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Aliases for ELAVL3 Gene

Aliases for ELAVL3 Gene

  • ELAV Like RNA Binding Protein 3 2 3 5
  • Paraneoplastic Cerebellar Degeneration-Associated Antigen 2 3 4
  • Paraneoplastic Limbic Encephalitis Antigen 21 2 3 4
  • ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 3 (Hu Antigen C) 2 3
  • ELAV Like Neuron-Specific RNA Binding Protein 3 2 3
  • ELAV-Like Protein 3 2 3
  • Hu-Antigen C 3 4
  • Hu Antigen C 2 3
  • PLE21 3 4
  • HUC 3 4
  • HUCL 3
  • HuC 4

External Ids for ELAVL3 Gene

Previous GeneCards Identifiers for ELAVL3 Gene

  • GC19M011694
  • GC19M011786
  • GC19M011409
  • GC19M011425
  • GC19M011562
  • GC19M011140

Summaries for ELAVL3 Gene

Entrez Gene Summary for ELAVL3 Gene

  • A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ELAVL3 Gene

ELAVL3 (ELAV Like RNA Binding Protein 3) is a Protein Coding gene. Diseases associated with ELAVL3 include Paraneoplastic Cerebellar Degeneration and Limbic Encephalitis. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is ELAVL4.

UniProtKB/Swiss-Prot for ELAVL3 Gene

  • Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance.

Gene Wiki entry for ELAVL3 Gene

Additional gene information for ELAVL3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELAVL3 Gene

Genomics for ELAVL3 Gene

GeneHancer (GH) Regulatory Elements for ELAVL3 Gene

Promoters and enhancers for ELAVL3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J011478 Enhancer 1.6 FANTOM5 Ensembl ENCODE 654 -0.6 -580 5.4 CLOCK MLX DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 SP3 NFYC ELAVL3 ILF3 KRI1 ZNF136 ZNF627 TIMM29 ZNF44 ZNF442 ZNF763 ZNF700
GH19J011373 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.2 +104.7 104726 6.2 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 TMEM205 PIR61774 SWSAP1 ENSG00000267277 ILF3 ZNF136 KRI1 ZNF627 ZNF442 ZNF625
GH19J011452 Enhancer 1 Ensembl dbSUPER 13.2 +27.3 27306 2.5 ARID4B ZNF48 RARA TCF12 ZNF366 ZNF143 THAP11 ZNF362 CEBPB ATF4 ELAVL3 TSPAN16 EPOR SWSAP1 GC19M011460 CCDC151
GH19J011447 Promoter/Enhancer 0.8 EPDnew dbSUPER 12.4 +33.5 33510 0.1 EGR2 PRKCSH EPOR ELAVL3 TSPAN16 KANK2 GC19M011460 CCDC151
GH19J011450 Enhancer 0.6 ENCODE dbSUPER 13.3 +30.1 30084 0.8 POLR2A SP2 ELAVL3 EPOR PRKCSH GC19M011460 CCDC151
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ELAVL3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ELAVL3 gene promoter:
  • Olf-1
  • Nkx2-5
  • IRF-1
  • Lmo2
  • E47
  • GATA-1
  • Tal-1
  • Spz1
  • HTF

Genomic Locations for ELAVL3 Gene

Genomic Locations for ELAVL3 Gene
29,721 bases
Minus strand
29,721 bases
Minus strand

Genomic View for ELAVL3 Gene

Genes around ELAVL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELAVL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELAVL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELAVL3 Gene

Proteins for ELAVL3 Gene

  • Protein details for ELAVL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ELAV-like protein 3
    Protein Accession:
    Secondary Accessions:
    • Q16135
    • Q96CL8
    • Q96QS9

    Protein attributes for ELAVL3 Gene

    367 amino acids
    Molecular mass:
    39547 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ELAVL3 Gene


neXtProt entry for ELAVL3 Gene

Post-translational modifications for ELAVL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ELAVL3 Gene

Domains & Families for ELAVL3 Gene

Gene Families for ELAVL3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ELAVL3 Gene

Graphical View of Domain Structure for InterPro Entry



  • RRM 1 and RRM 2 bind cooperatively to AU-rich sequences in target mRNAs. RRM 3 binds to poly-A mRNA sequences (By similarity).
  • Belongs to the RRM elav family.
  • RRM 1 and RRM 2 bind cooperatively to AU-rich sequences in target mRNAs. RRM 3 binds to poly-A mRNA sequences (By similarity).
  • Belongs to the RRM elav family.
genes like me logo Genes that share domains with ELAVL3: view

Function for ELAVL3 Gene

Molecular function for ELAVL3 Gene

UniProtKB/Swiss-Prot Function:
Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance.
GENATLAS Biochemistry:
Drosophila Elav-like 3 (embryonic,lethal,abnormal vision),onconeural specific,expressed at an early stage of neural development,shuttling the ERG class of mRNA to the cytoplasm in response to regulatory signals,where they become stabilized,translated or rapidly degraded,required for neuronal differentiation in the mammalian nervous system

Gene Ontology (GO) - Molecular Function for ELAVL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0017091 AU-rich element binding IDA 10710437
genes like me logo Genes that share ontologies with ELAVL3: view
genes like me logo Genes that share phenotypes with ELAVL3: view

Animal Models for ELAVL3 Gene

MGI Knock Outs for ELAVL3:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ELAVL3 Gene

Localization for ELAVL3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ELAVL3 gene
Compartment Confidence
nucleus 4
cytoskeleton 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ELAVL3 Gene

Pathways & Interactions for ELAVL3 Gene

SuperPathways for ELAVL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ELAVL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ELAVL3: view

No data available for Pathways by source and SIGNOR curated interactions for ELAVL3 Gene

Drugs & Compounds for ELAVL3 Gene

No Compound Related Data Available

Transcripts for ELAVL3 Gene

Unigene Clusters for ELAVL3 Gene

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ELAVL3 Gene

No ASD Table

Relevant External Links for ELAVL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ELAVL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ELAVL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ELAVL3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x7.7), Brain - Cerebellum (x7.6), and Brain - Spinal cord (cervical c-1) (x4.6).

Protein differential expression in normal tissues from HIPED for ELAVL3 Gene

This gene is overexpressed in Fetal Brain (44.0) and Brain (18.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ELAVL3 Gene

Protein tissue co-expression partners for ELAVL3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ELAVL3 Gene:


SOURCE GeneReport for Unigene cluster for ELAVL3 Gene:


mRNA Expression by UniProt/SwissProt for ELAVL3 Gene:

Tissue specificity: Brain specific.

Evidence on tissue expression from TISSUES for ELAVL3 Gene

  • Nervous system(4.9)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with ELAVL3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ELAVL3 Gene

Orthologs for ELAVL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ELAVL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ELAVL3 34 33
  • 95.87 (n)
(Canis familiaris)
Mammalia ELAVL3 34 33
  • 93.98 (n)
(Bos Taurus)
Mammalia ELAVL3 34 33
  • 93.08 (n)
(Mus musculus)
Mammalia Elavl3 16 34 33
  • 91.76 (n)
(Rattus norvegicus)
Mammalia Elavl3 33
  • 91.57 (n)
(Ornithorhynchus anatinus)
Mammalia ELAVL3 34
  • 91 (a)
(Monodelphis domestica)
Mammalia ELAVL3 34
  • 85 (a)
(Anolis carolinensis)
Reptilia ELAVL3 34
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia elavl3 33
  • 76.41 (n)
Str.10863 33
(Danio rerio)
Actinopterygii elavl3 34 33
  • 80.87 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8000 33
fruit fly
(Drosophila melanogaster)
Insecta fne 34 35
  • 59 (a)
EG:132E8.1 35
  • 49 (a)
Rbp9 34
  • 48 (a)
Sxl 35
  • 45 (a)
elav 34 35
  • 40 (a)
CG5213 35
  • 34 (a)
(Caenorhabditis elegans)
Secernentea exc-7 34 35
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9670 34
  • 52 (a)
Species where no ortholog for ELAVL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ELAVL3 Gene

Gene Tree for ELAVL3 (if available)
Gene Tree for ELAVL3 (if available)
Evolutionary constrained regions (ECRs) for ELAVL3: view image

Paralogs for ELAVL3 Gene

(4) SIMAP similar genes for ELAVL3 Gene using alignment to 4 proteins:

  • L8E8Z0_HUMAN
  • Q96J71_HUMAN
genes like me logo Genes that share paralogs with ELAVL3: view

Variants for ELAVL3 Gene

Sequence variations from dbSNP and Humsavar for ELAVL3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000091095 -- 11,452,297(-) A/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000426319 -- 11,475,920(-) A/G intron_variant
rs1000439053 -- 11,463,744(-) G/A intron_variant
rs1000549220 -- 11,465,201(-) CACACACA/CACACA intron_variant
rs1000583738 -- 11,469,454(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ELAVL3 Gene

Variant ID Type Subtype PubMed ID
esv3388355 CNV insertion 20981092
nsv1126512 CNV deletion 24896259
nsv519802 CNV loss 19592680
nsv819321 CNV gain 19587683
nsv819522 CNV loss 19587683

Variation tolerance for ELAVL3 Gene

Residual Variation Intolerance Score: 15.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ELAVL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELAVL3 Gene

Disorders for ELAVL3 Gene

MalaCards: The human disease database

(6) MalaCards diseases for ELAVL3 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ELAVL3

genes like me logo Genes that share disorders with ELAVL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ELAVL3 Gene

Publications for ELAVL3 Gene

  1. RNA-binding analyses of HuC and HuD with the VEGF and c-myc 3'-untranslated regions using a novel ELISA-based assay. (PMID: 10710437) King PH (Nucleic acids research 2000) 3 4 22 58
  2. A hippocampal protein associated with paraneoplastic neurologic syndrome and small cell lung carcinoma. (PMID: 7511893) Sakai K … Steinman L (Biochemical and biophysical research communications 1994) 3 4 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Novel products of the HUD, HUC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library. (PMID: 12209604) Behrends U … Mautner JM (International journal of cancer 2002) 3 22 58
  5. Localization of HuC (ELAVL3) to chromosome 19p13.2 by fluorescence in situ hybridization utilizing a novel tyramide labeling technique. (PMID: 9799595) Van Tine BA … King PH (Genomics 1998) 2 3 58

Products for ELAVL3 Gene

Sources for ELAVL3 Gene

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