Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ELAVL1 Gene

Aliases for ELAVL1 Gene

  • ELAV Like RNA Binding Protein 1 2 3 5
  • ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 1 (Hu Antigen R) 2 3
  • Embryonic Lethal, Abnormal Vision, Drosophila, Homolog-Like 1 2 3
  • Hu Antigen R 2 3
  • Hu-Antigen R 3 4
  • HUR 3 4
  • ELAV-Like Protein 1 3
  • ELAV1 3
  • MelG 3
  • Hua 3

External Ids for ELAVL1 Gene

Previous HGNC Symbols for ELAVL1 Gene

  • HUR

Previous GeneCards Identifiers for ELAVL1 Gene

  • GC19M007986
  • GC19M008132
  • GC19M007933
  • GC19M007929
  • GC19M008023
  • GC19M007693

Summaries for ELAVL1 Gene

Entrez Gene Summary for ELAVL1 Gene

  • The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012]

GeneCards Summary for ELAVL1 Gene

ELAVL1 (ELAV Like RNA Binding Protein 1) is a Protein Coding gene. Diseases associated with ELAVL1 include Pancreatic Ductal Adenocarcinoma and Juvenile Astrocytoma. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is ELAVL2.

UniProtKB/Swiss-Prot for ELAVL1 Gene

  • RNA-binding protein that binds to the 3-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462). Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3-UTR of target mRNAs (PubMed:8626503, PubMed:17632515, PubMed:18285462, PubMed:23519412). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5-UUUU[AG]UUU-3 motif in vitro (PubMed:8626503). With ZNF385A, binds the 3-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity).

Gene Wiki entry for ELAVL1 Gene

Additional gene information for ELAVL1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELAVL1 Gene

Genomics for ELAVL1 Gene

GeneHancer (GH) Regulatory Elements for ELAVL1 Gene

Promoters and enhancers for ELAVL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I008003 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 563.4 +0.3 322 3.3 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF207 ELAVL1 GC19P008006 ZNF557 XAB2 HNRNPM ZNF414 LOC105372266 CCL25 GC19M008006 GC19P007992
GH19I008004 Promoter 0.7 EPDnew 550.8 +2.1 2092 0.1 ADNP ZNF384 ELAVL1 GC19P007992
GH19I007521 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 73.1 +482.8 482802 2 MLX FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF143 ZNF548 SP3 NFYC MCOLN1 GC19M007510 HNRNPM ELAVL1 XAB2 ZNF557 MAP2K7 ZNF414 TIMM44 SNAPC2
GH19I008239 Enhancer 1.5 Ensembl ENCODE dbSUPER 88.4 -234.8 -234765 2 HDGF PKNOX1 CLOCK SMAD1 FOXA2 MLX ARNT ARID4B ZNF2 YY1 ENSG00000271717 ZNF558 HNRNPM ELAVL1 ZNF317 ENSG00000269300 XAB2 ZNF414 CERS4 ARHGEF18
GH19I008388 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 50.2 -387.2 -387185 10.3 MLX IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 NFYC GLIS1 RAB11B HNRNPM ELAVL1 ZNF699 ZNF558 XAB2 ZNF317 ENSG00000269300 MAP2K7 MARCH2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ELAVL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ELAVL1 gene promoter:

Genomic Locations for ELAVL1 Gene

Genomic Locations for ELAVL1 Gene
chr19:7,958,573-8,005,659
(GRCh38/hg38)
Size:
47,087 bases
Orientation:
Minus strand
chr19:8,023,457-8,070,543
(GRCh37/hg19)

Genomic View for ELAVL1 Gene

Genes around ELAVL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELAVL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELAVL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELAVL1 Gene

Proteins for ELAVL1 Gene

  • Protein details for ELAVL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15717-ELAV1_HUMAN
    Recommended name:
    ELAV-like protein 1
    Protein Accession:
    Q15717
    Secondary Accessions:
    • B4DVB8
    • Q53XN6
    • Q9BTT1

    Protein attributes for ELAVL1 Gene

    Size:
    326 amino acids
    Molecular mass:
    36092 Da
    Quaternary structure:
    • Monomer and homodimer (in vitro) (PubMed:17632515, PubMed:20219472). Interacts with ANP32A (PubMed:11729309). Interacts with ZNF385A; the interaction is indirect and mRNA-dependent and may regulate p53/TP53 expression (By similarity). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1 (PubMed:19029303). Interacts with AGO1 and AGO2 (PubMed:17932509). Interacts with IGF2BP2 and IGF2BP3 (PubMed:23640942). Interacts with HNRNPL (PubMed:18161049).

    Three dimensional structures from OCA and Proteopedia for ELAVL1 Gene

    Alternative splice isoforms for ELAVL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELAVL1 Gene

Post-translational modifications for ELAVL1 Gene

  • Methylated at Arg-217 by CARM1 in macrophages in response to LPS challenge.
  • Phosphorylated by MAPKAPK2 (PubMed:14517288). Phosphorylated by PRKCD (PubMed:18285462).
  • Ubiquitination at Lys50, Lys55, Lys72, Lys104, posLast=120120, posLast=191191, Lys313, and Lys320
  • Modification sites at PhosphoSitePlus

Other Protein References for ELAVL1 Gene

No data available for DME Specific Peptides for ELAVL1 Gene

Domains & Families for ELAVL1 Gene

Gene Families for ELAVL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ELAVL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15717

UniProtKB/Swiss-Prot:

ELAV1_HUMAN :
  • The first RRM (RNA recognition motif) domain is essential for binding to AU-rich elements.
  • Belongs to the RRM elav family.
Domain:
  • The first RRM (RNA recognition motif) domain is essential for binding to AU-rich elements.
Family:
  • Belongs to the RRM elav family.
genes like me logo Genes that share domains with ELAVL1: view

Function for ELAVL1 Gene

Molecular function for ELAVL1 Gene

GENATLAS Biochemistry:
Drosophila Elav-like 1 (embryonic,lethal,abnormal vision),HuR,widely expressed,shuttling the ERG class of mRNA to the cytoplasm in response to regulatory signals,where they become stabilized,translated or rapidly degraded
UniProtKB/Swiss-Prot Function:
RNA-binding protein that binds to the 3-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462). Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3-UTR of target mRNAs (PubMed:8626503, PubMed:17632515, PubMed:18285462, PubMed:23519412). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5-UUUU[AG]UUU-3 motif in vitro (PubMed:8626503). With ZNF385A, binds the 3-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity).

Phenotypes From GWAS Catalog for ELAVL1 Gene

Gene Ontology (GO) - Molecular Function for ELAVL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA,IEA 19561594
GO:0003725 double-stranded RNA binding IDA 21266579
GO:0003729 mRNA binding TAS 10660597
GO:0003730 mRNA 3-UTR binding ISS --
genes like me logo Genes that share ontologies with ELAVL1: view
genes like me logo Genes that share phenotypes with ELAVL1: view

Animal Models for ELAVL1 Gene

MGI Knock Outs for ELAVL1:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ELAVL1 Gene

Localization for ELAVL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELAVL1 Gene

Cytoplasm. Nucleus. Note=Translocates into the cytoplasm following phosphorylation by MAPKAPK2 (PubMed:14517288). Likewise, phosphorylation by PRKCD promotes translocation from the nucleus into the cytoplasm, where it is associated with free and cytoskeleton-bound polysomes (PubMed:18285462). {ECO:0000269 PubMed:14517288, ECO:0000269 PubMed:18285462}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ELAVL1 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ELAVL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 14517288
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA,IEA 14517288
GO:0005829 cytosol TAS --
GO:0016020 membrane HDA,IDA 19946888
genes like me logo Genes that share ontologies with ELAVL1: view

Pathways & Interactions for ELAVL1 Gene

genes like me logo Genes that share pathways with ELAVL1: view

Pathways by source for ELAVL1 Gene

SIGNOR curated interactions for ELAVL1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ELAVL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0007275 multicellular organism development TAS 9003489
GO:0043488 regulation of mRNA stability TAS --
GO:0045727 positive regulation of translation IDA 21613615
GO:0048255 mRNA stabilization IDA,IMP 19029303
genes like me logo Genes that share ontologies with ELAVL1: view

Drugs & Compounds for ELAVL1 Gene

(12) Drugs for ELAVL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(7) Additional Compounds for ELAVL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ELAVL1: view

Transcripts for ELAVL1 Gene

Unigene Clusters for ELAVL1 Gene

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ELAVL1 Gene

No ASD Table

Relevant External Links for ELAVL1 Gene

GeneLoc Exon Structure for
ELAVL1
ECgene alternative splicing isoforms for
ELAVL1

Expression for ELAVL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ELAVL1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ELAVL1 Gene



Protein tissue co-expression partners for ELAVL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ELAVL1 Gene:

ELAVL1

SOURCE GeneReport for Unigene cluster for ELAVL1 Gene:

Hs.184492

mRNA Expression by UniProt/SwissProt for ELAVL1 Gene:

Q15717-ELAV1_HUMAN
Tissue specificity: Ubiquitous. Detected in brain, liver, thymus and muscle.

Evidence on tissue expression from TISSUES for ELAVL1 Gene

  • Intestine(4.5)
  • Nervous system(4)
  • Lung(3.1)
  • Kidney(2.4)
  • Muscle(2.4)
  • Heart(2.1)
  • Blood(2)
  • Liver(2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with ELAVL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ELAVL1 Gene

Orthologs for ELAVL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ELAVL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ELAVL1 34 33
  • 99.69 (n)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 97 (a)
OneToMany
ELAVL1 33
  • 93.25 (n)
-- 34
  • 66 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ELAVL1 34 33
  • 93.15 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ELAVL1 34
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Elavl1 33 16 34
  • 91 (n)
rat
(Rattus norvegicus)
Mammalia Elavl1 33
  • 90.59 (n)
oppossum
(Monodelphis domestica)
Mammalia ELAVL1 34
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves ELAVL1 33 34
  • 86.3 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia elavl1 33
  • 79.24 (n)
Str.2596 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.5177 33
zebrafish
(Danio rerio)
Actinopterygii elavl1 34 33
  • 81 (a)
OneToMany
hug 33 34
  • 74.53 (n)
fruit fly
(Drosophila melanogaster)
Insecta fne 35 34
  • 58 (a)
elav 35 34
  • 52 (a)
EG:132E8.1 35
  • 46 (a)
Rbp9 34
  • 44 (a)
ManyToMany
Sxl 35
  • 44 (a)
CG5213 35
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea exc-7 35 34
  • 54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9670 34
  • 48 (a)
OneToMany
Species where no ortholog for ELAVL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ELAVL1 Gene

ENSEMBL:
Gene Tree for ELAVL1 (if available)
TreeFam:
Gene Tree for ELAVL1 (if available)

Paralogs for ELAVL1 Gene

(14) SIMAP similar genes for ELAVL1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ELAVL1: view

Variants for ELAVL1 Gene

Sequence variations from dbSNP and Humsavar for ELAVL1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000036976 -- 7,994,702(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000041193 -- 7,958,792(-) T/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1000089472 -- 7,996,163(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000112037 -- 7,983,860(-) G/A intron_variant
rs1000213826 -- 8,000,873(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ELAVL1 Gene

Variant ID Type Subtype PubMed ID
dgv1705n106 CNV deletion 24896259
nsv1071903 CNV deletion 25765185
nsv138435 CNV insertion 16902084
nsv472991 CNV novel sequence insertion 20440878
nsv833733 CNV gain 17160897
nsv833734 CNV loss 17160897
nsv953963 CNV deletion 24416366

Variation tolerance for ELAVL1 Gene

Residual Variation Intolerance Score: 16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ELAVL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ELAVL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELAVL1 Gene

Disorders for ELAVL1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ELAVL1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pancreatic ductal adenocarcinoma
  • ductal adenocarcinoma of the pancreas
juvenile astrocytoma
  • pediatric astrocytoma
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ELAVL1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ELAVL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ELAVL1 Gene

Publications for ELAVL1 Gene

  1. The x-ray crystal structure of the first RNA recognition motif and site-directed mutagenesis suggest a possible HuR redox sensing mechanism. (PMID: 20219472) Benoit RM … Auer M (Journal of molecular biology 2010) 3 4 22 58
  2. Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA. (PMID: 18285462) Doller A … Eberhardt W (Molecular and cellular biology 2008) 3 4 22 58
  3. Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2. (PMID: 14517288) Tran H … Nagamine Y (Molecular and cellular biology 2003) 3 4 22 58
  4. Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase. (PMID: 12237300) Li H … Laird-Offringa IA (The Journal of biological chemistry 2002) 3 4 22 58
  5. Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein. (PMID: 8626503) Ma WJ … Furneaux H (The Journal of biological chemistry 1996) 2 3 4 58

Products for ELAVL1 Gene

Sources for ELAVL1 Gene

Content
Loading form....