Aliases for EIF5A Gene

Aliases for EIF5A Gene

  • Eukaryotic Translation Initiation Factor 5A 2 3 5
  • EIF-5A 2 3 4
  • Eukaryotic Translation Initiation Factor 5A-1 3 4
  • Rev-Binding Factor 3 4
  • EIF5A1 2 3
  • EIF-4D 3 4
  • Eukaryotic Initiation Factor 5A Isoform 1 4
  • Eukaryotic Initiation Factor 5A 3
  • MGC104255 2
  • MGC99547 2
  • EIF-5A-1 4
  • EIF-5A1 4
  • EIF5AI 3
  • EIF5A 5

External Ids for EIF5A Gene

Previous GeneCards Identifiers for EIF5A Gene

  • GC17P007609
  • GC17P007940
  • GC17P007153
  • GC17P007411
  • GC17P007412
  • GC17P007151
  • GC17P007210
  • GC17P007104

Summaries for EIF5A Gene

GeneCards Summary for EIF5A Gene

EIF5A (Eukaryotic Translation Initiation Factor 5A) is a Protein Coding gene. Diseases associated with EIF5A include Human Immunodeficiency Virus Type 1 and Retinitis Pigmentosa 14. Among its related pathways are eIF5A regulation in response to inhibition of the nuclear export system and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include protein N-terminus binding. An important paralog of this gene is EIF5AL1.

UniProtKB/Swiss-Prot Summary for EIF5A Gene

  • mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.

Gene Wiki entry for EIF5A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EIF5A Gene

Genomics for EIF5A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for EIF5A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EIF5A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EIF5A

Top Transcription factor binding sites by QIAGEN in the EIF5A gene promoter:
  • COUP
  • COUP-TF
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for EIF5A Gene

Genomic Locations for EIF5A Gene
chr17:7,306,999-7,312,463
(GRCh38/hg38)
Size:
5,465 bases
Orientation:
Plus strand
chr17:7,210,318-7,215,782
(GRCh37/hg19)
Size:
5,465 bases
Orientation:
Plus strand

Genomic View for EIF5A Gene

Genes around EIF5A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF5A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF5A Gene

Proteins for EIF5A Gene

  • Protein details for EIF5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63241-IF5A1_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 5A-1
    Protein Accession:
    P63241
    Secondary Accessions:
    • A8K9A0
    • D3DTP2
    • P10159
    • Q16182
    • Q7L7L3
    • Q7Z4L1
    • Q9D0G2

    Protein attributes for EIF5A Gene

    Size:
    154 amino acids
    Molecular mass:
    16832 Da
    Quaternary structure:
    • Interacts with DHPS, with SDCBP and DOHH. Interacts with HIV-1 protein Rev. Found in a complex with Ran and XPO4. The hypusine modification increases the interaction with XPO4.

    Three dimensional structures from OCA and Proteopedia for EIF5A Gene

    Alternative splice isoforms for EIF5A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF5A Gene

Post-translational modifications for EIF5A Gene

  • Acetylated. Deacetylated by SIRT2.
  • eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for EIF5A Gene

Domains & Families for EIF5A Gene

Gene Families for EIF5A Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Protein Domains for EIF5A Gene

InterPro:
Blocks:
  • Eukaryotic initiation factor 5A hypusine (eIF-5A)
ProtoNet:

Suggested Antigen Peptide Sequences for EIF5A Gene

GenScript: Design optimal peptide antigens:
  • eIF-4D (IF5A1_HUMAN)
  • UORF A (Q8WXQ9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P63241

UniProtKB/Swiss-Prot:

IF5A1_HUMAN :
  • Belongs to the eIF-5A family.
Family:
  • Belongs to the eIF-5A family.
genes like me logo Genes that share domains with EIF5A: view

Function for EIF5A Gene

Molecular function for EIF5A Gene

UniProtKB/Swiss-Prot Function:
mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.
GENATLAS Biochemistry:
eukaryotic translation initiation factor 5 A complexing with CRM1,cofactor for the HIV-1 transactivator Rev

Phenotypes From GWAS Catalog for EIF5A Gene

Gene Ontology (GO) - Molecular Function for EIF5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 15303967
GO:0003746 translation elongation factor activity IBA,ISS --
GO:0005515 protein binding IPI 9442029
GO:0017070 U6 snRNA binding IDA 9285100
GO:0043022 ribosome binding IEA --
genes like me logo Genes that share ontologies with EIF5A: view
genes like me logo Genes that share phenotypes with EIF5A: view

Animal Model Products

CRISPR Products

miRNA for EIF5A Gene

miRTarBase miRNAs that target EIF5A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF5A

Clone Products

  • Addgene plasmids for EIF5A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF5A Gene

Localization for EIF5A Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF5A Gene

Cytoplasm. Nucleus. Endoplasmic reticulum membrane. Peripheral membrane protein. Cytoplasmic side. Nucleus, nuclear pore complex. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF5A gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 5
cytosol 5
extracellular 2
cytoskeleton 2
mitochondrion 2
plasma membrane 1
peroxisome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EIF5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 12210765
GO:0005642 annulate lamellae IDA 12210765
GO:0005643 nuclear pore IEA,IDA 10381392
GO:0005737 cytoplasm IEA,IDA 12210765
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with EIF5A: view

Pathways & Interactions for EIF5A Gene

genes like me logo Genes that share pathways with EIF5A: view

Pathways by source for EIF5A Gene

Gene Ontology (GO) - Biological Process for EIF5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006406 mRNA export from nucleus IMP 9465063
GO:0006412 translation IEA --
GO:0006414 translational elongation IEA --
GO:0006452 translational frameshifting IEA --
GO:0006611 protein export from nucleus IMP 8596953
genes like me logo Genes that share ontologies with EIF5A: view

No data available for SIGNOR curated interactions for EIF5A Gene

Drugs & Compounds for EIF5A Gene

(15) Drugs for EIF5A Gene - From: ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Mimosine Pharma 0
SNS01-T Pharma 0

(13) Additional Compounds for EIF5A Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Hypusine
  • N(6)-(4-amino-2-Hydroxybutyl)-L-lysine
34994-11-1

(1) ApexBio Compounds for EIF5A Gene

Compound Action Cas Number
L-Mimosine 500-44-7
genes like me logo Genes that share compounds with EIF5A: view

Transcripts for EIF5A Gene

mRNA/cDNA for EIF5A Gene

6 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF5A

Clone Products

  • Addgene plasmids for EIF5A

Alternative Splicing Database (ASD) splice patterns (SP) for EIF5A Gene

No ASD Table

Relevant External Links for EIF5A Gene

GeneLoc Exon Structure for
EIF5A

Expression for EIF5A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EIF5A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EIF5A Gene

This gene is overexpressed in Salivary gland (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EIF5A Gene



Protein tissue co-expression partners for EIF5A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EIF5A

SOURCE GeneReport for Unigene cluster for EIF5A Gene:

Hs.534314

mRNA Expression by UniProt/SwissProt for EIF5A Gene:

P63241-IF5A1_HUMAN
Tissue specificity: Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level).

Evidence on tissue expression from TISSUES for EIF5A Gene

  • Nervous system(4.8)
  • Muscle(4.6)
  • Liver(4.6)
  • Lung(4.3)
  • Skin(3.6)
  • Intestine(3.2)
  • Kidney(2.6)
  • Heart(2.4)
  • Pancreas(2.4)
  • Spleen(2.3)
  • Stomach(2.3)
  • Lymph node(2.3)
  • Blood(2.3)
  • Eye(2.2)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with EIF5A: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF5A Gene

Orthologs for EIF5A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF5A Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia -- 31
  • 100 (a)
OneToMany
EIF5A 30
  • 95.02 (n)
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 100 (a)
OneToMany
EIF5A 30
  • 99.78 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 99 (a)
ManyToMany
-- 31
  • 94 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Eif5a 30 17 31
  • 97.19 (n)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Eif5a 30
  • 96.54 (n)
Cow
(Bos Taurus)
Mammalia EIF5A 30 31
  • 94.59 (n)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 90 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia eif5a 30
  • 73.59 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20890 30
Zebrafish
(Danio rerio)
Actinopterygii eif5a2 30
  • 71.68 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta eIF-5A 31 32
  • 64 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea iff-2 31 32
  • 59 (a)
ManyToMany
iff-1 31 32
  • 48 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HYP2 31 33
  • 62 (a)
ManyToMany
ANB1 31
  • 61 (a)
ManyToMany
Rice
(Oryza sativa)
Liliopsida Os.23719 30
Species where no ortholog for EIF5A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for EIF5A Gene

ENSEMBL:
Gene Tree for EIF5A (if available)
TreeFam:
Gene Tree for EIF5A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EIF5A: view image

Paralogs for EIF5A Gene

Paralogs for EIF5A Gene

(2) SIMAP similar genes for EIF5A Gene using alignment to 3 proteins:

  • IF5A1_HUMAN
  • I3L397_HUMAN
  • I3L504_HUMAN

Pseudogenes.org Pseudogenes for EIF5A Gene

genes like me logo Genes that share paralogs with EIF5A: view

Variants for EIF5A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EIF5A Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs1555537758 Likely Benign: not specified 7,311,574(+) C/T INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for EIF5A Gene

Structural Variations from Database of Genomic Variants (DGV) for EIF5A Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
esv2665200 CNV deletion 23128226
esv3639865 CNV loss 21293372
esv3639866 CNV gain 21293372
nsv1143847 CNV deletion 24896259
nsv1963 CNV deletion 18451855
nsv457659 CNV loss 19166990
nsv509650 CNV insertion 20534489
nsv574322 CNV loss 21841781
nsv827872 CNV gain 20364138
nsv827873 CNV gain 20364138
nsv952118 CNV deletion 24416366
nsv960048 CNV duplication 23825009

Variation tolerance for EIF5A Gene

Residual Variation Intolerance Score: 54.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EIF5A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF5A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF5A Gene

Disorders for EIF5A Gene

MalaCards: The human disease database

(4) MalaCards diseases for EIF5A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
human immunodeficiency virus type 1
  • human immunodeficiency virus type 1, susceptibility to
retinitis pigmentosa 14
  • rp14
nephronophthisis 3
  • nphp3
syndromic x-linked intellectual disability snyder type
  • mental retardation, x-linked, syndromic, snyder-robinson type
- elite association - COSMIC cancer census association via MalaCards
Search EIF5A in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with EIF5A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF5A Gene

Publications for EIF5A Gene

  1. The effect of hypusine modification on the intracellular localization of eIF5A. (PMID: 19379712) Lee SB … Park MH (Biochemical and biophysical research communications 2009) 3 4 23
  2. Mutational analyses of human eIF5A-1--identification of amino acid residues critical for eIF5A activity and hypusine modification. (PMID: 18067580) Cano VS … Park MH (The FEBS journal 2008) 3 4 23
  3. Specificity of the deoxyhypusine hydroxylase-eukaryotic translation initiation factor (eIF5A) interaction: identification of amino acid residues of the enzyme required for binding of its substrate, deoxyhypusine-containing eIF5A. (PMID: 17213197) Kang KR … Park MH (The Journal of biological chemistry 2007) 3 4 23
  4. Eukaryotic translation initiation factor 5A induces apoptosis in colon cancer cells and associates with the nucleus in response to tumour necrosis factor alpha signalling. (PMID: 17187778) Taylor CA … Thompson JE (Experimental cell research 2007) 3 4 23
  5. Differential expression of eIF5A-1 and eIF5A-2 in human cancer cells. (PMID: 16519677) Clement PM … Park MH (The FEBS journal 2006) 3 4 23

Products for EIF5A Gene

  • Signalway Proteins for EIF5A

Sources for EIF5A Gene