Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S initiation complex. The resulting functional 80S ribosomal initiation complex is then active in peptidyl transfer and chain elongations (summary by Si et al., 1996 [PubMed 8663286]).[suppl... See more...

Aliases for EIF5 Gene

Aliases for EIF5 Gene

  • Eukaryotic Translation Initiation Factor 5 2 3 4 5
  • EIF-5 3 4
  • EIF-5A 3
  • EIF5 5

External Ids for EIF5 Gene

Previous GeneCards Identifiers for EIF5 Gene

  • GC14P101191
  • GC14P097615
  • GC14P101790
  • GC14P102870
  • GC14P103800
  • GC14P083978

Summaries for EIF5 Gene

Entrez Gene Summary for EIF5 Gene

  • Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S initiation complex. The resulting functional 80S ribosomal initiation complex is then active in peptidyl transfer and chain elongations (summary by Si et al., 1996 [PubMed 8663286]).[supplied by OMIM, May 2010]

GeneCards Summary for EIF5 Gene

EIF5 (Eukaryotic Translation Initiation Factor 5) is a Protein Coding gene. Diseases associated with EIF5 include Leukoencephalopathy With Vanishing White Matter. Among its related pathways are Viral mRNA Translation and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include binding.

UniProtKB/Swiss-Prot Summary for EIF5 Gene

  • Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).

Gene Wiki entry for EIF5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EIF5 Gene

Genomics for EIF5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for EIF5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EIF5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EIF5

Top Transcription factor binding sites by QIAGEN in the EIF5 gene promoter:
  • GATA-1
  • MIF-1
  • Pax-6
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for EIF5 Gene

Latest Assembly
chr14:103,333,544-103,345,025
(GRCh38/hg38)
Size:
11,482 bases
Orientation:
Plus strand

Previous Assembly
chr14:103,800,574-103,811,362
(GRCh37/hg19 by Entrez Gene)
Size:
10,789 bases
Orientation:
Plus strand

chr14:103,799,881-103,811,362
(GRCh37/hg19 by Ensembl)
Size:
11,482 bases
Orientation:
Plus strand

Genomic View for EIF5 Gene

Genes around EIF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF5 Gene

Proteins for EIF5 Gene

  • Protein details for EIF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55010-IF5_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 5
    Protein Accession:
    P55010
    Secondary Accessions:
    • Q53XB3
    • Q9H5N2
    • Q9UG48

    Protein attributes for EIF5 Gene

    Size:
    431 amino acids
    Molecular mass:
    49223 Da
    Quaternary structure:
    • Interacts with FMR1 isoform 6; this interaction occurs in a RNA-dependent manner.

    Three dimensional structures from OCA and Proteopedia for EIF5 Gene

neXtProt entry for EIF5 Gene

Post-translational modifications for EIF5 Gene

  • Ubiquitination at Lys55
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EIF5 Gene

Domains & Families for EIF5 Gene

Gene Families for EIF5 Gene

Protein Domains for EIF5 Gene

InterPro:
Blocks:
  • Translation initiation factor IF5
  • eIF4-gamma/eIF5/eIF2-epsilon

Suggested Antigen Peptide Sequences for EIF5 Gene

GenScript: Design optimal peptide antigens:
  • Eukaryotic translation initiation factor 5 (IF5_HUMAN)
  • EIF5 protein (Q05DF3_HUMAN)
  • EIF5 protein (Q32Q19_HUMAN)
  • EIF5 protein (Q6IBU0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P55010

UniProtKB/Swiss-Prot:

IF5_HUMAN :
  • Belongs to the eIF-2-beta/eIF-5 family.
Family:
  • Belongs to the eIF-2-beta/eIF-5 family.
genes like me logo Genes that share domains with EIF5: view

Function for EIF5 Gene

Molecular function for EIF5 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).
GENATLAS Biochemistry:
eukaryotic translation initiation factor 5,hydrolyzing GTP of the 40S ribosomal initiation complex

Phenotypes From GWAS Catalog for EIF5 Gene

Gene Ontology (GO) - Molecular Function for EIF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003723 RNA binding HDA 22681889
GO:0003743 translation initiation factor activity IBA 21873635
GO:0005092 GDP-dissociation inhibitor activity IBA 21873635
GO:0005515 protein binding IPI 24658146
genes like me logo Genes that share ontologies with EIF5: view
genes like me logo Genes that share phenotypes with EIF5: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF5 Gene

Localization for EIF5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF5 gene
Compartment Confidence
plasma membrane 5
cytosol 5
nucleus 3
mitochondrion 2
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EIF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 NOT nucleus IDA 12426392
GO:0005737 cytoplasm IDA 12426392
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with EIF5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF5 Gene

Pathways & Interactions for EIF5 Gene

genes like me logo Genes that share pathways with EIF5: view

Pathways by source for EIF5 Gene

1 KEGG pathway for EIF5 Gene
1 Qiagen pathway for EIF5 Gene
  • eIF2 Pathway
1 Cell Signaling Technology pathway for EIF5 Gene

SIGNOR curated interactions for EIF5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for EIF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001731 formation of translation preinitiation complex IBA 21873635
GO:0001732 formation of cytoplasmic translation initiation complex IBA 21873635
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA --
GO:0006446 regulation of translational initiation IDA 22156057
genes like me logo Genes that share ontologies with EIF5: view

Drugs & Compounds for EIF5 Gene

(4) Drugs for EIF5 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(2) Additional Compounds for EIF5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with EIF5: view

Transcripts for EIF5 Gene

mRNA/cDNA for EIF5 Gene

2 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EIF5

Alternative Splicing Database (ASD) splice patterns (SP) for EIF5 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13 ^
SP1: - - - - - - -
SP2: - - - - - - - -
SP3:
SP4:
SP5: - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - -
SP10: - - -
SP11: - - - -
SP12: - -
SP13: - - - - - - - - -
SP14: -
SP15: -
SP16:

ExUns: 14 ^ 15 ^ 16a · 16b ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for EIF5 Gene

GeneLoc Exon Structure for
EIF5

Expression for EIF5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EIF5 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EIF5 Gene



Protein tissue co-expression partners for EIF5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EIF5

SOURCE GeneReport for Unigene cluster for EIF5 Gene:

Hs.433702

Evidence on tissue expression from TISSUES for EIF5 Gene

  • Nervous system(5)
  • Liver(4.8)
  • Skin(4)
  • Lung(3.9)
  • Intestine(3.5)
  • Pancreas(3.1)
  • Stomach(3)
  • Kidney(2.9)
  • Heart(2.9)
  • Muscle(2.7)
  • Eye(2.4)
  • Blood(2.2)
  • Spleen(2.2)
  • Lymph node(2.1)
  • Bone marrow(2.1)
  • Bone(2)
genes like me logo Genes that share expression patterns with EIF5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF5 Gene

Orthologs for EIF5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia EIF5 29 30
  • 99.61 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia EIF5 30
  • 96 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia EIF5 29 30
  • 93.18 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia EIF5 29 30
  • 93.01 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia EIF5 30
  • 93 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Eif5 29
  • 92.46 (n)
Mouse
(Mus musculus)
Mammalia Eif5 29 16 30
  • 92 (n)
OneToOne
Chicken
(Gallus gallus)
Aves EIF5 29 30
  • 86.56 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia EIF5 30
  • 91 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia eif5 29
  • 80.88 (n)
Str.6939 29
Zebrafish
(Danio rerio)
Actinopterygii eif5 29 30
  • 72.02 (n)
OneToOne
wufb54h04 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6088 29
Fruit Fly
(Drosophila melanogaster)
Insecta eIF5 29 30 31
  • 58.25 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011203 29
  • 54.43 (n)
Worm
(Caenorhabditis elegans)
Secernentea C37C3.2 29 30
  • 54.8 (n)
OneToOne
C37C3.2a 31
  • 49 (a)
C37C3.2b 31
  • 44 (a)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AER400C 29
  • 59.65 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06095g 29
  • 54.47 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIF5 29 30 32
  • 51.68 (n)
OneToOne
Barley
(Hordeum vulgare)
Liliopsida Hv.2257 29
Rice
(Oryza sativa)
Liliopsida Os.8401 29
Corn
(Zea mays)
Liliopsida Zm.97 29
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.8311 30
  • 56 (a)
OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC2F7.05c 29
  • 52.78 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU00366 29
  • 50 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.5403 29
Species where no ortholog for EIF5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for EIF5 Gene

ENSEMBL:
Gene Tree for EIF5 (if available)
TreeFam:
Gene Tree for EIF5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EIF5: view image
Alliance of Genome Resources:
Additional Orthologs for EIF5

Paralogs for EIF5 Gene

Pseudogenes.org Pseudogenes for EIF5 Gene

genes like me logo Genes that share paralogs with EIF5: view

No data available for Paralogs for EIF5 Gene

Variants for EIF5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EIF5 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs115589341 Benign: not provided 103,339,164(+) C/T
NM_001969.5(EIF5):c.745-8C>T
INTRON
VAR_036467 A breast cancer sample p.Lys418Met

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for EIF5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for EIF5 Gene

Variant ID Type Subtype PubMed ID
nsv1054574 CNV loss 25217958
nsv1118299 CNV deletion 24896259
nsv827067 CNV gain 20364138
nsv9168 CNV loss 18304495

Variation tolerance for EIF5 Gene

Residual Variation Intolerance Score: 7.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EIF5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF5
Leiden Open Variation Database (LOVD)
EIF5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF5 Gene

Disorders for EIF5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for EIF5 Gene - From: COP

Disorder Aliases PubMed IDs
leukoencephalopathy with vanishing white matter
  • vwm
- elite association - COSMIC cancer census association via MalaCards
Search EIF5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for EIF5

genes like me logo Genes that share disorders with EIF5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF5 Gene

Publications for EIF5 Gene

  1. Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5). (PMID: 8663286) Si K … Maitra U (The Journal of biological chemistry 1996) 2 3 4
  2. Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolin. (PMID: 24658146) Taha MS … Ahmadian MR (PloS one 2014) 3 4
  3. The crystal structure of the carboxy-terminal domain of human translation initiation factor eIF5. (PMID: 16781736) Bieniossek C … Baumann U (Journal of molecular biology 2006) 3 22
  4. Structure of the eukaryotic initiation factor (eIF) 5 reveals a fold common to several translation factors. (PMID: 16584190) Conte MR … Proud CG (Biochemistry 2006) 3 22
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for EIF5 Gene

Sources for EIF5 Gene