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Aliases for EIF5 Gene

Aliases for EIF5 Gene

  • Eukaryotic Translation Initiation Factor 5 2 3 3 5
  • EIF-5 3 4
  • EIF-5A 3

External Ids for EIF5 Gene

Previous GeneCards Identifiers for EIF5 Gene

  • GC14P101191
  • GC14P097615
  • GC14P101790
  • GC14P102870
  • GC14P103800
  • GC14P083978

Summaries for EIF5 Gene

Entrez Gene Summary for EIF5 Gene

  • Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S initiation complex. The resulting functional 80S ribosomal initiation complex is then active in peptidyl transfer and chain elongations (summary by Si et al., 1996 [PubMed 8663286]).[supplied by OMIM, May 2010]

GeneCards Summary for EIF5 Gene

EIF5 (Eukaryotic Translation Initiation Factor 5) is a Protein Coding gene. Diseases associated with EIF5 include Leukoencephalopathy With Vanishing White Matter. Among its related pathways are Translation Factors and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. Gene Ontology (GO) annotations related to this gene include binding.

UniProtKB/Swiss-Prot for EIF5 Gene

  • Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).

Gene Wiki entry for EIF5 Gene

Additional gene information for EIF5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF5 Gene

Genomics for EIF5 Gene

GeneHancer (GH) Regulatory Elements for EIF5 Gene

Promoters and enhancers for EIF5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J103332 Promoter/Enhancer 2.7 UCNEbase EPDnew Ensembl ENCODE dbSUPER 650.7 +0.8 814 4.7 CLOCK ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC SSRP1 ZNF610 GLIS1 ENSG00000259775 EIF5 BAG5 XRCC3 CKB KLC1 MARK3 ENSG00000260285 ZFYVE21 PIR56134
GH14J103117 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.5 -208.8 -208762 14.2 HDGF PKNOX1 SMAD1 ARID4B SIN3A ZNF766 ZNF143 SP3 SP5 REST TNFAIP2 LINC00677 RCOR1 XRCC3 WDR20 NDUFB4P11 ENSG00000259444 TRAF3 EIF5 MARK3
GH14J103355 Enhancer 1.1 Ensembl ENCODE 12 +21.4 21373 0.2 PKNOX1 ZFP64 SIN3A ZNF2 RAD21 ZNF366 SCRT2 FOS RCOR1 SMARCA5 XRCC3 MARK3 RCOR1 EIF5 ENSG00000270591 GC14M103366 GC14M103345
GH14J103403 Enhancer 0.9 Ensembl ENCODE dbSUPER 11.2 +71.5 71470 2.4 OSR2 PRDM6 PRDM10 PRDM1 ATF2 MARK3 EIF5 RPL10AP1 GC14M103376
GH14J103354 Enhancer 0.8 ENCODE 12 +21.1 21115 0.2 PKNOX1 MZF1 SIN3A ZNF2 ZNF366 SCRT2 FOS RCOR1 GATAD2B ZNF217 MARK3 EIF5 GC14M103345 GC14M103366
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around EIF5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EIF5 gene promoter:

Genomic Locations for EIF5 Gene

Genomic Locations for EIF5 Gene
chr14:103,333,544-103,345,025
(GRCh38/hg38)
Size:
11,482 bases
Orientation:
Plus strand
chr14:103,799,881-103,811,362
(GRCh37/hg19)

Genomic View for EIF5 Gene

Genes around EIF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF5 Gene

Proteins for EIF5 Gene

  • Protein details for EIF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55010-IF5_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 5
    Protein Accession:
    P55010
    Secondary Accessions:
    • Q53XB3
    • Q9H5N2
    • Q9UG48

    Protein attributes for EIF5 Gene

    Size:
    431 amino acids
    Molecular mass:
    49223 Da
    Quaternary structure:
    • Interacts with FMR1 isoform 6; this interaction occurs in a RNA-dependent manner.

    Three dimensional structures from OCA and Proteopedia for EIF5 Gene

neXtProt entry for EIF5 Gene

Post-translational modifications for EIF5 Gene

  • Ubiquitination at isoforms=55
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EIF5 Gene

Domains & Families for EIF5 Gene

Gene Families for EIF5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for EIF5 Gene

Graphical View of Domain Structure for InterPro Entry

P55010

UniProtKB/Swiss-Prot:

IF5_HUMAN :
  • Belongs to the eIF-2-beta/eIF-5 family.
Family:
  • Belongs to the eIF-2-beta/eIF-5 family.
genes like me logo Genes that share domains with EIF5: view

Function for EIF5 Gene

Molecular function for EIF5 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).
GENATLAS Biochemistry:
eukaryotic translation initiation factor 5,hydrolyzing GTP of the 40S ribosomal initiation complex

Phenotypes From GWAS Catalog for EIF5 Gene

Gene Ontology (GO) - Molecular Function for EIF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0003743 translation initiation factor activity NAS 8663286
GO:0003924 GTPase activity TAS 8663286
GO:0005488 binding IEA --
GO:0005515 protein binding IPI 10982835
genes like me logo Genes that share ontologies with EIF5: view
genes like me logo Genes that share phenotypes with EIF5: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF5 Gene

Localization for EIF5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF5 gene
Compartment Confidence
plasma membrane 5
cytosol 5
nucleus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EIF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 NOT nucleus IDA 12426392
GO:0005737 cytoplasm IDA,TAS 12426392
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with EIF5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF5 Gene

Pathways & Interactions for EIF5 Gene

genes like me logo Genes that share pathways with EIF5: view

Pathways by source for EIF5 Gene

1 KEGG pathway for EIF5 Gene
1 Qiagen pathway for EIF5 Gene
1 Cell Signaling Technology pathway for EIF5 Gene

SIGNOR curated interactions for EIF5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for EIF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001731 formation of translation preinitiation complex IEA --
GO:0006412 translation IEA --
GO:0006413 translational initiation NAS 8663286
GO:0006446 regulation of translational initiation IDA 22156057
GO:0090630 activation of GTPase activity IEA --
genes like me logo Genes that share ontologies with EIF5: view

Drugs & Compounds for EIF5 Gene

(4) Drugs for EIF5 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(2) Additional Compounds for EIF5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with EIF5: view

Transcripts for EIF5 Gene

mRNA/cDNA for EIF5 Gene

Unigene Clusters for EIF5 Gene

Eukaryotic translation initiation factor 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF5 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13 ^
SP1: - - - - - - -
SP2: - - - - - - - -
SP3:
SP4:
SP5: - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - -
SP10: - - -
SP11: - - - -
SP12: - -
SP13: - - - - - - - - -
SP14: -
SP15: -
SP16:

ExUns: 14 ^ 15 ^ 16a · 16b ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for EIF5 Gene

GeneLoc Exon Structure for
EIF5
ECgene alternative splicing isoforms for
EIF5

Expression for EIF5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF5 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EIF5 Gene



Protein tissue co-expression partners for EIF5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF5 Gene:

EIF5

SOURCE GeneReport for Unigene cluster for EIF5 Gene:

Hs.433702

Evidence on tissue expression from TISSUES for EIF5 Gene

  • Nervous system(4.9)
  • Liver(4.7)
  • Lung(3.7)
  • Skin(3.6)
  • Intestine(3.2)
  • Pancreas(2.8)
  • Stomach(2.8)
  • Eye(2.4)
  • Heart(2.4)
  • Kidney(2.2)
  • Bone marrow(2.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with EIF5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF5 Gene

Orthologs for EIF5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF5 34 33
  • 99.61 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EIF5 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF5 34 33
  • 93.18 (n)
OneToOne
cow
(Bos Taurus)
Mammalia EIF5 34 33
  • 93.01 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF5 34
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif5 33
  • 92.46 (n)
mouse
(Mus musculus)
Mammalia Eif5 16 34 33
  • 92 (n)
chicken
(Gallus gallus)
Aves EIF5 34 33
  • 86.56 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF5 34
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif5 33
  • 80.88 (n)
Str.6939 33
zebrafish
(Danio rerio)
Actinopterygii eif5 34 33
  • 72.02 (n)
OneToOne
wufb54h04 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6088 33
fruit fly
(Drosophila melanogaster)
Insecta eIF5 34 35 33
  • 58.25 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011203 33
  • 54.43 (n)
worm
(Caenorhabditis elegans)
Secernentea C37C3.2 34 33
  • 54.8 (n)
OneToOne
C37C3.2a 35
  • 49 (a)
C37C3.2b 35
  • 44 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER400C 33
  • 59.65 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06095g 33
  • 54.47 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIF5 36 34 33
  • 51.68 (n)
rice
(Oryza sativa)
Liliopsida Os.8401 33
barley
(Hordeum vulgare)
Liliopsida Hv.2257 33
corn
(Zea mays)
Liliopsida Zm.97 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8311 34
  • 56 (a)
OneToOne
Cin.5403 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC2F7.05c 33
  • 52.78 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00366 33
  • 50 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5403 33
Species where no ortholog for EIF5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF5 Gene

ENSEMBL:
Gene Tree for EIF5 (if available)
TreeFam:
Gene Tree for EIF5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EIF5: view image

Paralogs for EIF5 Gene

Pseudogenes.org Pseudogenes for EIF5 Gene

genes like me logo Genes that share paralogs with EIF5: view

No data available for Paralogs for EIF5 Gene

Variants for EIF5 Gene

Sequence variations from dbSNP and Humsavar for EIF5 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
VAR_036467 A breast cancer sample p.Lys418Met
rs1000015216 -- 103,344,767(+) C/T 3_prime_UTR_variant
rs1000094663 -- 103,339,807(+) G/A intron_variant
rs1000211664 -- 103,344,101(+) C/A 3_prime_UTR_variant
rs1000610667 -- 103,341,747(+) T/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for EIF5 Gene

Variant ID Type Subtype PubMed ID
nsv1054574 CNV loss 25217958
nsv1118299 CNV deletion 24896259
nsv827067 CNV gain 20364138
nsv9168 CNV loss 18304495

Variation tolerance for EIF5 Gene

Residual Variation Intolerance Score: 7.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EIF5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF5 Gene

Disorders for EIF5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for EIF5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
leukoencephalopathy with vanishing white matter
  • cle
- elite association - COSMIC cancer census association via MalaCards
Search EIF5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for EIF5

genes like me logo Genes that share disorders with EIF5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF5 Gene

Publications for EIF5 Gene

  1. Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5). (PMID: 8663286) Si K … Maitra U (The Journal of biological chemistry 1996) 2 3 4 58
  2. Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolin. (PMID: 24658146) Taha MS … Ahmadian MR (PloS one 2014) 3 4 58
  3. The crystal structure of the carboxy-terminal domain of human translation initiation factor eIF5. (PMID: 16781736) Bieniossek C … Baumann U (Journal of molecular biology 2006) 3 22 58
  4. Structure of the eukaryotic initiation factor (eIF) 5 reveals a fold common to several translation factors. (PMID: 16584190) Conte MR … Proud CG (Biochemistry 2006) 3 22 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for EIF5 Gene

Sources for EIF5 Gene

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