Aliases for EIF4G3 Gene
External Ids for EIF4G3 Gene
Previous GeneCards Identifiers for EIF4G3 Gene
The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016]
GeneCards Summary for EIF4G3 Gene
EIF4G3 (Eukaryotic Translation Initiation Factor 4 Gamma 3) is a Protein Coding gene. Diseases associated with EIF4G3 include Mental Retardation, Autosomal Dominant 24 and Mouth Disease. Among its related pathways are Regulation of lipid metabolism Insulin signaling-generic cascades and Innate Immune System. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is EIF4G1.
UniProtKB/Swiss-Prot Summary for EIF4G3 Gene
Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1.