A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (P... See more...

Aliases for ELAVL3 Gene

Aliases for ELAVL3 Gene

  • ELAV Like RNA Binding Protein 3 2 3 5
  • Paraneoplastic Cerebellar Degeneration-Associated Antigen 2 3 4
  • Paraneoplastic Limbic Encephalitis Antigen 21 2 3 4
  • ELAV-Like Protein 3 2 3 4
  • PLE21 2 3 4
  • HUC 2 3 4
  • ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 3 (Hu Antigen C) 2 3
  • ELAV Like Neuron-Specific RNA Binding Protein 3 2 3
  • Hu Antigen C 2 3
  • Hu-Antigen C 3 4
  • HUCL 2 3
  • DKFZp547J036 2
  • MGC20653 2
  • ELAVL3 5
  • HuC 4

External Ids for ELAVL3 Gene

Previous GeneCards Identifiers for ELAVL3 Gene

  • GC19M011694
  • GC19M011786
  • GC19M011409
  • GC19M011425
  • GC19M011426
  • GC19M011562
  • GC19M011140

Summaries for ELAVL3 Gene

Entrez Gene Summary for ELAVL3 Gene

  • A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ELAVL3 Gene

ELAVL3 (ELAV Like RNA Binding Protein 3) is a Protein Coding gene. Diseases associated with ELAVL3 include Paraneoplastic Limbic Encephalitis and Sigmoid Disease. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is ELAVL2.

UniProtKB/Swiss-Prot Summary for ELAVL3 Gene

  • RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs, including VEGF mRNA (PubMed:10710437). May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance (By similarity). Plays a role in the stabilization of GAP43 mRNA and in spatial learning (By similarity).

Gene Wiki entry for ELAVL3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ELAVL3 Gene

Genomics for ELAVL3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ELAVL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J011478 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE 603.9 -0.2 -155 4 ZNF221 SP1 CREB1 CTCF TEAD4 PRDM10 ZNF629 REST TFE3 RFX1 ELAVL3 lnc-ELAVL3-1 ILF3 KRI1 ZNF136 ZNF627 TIMM29 ZNF44 ZNF441 ZNF625
GH19J011373 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 6.2 +104.7 104726 6.2 SP1 HNRNPL CREB1 CTCF ZNF629 TFE3 RFX1 KDM1A ZNF692 RCOR2 TMEM205 ENSG00000267277 SWSAP1 piR-38729 ILF3 ZNF136 ZNF627 ZNF442 ZNF625 ZNF823
GH19J011451 Enhancer 1 ENCODE CraniofacialAtlas dbSUPER 13.3 +29.3 29260 0.8 POLR2A ARID3A DPF2 RUNX3 GATAD2B BCL11A ARNT NBN IKZF1 NR2F1 ELAVL3 EPOR TSPAN16 SWSAP1 CCDC159 lnc-SWSAP1-4 CCDC151 lnc-PRKCSH-1
GH19J011447 Promoter/Enhancer 0.7 EPDnew dbSUPER 12.4 +33.5 33510 0.1 RBFOX2 ZNF513 EGR2 NONHSAG024841.2 piR-56626 PRKCSH EPOR ELAVL3 TSPAN16 KANK2 CCDC151
GH19J011457 Enhancer 0.6 Ensembl dbSUPER 13.2 +23.4 23446 0.4 ZNF692 REST ZFP69B ZNF148 ELAVL3 TSPAN16 EPOR SWSAP1 CCDC159 ENSG00000267174 lnc-PRKCSH-1 lnc-SWSAP1-4 CCDC151
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ELAVL3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ELAVL3

Top Transcription factor binding sites by QIAGEN in the ELAVL3 gene promoter:
  • E47
  • GATA-1
  • HTF
  • IRF-1
  • Lmo2
  • Nkx2-5
  • Olf-1
  • Spz1
  • Tal-1

Genomic Locations for ELAVL3 Gene

Genomic Locations for ELAVL3 Gene
chr19:11,451,326-11,481,046
(GRCh38/hg38)
Size:
29,721 bases
Orientation:
Minus strand
chr19:11,562,141-11,591,861
(GRCh37/hg19)
Size:
29,721 bases
Orientation:
Minus strand

Genomic View for ELAVL3 Gene

Genes around ELAVL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELAVL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELAVL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELAVL3 Gene

Proteins for ELAVL3 Gene

  • Protein details for ELAVL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14576-ELAV3_HUMAN
    Recommended name:
    ELAV-like protein 3
    Protein Accession:
    Q14576
    Secondary Accessions:
    • Q16135
    • Q96CL8
    • Q96QS9

    Protein attributes for ELAVL3 Gene

    Size:
    367 amino acids
    Molecular mass:
    39547 Da
    Quaternary structure:
    • Interacts with MAP1B light chain LC1.

    Alternative splice isoforms for ELAVL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELAVL3 Gene

Post-translational modifications for ELAVL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for ELAVL3
  • Boster Bio Antibodies for ELAVL3

No data available for DME Specific Peptides for ELAVL3 Gene

Domains & Families for ELAVL3 Gene

Gene Families for ELAVL3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ELAVL3 Gene

InterPro:
Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)
  • Paraneoplastic encephalomyelitis antigen family signature
ProtoNet:

Suggested Antigen Peptide Sequences for ELAVL3 Gene

GenScript: Design optimal peptide antigens:
  • Paraneoplastic limbic encephalitis antigen 21 (ELAV3_HUMAN)
  • Hu antigen C long (Q96J71_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14576

UniProtKB/Swiss-Prot:

ELAV3_HUMAN :
  • RRM 1 and RRM 2 bind cooperatively to AU-rich sequences in target mRNAs. RRM 3 binds to poly-A mRNA sequences (By similarity).
  • Belongs to the RRM elav family.
Domain:
  • RRM 1 and RRM 2 bind cooperatively to AU-rich sequences in target mRNAs. RRM 3 binds to poly-A mRNA sequences (By similarity).
Family:
  • Belongs to the RRM elav family.
genes like me logo Genes that share domains with ELAVL3: view

Function for ELAVL3 Gene

Molecular function for ELAVL3 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs, including VEGF mRNA (PubMed:10710437). May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance (By similarity). Plays a role in the stabilization of GAP43 mRNA and in spatial learning (By similarity).
GENATLAS Biochemistry:
Drosophila Elav-like 3 (embryonic,lethal,abnormal vision),onconeural specific,expressed at an early stage of neural development,shuttling the ERG class of mRNA to the cytoplasm in response to regulatory signals,where they become stabilized,translated or rapidly degraded,required for neuronal differentiation in the mammalian nervous system

Phenotypes From GWAS Catalog for ELAVL3 Gene

Gene Ontology (GO) - Molecular Function for ELAVL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0035925 mRNA 3'-UTR AU-rich region binding IDA 10710437
genes like me logo Genes that share ontologies with ELAVL3: view
genes like me logo Genes that share phenotypes with ELAVL3: view

Animal Models for ELAVL3 Gene

MGI Knock Outs for ELAVL3:

Animal Model Products

CRISPR Products

miRNA for ELAVL3 Gene

miRTarBase miRNAs that target ELAVL3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ELAVL3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ELAVL3 Gene

Localization for ELAVL3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ELAVL3 gene
Compartment Confidence
nucleus 4
cytoskeleton 3
plasma membrane 2
extracellular 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ELAVL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1990904 ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with ELAVL3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ELAVL3 Gene

Pathways & Interactions for ELAVL3 Gene

PathCards logo

SuperPathways for ELAVL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ELAVL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ELAVL3: view

No data available for Pathways by source and SIGNOR curated interactions for ELAVL3 Gene

Drugs & Compounds for ELAVL3 Gene

No Compound Related Data Available

Transcripts for ELAVL3 Gene

mRNA/cDNA for ELAVL3 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ELAVL3

Alternative Splicing Database (ASD) splice patterns (SP) for ELAVL3 Gene

No ASD Table

Relevant External Links for ELAVL3 Gene

GeneLoc Exon Structure for
ELAVL3

Expression for ELAVL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ELAVL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ELAVL3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x7.7), Brain - Cerebellum (x7.6), and Brain - Spinal cord (cervical c-1) (x4.6).

Protein differential expression in normal tissues from HIPED for ELAVL3 Gene

This gene is overexpressed in Fetal Brain (44.0) and Brain (18.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ELAVL3 Gene



Protein tissue co-expression partners for ELAVL3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ELAVL3

SOURCE GeneReport for Unigene cluster for ELAVL3 Gene:

Hs.1701

mRNA Expression by UniProt/SwissProt for ELAVL3 Gene:

Q14576-ELAV3_HUMAN
Tissue specificity: Brain specific.

Evidence on tissue expression from TISSUES for ELAVL3 Gene

  • Nervous system(4.9)
  • Eye(3.2)
  • Skin(3.1)
  • Muscle(2.8)
  • Intestine(2.5)
  • Heart(2.4)
  • Kidney(2.4)
  • Blood(2.3)
  • Thyroid gland(2.3)
  • Adrenal gland(2.1)
  • Lung(2)
genes like me logo Genes that share expression patterns with ELAVL3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ELAVL3 Gene

Orthologs for ELAVL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ELAVL3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ELAVL3 30 31
  • 95.87 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ELAVL3 30 31
  • 93.98 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ELAVL3 30 31
  • 93.08 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Elavl3 30 17 31
  • 91.76 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Elavl3 30
  • 91.57 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia ELAVL3 31
  • 91 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ELAVL3 31
  • 85 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ELAVL3 31
  • 84 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia elavl3 30
  • 76.41 (n)
Str.10863 30
Zebrafish
(Danio rerio)
Actinopterygii elavl3 30 31
  • 80.87 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8000 30
Fruit Fly
(Drosophila melanogaster)
Insecta fne 31 32
  • 59 (a)
ManyToMany
EG:132E8.1 32
  • 49 (a)
Rbp9 31
  • 48 (a)
ManyToMany
Sxl 32
  • 45 (a)
elav 31 32
  • 40 (a)
ManyToMany
CG5213 32
  • 34 (a)
Worm
(Caenorhabditis elegans)
Secernentea exc-7 31 32
  • 39 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.9670 31
  • 52 (a)
OneToMany
Species where no ortholog for ELAVL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ELAVL3 Gene

ENSEMBL:
Gene Tree for ELAVL3 (if available)
TreeFam:
Gene Tree for ELAVL3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ELAVL3: view image

Paralogs for ELAVL3 Gene

(4) SIMAP similar genes for ELAVL3 Gene using alignment to 4 proteins:

  • ELAV3_HUMAN
  • K7EPB5_HUMAN
  • L8E8Z0_HUMAN
  • Q96J71_HUMAN
genes like me logo Genes that share paralogs with ELAVL3: view

Variants for ELAVL3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ELAVL3 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
716500 Benign: not provided 11,466,211(-) G/A SYNONYMOUS_VARIANT
716501 Benign: not provided 11,466,783(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ELAVL3 Gene

Structural Variations from Database of Genomic Variants (DGV) for ELAVL3 Gene

Variant ID Type Subtype PubMed ID
esv3388355 CNV insertion 20981092
nsv1126512 CNV deletion 24896259
nsv519802 CNV loss 19592680
nsv819321 CNV gain 19587683
nsv819522 CNV loss 19587683

Variation tolerance for ELAVL3 Gene

Residual Variation Intolerance Score: 15.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ELAVL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ELAVL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELAVL3 Gene

Disorders for ELAVL3 Gene

MalaCards: The human disease database

(17) MalaCards diseases for ELAVL3 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ELAVL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ELAVL3 Gene

Publications for ELAVL3 Gene

  1. RNA-binding analyses of HuC and HuD with the VEGF and c-myc 3'-untranslated regions using a novel ELISA-based assay. (PMID: 10710437) King PH (Nucleic acids research 2000) 3 4 23
  2. A hippocampal protein associated with paraneoplastic neurologic syndrome and small cell lung carcinoma. (PMID: 7511893) Sakai K … Steinman L (Biochemical and biophysical research communications 1994) 3 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Novel products of the HUD, HUC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library. (PMID: 12209604) Behrends U … Mautner JM (International journal of cancer 2002) 3 23
  5. Localization of HuC (ELAVL3) to chromosome 19p13.2 by fluorescence in situ hybridization utilizing a novel tyramide labeling technique. (PMID: 9799595) Van Tine BA … King PH (Genomics 1998) 2 3

Products for ELAVL3 Gene

Sources for ELAVL3 Gene