A protein expression, thereby maintaining cells in a proliferative state (By similarity). Methylation is inhibited by NGF, which facilitates neurite outgrowth (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for ELAVL4
  • Boster Bio Antibodies for ELAVL4

No data available for DME Specific Peptides for ELAVL4 Gene

Domains & Families for ELAVL4 Gene

Gene Families for ELAVL4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ELAVL4 Gene

Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)
  • Paraneoplastic encephalomyelitis antigen family signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ELAVL4 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50619, highly similar to ELAV-like protein 4 (B1APY9_HUMAN)
  • cDNA FLJ55562, highly similar to ELAV-like protein 4 (B7Z4G7_HUMAN)
  • Paraneoplastic encephalomyelitis antigen HuD (ELAV4_HUMAN)
  • HuD protein (Q16234_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P26378

UniProtKB/Swiss-Prot:

ELAV4_HUMAN :
  • The RRM 3 domain is required for binding to poly(A) RNA, for the association with polysomes and with the EIF4F cap-binding complex and for the stimulation of translation (By similarity). The RRM 1 and RRM 2 domains may contribute to polysome association and stimulation of translation (By similarity).
  • Belongs to the RRM elav family.
Domain:
  • The RRM 3 domain is required for binding to poly(A) RNA, for the association with polysomes and with the EIF4F cap-binding complex and for the stimulation of translation (By similarity). The RRM 1 and RRM 2 domains may contribute to polysome association and stimulation of translation (By similarity).
Family:
  • Belongs to the RRM elav family.
genes like me logo Genes that share domains with ELAVL4: view

Function for ELAVL4 Gene

Molecular function for ELAVL4 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs (PubMed:7898713, PubMed:10710437, PubMed:12034726, PubMed:12468554, PubMed:17035636, PubMed:17234598). Plays a role in the regulation of mRNA stability, alternative splicing and translation (PubMed:7898713, PubMed:10710437, PubMed:12034726, PubMed:12468554, PubMed:17035636, PubMed:17234598). Binds to AU-rich element (ARE) sequences in the 3' untranslated region (UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA (PubMed:7898713, PubMed:10710437, PubMed:12034726, PubMed:12468554). Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function (By similarity). By binding to the mRNA 3'UTR, decreases mRNA deadenylation and thereby contributes to the stabilization of mRNA molecules and their protection from decay (PubMed:12034726). Also binds to the polyadenylated (poly(A)) tail in the 3'UTR of mRNA, thereby increasing its affinity for mRNA binding (PubMed:12034726). Mainly plays a role in neuron-specific RNA processing by stabilization of mRNAs such as GAP43, ACHE and mRNAs of other neuronal proteins, thereby contributing to the differentiation of neural progenitor cells, nervous system development, learning and memory mechanisms (PubMed:12034726, PubMed:12468554, PubMed:17234598, PubMed:18218628). Involved in the negative regulation of the proliferative activity of neuronal stem cells and in the positive regulation of neuronal differentiation of neural progenitor cells (By similarity). Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone of the hippocampus by binding to and stabilizing SATB1 mRNA (By similarity). Binds and stabilizes MSI1 mRNA in neural stem cells (By similarity). Exhibits increased binding to ACHE mRNA during neuronal differentiation, thereby stabilizing ACHE mRNA and enhancing its expression (PubMed:12468554, PubMed:17234598). Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity). May bind to APP and BACE1 mRNAS and the BACE1AS lncRNA and enhance their stabilization (PubMed:24857657). Plays a role in neurite outgrowth and in the establishment and maturation of dendritic arbors, thereby contributing to neocortical and hippocampal circuitry function (By similarity). Stabilizes GAP43 mRNA and protects it from decay during postembryonic development in the brain (PubMed:12034726). By promoting the stabilization of GAP43 mRNA, plays a role in NGF-mediated neurite outgrowth (By similarity). Binds to BDNF long 3'UTR mRNA, thereby leading to its stabilization and increased dendritic translation after activation of PKC (By similarity). By increasing translation of BDNF after nerve injury, may contribute to nerve regeneration (By similarity). Acts as a stabilizing factor by binding to the 3'UTR of NOVA1 mRNA, thereby increasing its translation and enhancing its functional activity in neuron-specific splicing (PubMed:18218628). Stimulates translation of mRNA in a poly(A)- and cap-dependent manner, possibly by associating with the EIF4F cap-binding complex (By similarity). May also negatively regulate translation by binding to the 5'UTR of Ins2 mRNA, thereby repressing its translation (By similarity). Upon glucose stimulation, Ins2 mRNA is released from ELAVL4 and translational inhibition is abolished (By similarity). Also plays a role in the regulation of alternative splicing (PubMed:17035636). May regulate alternative splicing of CALCA pre-mRNA into Calcitonin and Calcitonin gene-related peptide 1 (CGRP) by competing with splicing regulator TIAR for binding to U-rich intronic sequences of CALCA pre-mRNA (PubMed:17035636).
GENATLAS Biochemistry:
Drosophila Elav-like 4 (embryonic,lethal,abnormal vision),neural specific,expressed in brain,identified using sera from patients with a paraplastic multifocal neurologic disorder,homologous to HD,shuttling the ERG class of mRNA to the cytoplasm in response to regulatory signals,where they become stabilized,translated or rapidly degraded

Phenotypes From GWAS Catalog for ELAVL4 Gene

Gene Ontology (GO) - Molecular Function for ELAVL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0003729 mRNA binding IEA --
GO:0003730 mRNA 3'-UTR binding TAS 10848602
GO:0035925 mRNA 3'-UTR AU-rich region binding IDA 10710437
genes like me logo Genes that share ontologies with ELAVL4: view
genes like me logo Genes that share phenotypes with ELAVL4: view

Animal Models for ELAVL4 Gene

MGI Knock Outs for ELAVL4:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ELAVL4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ELAVL4 Gene

Localization for ELAVL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELAVL4 Gene

Cytoplasm. Perikaryon. Cell projection, dendrite. Cell projection, axon. Cell projection, growth cone. Note=Co-localizes with ribosomal RNA in polysomes. {ECO:0000250 UniProtKB:O09032}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ELAVL4 gene
Compartment Confidence
nucleus 4
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
cytosol 2
peroxisome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ELAVL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0030424 axon IEA --
GO:0030425 dendrite IEA --
GO:0030426 growth cone IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with ELAVL4: view

Pathways & Interactions for ELAVL4 Gene

PathCards logo

SuperPathways for ELAVL4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ELAVL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA,TAS --
GO:0007612 learning IEA --
GO:0007626 locomotory behavior IEA --
GO:0008380 RNA splicing IEA --
GO:0048813 dendrite morphogenesis IEA --
genes like me logo Genes that share ontologies with ELAVL4: view

No data available for Pathways by source and SIGNOR curated interactions for ELAVL4 Gene

Drugs & Compounds for ELAVL4 Gene

(2) Additional Compounds for ELAVL4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ELAVL4: view

Transcripts for ELAVL4 Gene

mRNA/cDNA for ELAVL4 Gene

14 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ELAVL4

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ELAVL4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - - - -
SP5: - -
SP6: -
SP7: - -
SP8:
SP9: - - -
SP10:

Relevant External Links for ELAVL4 Gene

GeneLoc Exon Structure for
ELAVL4

Expression for ELAVL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ELAVL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ELAVL4 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x11.3), Brain - Anterior cingulate cortex (BA24) (x8.6), Brain - Cortex (x6.5), Brain - Hypothalamus (x5.2), and Brain - Hippocampus (x4.2).

Protein differential expression in normal tissues from HIPED for ELAVL4 Gene

This gene is overexpressed in Brain (39.1) and Fetal Brain (19.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ELAVL4 Gene



Protein tissue co-expression partners for ELAVL4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ELAVL4

SOURCE GeneReport for Unigene cluster for ELAVL4 Gene:

Hs.213050

mRNA Expression by UniProt/SwissProt for ELAVL4 Gene:

P26378-ELAV4_HUMAN
Tissue specificity: Expressed in pancreatic beta cells (at protein level) (PubMed:22387028). Expressed in the brain (PubMed:1655278, PubMed:14702039).

Evidence on tissue expression from TISSUES for ELAVL4 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with ELAVL4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ELAVL4 Gene

Orthologs for ELAVL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ELAVL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ELAVL4 31 30
  • 99.36 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ELAVL4 31
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ELAVL4 31 30
  • 96.36 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ELAVL4 31
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ELAVL4 31 30
  • 95.35 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Elavl4 30
  • 94.91 (n)
mouse
(Mus musculus)
Mammalia Elavl4 17 31 30
  • 94.08 (n)
chicken
(Gallus gallus)
Aves ELAVL4 31 30
  • 87.7 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ELAVL4 31
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia elavl4 30
  • 84.88 (n)
African clawed frog
(Xenopus laevis)
Amphibia elrD 30
zebrafish
(Danio rerio)
Actinopterygii elavl4 31 30
  • 82.23 (n)
OneToOne
-- 30
fruit fly
(Drosophila melanogaster)
Insecta Rbp9 31 30
  • 62.2 (n)
ManyToMany
fne 31 32
  • 59 (a)
ManyToMany
Sxl 32
  • 46 (a)
EG:132E8.1 32
  • 43 (a)
elav 31 32
  • 40 (a)
ManyToMany
CG5213 32
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea exc-7 31 32 30
  • 54.05 (n)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9670 31
  • 55 (a)
OneToMany
Species where no ortholog for ELAVL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ELAVL4 Gene

ENSEMBL:
Gene Tree for ELAVL4 (if available)
TreeFam:
Gene Tree for ELAVL4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ELAVL4: view image

Paralogs for ELAVL4 Gene

(7) SIMAP similar genes for ELAVL4 Gene using alignment to 3 proteins:

  • ELAV4_HUMAN
  • B1APY8_HUMAN
  • B1APY9_HUMAN
genes like me logo Genes that share paralogs with ELAVL4: view

Variants for ELAVL4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ELAVL4 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs116391279 Uncertain Significance: Severe Myopia 50,145,095(+) G/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs17853531 - p.Ala361Thr
rs17853533 - p.Asp171Gly
rs2494876 - p.Pro275Ser

Additional dbSNP identifiers (rs#s) for ELAVL4 Gene

Structural Variations from Database of Genomic Variants (DGV) for ELAVL4 Gene

Variant ID Type Subtype PubMed ID
esv2665070 CNV deletion 23128226
esv3586005 CNV loss 21293372
nsv1003968 CNV gain 25217958
nsv1110659 CNV insertion 24896259
nsv498670 CNV loss 21111241
nsv810 CNV deletion 18451855
nsv829826 CNV gain 17160897

Variation tolerance for ELAVL4 Gene

Residual Variation Intolerance Score: 36.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ELAVL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ELAVL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELAVL4 Gene

Disorders for ELAVL4 Gene

MalaCards: The human disease database

(14) MalaCards diseases for ELAVL4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lambert-eaton myasthenic syndrome
  • eaton-lambert syndrome
sensory peripheral neuropathy
  • peripheral sensory neuropathy
hallucinogen abuse
paraneoplastic neurologic disorders
  • pcd
retinitis pigmentosa 49
  • rp49
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ELAVL4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ELAVL4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ELAVL4 Gene

Publications for ELAVL4 Gene

  1. Molecular analysis of the HuD gene in neuroendocrine lung cancers. (PMID: 19410329) D'Alessandro V … Vendemiale G (Lung cancer (Amsterdam, Netherlands) 2010) 3 23 41 54
  2. Post-transcriptional regulation of neuro-oncological ventral antigen 1 by the neuronal RNA-binding proteins ELAV. (PMID: 18218628) Ratti A … Silani V (The Journal of biological chemistry 2008) 3 4 23 54
  3. The RNA-binding protein HuD binds acetylcholinesterase mRNA in neurons and regulates its expression after axotomy. (PMID: 17234598) Deschênes-Furry J … Jasmin BJ (The Journal of neuroscience : the official journal of the Society for Neuroscience 2007) 3 4 23 54
  4. CARM1 regulates proliferation of PC12 cells by methylating HuD. (PMID: 16508003) Fujiwara T … Tohyama M (Molecular and cellular biology 2006) 3 4 23 54
  5. Post-transcriptional regulation of acetylcholinesterase mRNAs in nerve growth factor-treated PC12 cells by the RNA-binding protein HuD. (PMID: 12468554) Deschenes-Furry J … Jasmin BJ (The Journal of biological chemistry 2003) 3 4 23 54

Products for ELAVL4 Gene

Sources for ELAVL4 Gene