Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EIF5AL1 Gene

Aliases for EIF5AL1 Gene

  • Eukaryotic Translation Initiation Factor 5A-Like 1 2 3 5
  • Eukaryotic Translation Initiation Factor 5A Pseudogene 1 2 3
  • Eukaryotic Translation Initiation Factor 5A-1-Like 3
  • Eukaryotic Initiation Factor 5A Isoform 1-Like 4
  • EIF-5A-1-Like 4
  • EIF-5A1-Like 4
  • BA342M3.3 3
  • EIF5AP1 3

External Ids for EIF5AL1 Gene

Previous HGNC Symbols for EIF5AL1 Gene

  • EIF5AP1

Previous GeneCards Identifiers for EIF5AL1 Gene

  • GC10U900447
  • GC10P080943
  • GC10P081273
  • GC10P075267
  • GC10P081363

Summaries for EIF5AL1 Gene

GeneCards Summary for EIF5AL1 Gene

EIF5AL1 (Eukaryotic Translation Initiation Factor 5A-Like 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include RNA binding and translation elongation factor activity. An important paralog of this gene is EIF5A.

UniProtKB/Swiss-Prot for EIF5AL1 Gene

  • mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity).

Additional gene information for EIF5AL1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF5AL1 Gene

Genomics for EIF5AL1 Gene

GeneHancer (GH) Regulatory Elements for EIF5AL1 Gene


Top Transcription factor binding sites by QIAGEN in the EIF5AL1 gene promoter:
  • C/EBPbeta
  • c-Myb
  • deltaCREB
  • CREB
  • AML1a
  • Cart-1

Genomic Locations for EIF5AL1 Gene

Genomic Locations for EIF5AL1 Gene
chr10:79,512,601-79,516,440
(GRCh38/hg38)
Size:
3,840 bases
Orientation:
Plus strand
chr10:81,272,357-81,276,196
(GRCh37/hg19)
Size:
3,840 bases
Orientation:
Plus strand

Genomic View for EIF5AL1 Gene

Genes around EIF5AL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF5AL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF5AL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF5AL1 Gene

Proteins for EIF5AL1 Gene

  • Protein details for EIF5AL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IS14-IF5AL_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 5A-1-like
    Protein Accession:
    Q6IS14

    Protein attributes for EIF5AL1 Gene

    Size:
    154 amino acids
    Molecular mass:
    16773 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH70048.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for EIF5AL1 Gene

Post-translational modifications for EIF5AL1 Gene

  • eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EIF5AL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EIF5AL1 Gene

Domains & Families for EIF5AL1 Gene

Gene Families for EIF5AL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Suggested Antigen Peptide Sequences for EIF5AL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IS14

UniProtKB/Swiss-Prot:

IF5AL_HUMAN :
  • Belongs to the eIF-5A family.
Family:
  • Belongs to the eIF-5A family.
genes like me logo Genes that share domains with EIF5AL1: view

Function for EIF5AL1 Gene

Molecular function for EIF5AL1 Gene

UniProtKB/Swiss-Prot Function:
mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity).

Gene Ontology (GO) - Molecular Function for EIF5AL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003746 translation elongation factor activity IEA --
GO:0043022 ribosome binding IEA --
genes like me logo Genes that share ontologies with EIF5AL1: view
genes like me logo Genes that share phenotypes with EIF5AL1: view

Animal Model Products

miRNA for EIF5AL1 Gene

miRTarBase miRNAs that target EIF5AL1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF5AL1 Gene

Localization for EIF5AL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF5AL1 Gene

Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF5AL1 gene
Compartment Confidence
nucleus 3
endoplasmic reticulum 3

Gene Ontology (GO) - Cellular Components for EIF5AL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005643 nuclear pore IEA --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with EIF5AL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for EIF5AL1 Gene

Pathways & Interactions for EIF5AL1 Gene

SuperPathways for EIF5AL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EIF5AL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006414 translational elongation IEA --
GO:0006452 translational frameshifting IEA --
GO:0015031 protein transport IEA --
GO:0045901 positive regulation of translational elongation IEA --
genes like me logo Genes that share ontologies with EIF5AL1: view

No data available for Pathways by source and SIGNOR curated interactions for EIF5AL1 Gene

Drugs & Compounds for EIF5AL1 Gene

(1) Additional Compounds for EIF5AL1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Hypusine
  • N(6)-(4-amino-2-Hydroxybutyl)-L-lysine
34994-11-1
genes like me logo Genes that share compounds with EIF5AL1: view

Transcripts for EIF5AL1 Gene

mRNA/cDNA for EIF5AL1 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EIF5AL1 Gene

Eukaryotic translation initiation factor 5A-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF5AL1 Gene

No ASD Table

Relevant External Links for EIF5AL1 Gene

GeneLoc Exon Structure for
EIF5AL1
ECgene alternative splicing isoforms for
EIF5AL1

Expression for EIF5AL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF5AL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of EIF5AL1 Gene:

EIF5AL1

SOURCE GeneReport for Unigene cluster for EIF5AL1 Gene:

Hs.104825
genes like me logo Genes that share expression patterns with EIF5AL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF5AL1 Gene

Orthologs for EIF5AL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF5AL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC450554 33
  • 99.13 (n)
-- 34
  • 82 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Eif5a 34
  • 98 (a)
OneToMany
cow
(Bos Taurus)
Mammalia EIF5A 34
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 98 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 96 (a)
ManyToMany
-- 34
  • 90 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 88 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii eif5a 33
  • 72.29 (n)
fruit fly
(Drosophila melanogaster)
Insecta eIF-5A 34 33
  • 65.99 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011284 33
  • 65.32 (n)
worm
(Caenorhabditis elegans)
Secernentea iff-2 34 33
  • 62.28 (n)
ManyToMany
iff-1 34
  • 45 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR356C 33
  • 64.19 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ANB1 34 33
  • 62.96 (n)
ManyToMany
HYP2 34
  • 61 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E22199g 33
  • 62.04 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ELF5A-1 33
  • 59.49 (n)
rice
(Oryza sativa)
Liliopsida Os07g0112800 33
  • 59.64 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU05274 33
  • 65.51 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tif51 33
  • 62.56 (n)
Species where no ortholog for EIF5AL1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for EIF5AL1 Gene

ENSEMBL:
Gene Tree for EIF5AL1 (if available)
TreeFam:
Gene Tree for EIF5AL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EIF5AL1: view image

Paralogs for EIF5AL1 Gene

Paralogs for EIF5AL1 Gene

(2) SIMAP similar genes for EIF5AL1 Gene using alignment to 1 proteins:

  • IF5AL_HUMAN
genes like me logo Genes that share paralogs with EIF5AL1: view

Variants for EIF5AL1 Gene

Sequence variations from dbSNP and Humsavar for EIF5AL1 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000541403 -- 79,514,913(+) T/A 3_prime_UTR_variant
rs1000618802 -- 79,513,382(+) A/G 3_prime_UTR_variant
rs1001141439 -- 79,516,267(+) C/A 3_prime_UTR_variant
rs1001489190 -- 79,516,548(+) C/T downstream_transcript_variant
rs1001752271 -- 79,513,307(+) C/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for EIF5AL1 Gene

Variant ID Type Subtype PubMed ID
esv3623911 CNV gain 21293372
nsv436110 CNV deletion 17901297
nsv948082 CNV duplication 23825009

Variation tolerance for EIF5AL1 Gene

Residual Variation Intolerance Score: 64.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EIF5AL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF5AL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF5AL1 Gene

Disorders for EIF5AL1 Gene

Additional Disease Information for EIF5AL1

No disorders were found for EIF5AL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF5AL1 Gene

Publications for EIF5AL1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58
  3. Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover. (PMID: 24999758) Elzi DJ … Shiio Y (Journal of proteome research 2014) 3 58
  4. Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins. (PMID: 23891004) Stehling O … Lill R (Cell metabolism 2013) 3 58
  5. Differential expression of eIF5A-1 and eIF5A-2 in human cancer cells. (PMID: 16519677) Clement PM … Park MH (The FEBS journal 2006) 3 58

Products for EIF5AL1 Gene

Sources for EIF5AL1 Gene

Content
Loading form....